Sample Preparation
Articles tagged with Sample Preparation
Researchers develop an innovative method for large-scale analysis of metabolites in biological samples
The new AEC-MS protocol provides comprehensive analysis of highly polar and ionic metabolites, improving molecular specificity and selectivity. This innovation has led to new applications in metabolomics, including studies on gut microbiome metabolism and energy substrate utilization.
Offering self-collection kits in routine GP appointments could prevent 1,000 women a year from developing cervical cancer
A new study suggests that offering self-collection kits during routine GP appointments can increase participation rates among women overdue for cervical screening. The approach shows promise in reducing the number of cases and saving lives.
How our lungs back up the bone marrow to make our blood
Researchers at UCSF have discovered that human lung tissue contains hematopoietic stem cells (HSCs) capable of producing red blood cells, platelets, and immune cells. The finding suggests the lungs could be a potent source for life-saving stem cell transplants, particularly for patients with leukemia.
Scientists develop biocompatible fluorescent spray that detects fingerprints in ten seconds
Researchers have created a water-soluble fluorescent spray that can visualize latent fingerprints in just ten seconds. The new dye-based technology is non-toxic, biologically compatible, and reduces the risk of damaging DNA evidence.
A multiplex assay to assess activated p300/CBP in circulating prostate tumor cells
A new multiplex assay has been developed to assess activated p300/CBP in circulating prostate tumor cells, revealing correlations with clinical outcomes and potential therapeutic targets for castration-resistant prostate cancer. The study found that patients with upregulated p300/CBP activity had shorter response times to ARSI therapy.
Novel device holds promise for diagnosing tuberculosis in the “missing millions”
A new device using dielectrophoresis selectively isolates Mycobacterium tuberculosis from sputum samples, providing a purified sample for molecular confirmation. The technology has shown promising results in detecting TB in underserved areas, with high concordance rates compared to culture diagnosis.
New recipes for better solar fuel production
A team of researchers from China and the UK has developed new ways to optimise the production of solar fuels by creating novel photocatalysts. These photocatalysts, such as titanium dioxide with boron nitride, can absorb more wavelengths of light and produce more hydrogen compared to traditional methods.
Brown researchers develop new, automated, powerful diagnostic tool for drug detection
A team of Brown researchers has developed a new, highly accurate method for detecting antidepressants in patients using liquid chromatography tandem mass spectrometry. The technique requires minimal biological samples and can be fully automated using liquid-handling robots.
Specialty and standard coffee beans can be sorted using multispectral imaging and artificial intelligence
A Brazilian research team has developed a novel method to sort specialty and standard coffee beans using multispectral imaging and machine learning. The technique, which does not require roasting or human intervention, uses images of the beans at different wavelengths to distinguish between quality levels.
New method enables efficient sample preparation for single-cell proteomics
A new sample preparation method called 'water droplet-in-oil' (WinO) has been developed to improve efficiency in single-cell proteomics. The technique reduces sample loss and increases throughput by up to 10-fold compared to conventional methods.
Why drinking water needs monitoring for HIV drugs
Researchers emphasize the need for monitoring drinking water for HIV medications, as they can contaminate rivers and streams through wastewater. The lack of regulation on pharmaceuticals in wastewater treatment plants poses a significant challenge in ensuring safe drinking water.
New technique boosts cryo-electron microscopy clarity, safety
Researchers have developed a new method for preparing cryo-electron microscopy samples using liquid nitrogen, which cools at rates roughly 50 times slower than ethane. This results in sharper images with reduced beam-induced motion and simplified workflows.
NIH scientists develop faster COVID-19 test
Researchers at the National Eye Institute developed a new sample preparation method to detect SARS-Cov-2, simplifying purification and potentially reducing test time and cost. The method uses a chelating agent to preserve RNA in samples, allowing for direct detection and increasing sensitivity.
SLAC, Stanford to host national service center for cryo-ET sample preparation
The new Stanford-SLAC CryoET Specimen Preparation Service Center complements existing NIH-funded facilities at SLAC, providing streamlined processes for preparing cryo-ET samples. Researchers can learn state-of-the-art techniques and access multiple instruments to visualize cellular components in 3D.
World's first next-generation protein sequencing device to accelerate the study of diseases and pandemics
The Quantum-Si ecosystem enables sensitive and accurate research tools and diagnostics through digital proteomics, transforming the study of proteins on a large scale. The company's platform offers a complete solution for sample preparation, sequencing, and data analysis, reducing costs and increasing accessibility.
Waters and Andrew Alliance sign co-marketing agreement
The Waters Corporation and Andrew Alliance have signed a co-marketing agreement to promote their collaboration on protein therapeutics glycosylation profiling. The partnership enables laboratories to automate large numbers of routine, high-quality released N-glycan analyses with improved accuracy and precision.
Novel method to identify illegal drugs, faster and with greater accuracy
A new method for identifying illicit drugs has been developed, offering high sensitivity and fast results. This technique uses multi-dimensional chromatography combined with a micro-extraction method, allowing for rapid analysis in under 20 minutes.
Study to develop new forensic methods for human DNA cases
Researchers at Sam Houston State University are developing new sample preparation methods for skeletal and decomposing remains using emerging next generation DNA technology. The goal is to improve the ability to resolve more missing person cases, as conventional methods may fail.
Innovative handheld mineral analyzer -- 'the first of its kind'
A handheld mineral analyzer has been developed for mining applications, enabling rapid analysis of minerals in the field. The device combines X-ray diffraction (XRD) and X-ray fluorescence (XRF) techniques to identify and quantify minerals within 1-2 minutes.
Automated cDNA preparation system accelerates CAGE analysis on a single molecule sequence
Researchers at RIKEN developed an automated sample preparation system for the HeliScope single molecule sequencer, reducing preparation time from 42 days to 8 days. The new system uses Cap Analysis of Gene Expression (CAGE) and yields reproducible results comparable to manual prep.
Goddard scientist's breakthrough given ticket to Mars
A NASA scientist has added an experiment to the Sample Analysis at Mars (SAM) instrument, enhancing its ability to analyze large carbon molecules. The experiment aims to preserve information on how organic molecules formed, shedding light on the planet's carbon cycle.
Lab in a drop
Researchers developed a lab-on-a-chip PCR test that combines sample preparation with PCR on a single chip, reducing analysis time from hours to minutes.