A recent study by Yale University found that combining classroom instruction with behind-the-wheel training significantly improves driving performance among seniors aged 70 or older. The research suggests that this easily implemented intervention can enhance safe driving years and maintain independence.
Leading experts in organic solar cells have expressed concern over the field's reputation being damaged by reports of unrealistic results. The experts call for independent verification and accurate reporting to ensure the success of OSCs.
Researchers used capsule endoscopy to evaluate unexplained gastrointestinal bleeding and found six previously undiagnosed cases of Crohn's disease. The study highlights the tool's ability to detect inflammation in the small intestine, which can be missed by colonoscopies.
The structure of hemagglutinin on influenza B virus provides key insights into potential mutations that could spark a pandemic. By comparing it to a similar protein on influenza A virus, researchers may be able to understand the changes needed for avian flu to infect humans.
Researchers found equivalent survival rates for angioplasty and bypass surgery, refuting previous reports on diabetic patients. Bypass surgery led to fewer repeat procedures and more effective angina relief.
Researchers aim to create a new technology that stabilizes soil for road construction, improving the environment and cellulosic ethanol industry. Soil conditions in Iowa often require mixing chemicals to improve strength, but current practices have limitations.
Research highlights underreporting of NSAID use, leading to significant GI complications and healthcare costs. Administering proton pump inhibitors with NSAIDs can help mitigate these risks and reduce hospitalization costs.
A new study provides insight into trastuzumab resistance in breast cancer by identifying the PI3K pathway as a key factor. The research found that tumor suppressor PTEN and activating mutations of the PIK3CA gene contribute to trastuzumab resistance, suggesting a potential strategy for treating resistant patients.
Researchers from UC San Diego have developed a more accurate method for predicting breast cancer metastasis by analyzing protein interactions. Their approach, which uses a network of genes rather than individual genes, improves metastasis prediction accuracy to around 72%.
Researchers developed a hybrid technique to probe the dynamics of the Holliday junction, a four-stranded DNA structure that forms during homologous recombination. The study found that the intermediate structure is similar to that of a Holliday junction bound to its own processing enzyme.
The study reveals that f and m type plant thioredoxins are not only localized to chloroplasts but also found in nonphotosynthetic tissues such as stems, leaves, roots, and flowers. These findings suggest new roles for these proteins in cell division, germination, and plant reproduction.
Researchers at the University of Illinois have discovered that tropical maize can produce up to 25% sugar in its stalks, making it a promising alternative to corn for biofuel production. This could result in significant energy savings per acre and reduced nitrogen fertilizer costs.
Researchers studying elevated homocysteine levels on vision found that it disrupts the retina's blood vessel network. Elevated homocysteine levels can also interfere with protein synthesis, collagen structure, and folate transport, leading to retinal damage and vision loss.
A new study found that 18% of bariatric surgery candidates were not psychologically cleared for surgery, citing frequent overeating as a coping mechanism for stress and uncontrolled psychiatric disorders. Researchers emphasize the importance of pre-operative screening to determine suitable surgical candidates.
Researchers found that initial screening colonoscopy with polyp removal significantly reduces colon cancer mortality. The study suggests extending follow-up surveillance intervals from 3-5 years to 6 or more years, contingent on adequate bowel preparation and visualization of the colon.
Scientists from the University of Chicago and Kyoto University suggest that a DNA-repair mechanism normally prevents tumor growth may instead contribute to poor-prognosis breast cancer in BRCA1 carriers. Elevated RAD51 levels may help cells compensate for the defect, but also lead to genetic instability and increased tumor risk.
Post-hoc analyses of secondary endpoints from the long-term LIALDA trial show that the medication is effective in maintaining remission in various patient groups, including those with mild and moderate ulcerative colitis. The data also suggest that LIALDA can induce initial symptom resolution within weeks.
Scientists identified DMP1 as a tumor suppressor that activates Arf expression, inducing p53-dependent cell cycle arrest. DMP1 deletion or haploid insufficiency accelerates lung cancer development in K-ras mutated mice and patients, suggesting its potential as a target for drug therapy.
Researchers found that gastric bypass patients are at risk of developing small intestinal bacterial overgrowth (SIBO) and malabsorption of vitamins, minerals, and micronutrients. This can lead to conditions like osteopenia, osteoporosis, and osteomalacia.
