Scientists have discovered the genetic and molecular means by which roundworms develop resistance to Bt toxins, which are safe to humans but threaten long-term effectiveness. The researchers identified a galactosyltransferase enzyme as key to toxin recognition, enabling the development of strategies to delay or circumvent resistance.
Researchers found upper airway sensory impairment in snorers and OSA patients, increasing the risk of obstructive breathing episodes. The study also showed partial reversibility of sensory changes with continuous positive airway pressure treatment.
The National Science Foundation has funded a study that sheds light on the soft tissue biology of dinosaurs, specifically their nasal structures. The research, led by Lawrence Witmer, provides clues to how air flowed and affected olfaction and heat exchange in these prehistoric creatures.
Researchers have designed and synthesized highly potent inhibitor compounds that could lead to an effective treatment for Alzheimer’s disease. The new inhibitors are substantially smaller, comparable in size to HIV protease inhibitor drugs, and still potent.
Researchers pinpointed the gene on chromosome 3 that causes myotonic muscular dystrophy Type 2 (DM2), a complex disease affecting multiple systems. The discovery allows for the immediate development of a genetic test and paves the way for a more complete understanding and treatment of this form of muscular dystrophy.
A prospective study reveals coeliac disease patients experience a substantial excess of deaths, particularly within the first three years after diagnosis and those with malabsorption symptoms. Early diagnosis is crucial to prevent mortality, as delay in diagnosis and poor treatment adherence can significantly worsen outcomes.
Scientists have found that between 700,000 to 2.7 million people die annually from malaria, with African children being the hardest hit. The disease also has significant economic implications, as countries with severe transmission experience slower growth rates than those with fewer infections.
Research by Lawrence Witmer reveals that many dinosaurs had large nasal passages, contrary to previous depictions. The study suggests that these passages were positioned closer to the mouths and farther from the eyes, which could have been important for heat exchange and other physiological processes.
Researchers propose integrating highly-active antiretroviral therapy (HAART) into existing tuberculosis-control infrastructure in less-developed countries. Directly-observed therapy has shown effectiveness in resource-poor settings with sustained commitment to uninterrupted care that is free to the patient.
Hyperion successfully navigated through rough terrain, including scree slopes and mud flats, covering a distance of 9.1 kilometers in an extended experiment. The technology has proven fundamental ideas for robotic explorers to operate at the poles of the moon or in polar regions of Mars.
Researchers have identified a gene that confers high levels of resistance in the tobacco budworm moth to genetically engineered crops with built-in insecticides. This discovery will enable farmers and government officials to take early steps to prevent uncontrollable outbreaks by detecting the early signs of pests evolving resistance.
Researchers at NYU Langone Health successfully immunized mice against Alzheimer's disease using a new vaccine that reduces amyloid plaque and soluble beta levels. The vaccine, modeled on a modified peptide, appears to be non-toxic and shows great promise for the treatment of Alzheimer's disease.
Researchers at the University of Maryland Biotechnology Institute have engineered rats to contain the genome of HIV-1, making them a valuable model for studying AIDS-related diseases. The rats develop clinical signs similar to those of AIDS in humans, including neurological abnormalities and organ damage.
A large-scale population study found that low cholesterol concentrations were associated with higher death rates among elderly people. The study, which analyzed data from over 3,500 men aged 71-93, suggested that long-term persistence of low cholesterol concentration increases the risk of death.
A new study reveals that dinosaurs' noses were positioned closer to the mouth than previously thought, offering insights into their respiratory system and evolutionary advantages.
A qualitative study of 32 people with HIV-1 or AIDS found that disintegration and loss of community are key factors driving desire for euthanasia and assisted suicide. The study suggests that clinicians must consider the complexity of patients' experiences when evaluating requests for physician-assisted suicide.
A new study in the journal Science found that dinosaurs' fleshy nostrils were typically positioned forward of their bony nose openings. This finding has implications for how dinosaurs breathed, smelled, and regulated body temperature and water loss, potentially providing clues to their adaptations to different environments.
A study found that a specific mutation in the human MDR1 gene affects P-glycoprotein expression, leading to decreased effectiveness of HIV-1 protease inhibitors in West Africans and African Americans compared to Caucasians. This could have significant implications for drug treatment in these populations.
Young adults experiencing nontraumatic chest pains may have cocaine use, researchers say. Effective treatments include nitroglycerin or calcium blockers for constricted blood vessels.