A new hybrid agent, T-DM1, has shown promising results in a Phase 2 clinical trial for metastatic HER2-positive breast cancer. The compound shrunk tumors by 30% or more in 40% of women with confirmed HER2-positive cancers, and had a total clinical benefit rate of approximately 53%.
Using Herceptin with chemotherapy reduces the risk of cancer recurrence by 25% compared to using it after chemotherapy. This new standard of care may benefit up to 10,000 women worldwide each year.
Space agencies are collaborating to provide long-term global climate observations using Earth observation satellites. These data will support the UNFCCC and the International Panel on Climate Change by quantifying the state of our climate.
The study found that European plant communities are becoming more homogeneous, with rare species becoming extinct and phylogenetic diversity decreasing. This loss of uniqueness makes it harder for biological communities to adapt to environmental changes.
Researchers are studying phototrophic extremophiles to understand the evolution of oxygen-evolving high-energy photosynthesis. The study aims to illuminate gaps in genetic data and explore astrobiology connections, potentially revealing clues about extraterrestrial life.
Researchers successfully tested physical-layer quantum encryption over free space optical links with AOptix's patented adaptive optics correction, achieving low loss and stability. NuCrypt's AlphaEta quantum-noise randomized encryption technology enhances security without compromising current optical infrastructure.
A two-year study found that moderate weight loss improved four key measures of heart health in obese patients, including decreased heart muscle thickness and improved pumping functions. After weight regain, some cardiovascular benefits were retained.
Current UK guidelines limit postmenopausal women's treatment options due to bone mass T-score criteria. Alternative therapies are available but often require stricter conditions.
Researchers use Ulysses spacecraft and solar minimum to create a 200-million-mile-long virtual lab bench for turbulent flows. They find that the evolution of turbulence is governed by the same generalised scaling function, suggesting a universal basic property governing magnetohydrodynamic turbulence.
A recent study by UA-led researchers documents the health consequences of endemic warfare in northern Kenya, focusing on nutrition and its impact on community health. The research highlights the disproportionate burden of violence on women and children, who face food insecurity and increased mortality rates.
Boston College researchers successfully harvested elusive charges using ultra-thin solar cells, opening a potential avenue to improved solar power efficiency. The team developed a mechanism able to extract hot electrons in the moments before they cool, effectively opening an escape hatch for these highly energized particles.
Using ultracold atoms, Rice physicists confirmed a theory about a universal quantum mechanism that allows trimers to form in special cases where pairs cannot. The team observed Efimov's trimers appear and reappear repeatedly in a stepwise fashion.
AOptix Technologies successfully completed a two-phase flight test program for the Enhanced Air-to-Ground Lasercom System (EAGLS) Program. The tests demonstrated AOptix's capabilities in Pointing, Acquisition, and Tracking (PAT) and ultra-high bandwidth real-time communications.
A large-scale study found that less than half of eligible patients with heart failure receive cardiac resynchronization therapy (CRT) devices. The therapy is particularly beneficial for patients with disorganized heartbeats, but widespread variations in CRT use were observed among practices and patient characteristics.
Renowned psychopharmacology expert Stephen M. Stahl, MD, PhD, highlights low confidence in army mental health care, excessive opiate prescribing, and understaffing of services at Ft. Hood. He proposes redeploying primary-care providers and nurse case managers to centralize mental health care delivery.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a novel detection method that can identify circulating tumor cells (CTCs) after they undergo epithelial-mesenchymal transition (EMT), rendering them undetectable by current methods.
A study by Texas AgriLife Research has linked gene PFKFB3 to metabolic inflammation that leads to diabetes. The researchers believe that a focus on nutrition can prevent or reverse the disease by activating the gene.
A study by Spanish researchers found that roe of hake, lumpsucker and salmon contains high levels of omega-3 fatty acids, essential for metabolic functions. Minimal consumption satisfies the body's requirements, preventing cardiovascular disease and other conditions.
Emerging research reveals that post-menopausal women experience adverse changes in lipid profiles around the time of their final menstrual period, independent of age. Conversely, quitting smoking before or after a heart attack significantly improves long-term survival rates, with reductions comparable to those from lifestyle changes an...
A modified blood adult stem-cell transplant regimen has effectively reversed sickle cell disease in 9 of 10 adults with severe symptoms. The trial's results show that the treatment reduced toxicity and allowed patients to achieve stable mixed donor chimerism, completely replacing their disease-causing cells.
