A new study found that a novel histone deacetylase inhibitor drug, entinostat, can predict clinical benefit in breast cancer patients just days after treatment. The study showed that levels of protein lysine acetylation were related to clinical benefit, with patients who had elevated levels having a reduced risk of disease progression.
A state survey found that fewer than 6% of doctors fully follow national guidelines for assessing sudden cardiac death risk during high school sports physicals. Doctors reported missing critical questions, such as chest pain and family history of heart disease, in over half of the cases.
Researchers identified ALK amplification in up to 86% of inflammatory breast cancer patients, a potentially targeted therapy approach. Inhibiting ALK with a small-molecule inhibitor resulted in tumor cell death, paving the way for clinical trials.
Researchers from CSHL and St. Jude's Research Hospital have discovered new details of how a protein complex contributes to heterochromatin assembly and gene silencing in fission yeast. The team identified a previously unknown substructure at the end of Chp1, which plays a crucial role in heterochromatin formation at telomeres.
A wearable defibrillator can prevent sudden death in people with dangerous heart arrhythmias, saving up to 91.6% of those experiencing ventricular fibrillation or tachycardia. The device delivers an electric shock if needed and alerts bystanders for help.
Researchers at UC San Diego have identified a new class of drugs that can arrest division in virtually all tumor cells by altering the structure of the RAF enzyme. The discovery offers an effective alternative to current therapies and has shown promising results in tests on cancer cell lines, animal models, and human tissue biopsies.
A study from the University of Pennsylvania School of Medicine found that even trained individuals lack confidence in performing CPR due to inadequate hands-on practice time. Introducing 'hands-only' CPR techniques improved confidence among subjects.
Two studies presented at the American Society of Nephrology's Annual Kidney Week highlight concerns about dialysis clinic closures and their impact on patients' quality of life. The new initiative hopes to reduce new cases of chronic kidney disease and its progression, complications, disability, death, and economic costs.
Researchers found that intensive diabetes therapy can preserve kidney function in patients with type 1 diabetes, preventing impaired kidney function and kidney failure. The study's results demonstrate the importance of maintaining good glucose control early in the course of type 1 diabetes to prevent long-term kidney complications.
A long-term study found that early, intensive glucose-lowering therapy in type 1 diabetes patients prevented impaired glomerular filtration rates and reduced the risk of end-stage kidney disease. Participants who received intensive therapy showed a 50% lower risk of developing impaired GFR over a median follow-up period of 22 years.
A new study by the American Society of Nephrology found that sitagliptin is safer and just as effective as glipizide in managing type 2 diabetes and chronic kidney disease. Patients taking sitagliptin also tend to lose weight, while those on glipizide often gain weight.
A new study from the University of Pennsylvania School of Medicine reveals that discussions about cardiac arrest on Twitter can provide valuable opportunities for public health education. The researchers found that users frequently share information about CPR and AEDs, as well as discuss resuscitation topics in the news.
Horst Sievert, a leading expert in non-coronary interventions, has advanced the field of interventional cardiovascular medicine through technical excellence. He has performed over 25,000 percutaneous coronary interventions and 12,000 peripheral angioplasties.
A new supplement of Cartilage, published by SAGE, examines the effects of articular cartilage injury and degeneration in soccer players. The supplement provides a comprehensive overview of current knowledge on cartilage injury, prevention strategies, and treatment options.
A three-year grant will fund clinical trials testing patient navigator models and electronic health record enhancements for chronic kidney disease care. The study aims to improve treatment adherence and patient outcomes.
EPL has published its first paper submitted from space, detailing experiments conducted on the International Space Station by German and Russian researchers. The study reports on the measurement of the speed of sound within complex plasmas under microgravity conditions, providing new insights into material properties.
Dr. Jon Gelhaus, a Philadelphia scientist, received the 'Best Scientist in Nature and Environment' medal for his significant contributions to Mongolian Environmental Science. He is leading a multinational effort to improve water quality monitoring and standards in Mongolia.
A mid-pregnancy test can predict preeclampsia, a late-pregnancy disorder characterized by high blood pressure and excess protein in the urine. Women with high blood pressure during pregnancy are at increased risk of experiencing high blood pressure, kidney problems, and stroke later in life.
The PEPCAD-DES trial demonstrated paclitaxel-coated balloon angioplasty is more effective than plain old uncoated-balloon angioplasty in treating drug-eluting stent restenosis. The procedure resulted in lower late lumen loss, binary restenosis rates, and major adverse cardiac events.
The REMEDEE trial demonstrated that the new dual therapy stent effectively controls neointimal proliferation, with low rates of clinical events and comparable results to paclitaxel-eluting stents. The study showed non-inferiority compared to a clinically proven stent in ischemic heart disease patients.
