A new mouse model closely resembles the human body's reaction to early HIV infection, showing inflammatory responses, changes in brain cells, and neuronal loss. The study is a breakthrough in understanding how HIV affects brain functioning in its initial stages.
Researchers discovered protein-coding point mutations in all 22 hiPSC lines, with an estimated six mutations per exome. The findings suggest that genetic screening of hiPSCs before clinical use is crucial to ensure their safety and accuracy.
A recent study discovered a blood protein linked to lung adenocarcinoma, which could serve as a diagnostic marker for the disease. Elevated levels of serum amyloid A (SAA) were found in patients with lung cancer, making it a promising target for developing drugs that stop cancer spread.
A study of 23 longitudinal studies found that light-to-moderate alcohol consumption was associated with lower incidence rates of overall dementia and Alzheimer's disease. However, the impact on vascular dementia and cognitive decline is unclear.
A study by D. Keith Denton highlights the importance of creating an atmosphere of trust in the workplace to improve communication and reduce dissatisfaction. Face-to-face communication is found to be more effective than other channels, allowing for true dialogue to occur.
A recent study of 45-million-year-old pollen from Pine Island has led to a revised understanding of Florida's geologic history. The discovery of land-based pollen indicates that Florida may have been inhabited by land animals around 10-15 million years ago, contradicting previous theories.
Four new species of fungus have been discovered in the Brazilian rainforest, infecting ants and manipulating their behavior to secure prime locations for spore dispersal. The study sheds light on the complex interactions between parasites and fragmented habitats, providing tools for further research into disease dynamics.
Fire, cattle, and prairie dogs play a crucial role in maintaining the diversity of vegetation on the western Great Plains. This mosaic of diverse vegetation supports various wildlife species, including declining populations of grassland birds and ground-nesting birds.
Researchers assess clinical info systems, PHRs, and EHRs to understand their influence on patient care. Studies reveal concerns about privacy are not a barrier to PHR use, while clinicians spend significant time on EHR documentation.
Researchers found genetic rearrangements and 'copy number variations' associated with reprogramming adult cells to induced pluripotent stem cells. The study highlights the need for rigorous characterization of generated iPS lines to ensure genomic integrity.
A study published in The Lancet found that eribulin monotherapy extends the lives of breast cancer patients with extensive treatment by a median 2.5 months compared to physician's choice treatment. The drug targets microtubules, leading to cell death and improved survival rates.
A literature review finds lab tests and imaging have limited value in diagnosing JIA due to false positives; a full physical exam and patient history are crucial for accurate diagnosis
Researchers at Penn have created high-quality graphene that covers over 95% of its surface area using readily available materials and manufacturing processes. The production process can be scaled up to industrial levels, reducing costs and increasing flexibility.
The iPrEx study found daily oral Truvada effective in preventing HIV infection in gay and bisexual men and transgender women. Researchers also discovered small but significant decreases in bone mineral density among those taking Truvada compared to a placebo.
A new Harvard School of Public Health study found that adults who regularly take ibuprofen have a lower risk of developing Parkinson's disease. The researchers analyzed data from nearly 99,000 women and 37,000 men, finding that ibuprofen use was associated with a 38% reduced risk of Parkinson's disease.
Computer simulations suggest that changes in plasma flow within the Sun, which resembles ocean currents, contribute to prolonged solar minima. The team discovered that a faster flow during the first half of the solar cycle can lead to an extended period without sunspots and weak polar magnetic fields.
Research by physicists and ecologists found that overcast skies are up to three times brighter than clear nights, amplifying ecological light pollution in urban ecosystems. The study highlights the need to consider cloud cover when assessing biological impact of light pollution.
Researchers found lower potassium levels associated with higher diabetes risk in African-Americans, who are twice as likely to develop type 2 diabetes. Increasing potassium levels through diet or supplements could potentially prevent the most common form of diabetes.
Researchers created a new class of plant growth regulators that block auxin transport, controlling growth processes without hormonal activity or toxicity concerns. The inhibitors are expected to reduce environmental impact and safety risks associated with current growth regulators.
Dr. A.K. Ganguly, a renowned pharmaceutical researcher, received the Topliss Award Lecture at the University of Michigan for his lifetime contributions to medicinal chemistry. His lecture discussed lessons learned in drug discovery, highlighting approaches taken at Schering-Plough and ongoing work at Stevens.
