Researchers at Medical College of Georgia identified a new gene, chromodomain helicase DNA binding protein 7 (CHD7), responsible for some puberty disorders, including idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome. The study found that CHD7 mutations account for about 6% of IHH and Kallmann syndrome cases.
Purdue researchers found that invasive earthworms enrich forest litter with lignin, a harder-to-decompose plant material, while those with low earthworm activity accumulate more easily degraded carbon. This shift affects soil organisms' ability to decompose remaining carbon.
Researchers have uncovered an extensive network of regulatory interactions influencing protein production and placement in cells. A pervasive system of biological regulation, similar to transcription factors, guides the fates of most protein-coding RNA molecules by recognizing specific sequences.
Researchers have created reliable nanopatterns of a spin-transition compound on silicon oxide chips, paving the way for new molecular storage media. The development uses special unconventional micro- and nanolithographic techniques to print neutral iron(II) complexes onto silicon wafers in the form of fine lines.
Researchers found that PIN proteins are transported throughout the cell membrane and then endocytosed before being recycled and transported to the bottom of the cell. This mechanism allows plants to quickly adapt to changes in gravity, enabling new 'undersides' for roots and shoots.
Researchers found that sulfonylurea treatment failure is not due to cell death, but rather permanent depolarization of potassium channels. Reversible effects on insulin release were observed in mice treated with slow-release sulfonylureas.
The University of Illinois is receiving a $2 million NSF grant to develop sustainable biofuels infrastructure. Researchers will examine the engineering, social, environmental and economic constraints of building a sustainably-supporting bio-economy.
Researchers found that high doses of cortisone can prevent negative consequences of stress exposure, including increased startle response and behavioral freezing. This finding suggests a possible treatment option for post-traumatic stress disorder (PTSD) in its acute phase.
The Crop Science Society of America recognized six individuals for their outstanding contributions to crop science. Palle Pedersen received the ASA–CSSA–SSSA Early Career Professional Award for his work on soybean production problems. The award also went to Crystal Rose-Fricker, who developed cool-season turfgrasses with improved disea...
The American Society of Agronomy has recognized five individuals with prestigious awards for their excellence in agronomic education, extension, and service. Lee Burras received the Agronomic Resident Education Award for his outstanding teaching skills, while William J. Cox was honored with the Agronomic Extension Education Award for h...
Researchers have identified five compounds that block the activity of the trypanosomal REL1 enzyme, which is crucial for the parasite's survival. The approach uses computational tools to predict the dynamics of proteins and test hundreds of compounds for their ability to inhibit the enzyme.
A landmark study found that wearing masks and using hand sanitizers may reduce the spread of flu-like symptoms by as much as 50 percent. The study involved over 1,000 students from seven U-M residence halls and showed significant reductions in influenza-like illness symptoms after implementing mask use and hand sanitizer protocols.
Researchers discovered patterns of brain activity that underlie our ability to see and understand three-dimensional object structure. Higher-level visual regions represent objects as spatial configurations of surface fragments, which are encoded by individual neurons tuned to respond to specific surface fragment substructures.
The project uses laptops with built-in accelerometer chips to detect tremors, allowing for faster earthquake detection and more accurate location of strong motions. With many sensors, it's possible to provide several seconds of warning before an earthquake hits neighboring regions.
Researchers have isolated five new Rubrobacter strains that contribute to the biodeterioration of old buildings. These bacteria degrade building materials through vital activities.
A new study published in the Journal of Environmental Quality examines the health hazards of treated sewage sludge application to land. The risks of aerosol-borne infection for biosolids workers are generally low, at less than 1 or 2% per year.
The study reveals that diabetes prescriptions increased, with more medications prescribed per patient and higher costs, from $6.7 billion in 2001 to $12.5 billion in 2007. Insulin use decreased, while the use of newer drugs like glitazones increased.
Researchers created a first-ever genetic animal model to study anesthetic agents' effects on individuals genetically predisposed to arrhythmia and sudden cardiac death. The study found that some anesthetics trigger arrhythmias, particularly in models with long QT syndrome.
Individual investors are liquidating their holdings at record levels due to economic loss, opting for a risk-averse approach despite prospect theory's predictions. The MSU research challenges widely accepted behavioral theory, suggesting people prioritize preserving losses over recouping them through gambling.
Research suggests that most individuals' end-of-life treatment preferences do not change over three years, regardless of physical or mental decline. However, those who initially desired aggressive care and lacked advance directives showed the greatest changes in their wishes.