Two studies found that pomegranate juice can lower cholesterol, blood pressure, and the need for blood pressure medications in kidney disease patients. Meanwhile, over 15% of kidney disease patients take potentially harmful herbs or dietary supplements.
A national panel led by Iowa State University engineers is researching and developing technologies that capture, use and sequester carbon while enhancing food production, ecosystems, economic development and national security. The panel aims to develop an intellectual framework for a carbon negative economy by adopting a strategy of ac...
The TWENTE trial demonstrated non-inferiority between zotarolimus- and everolimus-eluting stents, with low rates of target vessel failure and stent thrombosis. The study showed similar efficacy in a broad patient population with complex lesions and 'off-label' indications.
Researchers at the University of Pennsylvania School of Medicine have discovered that two types of intestinal stem cells are related and can produce each other. This finding suggests that developmental pathways in human organs that regenerate quickly may be more flexible than previously appreciated.
The ADVISE trial demonstrated that instantaneous wave-free ratio (iFR) is comparable to fractional flow reserve (FFR) without the use of adenosine. The study found excellent diagnostic efficiency and correlation between iFR and FFR, with potential clinical implications for improving patient experience and workflow in cath labs.
Researchers found that polymer-free amphilimus-eluting stents resulted in significantly lower in-stent late loss at six months compared to paclitaxel-eluting stents. The trial, NEXT, demonstrated non-inferiority of these stents in de novo native coronary artery lesions.
A new treatment called Auditory-Motor Mapping Training (AMMT) has been shown to help nonverbal children with autism develop speech. The study found that children who received AMMT were able to approximate whole words and phrases, with noticeable improvements as early as two weeks into the treatment.
A new study by the University of North Carolina Health Care found that elderly patients are less likely to receive pain medication in hospital emergency departments compared to middle-aged patients. The study suggests that physicians may be cautious about potential side effects in older adults, leading to a significant gap in pain mana...
Scientists have identified a gene switch that regulates the choice of odorant receptor genes in olfactory sensory neurons. Regulatory elements in the genome act as on-off switches to determine which gene is chosen for expression.
A team of chemists has gained new understanding of the Haber-Bosch process, which converts atmospheric nitrogen into ammonia. By mimicking the process in solution using an iron-potassium complex, they discovered that three iron atoms break the strong N-N bonds to form a complex with Fe3N2 core.
Shanchol, a new oral cholera vaccine developed by IVI, has been prequalified by the World Health Organization for use in developing countries. The vaccine is ready to be used in large-scale immunization programs and has been shown to be safe and protective against cholera for three years.
The study reveals that while the Hib vaccine has reduced Hib disease in young children, other strains of the bacteria continue to cause substantial disease in older adults and infants. The burden of disease is highest among the elderly and youngest age groups, with nearly a quarter of cases being fatal.
A clinical trial testing rotational atherectomy prior to implantation of a drug-eluting stent found that the process was not superior to standard balloon angioplasty and decreased the efficacy of the stent. Rotablation followed by drug-eluting stenting is not supported by randomized studies in complex calcified lesions.
Researchers identify oncostatin M as a key player in the self-healing powers of the heart, allowing damaged heart muscle cells to reversion and produce new cells. This discovery holds promise for treating heart disease, but further research is needed to pinpoint the precise window of application.
Researchers discovered a one-third reduction in severe pneumonia among young children in homes equipped with smoke-reducing chimneys. Exposure to open fires and dirty cooking stoves increases respiratory infections, affecting billions worldwide.
Researchers have eliminated two possible causes of joint pain in women taking breast cancer medications: inflammatory arthritis and autoimmune disease. Despite finding no link between the medication and these conditions, doctors recommend continuing treatment to gain full benefits.
NYU Langone experts will present research on brain networks, cognition, and memory at the annual meeting. The institution's Neuroscience Institute connects scientists with clinicians to tackle complex healthcare issues.
The EVOLVE trial found that a bioabsorbable polymer stent was non-inferior to traditional durable polymer stents in treating de novo coronary artery disease, with lower rates of late events and reduced need for dual antiplatelet therapy.
Chronic opioid users have longer hospital stays, more post-surgical pain and complications, and are less likely to recover fully after knee replacement surgery. Researchers recommend strategies such as weaning patients off strong opioids prior to surgery to improve patient outcomes.
A massive set of mammal data from GBIF helped quantify the influence of environmental factors on species presence. The study found that climate is the biggest factor influencing mammal species communities at larger scales, while land use and land cover become more important at smaller scales.
