Biomedical engineers have developed a new probe that allows visualization of single RNA molecules within live cells, enabling scientists to study RNA's operation and interaction with binding proteins. The tool overcomes issues with fluorescent probes, allowing for hours-long imaging and distinguishing between targeted and unbound probes.
New Arctic satellite data shows a decade-long trend of shrinking sea ice extent, with thinner ice replacing older, thicker ice. The maximum sea ice extent for 2008-09 was 5.85 million square miles, 278,000 square miles below the average for 1979 to 2000.
Researchers discover that beta-arrestin1 mediates the flushing response but not the antilipolytic effect of nicotinic acid in mice. A drug design approach is proposed to retain therapeutic benefits without causing skin flushing.
Patients with schizophrenia can correctly identify a 'hollow mask' illusion, which may be related to their brains disconnecting visual information from internal thoughts. The study also found that cannabis users are less deceived by the illusion, suggesting a possible link between THC and brain connectivity.
A 16-week study found that reducing added sugar intake by 47 grams per day and increasing fiber intake by 5 grams per day improved insulin secretion and reduced visceral adipose tissue volume. Participants who increased fiber intake also saw significant reductions in body mass index and visceral fat.
Researchers develop novel method to identify stem cells in pancreas, showing acinar cells produce digestive enzymes and may have carcinogenic properties. The breakthrough paves the way for further study on proliferation mechanisms and potential dangers of these cells.
A Stanford study found that the US AIDS Relief program reduced HIV/AIDS death tolls by over 10% in targeted African countries, saving an estimated 1 million lives. However, there was no significant impact on disease prevalence rates.
Research by Joshua M. Ackerman and John A. Bargh found that imagining another person's self-control can lead to a depletion of one's own self-control, causing impulsive behaviors like overspending. In experiments, participants who imagined exerting self-control in someone else performed worse on cognitive tasks after the simulation.
The AIAA Journal of Energy was commended by the Space Foundation for its role in disseminating NASA's aerodynamic vehicle design technology, which reduced drag and increased fuel efficiency. The journal's publication played a key role in widely adopting the technology in the trucking industry.
North Carolina State University scientists developed a GaMnN thin film-based device that manipulates both charge and spin of electrons at room temperature, surpassing previous devices which only functioned at -173°C. The new technology uses lower voltages to switch electron bias, improving semiconductor efficiency and speed.
A new study found that men and women with a BMI score over 30 were nearly one-and-a-half times more likely to have RLS than those who were not obese. Additionally, people with the top 20% of waist circumference were more than one-and-a-half times more likely to have RLS than those in the bottom 20%
Eating two and a half ounces of baby broccoli sprouts daily for two months reduced HpSA levels by over 40% in infected individuals, suggesting potential protection against gastritis, ulcers, and stomach cancer. However, the study did not cure infection or eradicate H. pylori colonization.
A new standardized tool for assessing chronic pain has been developed and validated to differentiate between peripheral neuropathic pain and non-neuropathic low back pain. The tool, called STEP, takes just 10-15 minutes to administer and has been shown to have high diagnostic accuracy.
Researchers have developed a new mechanism for water splitting, which generates oxygen gas from water molecules. The process is divided into three stages, utilizing light and heat to produce clean fuel.
The researchers used mechanical forces to control catalytic activity, initiating chemical reactions and creating a 'molecular ripcord' that can switch between dormant and active states. This discovery enables the creation of self-repairing materials that strengthen under mechanical stress.
Substituting water for sugar-sweetened beverages can eliminate an average of 235 excess calories per day among children and adolescents, potentially preventing childhood obesity. The study suggests that this simple replacement has no detrimental effects on nutrition.
A new study by Dr. Jayakrishna Ambati and colleagues found that the siRNA treatment is toxic to both blood and lymphatic endothelial cells, with potential applications in cornea transplantation and treatment of lymphatic diseases.
A study identifies RNF6 as a protein that modifies androgen receptor activity in hormone-refractory prostate cancer. Inhibition of RNF6 shows promise as a new strategy for treating advanced prostate cancer, which no longer responds to traditional therapies.
AVEO scientists have developed a novel human-in-mouse (HIM) cancer model system, which allows for the creation of invasive human tumors that mimic human tumor behaviors and response. The models provide a more realistic genetic context for evaluating new anti-tumor therapies.
The European Society of Cardiology reports that heart failure is the most prevalent chronic cardiac condition in Europe, with 30 million cases identified. Recent improvements in diagnosis and treatment have led to a significant reduction in mortality rates, but challenges persist in prevention, diagnosis, and treatment.
