A multifaceted intervention improved clinical knowledge, skills, and practices in pediatric care among Kenyan hospital staff. The study found higher completion of admission tasks and guideline-recommended practices in intervention hospitals compared to control hospitals.
A McGill biologist's findings raise doubts about the Differential Adhesion Hypothesis, proposing that repulsive cues may drive tissue formation instead of adhesion. The study reveals a cycle of adhesion followed by repulsion at embryonic cell boundaries.
Dr. Mala S. Mahendroo will investigate biological mechanisms and causes of premature birth with a new $600,000 Burroughs Wellcome Fund grant. She aims to develop an imaging tool to assess collagen changes that precede preterm birth.
Vibrations in the inner ear persist even after a sound has stopped, potentially serving as a short-term memory of past stimuli. This phenomenon may help explain why some gaps between sounds are too brief to be perceived by the human ear.
A recent study found that even educators struggle to agree on the meanings of these terms, making it difficult to compare learning methods and provide accurate course previews. Researchers argue that a common understanding is crucial for evaluating best practices in student learning.
UCSD scientists create a new type of genetic tag visible under an electron microscope, allowing for detailed, three-dimensional images of individual cells. The modified protein, dubbed miniSOG, produces abundant singlet oxygen when exposed to blue light, enabling its visualization.
A brain imaging study found that meditation significantly reduced pain ratings and activity in the primary somatosensory cortex, an area crucial for creating the feeling of pain. Meditation also increased activity in areas including the anterior cingulate cortex, anterior insula, and orbito-frontal cortex.
A recent study analyzed data from almost 2,000 coral reef locations worldwide to determine the link between biodiversity and ecosystem functioning. The research found that biomass production decreases with increasing human density, especially in more diverse ecosystems.
Researchers at the University of Pennsylvania School of Medicine have found a novel drug combination that successfully treats advanced cancer patients. The temsirolimus-hydroxychloroquine combination was shown to halt tumor growth in two-thirds of patients, including those with melanoma, colorectal, and head and neck cancers.
A new study finds that vismodegib, a hedgehog pathway inhibitor, prevents the development of advanced basal cell carcinomas in patients with basal cell nevus syndrome. The treatment also shows promise for patients with an inherited predisposition to basal cell carcinoma.
A recent Penn study found that heart patients support discussions about ICD deactivation at the end of life and post-mortem donation for product improvement or reuse. Most patients want their ICDs deactivated in an end-of-life illness, and many support donating their devices to improve global health disparities.
Breast cancer survivors who experience extreme weight gain have an increased risk of death and cancer recurrence. Moderate weight gain did not affect breast cancer outcomes, according to a study presented at the AACR 102nd Annual Meeting.
A group of experts has identified 40 critical environmental questions to guide scientific research and inform natural resource management. These questions aim to balance economic, social, and ecological considerations, facilitating collaboration between researchers and policymakers.
A recent study suggests that estrogen-only hormone therapy may decrease the risk of breast cancer in women who have had a hysterectomy. However, experts caution against long-term use due to unknown consequences and conflicting evidence from previous studies.
A recent study published in Psychiatry Research found that 50% of patients with bipolar disorder experience work, social, or family disabilities. Factors associated with these disabilities include high recurrence of maniac episodes, recurrent psychiatric hospitalization, depression, and low educational levels.
Researchers at Fox Chase Cancer Center have found a direct correlation between the expression of a key tumor suppressor protein and premature aging in mice. The study suggests that blocking cell proliferation induced by the p16 protein leads to features of premature aging, not just molecular damage.
A study published in Cell Metabolism identifies a previously underappreciated cellular fat storage depot controlled by sterol regulatory element-binding protein 2 (SREBP-2), which plays a crucial role in balancing cellular cholesterol levels and regulating autophagy.
A study by Wake Forest Baptist Medical Center found that 40.3% of college students reported smoking tobacco from a hookah, while 17.4% were current users. Hookah smokers mistakenly believed it to be safer than cigarette smoking, with some even using hookahs as their first tobacco product.
A study published in PLOS Medicine analyzed whistleblower complaints related to 18 alleged cases of off-label marketing. The findings revealed common practices, including prescriber-related incentives and internal sales quotas, which can be challenging to regulate.
Researchers at the University of Warwick have found that Metformin treatment can decrease the invasiveness of endometrial cancer cells in women with PCOS. The study suggests that long-term use of Metformin may provide protection against endometrial cancer, a significant finding for women with Polycystic Ovary Syndrome.
