Articles tagged with Live Cell Imaging
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed AI-powered in silico labeling to analyze cell images without staining, preserving cell health. The system leverages context, such as cell shape and position, to accurately stain rare processes like cell division.
Researchers at IIT develop optical microscopy technique that combines polarization and dark-field microscopy to observe cells with high contrast, preserving their natural conditions. The next step involves using AI to enrich images with molecular information related to diseases.
Researchers at Colorado State University used AI to modify antibodies into stable intrabodies that can visualize histone modifications in real-time. This allows for better understanding of gene expression and its relationship with cancer and other disorders. The team created 19 new antibody-based probes with a 70% success rate, signifi...
Scientists have successfully used fullerenes as polarizing agents to improve MRI imaging capabilities, enabling clearer images with greater sensitivity. This breakthrough technique could lead to enhanced diagnostic capabilities and faster detection of diseases, potentially revolutionizing medical imaging.
Researchers developed a probe to visualize lipid breakdown in living cells, revealing differences in breakdown rates among individual droplets. The study found that an enzyme called ATGL drives these variations, which may contribute to abnormal lipid metabolism in liver cancer cells.
Researchers have created a method for simultaneous imaging of DNA and RNA in living cells using harmless infrared light, allowing for high-precision detection of all stages of cell death. This breakthrough enables the early detection of cellular damage that leads to aging or death.
Researchers have discovered that seaweed can be used as a biocompatible material for tissue engineering, reducing the need for animal testing. The study found that decellularized seaweed scaffolds promote cell growth and are compatible with human cardiomyocytes.
Cryo-optical microscopy captures high-resolution, quantitatively accurate snapshots of dynamic cellular processes at precisely selected timepoints. This technique enables the observation of transient biological events with unprecedented temporal accuracy.
Researchers developed a high-speed 3D imaging microscope that can capture detailed cell dynamics of an entire small whole organism at once. The new system, M25, extends classical multifocus microscopy to study development, locomotion, and neuroscience in real time.
Tetrandrine modulates autophagy by selectively removing damaged lysosomes through lysophagy while promoting new lysosome formation. This unique mechanism highlights tetrandrine's therapeutic potential for treating neurodegenerative diseases.
Researchers developed Localizatome to study oxidative stress-related changes in protein localization. The database provides comprehensive information on subcellular protein localization and dynamic localization changes under stress.
A collaborative research team led by KAIST has developed a groundbreaking technology that uses advanced optical techniques combined with an AI-based deep learning algorithm to create realistic 3D images of cancer tissue. This breakthrough paves the way for next-generation non-invasive pathological diagnosis.
A team from Peking University achieved a major breakthrough in imaging 15 cellular structures simultaneously using lipid membrane probes, dual-color spinning-disk confocal microscopy, and deep learning. This method enables real-time, long-term organelle tracking with improved efficiency and reduced phototoxicity.
A new imaging technology has been developed that combines super-resolution imaging with artificial intelligence to reveal subcellular structures and dynamics in living cells. This breakthrough enables scientists to better understand the root causes of diseases, leading to improved treatments.
Researchers use advanced imaging to study molecular movement through NPCs, finding that molecules move through narrow conduits and avoid congestion despite slow movement. This discovery could lead to new insights into conditions like neurodegenerative diseases and cancers.
Researchers at the University of Adelaide used quantum-sensitive cameras to image embryos, capturing biological processes in their natural state. The sensitive detection of photons allows for gentle illumination and minimizes damage from light, enabling researchers to study live cells and developing specimens.
Researchers have developed a powerful imaging technology to study cellular metabolism, enabling the visualization of biomolecules' synthesis and turnover in live cells and organisms. Heavy-water probing allows for the tracking of metabolic dynamics, providing insights into aging and age-related diseases.
A new universal photocage modification strategy based on thioketal enables real-time live cell subcellular imaging. The thioketal-based probe SiR-EDT exhibits improved dark stability and can be specifically activated by UV-visible light.
Researchers developed a new microscopy technique, HS-iFM, to study the dynamic mechanical properties of Escherichia coli membranes. The technique revealed increased stiffening during cell division and observed visible bridges that formed and eventually broke.
The researchers have developed a groundbreaking method to expand the color palette of bioluminescent protein to 20 distinct colors, enabling advanced simultaneous multi-color imaging. This innovation makes it significantly easier and more cost-effective to monitor multiple targets or track individual cells within a population.
