Articles tagged with Superoxides
Researchers at ISTA have discovered a way to tune singlet oxygen, a highly reactive ROS that causes cell damage and degrades batteries. By controlling the pH inside mitochondria, they can produce more 'good' triplet oxygen and reduce the production of 'bad' singlet oxygen.
Filipino researchers found a way to enhance tapuy lees for high polyphenol content and antioxidant activity, extending test animal lifespan and health. The study suggests repurposing tapuy lees as a health food to combat aging and oxidative stress-related diseases.
A novel cyclic thiosulfinate cross-linker has favorable drug-like properties and can stabilize the SOD1 dimer in vivo, indicating potential therapeutic benefits for fALS. This study uses a mouse model to evaluate protein cross-linking as a strategy to treat SOD1 variants associated with familial ALS.
A new study published in PNAS Nexus reveals that deep-sea corals and sponges produce the ROS superoxide, a highly reactive compound with previously unknown effects on ocean life and chemistry. The researchers used a one-of-a-kind deep-sea chemiluminescent sensor to detect superoxide in water closely surrounding corals.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers developed a novel hybrid protein complex by binding lysozyme to copper for enhanced reactive oxygen species (ROS) removal. The CuST@lysozyme hybrid protein showed high SOD activity and stability in biological fluids, paving the way for its therapeutic applications.
Researchers generated a POLDIP2 knockout ARPE-19 cell line and found reduced mitochondrial superoxide levels, consistent with upregulated SOD2. The study demonstrates a potential role of POLDIP2 in regulating oxidative stress in AMD.
Researchers have developed a new lithium-air battery that uses a solid electrolyte, boosting energy density four times above lithium-ion batteries. The battery can potentially power cars for over a thousand miles on a single charge and is also suitable for domestic airplanes and long-haul trucks.
Researchers found that astrocytes can transfer their mitochondria to damaged neurons after a brain hemorrhage, stimulating the production of an enzyme that neutralizes free radicals. This treatment showed improved neurological recovery in mice, but not if the mitochondria were without the protective enzyme Mn-SOD.
Research investigates ferric oxalate's role in atmospheric oxidation, revealing its contribution to the formation of secondary organic aerosols (SOA) and affecting radiative forcing. The study highlights the significance of superoxide radicals in oxidizing organic compounds.
Researchers have discovered that charcoal nanoparticles can effectively combat damaging levels of superoxides, which are toxic at high concentrations. The nanozymes could aid in the treatment of COVID-19 patients by reducing radical oxygen ions produced in response to an injury or stroke.
Research finds that ferropericlase transforms into superoxide when exposed to water at deep lower mantle conditions. The discovery suggests the lower mantle is locally oxidized where water is present, contrary to previous theories.
A recent study published in Water Research found that superoxide initiates the production of hydroxyl radicals, which then break down poorly biodegradable organic matter. This reaction is a natural process that can remove persistent natural and anthropogenic organic matter from lakes.
Researchers found that bilirubin protects the brain against oxidative stress by regulating superoxide levels. The study suggests a novel therapeutic approach for neurodegenerative diseases. Bilirubin's unique chemical structure allows it to neutralize harmful superoxide molecules.
Researchers discovered that reactive oxygen species, once thought to cause cellular damage, actually protect phytoplankton cells from overproducing a compound used for photosynthesis. This finding challenges conventional wisdom and may have implications for understanding ocean resilience to climate change.
Researchers discovered that overexpressing macrophage migration inhibitory factor (MIF) in mice with SOD1 mutations slows down disease progression and extends lifespan. MIF may play a potential therapeutic role in ALS treatment.
A recent study led by McGill University researchers offers a crucial step in unlocking the mystery of Leber hereditary optic neuropathy's cause. The team found that superoxide spreading among cells connecting the eye to the brain is likely the cause of the disorder.
Researchers discovered that zinc can activate a molecule helping to shield against oxidative stress, which contributes to aging and illnesses. Zinc combined with polyphenols in foods like coffee, tea, and chocolate may provide natural protection.
