Articles tagged with Cognitive Disorders
New research suggests that neck lymph node removal may interfere with cerebrospinal fluid drainage, contributing to cognitive impairment. Patients undergoing cervical lymphadenectomy had a higher rate of cognitive impairment than the general population.
Research reveals that nearly half of childhood cancer survivors experience symptoms of anxiety or depression as adults. The study found that cognitive functioning, psychological symptoms, and fatigue were significantly affected, with 28% reporting difficulties with cognitive functions.
A recent study published in Sleep Medicine found that adults with elevated risk of dementia who took at least 5,000 IU of vitamin D daily showed better cognitive function compared to those who didn't. The study also highlighted the significance of timing and the form of vitamin D supplementation.
The Michigan ADRC will support studies on basic science, clinical trials, caregiver interventions, and longitudinal research to advance Alzheimer's disease prevention, treatment, and care. The center aims to fast-track clinical trials and improve the health and well-being of caregivers.
A new study from Wake Forest University School of Medicine found that chronic stress and social support levels are associated with changes in cognitive abilities across different demographic groups. Higher social support was linked to less decline in attention over time, while women and Hispanic participants with higher chronic stress ...
Experiencing childhood trauma increases likelihood of smoking, substance use, and unhealthy eating habits due to behavioural problems in adolescence. Early interventions addressing these mental health difficulties may reduce long-term physical health consequences of childhood trauma.
Researchers found that lower bone mineral density in the spine was associated with faster cognitive decline and accelerated age-related white matter injury. Lower bone density was also linked to specific brain regions, including the corpus callosum and the internal capsule, which support executive function.
People experiencing homelessness often face cognitive impairment due to various factors such as fetal alcohol syndrome, childhood trauma, and substance use disorders. To address this, experts recommend 24-hour supervision, brain rehabilitation, and structured care, akin to dementia support.
A study of 3,895 participants found that higher cortisol levels, particularly in Black individuals, were associated with cognitive decline. Cortisol patterns varied by race, with Black participants showing lower overall levels and less change throughout the day.
A UChicago study reveals that when the brain is unsure which information matters, separate visual features get mixed up in the brain, leading to poor performance on tasks. This 'feature interference' affects not only humans but also animals, and may provide insights into cognitive diseases.
A new UCLA study has found a connection between brain aging and gut biology, suggesting that people's brains may be aging decades before symptoms appear. The study, published in eBioMedicine, analyzed brain scans and stool samples to identify a link between brain communication patterns, gut bacteria, and brain aging.
Binghamton University receives $500K grant for 'brain-on-a-chip' project to advance dementia research. The project will establish advanced imaging and electrophysiological analysis infrastructure for studying living brain tissue models.
Researchers at USC developed an algorithmic tool to improve screening of patients for Alzheimer's clinical trials, reducing unnecessary PET scans by over half. The tool uses blood plasma biomarkers to identify patients at risk of Alzheimer's disease, enabling faster and more efficient recruitment for trials like AHEAD 3-45.
Researchers mapped 61 dementia risk factors to show individual motivation and behavior change may not be enough to prevent dementia. Social and environmental influences like education, housing, and healthcare access play a crucial role in brain health.
A community-adapted brain health program in Kikuyo Town, Japan, has achieved significant improvements in attention scores and dietary balance among older adults. The 24-week program, combining aerobic exercise, cognitive exercises, and lifestyle guidance, resulted in high attendance rates and positive feedback.
A cohort study found that only 30.7% of brain donors with clinician-adjudicated dementia had neurodegenerative death certification. The study suggests factors like worsening cognitive symptoms and functional impairment may be associated with increased likelihood of neurodegenerative death certification.
Researchers found a pattern of brain atrophy visible on MRI that can predict disease progression in people with early-onset Alzheimer's disease. This discovery could help clinicians identify patients likely to have a slower or faster disease course, supporting treatment and care planning.
Researchers found that healthier superficial white matter is associated with stronger language skills, and that gray matter atrophy measures remain the strongest predictors of cognition. However, the relationship between gray matter and cognitive performance depends on superficial white matter health.
Researchers discovered how anesthesia, surgery, and intensive care stress alter gene activity in the brain, leading to cognitive impairment and delirium. A new drug, vorinostat, reversed these changes, restoring memory formation and regulating the internal biological clock.
New research suggests that leisure-time exercise, such as walking or sports, is associated with a lower risk of dementia, while physically demanding jobs may increase dementia risk. The study analyzed data from over 4.2 million people and found that household physical activity also appeared beneficial.
