Articles tagged with Rhodopsin
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Researchers uncover the role of opsin genes in driving coral speciation through habitat-specific adaptation to light cues. The study proposes a new hypothesis on the origin of species in corals, shedding light on the mechanisms behind reproductive isolation and biodiversity.
Two non-retinoid compounds were identified that improve cell surface expression of rhodopsin in 36 genetic subtypes of retinitis pigmentosa and protect against retinal degeneration in mice with the disease. The treatment showed improved overall retina health and function, prolonging photoreceptor survival.
Scientists have discovered a way to switch cellular activities on and off using light, opening up new possibilities for biological research and medical applications. The researchers created photoreceptors similar to those in the retina, which can be triggered by light pulses to initiate specific cellular signalling processes.
The study reveals that light-sensitive channels can be used to target specific ion signals in plants, allowing for the comparison of different signaling pathways. This breakthrough enables researchers to investigate plant stress responses in greater detail.
Researchers at Johns Hopkins Medicine used genetically engineered mice to study the mechanism of congenital stationary night blindness. The findings demonstrate that a mutation in the rhodopsin gene produces unusual background electrical activity, desensitizing rods and causing poor vision in low-light settings.
Scientists engineered yeast that can harness energy from light, growing 2% faster in the light than in the dark. This discovery provides key evolutionary insights into how rhodopsins spread across lineages and has potential applications for biofuel production and studying cellular aging.
A team of UC Irvine scientists discovered a llama-derived antibody called a nanobody that can halt Rhodopsin's misfolding and activation, potentially treating Retinitis Pigmentosa. This breakthrough offers new hope for targeting gene therapies for the condition.
Antarctic icefish have evolved special adaptations to cope with extreme cold, including antifreeze glycoproteins and changes to the rhodopsin protein. These changes enable them to see under sea ice and adapt to red-shifted wavelengths in low-light conditions.
Researchers at Technion-Israel Institute of Technology found that many aquatic microbes use a complex light-to-energy conversion mechanism involving rhodopsin proteins and carotenoid antennas. This process allows for more efficient energy production and increases the amount of energy entering the food chain.
Researchers have reconstructed what life was like for some of Earth's earliest organisms using light-capturing proteins in living microbes. The findings could help recognize signs of life on other planets with atmospheres similar to ancient Earth.
Researchers have captured the first real-time signaling cascade of a wild-type receptor in its native membrane environment using mass spectrometry. The study reveals the impact of lipids on rhodopsin signaling and regeneration, demonstrating potential new targets for therapeutic value in the visual system.
A study led by Przemyslaw Nogly at PSI has detailed insight into the mechanism of a light-driven chloride pump in bacteria, revealing how light energy converts to kinetic energy and transports chloride ions inside cells. The pump uses two molecular gates to ensure one-way transport, with the process taking around 100 milliseconds.
A UCI-led team has developed a high-throughput screen methodology to identify compounds that affect the functional role of Rh, a key G protein-coupled receptor. The study reveals new allosteric modulators that can alter rod light response kinetics or reduce rod sensitivity, paving the way for next-generation therapeutics.
Scientists have developed a new optogenetic tool using a mosquito-derived light-sensitive protein to investigate brain communication pathways. The researchers found that the protein enables precise control over specific neurons, allowing them to decipher neurotransmitter messages.
Researchers have developed a novel light sensor from two algae's rhodopsins that can produce the signaling molecule cGMP in response to UV or violet light, and inhibit its production with blue or green light. This breakthrough advances optogenetics by providing new tools for studying nerve cell function and other physiological processes.
Researchers use time-resolved serial femtosecond crystallography to capture dynamic changes in chloride ion-pumping rhodopsin, an atomic 'pump' driven by sunlight. The study reveals the mechanisms of energy conversion and has implications for designing light-sensitive molecular pumps.
Scientists at the University of Würzburg have successfully applied optogenetic methods in tobacco plants, enabling non-invasive manipulation of intact plants or selected cells by light. This breakthrough allows researchers to study molecular mechanisms of plant growth processes in detail.
New research on a Great Lakes fish species, kiyis, found that they have regained a genetic trait allowing them to see in dim blue-shifted waters, similar to their ancient ocean-dwelling ancestors. This adaptation is likely helping the fish thrive in the deeper regions of Lake Superior.
Researchers have obtained the structure of the light-sensitive KR2 protein in its active state, revealing the mechanism behind light-driven sodium ion transport. The study provides a detailed understanding of how this protein works and could lead to the development of new optogenetic tools.
