Recent studies on anticoagulants suggest that aspirin and heparin may not be effective in preventing unexplained, recurrent miscarriages. In contrast, a new study shows that dabigatran etexilate is as safe and effective as warfarin for treating venous thromboembolism.
Research finds that fruit flies' nutrient storage and consumption are controlled by opposing clocks in neurons and the fat body. The study reveals a complex interplay between metabolic signals and circadian rhythms, with implications for understanding human metabolism and disease.
Researchers have identified a specific gene on chromosome 16 called SH2B1 that plays a key role in regulating weight and handling blood sugar levels. The study found large chromosomal deletions associated with severe early-onset obesity in children.
A Scripps Research Institute team restored partial function to lung cells collected from patients with cystic fibrosis, opening a door to new therapies for this and other chronic diseases. The breakthrough uses a compound called suberoylanilide hydroxamic acid (SAHA) to correct protein misfolding.
Researchers have discovered that fruit fly neurons can rebuild themselves after injury, with a structurally and functionally different component replacing the damaged part. The study reveals a dynamic microtubule response, where dendrites convert to axons, offering potential avenues for understanding axon regeneration.
Scientists develop a mathematical model of a three-cell microcircuit in a chicken's brain, revealing an elegant compromise between abstraction and complexity. The model reduces the system to one equation with two parameters, shedding light on why it's difficult to understand the brain using traditional methods.
Early clinical trial results show bortezomib-based therapy improves control of graft-versus-host disease and immune system recovery. The treatment was safe with little toxicity, and immune cell reconstitution was significantly improved in the early post-transplant period.
Researchers used electrocorticography (ECoG) to record brain activity and found that patients could type alphanumeric characters on a screen by focusing on specific letters. The technique showed promise for people with disorders like Lou Gehrig's disease and spinal cord injuries.
A randomised trial found that medroxyprogesterone acetate is significantly more effective than venlafaxine at reducing hot flushes in men treated with androgen suppression therapy. Cyproterone acetate was also effective, but medroxyprogesterone is recommended as the standard treatment due to its fewer side effects.
The study analyzes OES beads from SDG site, concluding that the two pathways of manufacture differed in drilling and trimming stages. The findings suggest prehistoric artisans had excellent skills, using standardized bead sizes to convey messages.
A new study found that only a small percentage of providers prescribe hydroxyurea to eligible children with sickle cell disease due to concerns about future reproductive issues and low patient compliance. Despite its efficacy in preventing pain, many providers prescribe the drug for other complications without sufficient evidence.
Researchers used computer search algorithms to identify fragments of FDA-approved drugs that could inhibit neuraminidase proteins, a key target for treating swine and avian influenza. The study suggests six compounds with potential as new medicines if emerging viruses develop resistance to current therapies.
Researchers have made significant breakthroughs in understanding the genetic basis of sickle cell disease, exploring the potential of activating fetal hemoglobin to reduce complications. A new study found that activating BCL11A could lead to increased production of healthy hemoglobin, providing a promising avenue for treatment.
A new study by McMaster researcher Sam Schulman found that an oral drug called dabigatran etexilate is as safe and effective as warfarin for treating venous thromboembolism (VTE), a common clotting disorder affecting millions annually. The drug does not require frequent monitoring or dose adjustments, making it a convenient alternative.
Researchers use live imaging to study breast cancer cell spread, finding TGFb as the control switch. Single cells break away when TGFb is active, while clumps do so when inactive, limiting spread to local lymphatic system.
Researchers identify pheromone-detecting neurons in the fly's antenna that promote aggression, leading to increased fighting among males. The discovery provides insight into how aggression is hardwired into the brain by an animal's genes.
A new study published in Nature Geoscience suggests that the Earth's temperature is more sensitive to atmospheric carbon dioxide than previously estimated. The research found that including factors like land-ice and vegetation in climate models increases the temperature response to carbon dioxide, indicating a higher sensitivity.