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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Scientists uncover key step in how diazotrophs “fix” nitrogen

Researchers at the University of California - San Diego uncovered the 'method of last resort' mechanism used by diazotrophs to protect their nitrogenase enzyme from oxygen damage. This complex process involves a protein called FeSII, which binds to the nitrogenase and halts ammonia production when oxygen levels increase.

A taste for carbon dioxide

Researchers discovered that the iron nitrogenase can convert CO2 into methane and formic acid, making it a promising starting point for developing novel CO2 reductases. The enzyme's low selectivity for CO2 also suggests its potential for widespread use in nature.

New Rhizobia-diatom symbiosis solves long-standing marine mystery

Scientists find new partnership between diatoms and Rhizobia bacteria in ocean nitrogen fixation, playing a crucial role in sustaining marine productivity. The discovery has exciting implications for agriculture, particularly for breeding crops that can thrive without fertilizers.

Powering nitrogenases

Researchers have identified two essential ferredoxins that play a key role in determining the performance of iron nitrogenase. The discovery opens up new possibilities for elucidating and maximizing nitrogenase's potential, which could lead to sustainable enzymatic production of ammonia and carbon compounds.

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A better way to produce fertilizers

Researchers engineer crops and symbiotic bacteria to produce nitrogen fertilizer, reducing reliance on industrially produced fertilizers. The approach aims to create a symbiotic relationship between the bacteria and crop plants, promoting efficient nutrient exchange.

Researchers take first-ever cryo-EM images of nitrogenase in action

Scientists at the University of California San Diego have taken the first-ever cryo-EM images of nitrogenase during catalytic action, providing new insights into the enzyme's mechanism and its potential for cost-effective and environmentally friendly ammonia production. The atomic-level-resolution images may pave the way for understand...

Binding of a second CO molecule observed

Researchers at University of Freiburg discover how vanadium-dependent nitrogenase binds two CO molecules simultaneously, enabling reductive process for industrial applications. This breakthrough sheds new light on the mechanistic principles behind nitrogenase's ability to reduce toxic gas carbon monoxide.

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Early life on Earth limited by enzyme

A study proposes that the nitrogenase enzyme, essential for photosynthesis, blocked its own activity at 2% atmospheric oxygen levels, stabilizing oxygen levels for nearly two billion years. This negative feedback loop prevented further oxygen production and explains why oxygen levels rose to today's levels.

Newly designed molecule binds nitrogen

A newly designed borylene molecule has been found to bind nitrogen at room temperature and normal air pressure, surpassing the capabilities of traditional catalysts like iron and molybdenum. This breakthrough may pave the way for a more energy-efficient method to convert nitrogen into ammonia.

Unexpected environmental source of methane discovered

Researchers uncover an enzymatic pathway in certain microorganisms that produces both ammonia and methane simultaneously. This previously unknown route for natural methane production has significant implications for understanding microbial interactions and the environment.

Clarifiying complex chemical processes with quantum computers

Researchers from ETH Zurich and Microsoft Research demonstrate that quantum computers can evaluate complex chemical reactions scientifically relevant results. Quantum computers can potentially calculate the reaction mechanism of nitrogenase step by step, but they will serve as a supplement to classical computers.

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On the way to a biological alternative

Researchers at the University of Freiburg have made a significant step towards understanding nitrogenase's function by analyzing its spatial structure. The team discovered that a vanadium ion replaces molybdenum in the enzyme, leading to distinct effects on its geometric and electronic structure.

A cooperative way to make ammonia

Bacterial nitrogenase produces ammonia by combining atmospheric nitrogen with protons and electrons, moving one electron at a time between symmetrical halves. The enzyme's two-stage engine works efficiently through complex communication between the two halves.

Dynamic duo: Biochemists describe cooperative halves of life-critical enzyme

A team of researchers from Utah State University and other institutions found that the two symmetrical halves of nitrogenase work together to regulate electron movements. This cooperative effort allows for more efficient conversion of nitrogen into ammonia, a crucial process for food production and energy development.

The world's nitrogen fixation, explained

Yale University scientists have designed a new chemical compound that mimics the properties of nitrogenase, an enzyme responsible for natural nitrogen fixation. The findings could lead to the development of synthetic catalysts that turn nitrogen into ammonia, reducing transportation and production costs.

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In an enzyme critical for life, X-ray emission cracks mystery atom

Scientists used powerful synchrotron spectroscopy and computational modeling to reveal carbon as the mystery atom in nitrogenase, a complex enzyme crucial for life. The research was published online in Science and provides insight into the chemistry of how the cluster behaves, a step toward unraveling its mechanism.

SLAC research cracks puzzle of enzyme critical to food supply

Researchers identified carbon as the key atom in nitrogenase, an enzyme that converts atmospheric nitrogen into a usable form for living things. The discovery could lead to a more efficient and environmentally friendly method for manufacturing fertilizer.

Nature's process for nitrogen fixation caught in action

Researchers witness steps in biological nitrogen fixation process, enabling microbes to convert atmospheric nitrogen to nutrients. The study suggests the biological process does not follow the same pathway as the chemical method.