The USDA Forest Service has developed an early warning system to monitor forest health using satellite imagery and land surface phenology data. The system aims to provide near-real-time information on forest conditions impacted by insects, diseases, wildfires, or extreme weather events.
Researchers at the University of Iowa have found a new inherited retinal disease affecting the macula, which is an area critical for central vision. The disease causes abnormal blood vessels to form, leading to swelling or scars that can blur parts of the visual field.
A Kaiser Permanente study of 16,000 women in Hawaii found that Korean-American and Chinese-American women are at one-third higher risk for gestational diabetes. Pacific Islanders, Filipinos, and Puerto Ricans also face a higher risk compared to Caucasian and African-American women.
Cyclone Cleo's rainfall has significantly diminished over the last 24 hours, with its maximum sustained winds down to 40 mph. The storm is expected to dissipate in the next day or two due to wind shear and dry air.
Researchers at the University of Montreal identified a novel molecular mechanism that prevents cancer by regulating the p53 gene. The SOCS1 molecule plays a crucial role in suppressing cancer-causing cytokine activity, offering potential new treatments for chronic inflammatory diseases and cancer prevention strategies.
Researchers found that combining targeted therapies lapatinib and trastuzumab significantly extends survival in HER2-positive breast cancer patients, with a median overall survival of 60.7 weeks compared to 41.4 weeks alone.
A new study by the University of Exeter shows that anxious penalty takers are more likely to focus on the goalkeeper, leading to shots that centralize and become easier to save. The research suggests that coaches can address this issue through training, emphasizing the importance of practicing aiming strategies under pressure.
A UT Southwestern study found that physician advice is a key motivator in placing infants on their backs to sleep, reducing the risk of SIDS. The rate of SIDS has plummeted since the "Back to Sleep" campaign was launched in 1994.
Scientists applied physics techniques to study bacteria's survival strategies, gaining insights into human decision making. The study found that bacteria's game theory decision making process is more advanced than the Prisoner's Dilemma, enabling them to weigh pros and cons in complex environments.
A new study presents a promising approach to re-sensitize breast cancer to standard therapy after it becomes resistant. The treatment combination of an aromatase inhibitor and sorafenib shows encouraging responses in 20% of post-menopausal women with metastatic breast cancer, offering a potential new treatment option.
The MDC researchers have discovered a crucial scaffold regulating the identification and disposal of defective proteins. The study reveals that the flexible Usa1 subunit tethers specific modules of the enzyme complex, connecting them to form a larger complex to degrade insoluble membrane proteins.
Researchers have discovered that the deep ocean's temperature variability and circulation system are more complex than previously thought, leading to more accurate predictions of sea level rise and ice volume changes. The study uses a 3-D reconstruction of an ocean during a past warm period to gain insights into global climate dynamics.
Researchers at the University of Alberta designed materials that link mathematical concepts to real-world scenarios, such as disease transmission, to enhance learning. Students used these materials to calculate the West Nile virus's reproductive number, gaining a deeper understanding of math in science.
A recent study found that black women with hormone receptor-positive breast cancer have worse disease-free and overall survival rates than women of other races. This disparity persists even after controlling for other factors such as medical care and comorbidities.
The University of Nevada, Reno has developed a new curriculum that combines nanotechnology with skiing, aiming to prepare mechanical engineers for emerging challenges. Students will design and manufacture innovative materials and technologies to create extraordinary ski designs, including energy-efficient systems and dynamic structures.
A French team has developed a computerized 3D model that predicts the movement of the heart as it beats, allowing robotic tools to move in concert with each beat. This innovation could enable less invasive surgical procedures with high precision and reduce complications.
A study presented at the CTRC-AACR San Antonio Breast Cancer Symposium found that anti-estrogen therapy for breast cancer patients reduced their risk of dying from lung cancer. The research involved 6,715 women diagnosed with breast cancer between 1980 and 2003.
Tropical Cyclone 05B has formed in the Northern Indian Ocean, expected to approach southeastern India and make landfall on Monday, December 14. The storm is forecast to intensify due to low wind shear, but may be impacted by a zonal jet stream.
A study by Natividad et al. found that adolescent rats exhibit fewer physical and neurochemical withdrawal signs than adult rats after nicotine withdrawal, suggesting age alters neurological systems relevant to nicotine use. This increased sensitivity makes adolescents more prone to drug abuse.
