This study investigated microproteinuria as an indicator for CNI-related nephrotoxicity in liver transplant recipients. Microproteinuria, including β2-microglobulin and α1-microglobulin, was found to be a sensitive marker for detecting CNI-related nephrotoxicity, with correlations between urinary levels and renal function reductions.
Researchers investigated hepatic encephalopathy (HE) and prehepatic portal hypertension in rats. The study found increased GS activity and decreased glutamate uptake in the hippocampus, leading to CNS damage. These findings may help understand HE mechanisms and develop new treatments.
Research reveals Alisol B acetate inhibits proliferation of gastric cancer cells and induces apoptosis through mitochondrial and PI3K/Akt signaling pathways. This could lead to the development of a new anticancer agent for treating gastric cancer, one of the most common cancers worldwide.
A study published in the World Journal of Gastroenterology found that preoperative biliary drainage significantly reduced wound infection rates in patients undergoing resectional surgery for ampullary carcinoma. The findings suggest that PBD may have a positive impact on surgical outcomes, particularly in terms of infectious morbidity.