Scientists have discovered a new clue for understanding how misfolded proteins cause cell death in Huntington's disease. The study found that polyQ-expanded proteins interact with and trap other proteins, leading to a breakdown in protein quality control, which may contribute to the disease's toxicity.
Researchers found that immune cells known as killer T cells recruit other accessory cells to drive the disease, causing blood vessel damage. This discovery offers a new avenue for possible treatments for deadly meningitis.
A study by Associate Professor Katherine Samaras reveals that HIV treatment causes inflammation, leading to increased cardiac and metabolic risk. Patients with HIV-infection tend to gain weight around their abdomen, increasing their risk of heart disease and diabetes.
A large-scale clinical trial found no significant protection against cancer from long-term vitamin E or C supplements. Researchers followed over 14,000 physicians for up to 10 years without detecting a link between these supplements and reduced cancer rates.
The article reveals substantial inequalities in healthy life years (HLYs) from the age of 50 across EU countries, with GDP and spending on elderly care being key factors. HLYs at 50 are highest in Denmark and Malta for men, and France, Italy, and Spain for women, while lowest in Estonia and Hungary.
Researchers found that men taking aspirin had significantly lower PSA levels, especially among those with prostate cancer. However, this may affect the ability to detect early-stage prostate cancer through PSA screening.
Researchers found that DFMO treatment reduced dysplasia progression in patients with Barrett's esophagus, while also lowering putrescine levels and KLF5 expression. The study suggests a potential mechanism for the chemopreventive effects of DFMO.
New research reveals FoxJ1 helps create left-right asymmetry by orchestrating the formation of nodal cilia, which generate fluid flow to orient tissues. The study finds that increasing FoxJ1 levels leads to the formation of ectopic cilia, challenging current theories on its role.
A University of New South Wales researcher calls for a more flexible approach to vaccine funding, considering quality-of-life impacts. This could lead to improved productivity, reduced sick leave for parents, and enhanced herd immunity against diseases such as chickenpox and shingles.
A study found that cocaine-addicted individuals prefer drug-related images over neutral ones, challenging the assumption that pleasure drives drug choice. The tasks developed in this research can help clinicians monitor choice behavior in addicted individuals, potentially predicting treatment effectiveness and outcomes.
A large clinical trial found that calcium supplementation reduced colorectal adenoma recurrence risk by 32% only in those with low magnesium to calcium ratio. This suggests a personalized diet/supplementation regimen considering both nutrients may be more effective than supplementing with one alone.
Comet particles from Wild 2 provide a glimpse of the solar system's early convulsions, flinging primordial material out into the cold regions. The particles contain minerals formed at high temperatures, suggesting transport from the inner to outer solar system.
Researchers at Northwestern University's Feinberg School of Medicine discovered that super-aged brains have a lower number of fiber-like tangles, which accumulate inside brain cells and are thought to kill them. This finding suggests that individuals with fewer tangles perform better cognitively.
A team of Boston College and MIT scientists has discovered a new class of exceptionally effective catalysts that promote the powerful olefin metathesis reaction, opening up a vast new scientific platform. The new catalysts provide unprecedented control and selectivity for complex chemical reactions.
Scientists have identified new species of bacteria that can grow at low temperatures and spoil raw milk even when refrigerated. The discovery highlights the complex microbial population of raw milk and underscores the importance of developing tools to monitor cold-tolerant bacteria.
Glioblastoma cells release exosomes containing RNA and proteins that promote tumor growth, but also carry data that can be used to guide targeted therapy. The study identified factors in these exosomes that could be used as biomarkers to monitor treatment response.