Articles tagged with Histidine
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Researchers discovered that spatial orientation, facilitated by flexible linker groups, enhances biological properties in ligand-receptor interactions. Optimal ligand density and linker chain length also influence these interactions, leading to improved gene transfection efficiency.
Researchers from NARO and University of Tokyo successfully enhanced essential amino acids in BSF larvae through biotechnological approaches, boosting histidine and methionine levels by over 2.5 times. This development is expected to contribute to a stable food supply and promote sustainable food production.
Researchers identified a new post-translational modification of the glycolytic enzyme enolase, specifically at histidine residue His-190. This finding suggests that histidine methylation may play a crucial role in intermolecular hydrogen bonding and enzyme activity.
Researchers have identified a new method to distinguish histidine methylation in histone proteins, revealing its role in regulating genomic DNA folding. The study found histidine methylation at specific residues in histones H2A and H3, primarily affecting lysine residues.
Researchers from Tokyo Tech created hybrid ferritin nanocages with histidine residues, achieving 1.5 times higher metal ion uptake and improved catalytic efficiency for alcohol production. The new cages show promising potential as viable catalysts in the chemical industry.
Researchers at TTUHSC have identified novel targets for treating stroke, focusing on enhancing neurolysin activity. The study discovered small molecules that can selectively enhance the activity of neurolysin, which showed promise in reducing damage to the brain after a stroke.
Researchers developed a new method to label histidine residues in proteins, enabling rapid and selective chemical modification. This breakthrough offers new possibilities for protein analysis and drug delivery systems.
Researchers found that altered chirality of vitamin-D derivatives can change the protonation states of histidine residues in the VDR protein, leading to stronger binding and more stable complexes. This discovery emphasizes the importance of considering protonation states in molecular simulations for drug design.
Researchers identified a tumor suppressor protein called LHPP that can help diagnose and monitor liver cancer. Reintroducing LHPP into the liver of model mice prevented tumor formation, suggesting its potential as a new therapeutic approach for treating liver cancer.
These enzymes play essential roles in neurotransmitter synthesis and various physiological processes. A review highlights the importance of specific residues and regions for catalytic competence, including a mobile catalytic loop that undergoes an open-to-close conformational change upon coenzyme binding.
Scientists at Washington University School of Medicine used evolutionary clues to reveal how a key clotting protein assembles. They found that two histidines play a crucial role in sensing pH changes and guiding the assembly of von Willebrand Factor, leading to new insights into common bleeding disorders.
Researchers at Iowa State University and the Ames Laboratory discovered the flu virus uses a shuttle mechanism to relay protons through a channel, necessary for infection. This finding may lead to designing drugs that stop protons from moving through the channel.
Research at the University of East Anglia reveals that adding histidine to salmon diets prevents cataract formation. The nutrient was found to be deficient in post-1990s fish feed due to BSE concerns, leading to a significant increase in cataracts.
Researchers have developed a new way to peer into the inner workings of proteins and detect specific atoms at work. By analyzing myoglobin's structure and motion, they identified the critical amino acid controlling oxygen binding, with implications for custom-crafted proteins and biotechnologies.
Researchers at Rockefeller University Press identified an amino acid switch that flaviviruses use to gain access to cells. The team discovered that mutating one specific histidine residue can completely abolish fusion ability in tick-borne encephalitis virus, a dangerous human pathogen.
Researchers have discovered that two alphaproteobacteria lack the universal extra guanylate nucleotide typically found in transfer RNA molecule tRNAHis, which assists in incorporating amino acid histidine into new proteins. This finding suggests a radical departure from previously known identity rules for histidine-carrying tRNAs.
Researchers created a modified form of troponin I to improve cardiac function in mice and damaged human heart cells. The protein helps the heart respond to stress by boosting performance during periods of hardship.
Researchers discovered that globular proteins can utilize their barrel structure to transport small molecules like ammonia, improving chemical reactions. This process, known as substrate channeling, allows for efficient delivery of reactants and enhances reaction rates.