A team of researchers discovered that mutant enzymes in leukemia create a chemical poison to cause cancer. This finding suggests a new avenue for treating acute myelogenous leukemia and other cancers.
Astronomers have made new discoveries about exploding stars, including pauses, flickers, and flares that were not previously observed. Using sensitive data from a satellite, they studied four novae and found three stalls before reaching peak brightness, with all experiencing flickering or flaring during the outburst.
A study using the MEADERS (Medication Error and Adverse Drug Event Reporting System) system found that communication problems and lack of knowledge are leading causes of medication errors, with cardiovascular medications being the most commonly associated. The system has been successful in reducing harm to patients, documenting 11% of ...
The Cone Beam Computed Tomography (CBCT) scanner provides high-quality images without compressing the breast tissue, making it a promising supporting role to conventional mammography. Preliminary research shows that breast coverage and radiation dose are comparable to mammography.
Researchers discover JavaScript code accessing browser histories without user consent, highlighting potential for malicious activities such as phishing. Latest browsers have patched vulnerabilities, but users on outdated versions remain at risk.
Scientists in Mexico and the US have synthesized gold and silver nanoparticles just 25 nanometers in diameter, which could have potential applications as catalysts, drug-delivery agents, and quantum dots. The analysis reveals multiple layers of shells within each particle, with some blending or alloying of metals.
A study found that decreased physician reimbursement for hormone therapy reduced its use in low-risk prostate cancer cases by 40%. However, AST usage remained unchanged in patients with metastatic disease. The decrease is attributed to the real effect of reimbursement change.
The ImREAL project aims to create a simulated learning environment that responds to users' behavior and adapts accordingly. Researchers will develop intelligent tools to encourage trainees to detect subtle differences in communication and social cues across cultures.
The US Department of Health and Human Services has set ambitious targets to improve breastfeeding rates in the country. The Healthy People 2020 goals aim to increase the percentage of Baby Friendly Hospitals and workplaces that accommodate working mothers, as well as reduce formula supplementation during maternity hospital stays.
A study by Washington University School of Medicine reveals that genes alone do not predict disease risk, as environment interacts with DNA in complex ways. The research found that genetic variants have different effects in different environments, making it challenging to make accurate predictions.
Recent AGU research highlights increased flood fatalities in Africa due to population trends, not climate change, as well as lake warming caused by climate change. The study also found that the ozone hole affects upper-atmosphere temperature and circulation, while solar wind contains more oxygen than previously thought.
A faulty MAP3K1 gene has been identified as a cause of disorders of sex development (DSD) in male embryos, leading to genital abnormalities and feminine appearance.
A recent study by chemists from University of Copenhagen and NASA found that anesthetic gases have a significant impact on the climate. One kilo of anaesthetic gas affects the climate as much as 1620 kilos of CO2, with three commonly used gasses having global warming potentials ranging from 210 to 1620 times that of CO2.
Onconova Therapeutics presents updated clinical trial results for Estybon (ON 01910.Na) in patients with myelodysplastic syndromes, showing increases in overall survival and bone marrow blast responses. Additionally, ON 013105, a Cyclin D1 inhibitor, demonstrates efficacy in nonclinical models of mantle cell lymphoma.
A $7 million grant from the Bill & Melinda Gates Foundation will support a four-year research project to develop clinical guidelines for pre-eclampsia diagnosis and treatment in lower- and middle-income countries. The project aims to reduce maternal, fetal, and newborn deaths related to pre-eclampsia.
New research in Psychological Science found that the fear of being the target of malicious envy motivates people to act more helpfully toward those they think might be jealous. This fear encourages prosocial behavior, such as sharing resources with others.
A review of 134 studies on breast reconstruction found inconsistent reporting and a lack of standardization in outcome assessment. The authors highlight the need for non-clinical factors such as patient-reported outcomes to be incorporated into outcome assessment.
Researchers found that dynamic Hsp27 regulation is crucial for clearing abnormal tau protein and preventing neurofibrillary tangles. Effective Hsp27 switching promotes tau recycling in healthy nerve cells and clears brain abnormalities.