Researchers developed an AI-powered technology that transforms low-resolution, label-free images into high-resolution, virtually stained ones without fluorescent dyes. This innovation delivers stable and accurate cell visualization, overcoming limitations of traditional imaging methods.
Researchers uncover the relationship between lysosomal exocytosis and focal adhesions, structures critical for cell anchoring and communication. The study identifies MYO18B as a key regulator of lysosomal exocytosis through focal adhesion maturation.
G protein-coupled receptors can form heteromers, affecting ligand binding properties and downstream signaling pathways. Recent advances in live cell imaging techniques provide crucial information on physical interactions in GPCR heteromers.
Osaka University researchers have reported a method that gives high-resolution Raman microscopy images of biological samples, up to eight times brighter than previous methods. This technique uses no stains and doesn't require chemicals to fix cells in position, providing a highly representative view of processes and cell behavior.
Researchers at Rice University developed soTILT3D, an innovative imaging platform that enables fast and precise 3D imaging of multiple cellular structures while controlling the extracellular environment. The platform improves upon conventional fluorescence microscopy by reducing background fluorescence and increasing imaging speed.
Researchers at Osaka University have created an innovative device called INSPCTOR that enables real-time remote monitoring of cell growth in incubators. This technology allows for effective quality control and precise measurement of cellular transformation, which is crucial for advancements in regenerative medicine and drug discovery.
Holotomography offers a promising approach to biomedical research, providing high-resolution images of live cells and tissues at the organelle level. The KAIST research team has developed core technologies and demonstrated its applications in various fields, including regenerative medicine and cancer research.
The CRISPR/Cas9 system has been adapted for genome visualization, enabling the study of chromatin dynamics and genome organization in living cells. Recent advancements have expanded its applications to live cell imaging, providing a robust tool for visualizing genomic loci.
Researchers from Brookhaven National Laboratory have developed an effective way to image a single cell using multiple techniques, providing significant implications in medicine and agriculture. The team used advanced X-ray imaging technologies to capture high-resolution images of the cellular structure and chemical processes within cells.
Researchers discovered a transient structure in fruit fly leg development that guides its final shape, shedding light on mechanisms determining an organism's body shape. This finding could lead to better understanding of processes shaping insect and other organisms' bodies.
Researchers from Osaka University have developed a new approach for super-resolution microscopy that can observe dense microstructures inside cells with excellent sharpness. By selecting only a desired plane to image using thin 'light sheet' illumination, they were able to achieve background-free super-resolution imaging.
A team at the University of Tokyo has constructed an improved mid-infrared microscope that enables them to see the structures inside living bacteria at the nanometer scale with a resolution of 120 nanometers. This breakthrough can aid multiple fields of research, including into infectious diseases.
Researchers found that nutrient-starved cells divert ER exit sites to lysosomes for degradation, using a novel pathway to free up amino acids. This process involves the recruitment of molecules to direct ER exit sites to lysosomes, where they are destroyed and their components recycled.
A new method called NIRE enables large-scale and long-term observation of neuronal structures and activities in awake mice. The method uses fluoropolymer nanosheets covered with light-curable resin to create larger cranial windows, allowing for high-resolution imaging with sub-micrometer resolution.
A new method for phase-modulated stimulated Raman scattering tomography enables rapid, label-free 3D chemical imaging of live cells and tissues. This technique improves lateral resolution and imaging depth compared to conventional methods.
Researchers developed a high-speed modulation system combining digital display with super-resolution imaging, significantly improving lateral and axial resolution. This enables detailed study of subcellular structures in animal cells and plant ultrastructures, paving the way for future biological discoveries.
USC researchers have designed nanoparticles that can target and highlight cancer cells in lymph nodes, allowing for earlier detection of metastasis. The particles work by hitchhiking on immune cells to reach the lymph nodes, where they can amplify the signal detected by MRI scans.
Researchers provide new insights into STING's function in innate immunity, revealing its role as a scaffold that activates TBK1. They also found that cholesterol plays a crucial role in STING clustering and activation, offering a potential target for treating diseases associated with STING inflammation.
MIT researchers have developed a new method to track cell differentiation and study long-term processes like cancer progression or embryonic development. They used noninvasive Raman spectroscopy to monitor embryonic stem cells as they differentiated into multiple cell types over several days.
Ashok Veeraraghavan, a Rice University professor, has won the Edith and Peter O'Donnell Award in Engineering from the Texas Academy of Medicine, Engineering, Science and Technology. His research focuses on making invisible objects visible through imaging technology that tackles challenges beyond current technologies.