Researchers at Newcastle University have identified a key brain link that causes schizophrenia, revealing NMDA receptors play a critical role in modifying brain oscillations. Optimizing receptor function could lead to new treatment approaches for the mental illness, affecting one in 100 people.
The University of British Columbia and the University of California, San Diego are partnering to develop methods for sharing greenhouse gas emission data and baseline emission data for cyberinfrastructure. This partnership aims to create carbon-neutral environments through research and collaboration.
A study published in Nature Biotechnology found that feeding knockout mice with powdered purple tomatoes increased their lifespan by an average of 40 days. The high anthocyanin content of the tomatoes demonstrated significant antioxidant activity, potentially leading to new ways to prevent diseases like cancer and cardiovascular disease.
Mayo Clinic researchers have discovered a way to control oncolytic viruses using microRNAs, which can restrict them to specific tissues and make them safer for use in cancer therapy. This discovery could lead to new methods of making safer vaccines.
A University of Iowa study identifies a faulty signaling pathway that causes exercise-induced fatigue in mouse models of muscular dystrophy. The research suggests that targeting this pathway may lead to therapies for this type of fatigue. Viagra was shown to overcome the signaling defect and relieve the fatigue.
The discovery of burned flint at Gesher Benot Ya'aqov site pushes back the accepted date for man's fire-making ability by half a million years, indicating that early humans controlled fire from 790,000 years ago. This skill enabled ancient humans to leave their surroundings and populate new environments.
A review found that off-label use of anticancer drugs ranged from 6.7% to 33.2% between 1990 and 2002, primarily used in palliative care. The study highlights the need for accurate data on off-label use to inform decision-making by health professionals.
Phase III trials demonstrate iclaprim's effectiveness in treating complicated skin and skin structure infections caused by Gram-positive bacteria, including MRSA. The antibiotic showed a high clinical cure rate similar to linezolid and was well-tolerated with a favorable safety profile.
A CDC-funded study found that vaccinating new mothers and family members against influenza before a newborn leaves the hospital significantly boosts immunization rates. The 'cocooning effect' also protects unprotected children from the flu, which can be life-threatening to infants.
Researchers found a 71% higher risk of death for patients who deferred treatment compared to those who started HAART earlier. The study's findings suggest that initiating therapy at an earlier stage of HIV disease may improve patient outcomes.
Researchers have successfully expressed genes from snapdragon into tomatoes, resulting in higher levels of anthocyanins. The purple tomatoes showed promise in extending the lifespan of cancer-susceptible mice, suggesting potential health benefits for consumers.
A Phase III study found that the high-dose influenza vaccine increased immune responses to all three influenza strains compared to the standard vaccine in adults 65 years old and older. The new vaccine also showed increased immune response in those with no measurable protective antibodies before vaccination.
A study found that a higher dose of flu vaccine boosts the immune response in people aged 65 and older, increasing antibody levels by 30-80% compared to the standard dose. This could lead to better protection against the flu for those most at risk.
The guidelines aim to ensure physicians worldwide are aware of available treatments for patients with psoriatic arthritis. Newer medications inhibiting tumor necrosis factor (TNF) are recommended for consideration.
The study found that magnetized water exhibits magnetism, a saturation effect, and memory properties. New phenomena, such as irreversible infrared absorption and exponential UV absorption, were also discovered. These findings support the theory of magnetization of water proposed by Professor Pang Xiao-Feng.
Rheumatoid arthritis incidence and prevalence are on the rise among women in the US, with a 54% increase in female cases from 36 to 54 per 100,000 annually, according to a Mayo Clinic study. Researchers believe an environmental factor may be contributing to this trend, which could indicate a need for further research.
Research at the American College of Rheumatology 2008 Annual Meeting found that rheumatoid arthritis patients are at a higher risk of dying from heart-related complications after a heart attack. Biomarkers have been identified to determine the most effective treatment for muscle tissue inflammation and age-related bone loss in men and ...
A study at Henry Ford Hospital found that rapid HIV testing in the Emergency Department increased diagnoses by 56%, particularly among African American patients. The test provided results in just 20 minutes and helped identify high-risk individuals, who were more likely to modify their behavior and reduce transmission.
Researchers at Hospital for Special Surgery found that women with stable or mildly active lupus have relatively infrequent flares during pregnancy and deliver healthy babies. The PROMISSE study identified factors to help plan a low-risk pregnancy, including monitoring antiphospholipid antibodies.
Frank L. Meyskens Jr., a renowned cancer prevention researcher, has received the AACR-Prevent Cancer Foundation Award for his significant contributions to the field. His work on chemoprevention, including the development of topical all-trans-retinoic acid for cervical intraepithelial neoplasia, has moved the field forward.
