Articles tagged with Polymerase Molecules
Researchers developed a novel method to create deep nanochannels in hard and brittle materials like silica, diamond, and sapphire. By employing femtosecond laser direct writing technology, they achieved sub-100-nm feature sizes and ultrahigh aspect ratios.
A new lab test has been developed by Rutgers scientists to identify COVID-19 variants. The test uses molecular beacon technology and can detect eight different mutations in the spike protein, increasing the transmissibility of the virus and evading immune defenses.
Researchers at UCI have made a breakthrough in understanding the Taq enzyme, which is crucial for DNA sequencing. They found that Taq behaves unexpectedly, rejecting correct bases more frequently than expected. This discovery has significant implications for personalized medicine and the accuracy of sequenced genomes.
Researchers at KAUST have developed an approach to detect rare gene mutations in a pool of cells, which is crucial for early cancer detection and evaluating CRISPR/Cas9 editing outcomes. The technique, called IDMseq, accurately detects single mutations and analyzes large DNA deletions with high accuracy and sensitivity.
A library of molecules with unique structural and chemical features have been identified to shut down the SARS-CoV-2 polymerase reaction, a key drug target for COVID-19. Five of these molecules are already FDA-approved for use in treating other viral infections.
Researchers have imaged remdesivir bound to SARS-CoV-2 viral polymerase, revealing precise residues that interact with RNA and the antiviral drug. This detailed information will inform efforts to design more effective therapies that mimic nucleosides to disrupt viral replication.
Researchers at Cornell University found that enzyme RNA polymerase II assembles at the site of an activated gene, regardless of its position. This challenges the traditional view of 'transcription factories' and provides new insights into the gene transcription mechanism.