Researchers have found evidence of CO2 binding in brine channels within sea ice, where microorganisms thrive. This phenomenon diminishes the greenhouse effect and could inform global climate models.
The PROFI trial found that proximal balloon occlusion resulted in fewer cerebral ischemic lesions compared to filter protection during carotid artery stenting. This reduction was associated with a lower risk of stroke and other major adverse cardiovascular events.
A new report proposes science-based strategies to monitor and set limits for air pollution, aiming to protect and restore U.S. ecosystem health. The authors review current pollution evaluation criteria and propose critical loads of pollutants to design policy and manage ecosystems.
The COBRA trial found that cryoplasty post-dilation decreases the risk of in-stent restenosis by 26.5% compared to conventional balloon angioplasty in patients with diabetes. Researchers used a cryoplasty dilatation system that simultaneously dilates and cools the vessel wall, inducing smooth muscle cell apoptosis.
A Spanish study of 945 adults found that high fish consumption was linked to lower glucose concentrations and a reduced risk of developing diabetes. In contrast, excessive red meat consumption was associated with increased weight gain, obesity, and higher cardiovascular risk.
A nationwide study finds depression and a history of suicide attempts in young people markedly increase their risk for dying from heart disease. Women are particularly at risk, with a three times higher risk of cardiovascular disease and 14 times higher risk of ischemic heart disease.
Scientists at MIT's Alcator C-Mod tokamak reactor have successfully maintained I-mode operation over a wider power range. This breakthrough could enable the application of I-mode to larger ITER projects and future fusion reactors.
A new method has been developed to separate enantiomers, which are pairs of molecules with a mirror-inverted structure. The method uses porous molecular organic frameworks (MOFs) to sort molecules, allowing for rapid and efficient separation of enantiomers in pharmaceutical production.
A large-scale clinical study has provided insights into the causes of temporomandibular joint disorders, known as TMD, and identified demographic, biological, psychological, and genetic factors associated with chronic cases. The study's findings may lead to new methods of diagnosing facial pain conditions and predicting susceptibility.
A team of ecologists challenges the idea of a universal species-area relationship, finding that geometric constraints and biological effects shape the connection between species richness and plot size. They discovered specific geometric limits that restrict how quickly the number of species can increase with area.
Researchers at Duke University discovered that certain mid-ocean creatures can control their reflection by changing skin pigments in response to blue light. This allows them to avoid predators using searchlights, such as squid and octopuses that use this tactic to catch prey.
A European herb has figured out its own way to survive in environments with low pollinator density, using a delayed selfing mechanism to guarantee seed production. The study found that when populations are small and/or pollinators are scarce, plants can augment seed production via autonomous self-pollination.
A new study published in PLoS Pathogens reveals that Staphylococcus aureus can develop resistance to the last-line antibiotic vancomycin by acquiring a single mutation in its DNA. This discovery highlights the high adaptability of Staph and emphasizes the need to improve antibiotic treatment strategies for serious bacterial infections.
Four University of Toronto researchers received funding to develop new technologies in genomics research, including a software platform and automated pronuclear injection system. The projects aim to improve disease diagnosis and treatment options by analyzing DNA mutations and gene function.
Researchers used a novel experiment to investigate the brain's perception of surface lightness, finding that the ratio hypothesis does not explain the observed performance. Instead, participants could distinguish between shades with ratios up to 50 times higher than expected, suggesting other mechanisms are at work.
Researchers at the Princeton Plasma Physics Laboratory have created a video simulation showcasing the complex dynamics of a plasma pulse within an experimental fusion machine, offering new insights into particle confinement and magnetic field manipulation. The simulation provides a detailed 3D picture of the plasma, allowing researcher...
A new study estimates that around 90 million children contract seasonal flu each year, causing approximately 1 million hospital admissions and up to 111,500 deaths due to influenza-related pneumonia. The majority of these deaths occur in developing countries.
The DEB-AMI trial found that drug-eluting balloons with bare metal stents did not meet the primary endpoint of reduced late lumen loss compared to drug-eluting stents. The study also showed that these procedures may induce more pronounced morphological changes, resulting in inferior angiographical and clinical outcomes.
Researchers installed a movable 30-ton particle-beam heating system to develop fusion plasmas that can burn indefinitely. The system allows scientists to vary the spatial distribution of the plasma current to maintain optimal conditions for sustaining high-temperature plasmas needed for fusion energy production.
An international team of scientists discovered how a bacterial pathogen kills cells by preventing protein synthesis, paving the way for novel therapies to combat melioidosis. The study, led by the University of Sheffield, used intense X-rays to solve the structure of a protein from Burkholderia pseudomallei.