Researchers from Uppsala University have discovered a mechanism that silences several genes on a chromosome domain, leading to the genetic disorder Beckwith-Wiedemann syndrome. The long Kcnq1ot1-RNA molecule mediates silencing by recruiting enzymes that modify DNA-binding proteins, protecting the silenced domain during cell division.
A team of Arizona State University researchers is investigating human vulnerability to deadly heat exposure in the face of climate change. The study aims to guide policymakers and planners in bolstering protective measures to prevent heat-related illness and deaths.
The University of California, San Diego School of Medicine has received a $10 million NIH contract to lead the Neuroscience Information Framework (NIF), a dynamic inventory of web-based neurosciences data and tools. The NIF enables discovery and access to public research data and tools worldwide, advancing neuroscience research through...
Researchers from Boston Medical Center developed a Chief Resident Immersion Training (CRIT) program to educate generalist physician trainees about addiction. The program resulted in improved knowledge, skills, and clinical practices among participants.
Phyllis R. Magrab is recognized as an outstanding advocate and researcher for children with disabilities, dedicating her career to improving their quality of life. She has received numerous honors for her work, including the Distinguished Contributions Award from the American Psychological Association.
A new study published in Psychological Medicine found that late teens from disadvantaged neighborhoods are four times more likely to attempt suicide. The researchers also discovered that these youth experience higher levels of depressive symptoms and lower social support.
Researchers have discovered a new genetic disease that can lead to severe liver damage due to inadequate bile secretion. A mutation in the ABCB4 gene causes low levels of phosphatidylcholine in bile, resulting in liver cell damage and cirrhosis.
The Center for Minority Health (CMH) at the University of Pittsburgh School of Public Health has developed innovative programs to improve the health and well-being of racial and ethnic minorities, including a prostate cancer prevention program that trains barbers to deliver accurate health information. The organization also partnered w...
Researchers at the University of Denver are conducting a groundbreaking study to improve teaching methods for young children with Down syndrome. The study aims to compare two early literacy intervention approaches and will involve parents implementing an at-home program for approximately 10 months.
The St. Baldrick's Foundation has awarded $330,000 to Dr. Alex Huang at Case Western Reserve University School of Medicine to support his research on enhancing immune surveillance in pediatric sarcomas.
A recent study published in Psychological Science found that socially rejected individuals are particularly good at discerning fake smiles from real ones. This may be because they have an increased motivation to be accepted and are more sensitive to specific social cues indicating opportunities for inclusion.
Researchers at Queen Mary University of London discovered that bumblebees use flower scent to guide their nest-mates to good food sources. The bees learned the most from demonstrations by other bees bringing back scent, but also gained knowledge when the anise odour entered the nest.
Research suggests depression and anxiety can cause increased hospitalizations and exacerbations in COPD patients, with depressed individuals experiencing more symptom- and event-based exacerbations and longer hospital stays. Anxiety is also linked to a greater risk of exacerbations and longer hospital stays.
Researchers developed a simple blood test that measures inflammatory gene expression to evaluate cystic fibrosis patients' response to therapy. The test identified genes CD36, CD64, and ADAM9 as accurate biomarkers for therapeutic response.
The Institute for Operations Research and the Management Sciences (INFORMS) has announced 12 new recipients of the annual INFORMS Fellows Award, recognizing outstanding achievements in education, management, practice, research, and service to the profession. The award recognizes the contributions of distinguished professionals who have...
MedImmune presents nine abstracts on respiratory syncytial virus (RSV) and influenza, providing insight into infectious disease prevention. The research focuses on RSV therapy, healthcare costs, and mechanisms of action for the monoclonal antibodies palivizumab and motavizumab.
A new study suggests that incorporating vegetable juice into a daily diet can significantly increase vegetable intake. Researchers found that individuals who consumed one or two servings of V8 vegetable juice per day were more likely to meet the daily recommended amount, with over half of those who drank one serving meeting the recomme...
The common cold's immune response, not the virus itself, causes symptoms, according to a comprehensive genomic study. The research identifies therapeutic targets that can balance the immune response and potentially prevent infection.
Researchers have shown that HRV hijacks many of your genes, leading to an overblown immune response. The study identifies novel candidate genes that could be targeted for drug development to treat colds and exacerbations of asthma and COPD.
People with mild sleep apnea may be at increased risk for cardiovascular disease due to impaired endothelial function and increased arterial stiffness. A recent study found that minimally symptomatic obstructive sleep apnea can significantly increase cardiovascular risk, even in those without daytime sleepiness.