Researchers have developed a high-fidelity animal model of osteosarcoma by genetically modifying mice to lack the p53 and Rb tumor suppressor genes. This model closely recapitulates human osteosarcomagenesis, providing valuable insights into the disease's genetic contributions.
EhROM1 enzyme plays a crucial role in E. histolytica's immune evasion and surface protein shedding. The discovery paves the way for developing rhomboid inhibitors as a novel anti-parasitic strategy.
Researchers found a new enzyme, EhROM1, that helps the dysentery-causing amoeba evade the immune system. The enzyme is part of an ancient group of enzymes used by malaria parasites to enter host cells.