Late-acting insecticides targeting older mosquitoes show potential to reduce malaria transmission by 95% and slow down resistance. The approach could lead to evolution-proof insecticides that never become obsolete.
James Crivello, a prominent polymer researcher at Rensselaer Polytechnic Institute, has been awarded the Herman F. Mark Senior Scholar Award by the ACS. His groundbreaking research on novel polymers and innovative applications in energy conservation, coating, and composites has earned him this prestigious recognition.
A new study by scientists from Imperial College London and University of Oxford found that young adults with a genetic variant associated with Alzheimer's Disease exhibit changes in brain activity decades before any symptoms appear. The researchers used functional Magnetic Resonance Imaging (fMRI) to compare the brains of healthy young...
The Miller Cyberinfrastructure Laboratory has rolled out 'Magic,' a state-of-the-art computer system that aggregates costly computational resources, enabling researchers to solve previously unsolvable problems. The machine is cost-effective and thousands of times faster than traditional systems.
Researchers develop first tri-continuous mesoporous material, named IBN-9, with a hexagonal minimal surface, opening possibilities for catalysis, separation and drug delivery applications. The material has unique nano-fiber morphology and distinct diffusion rates in different directions.
A study published in Molecular Ecology found that woodrats have genetic detoxification genes that enable them to consume creosote bushes, which are coated with a toxic resin. The researchers also discovered that these animals adapt their diets in response to climate change, and the findings may provide insights into how humans can modi...
Researchers found that genetic variants impact stress response differently in men and women. Women carrying the BDNF Val/Met genotype were shown to have a lower cortisol response than men with the same genotype, while men with the Val/Val variant exhibited higher cortisol levels.
Scientists at Boston University discovered Resolvins, a new family of biologically active products of omega-3 fatty acids with therapeutic potential. These compounds have been shown to resolve periodontal inflammation and regenerate tissues in experimental gum disease models.
A study of 36,903 men found significant associations between obesity measures and periodontal disease. Obesity was associated with a 25% and 29% increased risk of periodontal disease compared to normal weight, with waist circumference and waist-to-hip ratio also linked to an increased risk.
A new study led by NYU dental researcher Dr. Ananda P. Dasanayake found that pregnant women with periodontal disease are more likely to develop gestational diabetes. The study, conducted in Sri Lanka, eliminated smoking and alcohol use among participants to isolate the impact of gum disease on glucose levels.
Researchers have developed a method to generate complex, multilayer oral tissues using human embryonic stem cells. The tissues mimic normal oral cavity tissues and show promise for treating oral diseases through transplantation.
Studies link periodontal disease to infant prematurity, diabetes, and stroke. Treating pregnant women with scaling and root planing can save nearly $14 million worldwide.
Researchers used microscopy to study neuron growth in Caenorhabditis elegans and found that certain neurons work backward from their destination. The discovery suggests that the brain is wired based on connectivity rather than absolute distance, providing an explanation for how the brain grows in proportion to the organism.
New Brown University research suggests nicotine interferes with multiple cellular interactions, potentially developing new treatments for various diseases. The study identified 55 proteins interacting with the alpha-7 nicotinic receptor, which may have broader roles in the body than previously thought.
Researchers found that considering partner characteristics together is the strongest predictor for STDs. Adding simple questions about partner characteristics to STD screenings could help catch more patients who need testing and education.
A novel digital gene-expression profiling technique is gaining traction, offering a fully quantitative approach to gene-expression analysis. The method has been shown to provide robust and comparable expression profiling data, making it an attractive alternative to traditional microarray-based platforms.
The University of Bath will use the funding to launch spin-off companies and influence government policy through its research, aiming to enhance business-academia partnerships. The £44 million Knowledge Transfer programme aims to reduce barriers between businesses and academia.
A team of researchers from Massachusetts General Hospital has found evidence of cell-to-cell communication by amino acids, leading to faster recovery of hepatocyte activity. The study reveals that proline, a building block of collagen, plays a key role in this process.
A study found that periodontal disease caused by Porphyromonas gingivalis can reactivate latent HIV-1 in infected individuals. The bacteria induce histone acetylation, leading to HIV-1 reactivation. Maintaining oral hygiene is crucial for preventing AIDS progression.
A study found that parents with low income, limited education, and single status experience higher levels of stress, which increases the likelihood of their children developing tooth decay. Conversely, receiving treatment for a child's dental decay can decrease parental stress levels.