A team of researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg has combined artemisinin with coumarin to develop an autofluorescent compound that destroys certain malaria pathogens. The new compound is effective against drug-resistant strains and shows promise for treating malaria.
Researchers at UC Santa Barbara have created a novel method to measure osmotic pressure in living cells and tissues, allowing for the study of cellular behavior and its impact on organ function. This technique has promising industrial and medical applications, including monitoring skin hydration and diagnosis of diseases.
Researchers have developed a novel optical on-demand droplet release (OODR) system that uses lasers to efficiently sort and export single-cell cultures from static droplet arrays. The system reduces reagent usage and sample size, while maintaining cell viability and analysis accuracy.
The new microscope uses structured illumination and optical fibers to achieve fast super-resolution imaging over a wide field of view, enabling the study of individual cell responses to various drugs. The system can image multiple cells simultaneously with high resolution, providing statistical information about cell response.
Researchers from Rice University and Princeton University have developed a new technology that allows for the live monitoring of signaling protein networks in living cells. The 'live reporter' system uses unobtrusive proteins to tag specific proteins, which can activate fluorescent markers when they become phosphorylated.
A recent study elucidated the role of EGF and its downstream signaling cascade in controlling oral keratinocyte behavior, offering new insights for pharmacological manipulation. The findings suggest that activating the EGF/EGFR pathway can enhance oral keratinocyte motility and proliferation.
Researchers at USC have developed a new technique called Hybrid Unmixing, which allows for simultaneous imaging of bright and dim labeled components within organic tissue. This enables accurate insights into cellular behaviors and metabolism, providing a comprehensive understanding of complex biological systems.
Researchers have designed a novel imaging and experimental preparation system to record the activity of the enteric nervous system in mice, providing new insights into the complex processes of digestion and waste elimination. The findings suggest that physical distention of the gut controls how the entire neural network is coordinated.
Researchers developed high-throughput Raman microscope for rapid large-area imaging hundreds of times faster than traditional approach. The new technique enables label-free molecular analysis and multiplex chemical imaging, holding promise for efficient medical diagnoses and drug development.
Researchers develop hybrid brightfield-darkfield transport of intensity approach, expanding accessible sample spatial frequencies and achieving 5-fold resolution increase. This method enables precise detection and quantitative analysis of subcellular features in large-scale cell studies.
A new protocol for live imaging of adult C. elegans has been developed, extending imaging time to over two hours while avoiding heat stress in the specimen. This breakthrough allows for high-resolution imaging of cell dynamics and developmental processes.
A team of researchers identified the precise mechanism of nuclear envelope repair, finding that lamin C, BAF, and cGAS work together to facilitate rapid repair. The study provides insights into rare genetic disorders such as laminopathies and has potential applications for understanding and treating related diseases.
Researchers develop conditionally active immunofluorescence probe, C11_Fab Q-body, for imaging p53 biomarker protein in live cancer cells. The probe displays high sensitivity and target specificity, enabling precise visualization of intracellular dynamics.
Researchers developed a label-free Raman spectroscopy approach with enhanced sensitivity and speed, allowing for non-invasive imaging of biological samples. The new CARS microscopy system can acquire microscopic images and identify biomolecules with unprecedented resolution and speed.
Researchers have developed a groundbreaking 'toolbox' to study receptor mobility in the brain, revealing its critical role in certain types of memory. The study used high-resolution imaging and manipulation techniques to observe receptor dynamics in intact brain tissue, providing new insights into the mechanisms controlling memory.
Researchers used a new 3D imaging technique to analyze the interaction between T-cell therapies and solid mini-tumors, revealing a wide variety of behaviors in engineered T cells. The study identified specific gene signatures of highly potent T cells that can target multiple tumor cells.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
A new imaging technique allows scientists to study mRNA molecules in the brains of living mice, revealing insights into how memories are formed and stored. The research could provide new information about diseases like Alzheimer's and help understand the process of memory generation and retrieval.
Researchers at the Lew lab have created a novel hardware and algorithm that enables visualization of cell membranes and molecular motions in six dimensions. This breakthrough allows for the observation of 3D structures with additional information on molecular orientation, providing new insights into biological systems.
Researchers developed a live imaging system to observe collagen synthesis in fibroblasts, revealing the intracellular processing and transportation of collagen fibers. The study found that this step controls the speed of collagen synthesis, providing a new understanding of collagen production.