Articles tagged with Live Cell Imaging
A new method, GlioTrace, reveals how individual glioblastoma cells spread through the brain and adapt to treatment, offering insights into tumour cell invasion and potential therapies. The study also found that cancer treatments can affect tumour cell movement and shape, and that some cells may be more treatment-resistant than others.
The Quantum Biology Laboratory at Howard University publishes a landmark review on 'Quantum Biology 2.0', highlighting the field's shift to whole-biosystems integrated approaches. Researchers discover superradiance in solvated protein fibers, revealing a new window into the role of quantum processes in biological systems.
Researchers used machine learning-assisted live-cell imaging to investigate the impact of transcription on chromatin motion in living human cells. The study found that transcription by RNA polymerases I and II shapes the physical behavior of different chromatin classes, with varying effects on euchromatin and heterochromatin.
Researchers developed a high-speed microscopy technique that captures images at 19.2 images per second, enabling the creation of 3D
A team of researchers from Penn State has developed a fluorescent molecular tag that tracks viral RNA and host interactions in real-time, allowing for the study of Zika and chikungunya viruses. The tool, called Mango-II, provides insight into the viral-host cell interaction, a key step to developing effective antiviral strategies.
A research team at Max Planck Institute for the Science of Light shows that mechanical stress influences muscle cell fusion and tissue organization. Myoblasts fuse in areas of high mechanical stress, and the surrounding extracellular matrix mirrors the organization of the cell layer.
Research reveals that local DNA motion in human cells remains nearly constant throughout interphase, despite major physical changes, such as DNA replication and nuclear growth. This stability is notable and suggests that cells maintain similar physical conditions for housekeeping genome functions.
Researchers at the University of Bath have discovered a blueprint for designing powerful fluorescent materials, paving the way for better disease detection. The team developed a molecule that was five times brighter than the original azulene molecule, providing a promising candidate for future sensing and imaging applications.
Researchers developed a new lensless imaging method, called SF-PULSE, that enables long-term monitoring of living cells without staining or labels. The method provides quantitative information about cell growth, size, and changes in biomass, enabling accurate long-term tracking of individual cells.
Researchers at Tokyo Metropolitan University identified how deadly E. coli bacteria spread using a chain-like adherence pattern under flow, and discovered a new gene family mediating this process. This discovery provides new insights into infection mechanisms and potential treatments for LEE-negative strains.
Researchers at Janelia Research Campus have developed a method to study cellular communication across the entire animal, capturing signals from nearly every cell in a living vertebrate. This technique, called WHOLISTIC, provides a complete, concurrent picture of how biological systems interact, offering new insights into the machinery ...
The new imaging system allows scientists to capture high-resolution fluorescence images in real time under normal room lighting, giving them a more complete picture of biological changes. SphynxVision can capture multiple images per second and reveal remarkably small details, such as tiny blood vessels and clusters of cancer cells.
Researchers distinguish multiple fluorescent proteins with overlapping emission colors by their lifetime using fluorescence lifetime imaging microscopy (FLIM). FLIM successfully distinguishes several fluorescent proteins with overlapping color emissions within plant cells, enabling simultaneous analysis of multiple proteins.
Researchers at Texas A&M University have developed a technique that maps chemical changes directly, using natural molecular vibrations. This allows for the observation of biological processes in real-time, giving researchers a more complete picture of how diseases emerge and evolve.
Researchers are developing an AI assistant to analyze petabytes of imaging data from high-resolution microscopes, which can track cells and molecular interactions in real-time. The goal is to help biologists understand complex biological systems and make new discoveries.
Researchers have developed a new molecular imaging technology that illuminates proteins inside living cells and animals far more clearly than before. The system uses engineered fluorescent nanobodies to reduce background noise by as much as 100-fold, enabling sharper visualization of protein location and dynamics.
Salk scientists and collaborators advance visualization technology using visible-spectrum antigen-stabilizable fluorescent nanobodies (VIS-Fbs), reducing background fluorescence by up to a hundredfold. The new probe enables high spatial and temporal precision, allowing for real-time tracking of dynamic changes in living models.
Researchers at Kyushu University develop a new tissue-clearing reagent, SeeDB-Live, enabling repeated, reversible, and real-time imaging of living brains at greater depth and clarity. This breakthrough allows scientists to visualize neural activity in living mice and brain slices, offering new insights into brain dynamics and function.
New research reveals that tumor cells in supratentorial ependymomas cluster into distinct neighborhoods, each with a specific role, such as proliferating or invading. Understanding these cell subtypes could help predict treatment response and inform targeted therapies for this aggressive childhood brain cancer.
