The UCSF team emphasizes that outpatient care for chronic disease patients poses unique challenges, including lack of communication, inadequate resources, and medication management. To improve safety, the authors advocate for targeted safety promotion efforts and robust health information technology systems.
New research on jade found in Guatemala's Motagua fault reveals two collision events between the North American and Caribbean plates. The study uses eclogite dating to pinpoint a 130 million-year-old collision, followed by a second event at 70 million years ago.
Researchers analyzed data from studies on type 1 diabetes to find that intensive treatment can significantly reduce the risk of complications. The study showed improved outcomes in patients treated with more intensive therapy.
Researchers at Yale University have recorded movies of viral activity within cells, revealing that retroviruses assemble daughter viruses at the point of contact between cells. This process is facilitated by a sticky viral protein called Env that attracts viral particles to these sites.
A study of 13,817 individuals with diabetes aged 66 and older found that starting antipsychotic treatment increased the risk of hospitalization for hyperglycemia. The risk was highest among those just beginning treatment, highlighting the need for enhanced glucose monitoring.
Researchers found a significant association between low sunlight exposure and cognitive impairment in depressed individuals. The study used NASA satellite data to measure sunlight exposure across the US, linking it to depression and cognitive function.
A study by the Association of American Medical Colleges predicts a 46% increase in demand for cardiothoracic surgeons while supply decreases by 21% by 2025. This shortage could lead to extended waiting times, unnecessary complications, and deaths, particularly affecting populations with limited access to medical care.
Two UBC researchers are part of an international team recommending standards for DNA barcoding of land plants. They selected two genomic regions as the best candidates for generating barcode data, with a near-unique signature for barcoding and high accuracy in identifying plant species.
Researchers at the University of Illinois have developed a new method using electrolyzed water to pretreat ethanol waste products, producing an acetone-butanol-ethanol fuel mix. The traditional chemical-based method is eliminated, reducing inhibitor production and increasing sugar yield.
A $226,890 grant will fund a study on the effects of eastern redcedar encroachment on Oklahoma's tallgrass prairie ecosystem, which can alter precipitation and water loss patterns. The research aims to provide insights for land managers to better understand the impact of woody plant proliferation on water availability.
Research finds that a weight-loss program significantly improves symptoms of depression and reduces triglycerides in obese patients. After a 6-month behavioral weight loss program, depressed patients lost 8% of their initial weight and reported improvements in depressive symptoms.
A UC Riverside-led study found that ancient lake deposits in South China harbor the first animal fossils, dating back 600 million years. The discovery raises questions about where early animals lived and how they adapted to their environment.
The EMSL's Chinook supercomputer, commissioned for research, can perform over 160 trillion calculations per second, ranking it among the world's top 40 fastest computers. It will aid in understanding complex biological, chemical, and physical processes to address environmental and energy challenges.
A study by University of Chicago sociologist Linda Waite found that divorce and widowhood have a detrimental impact on health, even after remarriage. Research based on 8,652 people aged 51 to 61 shows that those who have been divorced or widowed experience worse health outcomes compared to those who remain married.
A new FDA regulation on tobacco products has been met with criticism from advocates, who argue that it compromises long-term progress in tobacco control. The law repeals federal pre-emption of state and local regulations, but also allows the tobacco industry to rehabilitate its image through FDA-regulated products.
Researchers have found that placenta-derived stem cells can reduce lung fibrosis and inflammation in mice with bleomycin-induced injury. The study's findings suggest these cells may be useful for cell therapy of fibrotic diseases in the future.
A new study published in CMAJ found that anemia in very elderly individuals aged 85 and older is associated with a higher risk of death. The study, which followed 562 participants for five years, found that prevalent anemia at age 85 was linked to increased mortality rates.
A study published in Neurology found that people over 60 with high blood pressure are more likely to experience silent strokes. High blood pressure increases the risk by 60%, while white matter hyperintensities nearly double the likelihood of silent strokes.
Scientists at the University of Bath and University of Exeter have developed a technique to study bacterial infections in real-time with living organisms. They used fruit fly embryos to track bacterial movement and interaction with the immune system.
A subset of infiltrating monocyte-derived macrophages, expressing interleukin-10, exhibits an anti-inflammatory role in spinal cord injuries. This suggests that these cells may have a beneficial effect on recovery from such injuries.