A large study found a significant association between severe mental illness and dementia at every age, with adults aged 30-39 showing a 20-fold increased risk of dementia. The study also found a higher risk of stroke in early and middle adulthood, particularly in those with severe mental illness.
According to a national survey commissioned by The Ohio State University Wexner Medical Center, most U.S. adults believe brain health habits should begin before age 40. Regular exercise, quality sleep, healthy eating, and strong social connections can help support long-term brain health.
A study from Karolinska Institutet found that people treated with modern NOAC blood-thinning medicines experienced a slower rate of cognitive decline compared to those receiving warfarin or no anticoagulant treatment. This was associated with lower risk of other health problems, including death, stroke, and fractures.
A new ACC Scientific Statement highlights the importance of considering cognitive impairment and frailty in cardiovascular care for older adults. The statement outlines practical strategies for prevention, screening, assessment, and management, aiming to improve outcomes such as independence, mobility, and caregiver burden.
A new study reveals that patients with metabolic dysfunction-associated steatotic liver disease (MASLD) have elevated lipocalin-2 levels and exhibit early signs of cardiovascular and cognitive impairment. The findings highlight the importance of considering MASLD as a systemic condition affecting multiple organ systems.
A new study found that avoiding three risk factors in middle age is linked to nearly 13 more years without dementia. Participants who had no risk factors lived without developing dementia an average of 30 years, compared to 17 years for those with the three risk factors.
Researchers used real human brain tissue samples to test the underlying mechanisms of deep brain stimulation. They found that brain cells became more synchronized in communicating, similar to memory formation, while altering gene expression across different types of brain cells.
A study published in Molecular Psychiatry found that about 65% of patients who developed psychosis after age 40 showed abnormal tau buildup, compared to 15% of healthy older controls. The findings suggest diverse tau-related brain changes may be involved in late-onset psychosis.
A new report finds that delayed discharges and poor hospital environments keep people with dementia in hospitals unnecessarily, costing £328 million annually. The study suggests community-centric approaches can reduce hospitalisations and improve care.
A new study from UT Health San Antonio found that any degree of physical activity can slow cognitive decline in Hispanics. The research, which included 402 participants, also showed that controlling blood sugar levels and cardiovascular health are associated with a slower rate of cognitive decline.
The LifeAfter90 study found that women 90 and older are at two-fold greater risk for dementia, while Black participants have a 75% greater risk than Asian participants. APOE2's protective effects continue past age 90, reducing risk by 60%, but APOE4 increases the risk among men and Black participants.
A new USC study uses AI to generate detailed maps of brain aging, revealing distinct patterns of neurodegeneration in specific regions. The approach sheds light on how local brain age correlates with changes in cognitive function across the lifespan.
A Phase 2 clinical trial shows that a THC/CBD combination significantly reduces agitation in hospice-eligible people with dementia. The study, conducted across multiple US sites, achieved its primary and key secondary endpoints, demonstrating the efficacy of this treatment approach for end-of-life agitation.
A new $3.3 million study aims to investigate how people perceive cognitive changes as they age, with a focus on identifying predictive markers for dementia. The 'worried well' - individuals with cognitive complaints but normal test results - may hold clues to early disease detection.
A Canadian pilot study examined ways to link dementia patients' medical records with those of their caregivers. The report highlights critical gaps in clinical application due to EMR incompatibility, varying provincial privacy rules, and consent requirements.
Patients with autoimmune limbic encephalitis experience altered hippocampus size and function, leading to memory loss and apathy. This study reveals a link between hippocampus damage and behavioral changes, shedding light on the condition's effects on cognition and motivation.
A new paper reveals a live concert and lecture series improves emotional well-being, intellectual stimulation, and social interaction among dementia patients. Participants reported high satisfaction and improved mood following sessions.
A new study by Sanford Burnham Prebys found that bolstering the SORLA protein can reduce tau tangle toxicity, a common culprit in Alzheimer's disease and other neurodegenerative disorders. This suggests potential as a therapeutic strategy for treating these conditions.
A blood test measuring phosphorylated tau 217 (P-tau217) can estimate an individual's risk of developing cognitive impairment over 2, 5, and 10 years. Higher P-tau217 levels are associated with increased risk of progression to cognitive impairment in cognitively unimpaired older adults.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
A study analyzing 30,527 English dementia patients found hospital readmissions associated with multiple factors including sex, health conditions and post-discharge care. The research highlights the importance of monitoring and managing these risk factors to prevent hospital readmissions.