Researchers at the University of Pennsylvania School of Medicine found that protein p53 controls glucose metabolism, enabling cells to grow uncontrollably in tumors. This discovery may lead to new cancer therapeutics by targeting an inefficient metabolic pathway.
Researchers at Hebrew University identified a previously uncharacterized type of bacterial communication mediated by nanotubes that bridge neighboring cells. This mechanism enables bacteria to exchange small molecules, proteins, and even small genetic elements, facilitating the acquisition of new features such as antibiotic resistance.
Researchers at MIT propose an experiment using a large number of photons and beam splitters to calculate complex distributions. The challenge lies in simulating the sampling process, which is currently computationally intractable.
Researchers at York University have identified a key role for microRNA 376c in allowing ovarian cancer cells to thrive despite chemotherapy. By targeting the receptor ALK7, this microRNA enables cancer cells to survive and resist cell death.
Researchers at the University of Illinois have developed a model for interacting electrons in unconventional superconductors by mimicking the behavior of charged black holes. This work resolves the Mott problem, which has puzzled physicists for decades, and sheds light on the origin of superconductivity in copper oxide materials.
Caspase 8, long viewed as an executioner of cellular suicide, has a surprising dual function: initiating apoptosis and restraining an independent programmed death pathway. The enzyme's absence can be compensated by RIP3, allowing mice to develop normally and potentially offering new therapeutic avenues for diseases.
A study by Richard Eibach and Steven Mock found that parents who focus on the financial costs of parenthood tend to idealize parenting more, while those considering both costs and benefits report lower enjoyment in other activities. The researchers suggest this myth is a modern psychological phenomenon linked to changing societal values.
Scientists have developed an instrument that tracks protein conformation and translocation with nanoscale precision. This breakthrough enables researchers to study proteins that regulate DNA replication and transcription, revealing new insights into their mechanisms.
A study published in the Journal of Consumer Affairs found that rural Appalachian women are more likely to perform breast health self-examinations and seek medical attention when their caregiving responsibilities are recognized. The research suggests that appealing to their strength as caretakers encourages them to take care of themsel...
Researchers found that flood-tolerant rice plants with the Sub1A gene not only survive flooding but also recover well from drought, growing new shoots. This breakthrough could greatly benefit rice growers and consumers globally.
A UCLA study found that body language is more likely to be judged as masculine when it conveys anger and as feminine when it conveys sadness during baseball tosses. Researchers used technology to disguise the actors' sex and presented videos to observers, who made judgments about their emotions and gender.
A study by North Carolina State University found that superficial similarities between training participants and helper agents enhance performance. Participants reported better engagement and focus when the helper's communication style matched their own, leading to improved learning outcomes.
A €2.6 million research program is training Malawian clinical officers to improve prenatal care and reduce childbirth mortality rates. The goal is to educate 50 clinical officers, who will then teach others, and ultimately assess the impact on mortality rates.
Researchers found that C. elegans worms gain resistance to one microbe at the cost of becoming more vulnerable to another, highlighting a see-saw balance between immunity to different diseases across the animal kingdom.
Researchers found that apple polyphenols prolonged lifespan and preserved physical function in fruit flies, supporting previous studies on antioxidant benefits of apples.
Researchers at the University of Pennsylvania identified the neurological and cellular signaling mechanisms that contribute to satiety and body-weight loss. They found that GLP-1 drugs target the nucleus tractus solitarius, which regulates food intake suppression.
A study published in PLoS Medicine found that intensive adherence counseling significantly reduces poor adherence and virologic treatment failure in patients with HIV. Patients receiving counseling were 29% less likely to experience poor adherence, and those receiving early counseling had a 59% lower risk of viral failure.
Researchers have discovered that specific human astrocytes derived from stem cells can repair damaged nervous systems and promote locomotor function in spinal cord injured rats. The study reveals the importance of creating beneficial cell types through tissue culture before transplantation, providing a potential new avenue for treating...
A recent study published in JNCI found that shift work may be associated with a reduced risk of skin cancer in women. The researchers analyzed data from the Nurses' Health Study and discovered that rotating night shifts were linked to a lower risk of skin cancer, particularly melanoma. Darker-haired women had the lowest risk.
A 6-month daily dose of the antiretroviral drug nevirapine significantly reduced HIV transmission through breast milk to infants of HIV-infected mothers. The extended regimen achieved a 54% reduction in HIV transmission risk compared to six-week treatment, while preserving health benefits of extended breastfeeding.
