Articles tagged with Asymmetric Catalysis
A nickel-catalyzed approach yields chiral benzylic amines with broad substrate scope and excellent enantioselectivity. The method bypasses common challenges in asymmetric imine functionalization.
Researchers developed a machine-learning system that predicts how molecules form, cutting lab work time from months to days and reducing costs. The system uses asymmetric cross-coupling reactions to build complex compounds and can be applied across fields, deepening our understanding of chemistry.
Nagoya University researchers have developed an iron-based alternative to expensive chiral ligands in metal-based photocatalysts, achieving a precise radical cation cyclization and the first total asymmetric synthesis of (+)-heitziamide A using blue LED light and abundant iron.
Researchers from EHU's spectroscopy group investigated prolinol's interactions with one, two, and three water molecules, finding that water acts as a conformational switch. The study connects the isolated molecule to behavior in solution, shedding light on how water affects biological systems.
A new catalytic system achieves simultaneous enantiomeric transformation of silicon chiral centers and precise control over olefin Z/E configurations, enabling efficient synthesis of all four stereoisomers. The method exhibits excellent yields, good to excellent enantiomeric selectivity, and 100% atom economy.
Researchers developed an organocatalytic method to create planar chiral cyclophanes with high stereoselectivity and diastereoselectivity. The method uses a chiral phosphoric acid catalyst and generates a reactive naphthoquinone methylene intermediate, leading to the formation of stable planar chiral type III cyclophanes.
Researchers developed a technology that precisely analyzes 21 types of reactants simultaneously using high-resolution fluorine nuclear magnetic resonance spectroscopy. This breakthrough contributes to new drug development and catalyst optimization in AI-driven autonomous synthesis.
A novel mixed-ligand strategy creates ultrahigh surface area, chemically stable chiral MOFs ideal for practical applications in asymmetric catalysis. The frameworks demonstrate record-breaking surface areas and exceptional structural features, making them suitable as heterogeneous catalysts.
Researchers at the University of Münster develop a novel concept to regulate reactivity and selectivity in chemical reactions using light as an external energy source. The aluminum complex catalyst enables the selective conversion of chiral molecules into a single form, improving spatial control in organic chemistry.
A team of scientists from City University of Hong Kong and HKUST discovered novel, tridimensional compounds with high anticancer activity and low toxicity. These compounds can overcome drug resistance in cancer cells by inducing a different cell death pathway.
Researchers developed a machine learning model using advanced 2D chemical descriptors to predict highly selective asymmetric catalysts without quantum chemical computations. The model demonstrated high accuracy in predicting catalyst structures and selectivity, outperforming existing methods.
Researchers at Hokkaido University have developed a new method for creating chemical subunits using blue LEDs and copper, reducing the need for precious metals. This breakthrough has potential applications in pharmaceutical and photoelectronic development.
Researchers at Osaka University have developed a highly efficient way to make unique screw-like chemicals that can produce pure mirror images of other molecules. The new sulfur-containing group could be used as asymmetric catalysts in reactions.