A team of scientists discovered that ceramides accumulate in muscles during aging, leading to a decline in muscle function. Treating old mice with ceramide blockers prevented age-related loss of muscle mass and improved muscle strength.
A new study suggests that exercise training is crucial for individuals with diet-resistant obesity, improving skeletal muscle metabolism and enhancing weight loss capacity. The research challenges the one-size-fits-all approach to treating obesity and has the potential to help reshape the science of weight-loss programs.
Researchers at EPFL's School of Life Sciences discovered that blocking sphingolipid synthesis can reverse the symptoms of Duchenne muscular dystrophy, including loss of muscle function and inflammation. This study identifies sphingolipid inhibition as a potential treatment for muscular dystrophies.
Researchers discovered a potential way to prevent mosquito-borne diseases like Zika and dengue by targeting the sphingolipid pathway in the midgut. This approach could stall viral replication and prevent transmission to humans.
The American Society for Biochemistry and Molecular Biology (ASBMB) has selected eight scientists for its annual awards competition, recognizing their contributions to science. The award winners include David Davies, John Kuriyan, Sarah Spiegel, Susan Lindquist, Douglas Rees, Phillip Zamore, Sandra Schmid, and Rochelle Schwartz-Bloom.