Researchers warn that antiviral treatment for the elderly may not reduce mortality and could lead to increased resistance. Age-prioritized use of antivirals is suggested as a more efficient way to treat patients.
Researchers at the University of Bath are constructing a two-storey BaleHaus made of prefabricated straw bales and hemp cladding panels to test the sustainability of straw houses. The project aims to reduce carbon emissions and provide eco-friendly housing options.
Researchers have discovered a way to produce working SMN proteins using the SMN2 gene, potentially treating Spinal Muscular Atrophy. The technology could also be applied to other diseases caused by aberrant gene splicing.
Researchers have developed a yeast model to identify genes that contribute to cancer growth. The study found that point mutations in just a few genetic loci are responsible for the faster growth of cells, rather than aneuploidy. This discovery could help guide the search for new cancer genes in humans.
Researchers used high-speed microscopy to observe NK cell behavior when interacting with healthy or diseased cells, discovering that the cell's surface receptors determine whether it kills or leaves a cell alone. Understanding this process could lead to new ways of boosting immune defenses to treat disease.
Case Western Reserve researchers found that prenatal exposure to Plasmodium falciparum results in parasite tolerance, increasing susceptibility to malaria and anemia in young children. The study identified three groups: sensitized, exposed-not-sensitized, and not-exposed, with the latter group having a higher risk of malaria infection.
New study reveals that women with lower dopamine activity in food reward regions are more prone to weight gain. Increasing physical activity may help compensate for blunted brain reward and reduce unhealthy weight gain.
A study published in The New England Journal of Medicine found that colon capsule endoscopy diagnosed 64% of all lesions located by means of conventional colonoscopy. While this is a lower sensitivity rate compared to the conventional procedure, the diagnostic efficacy curve improves with experience.
Researchers at the Trudeau Institute have identified a single protein, omega-1, secreted from schistosome eggs that induces a specific immune response. This discovery may lead to new treatments and therapies for schistosomiasis, one of the most important neglected tropical diseases.
Scientists at Rutgers University and UCLA have developed a highly accurate way to peer into the brain to uncover a person's mental state. They found that specific mental functions do not correspond directly with certain brain areas but rather a unique pattern of neural connections.
Researchers found bats possess two spectral cone photoreceptor types for daylight and colour vision, as well as increased sensitivity to UV light in cone-stimulating conditions. This adaptation is expected to improve visual orientation at twilight, predator avoidance, and flower detection.
Research led by St. Jude Children's Research Hospital scientists shows that switching off a key DNA repair system in the developing nervous system is linked to smaller brain size and problems with movement, memory, and emotion. The study provides new insights into the role of DNA damage response in preventing neurological disease.
Long-term adult cancer survivors face a higher risk of experiencing serious psychological distress due to effects on physical health and social adaptation. Approximately 5.6% of cancer survivors screened positive for severe psychological distress within the previous 30 days.
A nationwide tiger population estimate in Nepal reveals the presence of 121 breeding tigers, a promising sign for conservation efforts. The study employed camera trapping and habitat occupancy surveys to derive information on abundance and distribution.
Researchers at Northwestern University use nanodiamonds to deliver insulin for wound healing, demonstrating a method for localized release of therapeutic proteins. The nanodiamond-insulin clusters show promise for wound-healing applications and could be integrated into various treatments.
A meta-analysis of 50,000 patients found GPs accurately diagnose only about half of those with depression, while misdiagnosing others. The authors suggest additional consultation time and repeated assessments to improve accuracy.
Elevated levels of ECE-2 enzyme are linked to reduced blood flow in the brain, a hallmark of Alzheimer's disease. The findings suggest that drugs blocking endothelin-1 may also benefit Alzheimer's patients.
Research by Stony Brook University researchers found that temperature explains much of the geographic variation in lifespan within species. For a diverse range of species, ambient temperature is the dominant factor controlling lifespan.
The study provides the first experimental evidence of how individual carbon atoms are added to growing nanotubes. The rotation proceeds in discrete steps, resembling the halting motion of a mechanical clock's second hand, with approximately 24 steps per rotation.
A study found that expecting tasty food activates brain's orexin system, which is also involved in drug addiction and rewards. This mechanism may explain why people overeat in contexts associated with good food, with implications for obesity treatment.
A study found that babies exposed to malaria before birth are more susceptible to the disease and anemia, while others develop a tolerant phenotype. This finding has implications for malaria vaccine design and prevention strategies during pregnancy.
