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Science News for March 2, 1999


A Versatile Signal In Vertebrate Embryogenesis: Wnt-4 Regulates Kidney Development, Sex Organ Differentiation, Neuronal Survival And Axonal Guidance

Researchers discovered Wnt-4's role in regulating kidney development through inducing tubulogenesis in isolated mesenchyme. Additionally, Wnt-4 suppresses male cell fates in female embryos, affecting sex organ differentiation. It also mediates tissue interactions involved in neuronal growth and axonal guidance.

Better Binding Through Chemistry

Researchers at HHMI and Stanford University have developed a new method to engineer drug molecules that bind more effectively to their targets. By attaching small molecule inhibitors to larger proteins, the team increased the binding affinity of the inhibitor, making it easier to inhibit protein-protein interactions.

SourceHoward Hughes Medical Institute·JournalProceedings of the National Academy of Sciences·DateMar 2, 1999

Degrading Plastics To Reduce Waste

A new type of degradable polyethene, SPI-TEK, breaks down in five years and allows other organic materials to decompose, increasing landfill site capacity. Bayer is also testing a new 100% degradable polyester suitable for industrial production in agriculture and food sectors.

SourceInstitute of Materials·JournalMaterials World·DateMar 2, 1999

Oregon Scientists Discover A Second Blood-Brain Barrier; Important Finding For Patients With Brain Cancers And Neurological Disorders

Researchers have found a secondary barrier in the brain that prevents certain drugs from reaching tumors and neurological disorders. The barrier is called the basement membrane and traps stealth agents while allowing others to pass through, highlighting challenges for gene therapy and drug delivery.

SourceOregon Health & Science University·JournalAmerican Journal of Neuroradiology·DateMar 2, 1999

A Little Volunteering Can Prolong Your Life

A University of Michigan study found that seniors who volunteer for less than an hour a week are more likely to live longer. The study analyzed data from 1,211 older adults and discovered that volunteering is directly associated with increased survival rates, rather than just being a result of better health.