Research led by Salk Institute scientist Gerald Shadel found that short-term stress can trigger sustained production of antioxidants and increase mitochondria efficiency, potentially extending lifespan. Cells exposed to brief stress showed higher antioxidant levels, more mitochondria, and less superoxide buildup than unstressed cells.
New research reveals the mechanism behind perovskite solar cell breakdown in air, which causes significant degradation and reduces their efficiency. By understanding this process at an atomic scale, scientists have proposed possible solutions to engineer defects out of the material.
Researchers at TU Graz have found that superoxide dismutase enzyme function can prevent ageing in non-aqueous batteries by eliminating singlet oxygen. This discovery could lead to the development of more efficient and sustainable battery systems.
Researchers from Woods Hole Oceanographic Institution found that superoxide produced at coral surfaces may help corals resist bleaching. Contrary to previous findings, corals producing high concentrations of superoxide had greater resilience to bleaching than those with low production levels.
Researchers used computer simulations to study the formation of superoxides, a type of free radical that can damage cells and contribute to aging. The study found that an oxygen molecule can penetrate specific locations in proteins, leading to the formation of superoxides.
Researchers identified a gene mutation increasing superoxide production, which damages DNA and cellular components. The study also shows the importance of understanding living systems and developing therapies for patients with related gene mutations.
A new prototype lithium-air battery has been shown to produce only lithium superoxide, not peroxide, as it discharges, offering high efficiency and good cycle life. This discovery was made using a state-of-the-art mass spectroscopy apparatus that measures electrochemical reaction products in situ during charging or discharge.
Researchers at Argonne National Laboratory have discovered a way to produce stable crystallized lithium superoxide, which can easily dissociate into lithium and oxygen. This breakthrough has the potential to create a new kind of battery with five times the energy density of lithium-ion batteries.
Researchers have successfully tested nanoparticles that can quickly quench damaging superoxides, potentially protecting against further brain damage in traumatic injuries. The particles, known as PEG-HCCs, have shown an enormous capacity to neutralize thousands of reactive oxygen species molecules, restoring normal oxygen levels.
A new theory proposes that stimulating mitochondrial function and superoxide production can improve markers of renal, cardiovascular, and nerve dysfunction in diabetes. This approach may help promote tissue healing and is linked to improved outcomes for diabetic kidney disease.
A new study by CU-Boulder reveals that an antioxidant called MitoQ can reverse the negative effects of aging on arteries, improving vascular function and reducing the risk of heart disease. MitoQ targets mitochondria, specific cell structures responsible for oxidative stress, and restores endothelial function in old mice.
A new study reverses the prevailing theory on diabetic kidney disease, finding that elevated glucose levels do not cause the condition but rather suppressing mitochondrial activity. The researchers discovered that boosting beneficial AMPK activity through lifestyle changes or drug activation can reduce kidney disease severity.
Researchers have discovered a light-independent source of superoxide in the depths of oceans and dark environments. Bacteria common in these areas produce superoxide, which has both toxic and beneficial effects on the environment.
A new study suggests that increasing Hsp70 expression may help reduce excessive reactive oxygen species production, a key contributor to cardiovascular disease. Researchers found that Hsp90 inhibitors can increase Hsp70 levels, leading to decreased oxidative stress and improved blood vessel function.
Researchers at Rice University have discovered a nanoparticle that can restore balance to the brain's vascular system after an injury. The PEG-HCC nanoparticles immediately quench superoxide activity and allow the autoregulatory system to regain its balance, potentially treating mild brain trauma by preventing further damage.
Chronic estrogen exposure has been linked to an increase in superoxide, a compound that causes stress in the body, leading to hypertension. Resveratrol has been shown to reverse this effect, suggesting a potential therapeutic avenue for female patients using hormone replacement therapy.
Researchers at NIH found that even tiny amounts of superoxide production in people with chronic granulomatous disease (CGD) are linked to better survival rates. The study allows for early assessment of patient risk, enabling personalized treatment options.
A study published in Genetics suggests that superoxides from the air can harm muscle tissue, leading to problems like aging and Parkinson's disease. Researchers found that introducing a mitochondrial enzyme helped protect muscle cells, increasing survival rates in fruit flies.
