Researchers identified a mutated separase gene responsible for chromosomal instability and increased tumor load in zebrafish exposed to carcinogens. The study highlights the importance of genomic stability genes in tumor development.
Researchers discovered that microRNA miR-133 targets the alternative splicing factor nPTB during early myogenesis, promoting muscle cell differentiation. This regulation affects a larger temporal program of muscle cell gene expression by altering mRNA splicing.
Researchers at Cold Spring Harbor Laboratory discovered that DNA damage response pathways mediate oncogene-induced senescence. The study suggests that targeting these pathways could lead to novel approaches for preventing cancer formation.
Researchers discovered that Rb is required for the maintenance of trophoblast stem cell population, which is critical for forming the placenta. Specific loss of Rb in trophoblast stem cells leads to overexpansion of trophoblast cells and aberrant placental formation.