A team of Canadian scientists identified a potentially useful target for drugs to treat type II diabetes and obesity by genetically engineering mice lacking a specific enzyme. The results showed that these mice resisted weight gain and insulin resistance on a high-calorie diet, suggesting a possible approach for treating the disease.
Scientists discover that the sense of smell in mammals uses a combinatorial code to recognize and process odors, allowing for the detection of thousands of scents with relatively few odor receptors. The study reveals that different combinations of receptors are used to describe various smells.
A 40-kilometer-long fault system has been identified directly under the Los Angeles metropolitan area, which is believed to have caused significant damage in recent earthquakes. The newly mapped 'blind-thrust' fault system stretches from downtown LA to northern Orange County and could potentially generate massive 7.0-magnitude quakes.
A study by Duke University Medical Center researchers found that highly depressed individuals have reduced autonomic regulation of blood pressure, increasing the risk of heart damage. Exercise was shown to be an effective treatment to restore this function and improve heart health.
Researchers created a test-tube photosynthesis system that mimics the metal cluster in green plants, shedding light on how life-giving oxygen is produced. The study, led by University of Delaware chemist Arnold Rheingold, may suggest new strategies for converting sunlight into electricity and enhance our appreciation of the natural world.
Scientists at Georgia Tech create a device that can accurately measure the mass of small particles by inducing resonance in individual carbon nanotubes. This technique has potential for weighing viruses and other sub-micron scale particles.
Linda Buck and colleagues found that the olfactory system uses a combination of odorant receptors to recognize different odors. The nose can discriminate a vast number of diverse odorants by recognizing distinct combinations of receptors.
Mice lacking a gene for making telomeres displayed symptoms of aging, including graying hair and increased tumor incidence. However, the study reveals that telomere loss is not solely responsible for aging, suggesting other mechanisms at play.
A study at the University of Pennsylvania Medical Center found that certain retrotransposons can pick up flanking genetic sequences and insert themselves along with tag-along DNA, creating novel genetic combinations. This mechanism may contribute to evolutionary change in humans and other mammals by generating genomic diversity.
The 1999 Tyler Prize honors Te-Tzu Chang's research on rice genetics and conservation, which has led to major advances in plant breeding, productivity, and disease resistance. Joel E. Cohen's contributions to understanding food webs and population growth have also had a lasting impact on both.
A new protein in Candida albicans allows the fungus to adhere strongly to mucosal cells, facilitating its growth and proliferation. The discovery could lead to the development of inhibitors to prevent or treat Candidiasis infections.