Researchers developed AI-powered in silico labeling to analyze cell images without staining, preserving cell health. The system leverages context, such as cell shape and position, to accurately stain rare processes like cell division.
Researchers at IIT develop optical microscopy technique that combines polarization and dark-field microscopy to observe cells with high contrast, preserving their natural conditions. The next step involves using AI to enrich images with molecular information related to diseases.
Researchers at Colorado State University used AI to modify antibodies into stable intrabodies that can visualize histone modifications in real-time. This allows for better understanding of gene expression and its relationship with cancer and other disorders. The team created 19 new antibody-based probes with a 70% success rate, signifi...
Scientists have successfully used fullerenes as polarizing agents to improve MRI imaging capabilities, enabling clearer images with greater sensitivity. This breakthrough technique could lead to enhanced diagnostic capabilities and faster detection of diseases, potentially revolutionizing medical imaging.
Researchers developed a probe to visualize lipid breakdown in living cells, revealing differences in breakdown rates among individual droplets. The study found that an enzyme called ATGL drives these variations, which may contribute to abnormal lipid metabolism in liver cancer cells.
Researchers have created a method for simultaneous imaging of DNA and RNA in living cells using harmless infrared light, allowing for high-precision detection of all stages of cell death. This breakthrough enables the early detection of cellular damage that leads to aging or death.
Researchers have discovered that seaweed can be used as a biocompatible material for tissue engineering, reducing the need for animal testing. The study found that decellularized seaweed scaffolds promote cell growth and are compatible with human cardiomyocytes.
Cryo-optical microscopy captures high-resolution, quantitatively accurate snapshots of dynamic cellular processes at precisely selected timepoints. This technique enables the observation of transient biological events with unprecedented temporal accuracy.
Researchers developed a high-speed 3D imaging microscope that can capture detailed cell dynamics of an entire small whole organism at once. The new system, M25, extends classical multifocus microscopy to study development, locomotion, and neuroscience in real time.
Tetrandrine modulates autophagy by selectively removing damaged lysosomes through lysophagy while promoting new lysosome formation. This unique mechanism highlights tetrandrine's therapeutic potential for treating neurodegenerative diseases.
Researchers developed Localizatome to study oxidative stress-related changes in protein localization. The database provides comprehensive information on subcellular protein localization and dynamic localization changes under stress.
A collaborative research team led by KAIST has developed a groundbreaking technology that uses advanced optical techniques combined with an AI-based deep learning algorithm to create realistic 3D images of cancer tissue. This breakthrough paves the way for next-generation non-invasive pathological diagnosis.
A team from Peking University achieved a major breakthrough in imaging 15 cellular structures simultaneously using lipid membrane probes, dual-color spinning-disk confocal microscopy, and deep learning. This method enables real-time, long-term organelle tracking with improved efficiency and reduced phototoxicity.
A new imaging technology has been developed that combines super-resolution imaging with artificial intelligence to reveal subcellular structures and dynamics in living cells. This breakthrough enables scientists to better understand the root causes of diseases, leading to improved treatments.
Researchers use advanced imaging to study molecular movement through NPCs, finding that molecules move through narrow conduits and avoid congestion despite slow movement. This discovery could lead to new insights into conditions like neurodegenerative diseases and cancers.
Researchers at the University of Adelaide used quantum-sensitive cameras to image embryos, capturing biological processes in their natural state. The sensitive detection of photons allows for gentle illumination and minimizes damage from light, enabling researchers to study live cells and developing specimens.
Researchers have developed a powerful imaging technology to study cellular metabolism, enabling the visualization of biomolecules' synthesis and turnover in live cells and organisms. Heavy-water probing allows for the tracking of metabolic dynamics, providing insights into aging and age-related diseases.
A new universal photocage modification strategy based on thioketal enables real-time live cell subcellular imaging. The thioketal-based probe SiR-EDT exhibits improved dark stability and can be specifically activated by UV-visible light.
Researchers developed a new microscopy technique, HS-iFM, to study the dynamic mechanical properties of Escherichia coli membranes. The technique revealed increased stiffening during cell division and observed visible bridges that formed and eventually broke.
The researchers have developed a groundbreaking method to expand the color palette of bioluminescent protein to 20 distinct colors, enabling advanced simultaneous multi-color imaging. This innovation makes it significantly easier and more cost-effective to monitor multiple targets or track individual cells within a population.
Researchers developed an AI-powered technology that transforms low-resolution, label-free images into high-resolution, virtually stained ones without fluorescent dyes. This innovation delivers stable and accurate cell visualization, overcoming limitations of traditional imaging methods.
