Illumination Microscopy
Articles tagged with Illumination Microscopy
Let there be light: ERC project explores cells that control light from within
The ERC Consolidator Grant will support advanced microscopy and spectroscopic analysis to examine bacteria's interaction with light, potentially leading to new imaging technologies. This research may inspire Living Photonic Circuits where organelles control and guide light paths within living cells.
Elizabeth Hillman joins St. Jude as chair of Imaging Sciences
Elizabeth Hillman, a pioneer in imaging method development, is leading the new Department of Imaging Sciences at St. Jude Children's Research Hospital. The department aims to develop innovative new imaging and measurement approaches that will enable groundbreaking scientific studies and improve patient care.
Observing mammalian cells with superfast soft X-rays
Researchers developed a new technique to view living mammalian cells using ultrafast pulses of illumination from a soft X-ray free electron laser. The microscope captured images of carbon-based structures in living cells with high spatial resolution and a wide field of view, revealing new insights into cellular biology.
Researchers add swept illumination to open-top light-sheet microscope
A new open-top light-sheet microscope with swept illumination enhances the technique for nondestructive 3D pathology. The improved design quadruples the field of view and doubles optical sectioning ability, making it suitable for analyzing complex tissue structures.
Smaller, denser, better illuminators for computational microscopy
A team of researchers at the University of Connecticut created freeform illuminators that enable flexible illumination design and calibration using a blood-coated sensor. The newly developed technology simplifies microscopy experiments by reducing size, increasing density, and adjusting angle of illumination.
Speckle-illumination proves useful in photoacoustic microscopy
Researchers have successfully applied speckle illumination to photoacoustic microscopy, reducing tissue damage and improving image reconstruction. The technique harnesses the power of structured illumination methods initially developed for optical microscopy, allowing for more efficient imaging with acoustic detection.
High-throughput computational microscopy imaging
Researchers develop hybrid brightfield-darkfield transport of intensity approach, expanding accessible sample spatial frequencies and achieving 5-fold resolution increase. This method enables precise detection and quantitative analysis of subcellular features in large-scale cell studies.
The invention of a flexible ultra-thin endoscope thinner than a needle
Researchers developed a high-resolution holographic endoscope system that can reconstruct microscopic images without attaching equipment to the fiber bundle. The new endoscope has a diameter of 350 μm and achieves spatial resolution of 850 nm, far smaller than the core size of optical fibers.
Chip-scale metamicroscope for high-performance imaging
A newly developed polarizer-embedded metalens microscope system achieves high-quality, wide-field imaging with a large depth-of-field, significantly expanding human eyesight to the microworld. The chip-scale device offers a thousand-fold reduction in volume and weight compared to traditional microscopes.
A new microscope allows for high-throughput 3D adaptive optical imaging
A new microscope allows for real-time aberration-free dynamic speckle microscopy using compressed time-reversal matrix technology. This enables almost real-time volumetric adaptive optical imaging with reduced data acquisition time and improved lateral resolution.
Can the diffraction limit overcome in the linear imaging system?
Researchers develop chip-compatible 3D nanoscopy that surpasses the Abbe diffraction limit using a broadly-tunable large-spatial-frequency-shift effect. This method offers advantages over existing superresolution techniques, including high stability, low cost, and integration with microfluidic and optoelectronic functional chips.
Evolving the surgical microscope
The article reviews the development of surgical microscopes, from their introduction in 1921 to the latest advancements. Advanced technologies such as augmented reality displays, hyperspectral imaging, and robotic visualization platforms are increasing the capabilities of surgical microscopes. These improvements enable better visualiza...
The self-driving microscope
Researchers developed an adaptive microscope that can analyze and optimize its settings in real-time, achieving five-fold improvements in resolution. This technology enables long-term imaging of entire embryos and has significant implications for high-throughput drug screens and biological modeling.
New microscopes at NIH reveal live, developing cells in unprecedented 3-D clarity
Researchers have developed two new microscopes that capture fast-moving cells in 3-D and reduce light exposure to preserve cell health. The iSIM microscope enables real-time super resolution imaging of small structures at high speed.
Filming life in the fast lane
The new Multi-View SPIM microscope allows scientists to image rapid biological processes in thick samples at high resolution. It can record the movements of every nucleus in the embryo throughout its life, providing valuable insights into embryonic development.
New microscope produces dazzling 3-D movies of live cells
The new microscope allows researchers to study the dynamic inner lives of living cells without damaging them. It uses a combination of structured illumination and two-photon microscopy to create high-resolution, three-dimensional images of cellular landmarks.
A clearer view on biology
Scientists have developed a deconvolution algorithm that improves the resolution of Single Plane Illumination Microscope (SPIM) images. This advancement provides new opportunities for studying sub-cellular processes in large living specimens.
Researchers seek to discover what really happens when a virus enters the body
A new NIH grant will use electrical engineering concepts to profile host-virus interactions and identify immune responses. The study aims to develop a quantitative method to analyze the interaction between viruses and host cells, potentially leading to faster diagnosis and treatment of viral infections.