The study successfully captured images of the sodium pump in action, documenting molecular changes necessary for sodium transport. The findings have implications for advancing optogenetics and improving experiments in neurobiology.
Researchers found that cool temperatures reduce the appeal of sweetness by activating other sensory cells via protein rhodopsin 6, which is typically associated with light detection. This suppresses communication between sweet-sensing taste neurons and the brain, leading to reduced feeding behavior in fruit flies.
Scientists from the Moscow Institute of Physics and Technology have determined the high-resolution structure of a protein from the recently discovered heliorhodopsin family. The study reveals a unique 'inverted' structure, with key differences from other known rhodopsins, and suggests possible functions for heliorhodopsins.
A team of scientists at UC Santa Barbara has discovered that multiple opsin proteins function as taste receptors, enabling the detection of subtle chemical signals. This finding raises questions about the original role of opsin proteins in ancient organisms and may extend to mammals, including humans.
A team developed a new instrument to detect rapid and irreversible reactions in biological molecules like rhodopsin. The Féry spectrometer allows analysis of very fast processes with high time resolution.
Researchers have determined the structure of OLPVRII, a unique protein found in giant viruses. The protein forms pentamers and may act as an ion channel, shedding light on its potential role in hosting green algae during viral infection.
The study reveals that the compound eyes of fruit flies play a crucial role in synchronizing their circadian clocks with light exposure. As daylight periods increase, the evening activity peak is delayed and the 'siesta' period is extended, highlighting the flexibility of the circadian clock mechanism.
Researchers report the discovery of a giant marine virus genome in predatory unicellular flagellates, encoding three rhodopsin photosensitive proteins. The findings suggest these viruses may confer phototrophic abilities on their hosts.
A single amino acid change in the light-sensing rhodopsin protein is crucial for herring adaptation to the Baltic Sea. Over 1/3 of all fish in brackish or freshwater carry this genetic change, enabling them to thrive in the region.
A USC-led study reveals that marine microbes containing rhodopsins are more abundant than thought and can capture more light energy than chlorophylls. This shift in microbial communities may result in less carbon fixation in the ocean, potentially leading to increased CO2 levels and faster warming.
Researchers use ultra-fast lasers to study chemical bond dissociation, shedding light on molecular behavior. The technique allows for detailed understanding of photochemical reactions and potential manipulation of chemical bonds.
Researchers discovered rhodopsin forms transient clusters within disc membranes in retina, acting as platforms for light to chemical signal conversion. These clusters are concentrated in the center of disc membranes and exhibit properties similar to rafts.
Vertebrates have evolved advanced night vision due to the adaptation of ancestral rhodopsins. Early tetrapods likely developed nocturnal traits, while mammals occupied both nocturnal and crepuscular niches.
Scientists from Johns Hopkins Medicine have challenged long-held assumptions about the processing of light in mammalian retinas. The study, published in Proceedings of the National Academy of Sciences, suggests that only 10-20 G protein molecules are activated by one rhodopsin molecule.
Researchers found that deep-sea fish have expanded rhodopsin genes to detect bioluminescent signals, giving them an evolutionary advantage. The silver spinyfin has the most photopigment genes of any vertebrate, allowing it to detect specific wavelengths of light produced by bioluminescent organisms.
Researchers have discovered a new light sensor in green algae that inhibits cGMP production, reducing its concentration. This finding is significant as it mirrors the human eye's response to light, and could lead to breakthroughs in optogenetics.
Researchers developed a new way to engineer rhodopsin proteins, enabling the creation of tools with distinct properties. This technique doubles the number of available optogenetics tools, allowing for more precise experiments and advancing neuroscience research.
Researchers developed a gene therapy that eliminates the abnormal copy of rhodopsin and restores it with a healthy copy, preserving retina's light-sensing photoreceptor cells. This approach has the potential to treat a large percentage of patients with rhodopsin autosomal dominant retinitis pigmentosa.
Researchers developed a single gene therapy vector that preserved retinal structure and function for over 8 months in a canine model of autosomal dominant retinitis pigmentosa. The treatment had potential implications for treating inherited retinal degeneration associated with the rhodopsin gene.
Scientists have developed a novel gene therapy that effectively reduces rhodopsin production and prevents photoreceptor death in dogs with autosomal dominant retinitis pigmentosa. The treatment, which combines shRNA interference with a replacement gene, shows promise for slowing or preventing vision loss in humans.