Research by Yale University reveals that bird feathers create bright colors through nanostructures resembling a sponge with air bubbles. The structures self-assemble as the feather grows, replacing water bubbles with air, and have significant implications for the role of color in birds' plumage.
Physicians can reduce radiation exposure by using tube current modulation in 'triple rule-out' coronary CT angiography. This technique reduces effective radiation doses from 9.9-31.3 mSv to 5.4-16.6 mSv, comparable image quality and less than nuclear stress test radiation.
A Norwegian Institute of Public Health study analyzed children's diets combined with psychological and sociodemographic variables in mothers. The results show that mothers with high negative affectivity are more likely to give their children unhealthy food, but not the opposite for healthy food.
Researchers found that allergens can bind to and travel through the epithelium of allergic patients but not healthy subjects. This transport mechanism is crucial for the development of allergic reactions.
Researchers found that dopamine neuron bursting activity is crucial for learning rewarding outcomes. The study suggests that the NMDA receptor plays a key role in regulating burst firing in dopamine neurons.
The project aims to create a Medicago HapMap, mapping the genetic variations in the legume to reveal which genome regions control symbiosis and other legume-specific traits. Legumes are a crucial source of dietary protein and environmentally-friendly fertilizer, providing millions of tons of nitrogen to plants.
Researchers at Penn have identified a fluorescent anesthetic compound, 1-aminoanthracene (1-AMA), that allows for precise imaging of anesthetics in the body. This new tool enables high-throughput screening of novel anesthetic compounds, which could lead to safer and more effective drugs.
Researchers at the University of Pennsylvania have found a new way to combat malaria by trapping parasites inside host cells. They identified an enzyme called calpain-1, which parasites use to break out of infected cells, and developed a method to block it, leaving parasites trapped.
A new study from the Sahlgrenska Academy reveals that big men are more susceptible to atrial fibrillation, a disturbance in the heart's rhythm. The risk of atrial fibrillation increases linearly with both body size and weight gain, putting larger men at higher risk.
A recent study by NYU researchers found that sports drinks can cause tooth erosion and hypersensitivity due to high levels of citric acid. The condition affects one in 15 Americans and can lead to severe tooth damage if left untreated.
New research suggests Titan, Saturn's largest moon, has a subterranean ocean of hydrocarbons and unusual topography, including mountains with lower elevations than surrounding plains. The findings may help explain the presence of large lakes of hydrocarbons at both poles.
The analysis reveals highly polarised gamma rays, providing insight into the central engine's magnetic field structure. The team favours a synchrotron model, suggesting that the jet lifted the magnetic field into space.
Researchers at Duke University have identified a receptor on human glioblastoma cells that may be an appropriate target for therapies. Activation of the neurokinin 1 receptor leads to increased cell growth, but blocking this activity can reduce cell death and potentially stall cancer growth.
Physicists at the University of Leeds and IBM Research have made advances in racetrack memory, a new kind of computer memory that could replace hard disks. The technology is estimated to be 100 times cheaper per bit than flash memory and promises faster speeds.
Scientists have re-examined Hawaii's formation, finding the Pacific oceanic plate moved under a drifting hotspot, creating a 50 million-year-old bend in the seamount chain. Mantel circulation models aid understanding of forces on tectonic plates and stress estimation for major earthquakes.
Researchers from Regenstrief Institute have developed a technology that allows public health officials to send instant alerts to doctors and hospitals using an existing clinical messaging service. This approach minimizes delays in notification, which can be critical in disease outbreak response.
A novel compound called azelaic acid has been identified as a primer for the plant's immune system, leading to increased systemic plant immunity and disease resistance. The discovery was made by researchers at Oak Ridge National Laboratory and the University of Chicago.
Researchers create 'composite doublers' that take stress from joints and allow it to pass through without stressing the structure, extending its lifespan. The technology also serves as a warning system for inspectors and road workers when it begins to wear out.
A study at the University of Erlangen found that reducing tube voltage from 120 kV to 100 kV lowered cardiac CT radiation doses in adult patients weighing 185 pounds or less by 39% without compromising image quality. The lower dose resulted in effective radiation doses ranging from 4.9 to 11.9 mSv, compared to 8.8 to 16.9 mSv at 120 kV.
A computer-based model has been developed to aid radiologists in diagnosing breast cancer by analyzing mammogram images. The model was trained on 48,744 mammograms and found that it could detect 41 more cancers than routine practice, with potential benefits including reduced unnecessary biopsies.