Researchers at Fox Chase Cancer Center have developed a screen to identify proteins that work with histone deacetylases and DNA methyltransferases to repress gene expression. The method revealed 128 factors involved in regulating gene expression, potentially leading to broader cancer therapies
A University of Missouri study finds that students justify cheating with excuses like 'too hard to do' or 'severe illness'. Instructors can reduce cheating by communicating clear expectations and providing consistent enforcement, according to the researcher.
Mattress Firm has named Translational Genomics Research Institute as its charitable partner of choice to support globalCure's fight against pancreatic cancer. The company will donate $50 to globalCure for every Simmons Beautyrest dual floor sample sold nationwide, aiming to raise over $100,000.
A Purdue University biochemist has created a nanopolymer that can be coated with drugs and then removed to determine which proteins the drug has entered. This development may help reduce side effects associated with cancer drugs by allowing for more targeted drug delivery.
Rafael Davalos has developed a method to treat cancerous tumors using irreversible electroporation, achieving complete remission in a seven-year-old dog. He aims to explore its potential in treating other pathologies, such as cardiac arrhythmias and glioblastoma multiforme.
A new study from the British Journal of Social Psychology examines the impact of materialistic messages on women's feelings about their bodies. Women who focus more strongly on their appearance when materialistic values are highlighted are more vulnerable to negative body image.
A study by Georgetown University Medical Center researchers suggests that activation of the beta-catenin oncogene is key to understanding why many women with HPV infection do not develop cervical cancer. The discovery could lead to new screening methods and therapeutic approaches, including targeting the Wnt pathway.
Scientists discovered minerals requiring liquid water for formation in comet Wild-2, shattering the current paradigm that comets are frozen in time. The discovery provides evidence of a warm water phase and puts an upper limit on temperatures encountered by the comet during its origin.
A recent study published by the American Association for Cancer Research found that consuming soy food did not increase the risk of cancer recurrence or death among breast cancer survivors. In fact, women who consumed more soy isoflavones had a reduced risk of mortality and cancer recurrence compared to those with lower intake levels.
Breast cancer survivors who experience large weight gain (10% or more over pre-diagnosis weight) are 14% more likely to experience a cancer recurrence compared to women whose weight remains stable. Researchers found that moderate weight gain does not affect breast cancer outcomes.
A study found that early menstruation (before age 10) increases the risk of lung complaints in adulthood, with southern European women being most affected. Women who started their periods earlier also tend to have lower lung capacity and higher body fat.
A new study reveals that Huntington's disease protein causes metabolic imbalances in the hypothalamus, leading to increased appetite and weight. The research provides evidence of a causal link between mutant huntingtin expression and metabolic dysfunction.
A new study found that long-term depression is associated with premature aging of immune cells, potentially leading to increased susceptibility to other illnesses. Researchers also discovered a link between telomere shortening and oxidative stress in depressed individuals.
Researchers found that thiazolidinediones (TZDs) and fibrates, commonly used to treat type-2 diabetes, may help counteract nicotine and alcohol addiction by activating specific receptors in the brain. These drugs stimulate PPAR-α and PPAR-γ receptors, reducing inflammation and increasing high-density lipoprotein (HDL) levels.
Researchers investigated the association between bleeding and mortality in patients on dual antiplatelet therapy (DAPT) versus aspirin alone. The study shows patients with moderate or severe bleeding had a higher incidence of all-cause, cardiovascular and cancer mortality.
A study by Kansas State University researchers found that producing eco-friendly diesel fuel from algae is technically feasible but economically unviable. The team's analysis revealed that scaling up algae production to meet demand would require a massive investment, surpassing the laws of physics and economics.
A systematic review and pooled analysis found that low-frequency HIV-1 drug resistance mutations are associated with a 2.3 times increased risk of virologic failure in treatment-naive adults, particularly those with NNRTI-resistant minority variants.
A study confirms that climate change is causing rapid environmental fluctuations, resulting in 'bluer' environments and higher extinction risks for animals. The research links temperature changes to population dynamics, with bluer populations indicating faster oscillations and lower extinction risks.
Researchers have mixed nanoparticles into heat-transfer oils to increase the efficiency of solar collectors. This could lead to significant revenue gains for solar power plants. The use of nanoparticles also has potential applications in filtering out pollutants from coal power plants.
The discovery of the SIRT3 protein's role in altering the nutrition of breast cancer cells has significant implications for cancer treatment. By identifying this protein as a 'guardian' of metabolism, researchers may develop targeted therapies to promote its activation and inhibit cancer growth.