Researchers found that superoxide plays a key role in bird migration by influencing the protein cryptochrome in their eyes. The molecule allows birds to 'see' Earth's magnetic field, enabling them to navigate. However, humans lack this ability due to evolutionary trade-offs between longevity and orientational ability
Researchers found that macrophages focus reactive oxygen species (ROS) on targets outside the cytoplasm to kill bacteria. The study shows that superoxide dismutases in bacterial periplasm protect bacteria from ROS, suggesting a new mechanism for macrophage-bacteria interaction.
Researchers question the long-held free radical theory of ageing, suggesting that oxidative stress is not a major cause of ageing. The study found no significant impact on lifespan when controlling superoxide levels in nematode worms.
A Brandeis study finds that mutated protein superoxide dismutase leads to toxic levels of the protein in motor neurons, causing cell death in ALS patients. The research aims to develop drugs targeting key proteins to prevent aggregation and treat the disease.
Researchers have discovered a new tool that can measure the extent of oxidative stress and determine how well antioxidants work. The study used a protein-based probe to detect fleeting bursts of superoxide production, which is associated with cellular damage in various diseases.
Researchers at ESRF successfully filmed an enzyme in action using cryogenic techniques, revealing intermediate states crucial to its function. The study contributes to understanding how the enzyme eliminates toxic molecules, offering hope for developing new drugs to combat neurodegenerative diseases.
Researchers at Oregon State University have developed a new technique to visualize and measure superoxide in animal cells, offering a breakthrough in understanding degenerative diseases such as Lou Gehrig's Disease, heart disease, diabetes, and aging. The discovery could significantly speed up research on these conditions.
The study found that antioxidant therapy with tempol prevented the onset of high blood pressure, proteinuria, and placental abnormalities, improving birth weight and fetal growth. Tempol treatment also reduced fetal deaths by half and normalized placentas, suggesting a promising approach to treating pre-eclampsia.
Researchers at NC State have successfully transferred genes from a heat-tolerant sea microbe, Pyrococcus furiosus, into tobacco and Arabidopsis plants to enhance their resistance to extreme temperatures. The study's findings show promise for developing plants that can thrive in harsh conditions on Mars and other planets.
A study published in Neuroscience found that calorie restriction had mixed effects on the brains of mice, improving grip strength, coordination, and flexibility, but having no effect on cognitive performance. The researchers suggest that free radical damage may contribute to age-related cognitive impairments, which could be prevented o...
Researchers found that chokeberry extract can protect coronary arteries from oxidant injury, while bilberry extract provides partial protection. The study suggests that individual components in berries may be responsible for their vascular effects.
Research reveals that peroxynitrite damages endothelial NO synthase (eNOS), promoting uncoupled catalysis and oxidative stress in vascular tissues. This damage can propagate to other susceptible enzymes, exacerbating inflammation and oxidative stress.
Researchers developed a superoxide dismutase (SOD) mimetic that substantially reduced cartilage and bone erosion, as well as chronic inflammation, in a standard animal model. The SOD mimetic also significantly reduced elevated levels of pro-inflammatory cytokines TNF-α and IL-1β.
MetaPhore will develop and test a highly active SOD mimetic to protect heart tissues from damage. The research aims to provide additional mechanistic information on the role of superoxide in reperfusion injury, which may also apply to other ischemic events.
Researchers have found that an enzyme mimetic compound significantly improves the functioning of blood vessels and nerves in diabetic animal studies, reducing vascular abnormalities and nerve damage. The study suggests a potentially significant new approach for treating and preventing complications associated with diabetes.
Researchers have identified a new treatment approach that could reverse the dramatic blood pressure drop associated with septic shock by removing excess superoxide free radicals. The treatment, a MetaPhore SOD mimetic, restored norepinephrine's ability to constrict blood vessels and reversed hypotension in rat models of septic shock.
Researchers at MetaPhore Pharmaceuticals developed a new class of anti-inflammatory drugs that simulate superoxide dismutase, combating inflammation and degradation in medical implants. The treatment resulted in a dose-dependent anti-inflammatory effect, including reduced acute and chronic inflammation.