Researchers found that rhodopsin accelerates visual performance in cold-water catfish at high altitudes, enabling survival. The study provides new insights into the evolution of complex biological processes and potential therapeutic targets for human disease.
Researchers found that Rh7 functions as a light sensor governing daily day-and-night activity cycles in fruit flies. The discovery expands the roles of light sensors, which were originally discovered over 100 years ago.
Researchers have identified a seventh rhodopsin, Rh7, expressed in the brain of fruit flies where it regulates circadian rhythms and daily activity patterns. The discovery sheds light on the role of light-sensitive opsins in setting circadian rhythms and has potential implications for understanding degenerative retinal disorders.
Researchers at Case Western Reserve University discovered a self-renewing mechanism to help retina sense light using biochemically manipulated vitamin A. This mechanism could lead to improved therapeutics for treating people with vision impairment and other nerve cell disorders.
Researchers found that Phospholipase D (PLD) plays a central role in coupling endocytosis with membrane recycling in light-sensitive cells. Without PLD activity, the retina gradually degenerates and mutant flies go blind.
Researchers at Baylor College of Medicine have determined the most likely configuration of rhodopsin in a living organism, finding it exists as a dimer, a two-molecule complex. This discovery may help develop future treatments for retinitis pigmentosa, a degenerative eye disease with no known cure.
Researchers successfully designed and built a molecule that mimics the behavior of rhodopsin, a crucial protein in vision. This breakthrough could lead to new technologies by bypassing cell communication mechanisms.
Researchers at Nagoya Institute of Technology have developed a new molecular pump that can transport cesium using light. The pump, inspired by rhodopsins found in bacteria, has the potential to facilitate collection and storage of cesium from the environment.
Researchers used computer models to study the melanopsin pigment in the eye, finding it may be more sensitive to light than its counterpart rhodopsin. The study could lead to new technologies and a better understanding of diseases like seasonal affecting disorders.
Researchers discovered that high-density bands in photoreceptor outer segments are more susceptible to breakage due to their rigidity. This finding supports the idea that mutations causing rhodopsin aggregation can destabilize the outer segment, leading to cell death and blindness.
Researchers have developed a new method to measure electrical activity in neural networks, cardiac cells, and developing embryos using re-engineered optogenetic switches. This breakthrough allows for faster and more efficient screening of potential drugs for various cardiac diseases.
Researchers discovered Crag's crucial role in maintaining photoreceptor integrity by regulating the trafficking of rhodopsin. The protein activates Rab11, which enables the transport of vesicles loaded with freshly made rhodopsin, resetting the light-sensing mechanism.
Researchers discovered a second step in the light receptor process that corrects for rhodopsin errors, resulting in more accurate reading of light under dim conditions. This finding has long-term significance for understanding and treating vision deficits.
A recent study on rhodopsin in Xenopus rod photoreceptor cells reveals that the geometry of micro-compartments formed by incisures affects its signaling. The researchers found that boundary geometry, rather than heterogeneity in diffusion or bound fraction, explains differences in rhodopsin distribution
Skin detects UVA radiation using a light-sensitive receptor found in eyes, leading to melanin production within hours. Researchers find that long-wavelength UVA light stimulates rhodopsin in melanocytes, triggering calcium signals and melanin accumulation.
Researchers identified a mechanism for regulating color vision by studying the fly's visual system, showing that Rhodopsins can prevent incorrect gene expression and maintain color discrimination. The findings also offer insights into how genes controlling color detection are turned on and off.
Using optogenetics, researchers were able to target one cell type and influence activity of nerve cells with laser light. The study found that activation of a specific G-protein-coupled receptor changed the activity pattern of Purkinje cells, leading to motor deficits in mice.
Researchers have demonstrated that chromophores do not need to change shape to trigger the visual signal, instead, an electronic coupling initiates the process. This discovery challenges the long-held assumption of isomerization as the first step in the visual signal initiation.
Researchers discovered that light-capturing pigment molecules can be triggered by heat, producing false alarms. The study found that red-sensing pigment triggers false alarms most frequently.
Researchers identified a critical node, defective proventriculus (dve), in a network regulating Rhodopsin gene expression. This interlocked feed-forward loop (FFL) motif controls cell-type specific expression, restricting and inducing Rhodopsin presence in different photoreceptors.
Researchers found that rhodopsin, a retina pigment, plays a role in detecting temperature sensations in fruit flies. The discovery reveals a new function of rhodopsin beyond its well-known role as a light sensor.