The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has established a national family registry for scleroderma research. The registry will study families with one or multiple cases of the disease to identify genetic factors, environmental triggers, and susceptibility genes.
A USC study found that administering a drug to lower insulin resistance in women at high risk for type 2 diabetes successfully prevents or stalls its onset. The study tested whether reducing the demands on beta cells could prevent diabetes in Latinas with recent gestational diabetes.
A USC study found that teenagers and young adults with type 1 diabetes have a higher risk of atherosclerosis, or plaque buildup in their arteries. The study suggests that physicians should monitor lipid levels in these patients, even at an early age, to prevent cardiovascular problems.
A USC-developed nutrition and exercise program has been shown to significantly reduce weight gain in children, increase fruit and vegetable consumption, and enhance physical activity. The Kids N Fitness program is effective in promoting healthy eating habits and regular exercise among obese children.
A large cohort study found that pregnancy complications such as low birthweight, preterm delivery, and pre-eclampsia are associated with an increased risk of maternal ischaemic heart disease. Women who experienced these complications were more likely to be hospitalized or die from IHD.
Febrile reactions occur in around a third of platelet transfusions. Researchers propose that CD40 ligand release from platelets triggers the production of proinflammatory prostaglandin E2, leading to fever. Keeping CD40 ligand levels low before transfusion might reduce adverse events.
Researchers developed a rapid ELISPOT assay to detect T cells responding to ESAT-6 protein, which is absent in BCG vaccine strains. The new test shows stronger correlation with exposure intensity than existing tuberculin skin test (TST), providing potential for improved tuberculosis control and targeted preventative therapy.