Researchers model how Neolithic transition was halted by population density of hunter-gatherers. The findings confirm archeological data that challenge the assumption of climate adaptation as a primary factor.
New research suggests that exposure to nicotine during pregnancy can lead to a decrease in adult stem cells and alter synaptic plasticity in the hippocampus, increasing the risk of behavioral problems such as ADHD. The findings may provide a brain-circuitry mechanism for learning disabilities in children born to smoking mothers.
Researchers at VCU Massey Cancer Center discovered a previously unknown mechanism in NSCLC cells that contributes to their ability to maintain and grow tumors. The study found that a protein factor regulates the expression of caspase-9, a main player in apoptosis, which could provide a new target for therapies.
The new report presents a statistical overview of the U.S. doctoral education system, showcasing trends and changes in the number of international students pursuing a doctorate at U.S. universities. The report aims to inform improvements in the U.S. doctoral education system, emphasizing the need to revitalize America's STEM pipeline.
Researchers developed a new high-performance fiber with superior strength and toughness, surpassing Kevlar. The fiber was created by combining carbon nanotubes with a polymer and testing its properties using in-situ electron microscopy.
Phase III trials should aim to find clinically important differences in survival outcomes, rather than just statistically significant ones. Pharmaceutical companies often prioritize minimal but detectable differences that are feasible within trial constraints.
Scientists are using Alvin and Sentry to explore the ocean floor in the Gulf of Mexico, searching for signs of impact from the 2010 oil spill. The expedition aims to map the seafloor, collect samples, and document the effects on deep-ocean communities.
Researchers have characterized a series of bismuth citrate complexes and modeled the structure of ranitidine bismuth citrate, a medicine used to treat peptic ulcers and gastric reflux disease. The polymeric framework may serve as a 'drug carrier' for delivering other drugs in the human body.
Researchers at UT Southwestern Medical Center have identified the molecular mechanisms underlying antiphospholipid syndrome (APS), a potentially life-threatening condition that causes blood clots. The study's findings suggest that targeting specific proteins may lead to new therapies for APS and its associated pregnancy complications.
A recent UC Riverside study evaluated five e-cigarette brands, revealing design flaws, inadequate labeling, and quality control concerns. The researchers urge regulators to remove e-cigarettes from the market until their safety is adequately evaluated.
The study used an extensional rheometer to measure flow properties of complex fluids, revealing intriguing effects depending on concentration and velocity. At high speeds, the fluid can fracture like a solid, behaving like a jammed system with clusters locking together.
A recent study found that nearly half of youth with type 1 and type 2 diabetes are current smokers, increasing their risk for heart disease. Aggressive smoking prevention and cessation programs are needed to prevent or delay heart disease in this population.
The Mental Health Research Network aims to make research faster, less expensive, and more relevant to real-world healthcare. By analyzing data from 10 million people in 12 states, researchers hope to find effective methods for detecting, treating, and preventing mental disorders.
The study identifies the early Katian Age as the commencement of the Kwangsian Orogeny, a significant event in South China's geological evolution. Continuous Ordovician sections in Yongxin and Chongyi Counties display a continuous graptolite sequence, indicating a sharp facies change from deep-water black shales to shallow-water clastics.
The new infrared camera features a 16-fold increase in pixels, enabling higher-resolution images in the dark. The Type-II superlattice technology reduces mercury content and improves uniformity, increasing yield and reducing cost.
Researchers develop system to analyze patient data, therapist interactions, for better understanding of depression causes and prevention strategies. The approach balances individual differences with observed similarities in behavior and response to treatment.
Scientists studied ice cores to find evidence of biomass burning fluctuations in Southern Hemisphere. Biomass burning trends differ from Northern Hemisphere records, suggesting changes for climate models.
A study by Dini et al. investigates the effect of 6 mT Static Magnetic Field (SMF) on phagocytosis in human macrophages, finding that it depends on the degree of macrophage differentiation. The results suggest that moderate intensity SMF can modify cell surface morphology and influence fluid-phase endocytosis and phagocytosis.