Chris Culbertson has received a 2007 Masao Horiba Award for his work on rapid analysis of individual T-lymphocyte cells using microfluidic devices. This honor recognizes the future potential and originality of his research, which could lead to unique measurement instruments.
Functional gastrointestinal disorders significantly impact daily activity and work productivity, with a loss of at least one day of work in a 40-hour workweek. Patients with conditions like IBS-C, CC, and FD report greater impairment than those with GERD alone.
A recent study found that ponds' community diversity converges after a drought, with only hardy species able to withstand the conditions. This convergence has important implications for wetland restoration and creation, highlighting the need to consider stochasticity and beta diversity in ecological restorations.
Researchers found that mesalamine use among patients with inflammatory bowel disease was associated with a decreased incidence of colorectal cancer. Mesalamine use was linked to an 89% reduction in risk of colorectal cancer, according to the study.
Research found obesity to be the highest attributable risk factor for developing colorectal cancer in women. Among participants, 20% were obese and 14% were smokers, with BMI accounting for one-fifth of significant polyps detected during colonoscopy.
A study found that modafinil is effective in treating excessive sleepiness associated with disorders of sleep and wakefulness. The medication was well-tolerated with a low risk of adverse events.
Bariatric surgery significantly increases the risk of death from heart disease and suicide, with nearly 6% of patients dying within five years. The study found that age and comorbidities play a significant role in these outcomes.
A new self-completed instrument, the Cleveland Adolescent Sleepiness Questionnaire (CASQ), measures excessive daytime sleepiness in adolescents. CASQ scores are positively correlated with age and display convergent validity with other surveys, showing promise as a valid measure for clinicians and parents.
The HORIZONS AMI trial enrolled over 3600 patients with a heart attack, examining the safety and effectiveness of stents and anticoagulants in heart attack patients undergoing angioplasty. The study aims to determine whether using bivalirudin provides the same benefit as standard anticoagulant therapy without causing excess bleeding.
Children diagnosed with breathing disorders show improved sleep quality and reduced hyperactivity after tonsillectomy, according to a study. The surgery also correlates positively with improvements in cognitive function and ADHD symptoms.
The STROBE Initiative recommends a 22-item checklist for accurate and complete report of observational studies. The guidelines enhance the assessment of study strengths and weaknesses, as well as its generalizability. By following these recommendations, researchers can improve the quality of their work.
Researchers from Indiana University School of Medicine and Regenstrief Institute advocate for collaborative dementia care model that extends beyond primary care doctor's office into patients' homes and communities.
MIT scientists propose that blood modulates how neurons process information and regulate brain activity. Blood flow affects the activity of nearby neurons, changing how they transmit signals and hence regulating information flow throughout the brain.
High-risk morbidly obese patients who lose 5-10% of their excess body weight before undergoing gastric bypass surgery have shorter hospital stays and more rapid postoperative weight loss. Preoperative weight loss also decreases surgical complications, reducing hospital stay length.
Depression is associated with an increased risk of mortality and adverse cardiovascular outcomes, including heart attacks and strokes. Antidepressant treatments have been shown to be safe and effective in reducing mortality and improving health behaviors in patients with coronary artery disease.
The European College of Neuropsychopharmacology emphasizes the need for early intervention and preventive measures for mental disorders. The vast majority of people with mental disorders remain untreated, particularly in adolescents and young adults.
Research found that people with GERD are more likely to experience sleep impairment, with 41.9% of those with nighttime acid reflux reporting poor sleep. In contrast, only 19.4% of those without GERD reported similar issues.
Researchers investigate various aspects of wound healing, including exercise, compression therapy, and medication. Studies show that patients with leg ulcers often lack physical activity and use inadequate compression therapy, while medication may have a protective association against leg ulcers. Additionally, injection drug use is lin...
A new systematic review of trials comparing coronary artery bypass graft (CABG) surgery and percutaneous coronary intervention (PCI) found that survival to 10 years was similar between the two procedures. CABG was more effective in relieving angina, but had a higher risk for procedural stroke, while PCI led to more repeated revasculari...
Researchers found a significant drop in blood pressure during the sleep trial, but not during resting or standing trials. This reduction occurred mostly after lights out, just before falling asleep, and may explain the lower cardiovascular mortality associated with siesta-taking.
The University of Chicago will establish a Center for Education and Research on Therapeutics (CERT) to focus on hospital medicine and economics. The grant will support research projects on the effective use of hospital therapeutics, gene-drug interactions, and quality-improvement teams.