A recent study found that only one group of mammals - humans, mice, and their close relatives - have seen their genomes decrease in size since the dinosaurs went extinct. This trend continues today, with human genomes undergoing a contraction, although noticeable changes won't be observed for several million years.
Researchers studied orangutan movement to understand how they adapt to challenging environments. Orangutans move with an irregular rhythm, allowing them to cope with tree vibrations and forage safely.
A new hybrid Linac-MR system has been developed to integrate medical linear accelerators and magnetic resonance imagers for treating certain types of cancer. The system promises to help doctors monitor moving tumors in real-time during radiation treatment, improving precision and reducing damage to surrounding healthy tissue.
The Peninsula College of Medicine and Dentistry has received a grant to study the role of brain tumors in deafness and develop non-invasive therapies. The research aims to identify how tumors grow and cause hearing damage, and test drug-based treatments.
Research found that smoking increases the likelihood of pancreatic ductal adenocarcinoma becoming metastatic, with osteopontin isoform OPNc playing a key role. High levels of OPNc were detected in 87% of invasive PDA lesions from smokers, correlating with nicotine exposure.
Researchers have discovered that HIV hijacks the autophagy process to facilitate viral replication and survival. By leveraging this cellular pathway, the virus can evade degradation and complete its maturation process.
A study of nearly 1,600 tumor samples found that CT-X genes are expressed in half of ER-negative and triple-negative breast cancers. This suggests a potential new therapy approach for these aggressive breast cancer types. Researchers plan to initiate clinical trials based on the findings.
The study reveals that alpha-synuclein aggregates can pass to new, healthy cells, contributing to the progression of Parkinson's disease. The researchers found that cell-to-cell transmission of alpha-synuclein occurs through endocytosis and is linked to impaired quality-control systems in recipient cells.
Dr. Kai Fu receives $300K Clinical Investigator Career Development Award for mantle cell lymphoma research, focusing on miR-17~92 expression and its correlation with patient survival. The funding aims to support a pre-clinical study to determine the effectiveness of suppressing miR-17~92 in improving chemotherapy outcomes.
A study in Medical Decision Making found that a large-scale anthrax attack would overwhelm hospital resources even with an effective public health response due to expected delays. Researchers developed best practices guidelines for modeling disaster responses, including striking the right balance between simplicity and complexity.
A computer program can now detect driver yawning, which is a common cause of fatigue and road crashes. The system uses an in-car camera and image-processing software to identify yawning patterns and correlates them with fatigue behavior.
Researchers at Yale University have discovered that infected cells produce viruses specifically at the point of contact between cells, making cell-to-cell transmission efficient and deadly. The study identified a possible weakness in this transmission chain by finding a sticky protein that docks with uninfected cells.
The article describes the functioning of MSF's independent ERB, which has reviewed over 23 proposals since its inception. The board provides crucial ethical oversight to ensure community empowerment and vulnerable individuals' protection in research settings. Additionally, PLOS Medicine editors discuss the role of journals in addressin...
A majority of healthcare leaders support a public health care option and innovative provider payment reform to control costs and ensure access to quality care. They also favor a national insurance exchange with standard-setting authority to standardize benefits and set rating rules.
A team of researchers has developed a new cell programming method called MAGE, which enables rapid refinement of bacterial genomes. By editing multiple genes in parallel, the researchers transformed E. coli cells into efficient factories that produce a desired compound in just three days.
Researchers discovered that a common allergy medication can reduce obesity and type 2 diabetes in mice by stabilizing mast cells. A separate study found regulatory T cells play a crucial role in controlling inflammation in fat tissue, suggesting a new connection between immune function and metabolic conditions.
Researchers at UCR manipulated ripples in graphene sheets using thermal manipulation, controlling their orientation, wavelength, and amplitude. This technique enables strain-based graphene electronics, which could have profound implications for electronic devices and magnetic fields.
A major study published in The Lancet found that surgery after chemotherapy and radiation can prolong survival without progression of the lung cancer, but does not improve overall survival compared to conventional treatment alone. Patients who underwent a section of the lung removal saw a major benefit from surgery.
Researchers at University of Bristol predict sea level rise will be between 7-82 cm by end of century, similar to IPCC projections. The new model uses fossil coral data and temperature records from ice-core measurements to achieve accurate predictions.