A digital therapy platform, iACT4CARERS, has been shown to reduce anxiety and depression in dementia carers after three and six months. The study, which involved almost 500 volunteers, found that carers using the platform had lower levels of anxiety and depression compared to those receiving usual care alone.
A new project developed by the University of Birmingham and Mind in Camden aims to improve understanding and response to people who hear voices, particularly when linked to suicidal thoughts. The resources encourage listening, curiosity, and collaboration to help individuals make sense of their experiences and feel more supported.
Research suggests alcohol interacts with Alzheimer's-related brain circuits in distinct ways, depending on the type of pathological change. Alcohol reduced communication in amyloid-beta models but increased it in tau models, highlighting an important principle in biology.
Researchers from Penn, NYU, and the Linguistic Data Consortium create virtual patients with adjustable psychiatric symptoms to simulate real-world conversations. The STELLAR platform aims to augment clinician training practices with essential conversation scenarios.
Researchers found minor cardiac dysfunction can predict microscopic tissue degradation in brain regions associated with Alzheimer's disease, leading to poor long-term memory performance.
A new Virginia Tech study finds that patterns of repetitive negative thinking can carry anxiety into deeper distress among dementia caregivers, but also suggests that mindfulness training may help identify and interrupt this progression. Researchers also found that introducing mindfulness early on can aid in managing stress before it d...
Research suggests that speaking more than one language can delay brain ageing and make individuals appear younger. The study found that those who spoke two languages had brains that appeared around six years younger, while those who spoke four languages appeared up to 13 years younger.
Researchers found that animal models with Alzheimer’s-related brain changes developed problems with cognitive flexibility months before showing signs of memory impairment. The study suggests that Alzheimer’s disease may affect neural circuits involved in executive function and adaptability before causing noticeable memory problems.
A new clinical trial led by University College London researchers found that ten weeks of cognitive rehabilitation can help people with long Covid symptoms such as brain fog achieve their goals in returning to work and hobbies. The treatment yielded benefits that lasted for at least six months for most participants.
Research suggests exposure to extreme heat and cold increases risk of emergency department visits among people with dementia. Extreme temperatures accelerate health events that would otherwise occur later, potentially leading to increased healthcare demand.
A new study published in Health Psychology reveals that individual personality traits play a significant role in how caregiving stress affects physical health. Caregivers with high neuroticism and low agreeableness experienced greater inflammation and poorer physical functioning, while others remained relatively resilient. The research...
A study led by Brown University researchers found that older adults who received the shingles vaccine had a 24% lower risk of being diagnosed with dementia within four years. The study analyzed health records and Medicare data from over 500,000 adults age 66 and older who were admitted to skilled nursing facilities.
A new study investigates whether obesity contributes to faster brain aging and earlier memory decline. Researchers found that high K63 polyubiquitination levels in young obese rats matched those seen in older brains, suggesting a connection between obesity-induced and age-related memory loss.
A study by DZNE shows that smartphone-based memory tests can detect subtle cognitive decline in people with mild cognitive impairment (MCI) more quickly than conventional testing. This approach has the potential to accelerate clinical trials for new dementia drugs and be used in routine care.
Researchers propose using low-dose lithium orotate to slow dementia progression in mild cognitive impairment, leveraging established neuroprotective mechanisms. The approach aims to mitigate kidney and thyroid risks associated with higher-dose formulations, offering a potentially accessible and inexpensive treatment option.
The JTMF Foundation has expanded its footprint with a $3.3 million gift to fund three main initiatives: identifying early signs of Alzheimer's in adults with Down syndrome, expanding access to cutting-edge clinical research, and developing best-practice guidelines.
A study led by Northwestern University identified a new biological culprit behind cognitive decline in people with HIV: the degradation of protective sugar molecules. Flu drugs preserved these sugar molecules and protected the brain in lab and mouse studies.
Dr. Owen Carmichael received the James W. and Neil Ann Parks Professorship for Dementia Research, Prevention and Treatment at Pennington Biomedical. His work focuses on developing advanced biomedical imaging techniques to better understand Alzheimer's disease and brain aging.
Researchers found biomarkers for Alzheimer's disease that correlated with minor cognitive differences in midlife adults. These biomarkers, measuring tau and amyloid plaque, were associated with a greater chance of cognitive decline, particularly in processing speed and executive function.