Researchers uncover the relationship between lysosomal exocytosis and focal adhesions, structures critical for cell anchoring and communication. The study identifies MYO18B as a key regulator of lysosomal exocytosis through focal adhesion maturation.
G protein-coupled receptors can form heteromers, affecting ligand binding properties and downstream signaling pathways. Recent advances in live cell imaging techniques provide crucial information on physical interactions in GPCR heteromers.
Osaka University researchers have reported a method that gives high-resolution Raman microscopy images of biological samples, up to eight times brighter than previous methods. This technique uses no stains and doesn't require chemicals to fix cells in position, providing a highly representative view of processes and cell behavior.
Researchers at Rice University developed soTILT3D, an innovative imaging platform that enables fast and precise 3D imaging of multiple cellular structures while controlling the extracellular environment. The platform improves upon conventional fluorescence microscopy by reducing background fluorescence and increasing imaging speed.
Researchers at Osaka University have created an innovative device called INSPCTOR that enables real-time remote monitoring of cell growth in incubators. This technology allows for effective quality control and precise measurement of cellular transformation, which is crucial for advancements in regenerative medicine and drug discovery.
Holotomography offers a promising approach to biomedical research, providing high-resolution images of live cells and tissues at the organelle level. The KAIST research team has developed core technologies and demonstrated its applications in various fields, including regenerative medicine and cancer research.
The CRISPR/Cas9 system has been adapted for genome visualization, enabling the study of chromatin dynamics and genome organization in living cells. Recent advancements have expanded its applications to live cell imaging, providing a robust tool for visualizing genomic loci.
Researchers from Brookhaven National Laboratory have developed an effective way to image a single cell using multiple techniques, providing significant implications in medicine and agriculture. The team used advanced X-ray imaging technologies to capture high-resolution images of the cellular structure and chemical processes within cells.
Researchers discovered a transient structure in fruit fly leg development that guides its final shape, shedding light on mechanisms determining an organism's body shape. This finding could lead to better understanding of processes shaping insect and other organisms' bodies.
Researchers from Osaka University have developed a new approach for super-resolution microscopy that can observe dense microstructures inside cells with excellent sharpness. By selecting only a desired plane to image using thin 'light sheet' illumination, they were able to achieve background-free super-resolution imaging.
A team at the University of Tokyo has constructed an improved mid-infrared microscope that enables them to see the structures inside living bacteria at the nanometer scale with a resolution of 120 nanometers. This breakthrough can aid multiple fields of research, including into infectious diseases.
Researchers found that nutrient-starved cells divert ER exit sites to lysosomes for degradation, using a novel pathway to free up amino acids. This process involves the recruitment of molecules to direct ER exit sites to lysosomes, where they are destroyed and their components recycled.
A new method called NIRE enables large-scale and long-term observation of neuronal structures and activities in awake mice. The method uses fluoropolymer nanosheets covered with light-curable resin to create larger cranial windows, allowing for high-resolution imaging with sub-micrometer resolution.
A new method for phase-modulated stimulated Raman scattering tomography enables rapid, label-free 3D chemical imaging of live cells and tissues. This technique improves lateral resolution and imaging depth compared to conventional methods.
Researchers developed a high-speed modulation system combining digital display with super-resolution imaging, significantly improving lateral and axial resolution. This enables detailed study of subcellular structures in animal cells and plant ultrastructures, paving the way for future biological discoveries.
USC researchers have designed nanoparticles that can target and highlight cancer cells in lymph nodes, allowing for earlier detection of metastasis. The particles work by hitchhiking on immune cells to reach the lymph nodes, where they can amplify the signal detected by MRI scans.
Researchers provide new insights into STING's function in innate immunity, revealing its role as a scaffold that activates TBK1. They also found that cholesterol plays a crucial role in STING clustering and activation, offering a potential target for treating diseases associated with STING inflammation.
MIT researchers have developed a new method to track cell differentiation and study long-term processes like cancer progression or embryonic development. They used noninvasive Raman spectroscopy to monitor embryonic stem cells as they differentiated into multiple cell types over several days.
Ashok Veeraraghavan, a Rice University professor, has won the Edith and Peter O'Donnell Award in Engineering from the Texas Academy of Medicine, Engineering, Science and Technology. His research focuses on making invisible objects visible through imaging technology that tackles challenges beyond current technologies.
A team of researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg has combined artemisinin with coumarin to develop an autofluorescent compound that destroys certain malaria pathogens. The new compound is effective against drug-resistant strains and shows promise for treating malaria.