New studies support continued colorectal cancer screening among healthy elderly Americans, with screenings leading to earlier stage of CRC diagnosis and improved survival. Researchers found that adenomas were detected more frequently in older patients, and asymptomatic patients had significantly improved survival rates.
Obese Medicaid patients undergoing Roux-en-Y gastric bypass surgery were more likely to return to work, with 37% working after surgery compared to 6% of non-surgical controls. Resolution of comorbid conditions post-surgery was a key factor in return to work.
Scientists have discovered a new gene, Dmp1, linked to human lung cancer, which is often deleted in lung tumors. The study found that the non-functional Dmp1 gene leads to reduced activity of tumor suppressors p53 and Arf, allowing cancer cells to grow unchecked.
The University of Delaware has been selected as a regional research site for the National Children's Study, which will follow 100,000 children from birth to age 21. Researchers will monitor child health and gather data on environmental factors to prevent and treat diseases such as autism and obesity.
African-Americans have a higher incidence of colorectal cancer, with advanced polyps on the right side of the colon more common. Latin Americans also show similar high-risk findings to African-Americans in colonoscopy screenings.
Researchers have made significant breakthroughs in Alzheimer's disease research, identifying A
The report found that cancer death rates declined by an average of 2.1 percent per year from 2002 to 2004, nearly twice the annual decrease of 1.1 percent per year from 1993 to 2002. Cancer incidence rates among American Indians and Alaska Natives varied two-fold across six geographic regions.
Researchers found acid reflux was a significant factor in patients experiencing serious chest pain and persistent cough. A cost-effective diagnostic tool may help determine which patients benefit from anti-reflux surgery.
Consumers eating raw fish may be at risk of intestinal parasitic infection Anisakiasis, which can cause sudden abdominal pain, nausea, and vomiting. Diagnosed by endoscopy or imaging tests, the condition is often treatable with fluid replacement and rest.
Researchers have found a genetic mutation in zebrafish that causes insomnia, providing a new animal model for studying sleep disorders. The study reveals that zebrafish experience reduced overall sleep and shorter sleep duration compared to normal fish.
A recent study by Laurie Rudman and Julie Phelan reveals that feminism is associated with improved relationship quality, stability, and sexual satisfaction in heterosexual couples. The research challenges the common assumption that feminism and romance are incompatible.
A study published in PLOS Medicine found that over one-third of patients receiving HIV medication in Africa discontinue treatment within two years. However, the average retention rate at two years was estimated at 61.6%, indicating some success in maintaining treatment. Researchers suggest improving retention rates by starting treatmen...
A recent editorial highlights the need for further research on bariatric surgery's risks and outcomes to convince non-believers of its benefits for morbidly obese patients. Studies suggest that routine upper GI tests may not be necessary, and complications can have devastating consequences if left untreated.
The HealthGrades Hospital Quality in America Study found a 71% lower mortality rate at top-rated hospitals compared to the lowest-rated hospitals across 18 procedures and conditions. Improvements were seen in procedures like pancreatitis, pulmonary embolism, and diabetic acidosis and coma.
A review of 13 randomized controlled trials found that only Bifantis showed significant improvement in IBS symptoms. The study evaluated the safety, efficacy, and tolerability of probiotics for IBS treatment.
A Phase 2 study showed ALO-01, an extended-release morphine sulfate plus sequestered naltrexone, provided similar effectiveness and tolerability to KADIAN Capsules for moderate-to-severe chronic osteoarthritis pain. The majority of patients rated both medications as good or excellent.
A study published in JCSM found that CPAP therapy significantly decreases symptoms of depression in OSA patients. Long-term follow-up assessments revealed sustained improvement in depressive symptoms after institution of CPAP therapy.
A new once-daily lamotrigine extended-release formula effectively controls partial seizures in people already taking one to two medications. The study found significant reductions in seizure frequency and improved medication adherence, making it a promising option for those with epilepsy.
Researchers at Baylor College of Medicine and Rice University have developed a molecular map of the influenza B virus's hemagglutinin protein. The study reveals similarities between the protein's sequence and function in flu A and B strains, suggesting that minor mutations could enable bird flu to spread among humans.
A study by Penn State professors finds that CEOs with stock option-heavy compensation packages lead companies to extreme performance, with more big losses than big gains. High levels of CEO stock options coupled with high investment spending produce a 'combustible combination' resulting in very extreme outcomes.