Researchers have uncovered the key to spider silk's incredible strength and toughness, revealing a serial arrangement of crystalline and amorphous subunits that outperforms random structures. This breakthrough may lead to the design of artificial silk fibers with similar properties.
A recent study found that hospital use of computed tomographic colonography (CTC), also known as virtual colonoscopy, is increasing. In 2008, 17% of hospitals offered CTC, up from 13% in 2005, with many citing a desire to provide alternative screening options for frail patients and those with failed optical colonoscopy.
A team of researchers has discovered a new enzyme, squalene mono-oxygenase (SM), that plays a key role in cholesterol production. Inhibiting SM may lead to more effective treatments with fewer side effects than current medications.
Research reveals that specific gene variants, particularly IVS5-13insC, are linked to an increased risk of type 2 diabetes in individuals of white European ancestry. The study's findings suggest that these genetic variations could serve as early predictive markers for insulin resistance and type 2 diabetes.
Researchers at UT Southwestern Medical Center discovered a brain signaling pathway that induces leptin resistance, leading to decreased satiety and increased visceral fat. Activating this pathway, known as cAMP-EPAC, can induce leptin resistance in hypothalamic neurons, a critical site of leptin action.
Researchers found a thin layer of epithelial cells on healthy tendons that prevent adhesion formation. Mice with defective cells developed tendon adhesions, highlighting the importance of tissue surface integrity.
A study by Indiana University School of Medicine found that tanning bed radiation can cause severe skin reactions, including toxic epidermal necrolysis, a life-threatening condition. The researchers advise caution when using tanning beds to treat undiagnosed skin conditions.
The £46 million study will track the lives of over 90,000 UK babies and their families, examining factors such as social disadvantage, environmental pollutants, and parenting style. The research aims to understand how biological and environmental influences shape children's health, development, and future life chances.
The 2011 conference attracted over 100 presentations, showcasing proposals to exploit next-gen suborbital spaceflight capabilities. The event demonstrated growing interest in commercial suborbital spacecraft among researchers and educators.
Tropical Cyclone Atu formed over New Caledonia on February 21, intensifying into a powerful storm with maximum sustained winds of 95 knots before weakening. The cyclone dissipated north of New Zealand by February 25, its life spanning just four days.
The University of Illinois Chicago has received a $950,000 USDA grant to integrate obesity-prevention strategies into programs for low-income families. The program, Hip-Hop to Health, was previously found effective in reducing body mass index in minority children and will now be tested with an additional population.
A new study published in Psychological Science finds that a short-term regime called cognitive-bias modification can help heavy drinkers change their impulsive responses to temptation, leading to improved treatment outcomes. The technique involves video-game-like tasks and was found to reduce relapse rates among alcoholics.
A study published in Circulation found that patients with mild heart failure and left bundle branch block significantly benefit from CRT-D therapy, experiencing a 53% reduced risk of heart failure events. The therapy also effectively prevents cardiac remodeling and ventricular tachyarrhythmias.
Researchers deciphered the molecular structure behind spider silk's remarkable mechanical properties, discovering that soft amorphous subunits contribute to its elasticity and crystalline subunits determine its maximal toughness. The study's findings may aid in designing artificial silk fibers with improved performance.
UCSF researchers have discovered a crucial hormone pathway that contributes to the development of fatty liver disease. By disrupting this pathway, they found that fat accumulation in the liver can occur even without alcohol consumption. The study's findings may lead to the development of new therapeutic drugs targeting this pathway.
A new study found that uterine fibroid treatment significantly improved quality of life for women, with non-minimally invasive options such as MRgFUS showing better outcomes. The study surveyed over 197 women who underwent different treatments, including hysterectomy and UAE.
Robotic surgery shows comparable or superior results to traditional laparoscopic procedures for treating kidney disease, benefiting more patients due to reduced learning curve. More surgeons may master the technique, expanding access to minimally invasive treatment.
The 'Teaching the Middle East' online resource provides comprehensive and objective teaching materials on topics ranging from prehistory to modern states. It features articles written by University of Chicago faculty, lesson plans, and links to additional resources, aiming to dispel stereotypes and promote understanding.
For patients with confirmed high-grade dysplasia, endoscopic eradication therapy is recommended. Surveillance may be considered in some cases, but it is not a substitute for treatment. The American Gastroenterological Association recommends regular screening for cardiovascular risk factors and interventions.
The American Sociological Association has launched a new journal dedicated to researching the sociology of mental health and illness. The journal features original studies applying sociological concepts to understand the social origins of mental health and illness.