Researchers have discovered a new primitive dinosaur species, Tawa hallae, in northern New Mexico with nearly complete skeletons providing insights into the evolutionary path of dinosaurs towards birds. The species, likely a meat-eater, had air sacs in its braincase and neck areas.
Researchers at the University of Illinois have designed a synthetic protein that mimics both the structure and function of nitric-oxide reductase, a key enzyme in the nitrogen cycle. The protein, which uses myoglobin as a scaffold, provides an excellent model for studying this enzyme and creating biocatalysts.
A team of researchers from the University of Manchester and University of Houston used advanced analytical techniques to test volcanic gases, revealing a clear meteorite signature that suggests the atmosphere came from outer space. The study's findings imply that ancient Earth's oceans also originated from extraterrestrial materials.
Researchers have discovered a correlation between excess gene copies and the severity of mental illness in males, with more copies leading to more serious handicaps. The study identifies GDI1 as the responsible gene on the X-chromosome, revealing a new mechanism for genetic disorders.
Giovanni Ossola's NSF-funded project aims to improve the accuracy of LHC computations using his OPP Method. He plans to involve students in the experiment, promoting stronger ties between CERN and City Tech.
A new study reveals that at least 1,250 and possibly more venomous catfish species exist, with North American species using their venom mainly to defend against predatory fish. The research also sheds light on the evolutionary origins of catfish venom glands.
Elena Baena-González will investigate how plants respond to stress and allocate energy stores, aiming to improve crop yields. Her research focuses on the SnRK1 protein, which is conserved across species, including mammals.
Researchers used Category Theory to explain why specific reasoning skills, such as Transitive Inference and Class Inclusion, develop in children around age five. These skills involve applying two lines of thinking simultaneously, allowing children to understand complex relationships between objects.
The new guidelines offer a range of therapeutic options and provide evidence-based recommendations for treating brain metastases. The guidelines aim to improve patient outcomes by identifying best treatment practices and fostering support for ongoing research.
Researchers studied gait to identify physical signs of Parkinson's disease in its early stages. The team found that people with Parkinson's had significantly asymmetrical arm swings compared to those without the disease.
Research shows Italy's poor are more likely to be hospitalized with avoidable conditions, mirroring global patterns. Socio-economic disparities exacerbate the issue, particularly among males and those aged 45-64.
A new study reveals that physical education teaching staff's responsibility, social interaction, and competence influence students' enjoyment of physical activities. Dispositional flow, a psychological state allowing optimal task engagement, is linked to these factors.
James A. Wells, a UCSF professor and director of the small molecule discovery center, has made groundbreaking contributions to protein engineering and discovery. He integrates multiple disciplines to design molecules that selectively activate or inhibit cellular processes.
Physicists in Sweden create a formula to identify distinct author styles by analyzing word frequencies in literature, challenging George Kingsley Zipf's maxim. The 'meta book' concept represents an imaginary infinite book containing each author's unique word frequency characteristics.
The Nuclear Regulatory Commission has awarded Penn State's nuclear engineering program nearly $1 million to boost nuclear education and expand the workforce. The funding will support a radiochemistry education program with a new laboratory course providing hands-on experience for students.
A landmark study by Dr. Kathy Albain of Loyola University Health System found that chemotherapy improves survival in postmenopausal breast cancer patients, while a multigene test can identify those who may not benefit from chemotherapy. The study established the standard of care for tamoxifen treatment in relation to chemotherapy.
Researchers analyze genetic diversity of 280 individuals from Armenia and Georgia, comparing with results from Russia and Turkey. They establish a core collection of 27 trees capturing 93% of alleles, making M. orientalis more accessible for breeding and research communities.
Scientists have found that activating Retinoid X Receptor (RXR) increases dopamine cell survival in models of Parkinson's disease, providing a novel strategy for treating the condition. The study used two cellular models to explore the neuroprotective function of RXR ligands LG268 and XCT.
Researchers discuss consent, privacy and clinical translation issues in iPS cell study. The emergence of iPS cells adds new challenges to the legal and social debates in stem-cell science.
A study of over 40,000 Danish patients found that those taking more than one anti-bleeding medication after a heart attack were at higher risk of non-fatal and fatal bleeding. Non-fatal bleeding was also associated with an increased risk of repeat heart attacks or death.
A recent study published in Nature Geoscience suggests that the climate may be 30-50 percent more sensitive to atmospheric carbon dioxide than previously thought. This increased sensitivity could lead to more accurate long-term projections and a better understanding of climate change's impacts on global temperatures.