A new study is planned to investigate the health effects of high lithium levels in drinking water on mothers and children in Andean villages. Researchers have found high levels of arsenic, lithium, and other substances in the drinking water and urine of women studied, which may pose a health risk.
Projections predict tsunami debris will spread out eastward, reaching Northwestern Hawaiian Islands in a year and US West Coast in three years. The debris will then enter the North Pacific Garbage Patch, where it will break into smaller pieces.
Scientists at UCSD and colleagues create a new type of genetic tag visible under electron microscopy, enabling detailed three-dimensional images of individual cells. The breakthrough enhances electron microscopy capabilities, allowing researchers to visualize proteins in unprecedented detail.
Researchers found that modern spinal fusion techniques do not cause significant damage to the spine just below the fused discs, contrary to previous beliefs. Patients who underwent surgery showed good functional scores, balance maintenance, and minimal lower back pain ten years post-operatively.
A recent study by University of Western Ontario researchers has identified a critical brain pathway responsible for the effects of cannabinoid drugs on emotional processing. The findings suggest that activating cannabinoid receptors in the amygdala region can significantly impact emotional information and memory processes.
A drastic shift in prescribing patterns has led to a fivefold increase in opioid addiction admissions, with prescriptions for hydrocodone and oxycodone accounting for 84.9% of opioid scripts. Experts recommend comprehensive training and public education to protect vulnerable populations.
A nutrient sensing pathway has been identified as responsible for disrupting cellular lipid homeostasis in obese and insulin-resistant mice. This discovery may lead to the development of new drugs to slow or stop diabetes progression, as well as improve current treatments.
Fox Chase researchers identify retinoic acid as a promising therapy for early-stage breast cancer, inhibiting cell growth and proliferation. The study's findings suggest that the treatment may be effective in stopping tumor progression at its earliest stages.
A new study by Yale researchers found that states with insurance coverage for infertility have significantly lower multiple birth rates. The study analyzed assisted reproductive technology cycle data and found a reduction in twin and triplet births among younger women, leading to improved maternal-fetal health and economic savings.
Scientists mimic the body's natural mechanism of fighting inflammation by using natural human microparticles to deliver anti-inflammatory therapeutics. This new approach could have application for various inflammatory diseases, including arthritis and temporomandibular disorders.
NYU School of Medicine researcher Cosimo Commisso will receive a grant to investigate the role of fluid uptake in pancreatic cancer cells. The goal is to understand how this process contributes to tumor development and identify potential targeting strategies.
Researchers at UMass Chan Medical School discovered a new function of the cilia protein IFT88 in mitosis, which could contribute to ciliopathies such as primary ciliary dyskinesia and polycystic kidney disease. IFT88 plays a transport role during mitosis, similar to its function in cilia formation.
A new study found that employee mood affects perceptions of customers and work quality, with positive moods linked to greater verbal fluency and reduced errors. Employees in a bad mood tend to answer fewer calls, need more breaks, and perform less well, while positive customers can help improve their mood.
Researchers found that breast cancer cells activate the unfolded protein response to evade anti-estrogen treatment, leading to increased resistance. Over-expression of XBP1 is a key driver of this process, suggesting a new target for restoring sensitivity to anti-estrogen therapies.
Researchers at the University of Gothenburg have developed a method to study lake-bottom sediments and infer fish death in acidified lakes. By analyzing microscopic remains of dead midge larvae, they can recreate the history of the lake back to the early 19th century.
Researchers found that caterpillars position themselves in areas with abundant twigs during the day to avoid detection, but switch to richer feeding grounds at night. This complex behavior shows that masquerading prey use habitat-selection strategies to exploit predators' hunting behavior.
A large case-control study found that taking aspirin at least once a month can reduce the risk of pancreatic cancer by 26% compared to non-users. The effect was also seen in those taking low-dose aspirin for heart disease prevention, with a 35% lower risk.
A team of University of Cincinnati researchers is sequencing individual glioblastoma genomes and tracking abnormalities in the bloodstream to establish personalized biomarkers. The study aims to guide treatment efforts and identify new therapeutic targets for this aggressive brain tumor.
Researchers from Universitat Autonoma de Barcelona have discovered formations in Catalonia resembling Mars' giant spring mounds. The study, published in Geodinamica Acta, suggests possible similarities in origin, shedding new light on the search for water on Mars.
A study published in the Journal of the American College of Surgeons found a 22% relative increase in women among USMG applicants to general surgery programs, with a corresponding 40% increase in those entering training. This trend aligns with increasing equal gender enrollment of medical students.