A study published in the Canadian Medical Association Journal found higher rates of complications in blood-based resuscitation compared to conventional resuscitation, with no difference in mortality rates. Researchers led by Dr. Sandro Rizoli recommend larger trials to confirm findings and explore alternatives.
Researchers at UC Davis show that individual protein molecules can restart at any speed achieved by the whole population of enzymes, demonstrating the ergodic theorem. This finding has implications for understanding protein folding, drug interactions, and enzyme engineering.
Researchers have discovered that cancer cells can fuse with blood cells, enabling them to travel through the body and seed new tumors. This breakthrough has major implications for treating metastatic cancers.
Researchers have developed a new graphene technique that significantly increases lithium-ion battery storage capacity by combining graphene nanoribbons with tin oxide. The resulting prototype battery retains more than double the capacity of standard graphite anodes after repeated charge-discharge cycles.
A new study suggests that Chinese people are at a higher risk of stroke than Caucasians. The research found a slightly higher overall risk of stroke in Chinese people, with a range of 205 to 584 strokes per 100,000 Chinese people age 45 to 74 compared to 170 to 335 strokes per 100,000 Caucasian people in the same age group.
A study published in Spine highlights the increased risk of complications among Medicaid beneficiaries after spinal surgery, even after adjusting for other factors. The researchers found that Medicaid recipients were 68% more likely to experience adverse outcomes than patients with private insurance.
Researchers link black-legged ticks to an increased risk of Powassan encephalitis, a rare but serious illness with a 10-15% fatality rate. The study found deer tick virus in over 13,500 ticks, with infected adult ticks concentrated east of the Hudson River.
A new 'conversation guide' aims to increase physicians' confidence in engaging patients in meaningful end-of-life discussions. The framework provides structured guidance on identifying high-risk patients, communicating prognosis, and involving substitute decision-makers.
A University of Colorado study shows that luteolin, a common autism supplement, blocks progesterone's action but promotes estrogen-stimulated breast cancer growth. The findings highlight the need for caution when consuming flavonoid supplements, as their effects on the endocrine system are not yet fully understood.
Typhoon Soulik maintained its eye just before making landfall in southeastern China on July 13, and NASA's Terra satellite captured the eye in an image. The storm caused hundreds of deaths and missing due to heavy rainfall in southern China.
Researchers at the University of Notre Dame have identified the importance of Wnt proteins and ARF6 in cancer cell signaling. The studies found that ARF6 can propagate Wnt signaling, leading to proliferation in epithelial tumors and melanoma spread. This understanding offers potential target molecules for cancer drug development.
Recent studies have found chemotherapy-associated adverse neurological effects, including vascular complications and neuropathic pains. Chemotherapy triggers changes in ion channels on dorsal root ganglia, resulting in secondary changes that affect neurogenesis and plasticity.
Prosthetic valve endocarditis is associated with significant morbidity and mortality, and early surgery does not appear to reduce one-year mortality compared to medical therapy. Approximately one-third of patients die within one year after diagnosis, mainly due to complications such as S aureus infection.
A new study published in Pediatrics reveals that over 25% of children with cerebral palsy suffer from moderate to severe chronic pain, limiting their activity. Pediatricians should focus on identifying and treating the underlying causes of pain to improve health and quality of life for these children.
Researchers at Vienna University of Technology have developed a method to steer the radiation emitted by a random laser into a pre-determined direction. This breakthrough allows for the creation of a new type of light source with potentially useful applications.
Researchers found that mice lacking the monoamine oxidase A and B enzymes displayed increased fear and generalized phobia to new contexts. This study suggests a correlation between MAO enzyme deficiency and autistic-like features, highlighting potential avenues for developing interventions for neuropsychiatric disorders.
A recent study outlines the intricate social hierarchy of California condors, highlighting the importance of dominance within the group. The research, conducted with the use of new technologies, reveals that individual birds must successfully integrate into the structure to ensure survivability.
Scientists have developed a method to generate functional blood vessels lasting up to nine months using human induced pluripotent stem cells. The breakthrough could lead to new treatments for cardiovascular disease and diabetes.
Researchers aim to identify genetic elements that enable animal hepatitis E strains to infect humans, with potential implications for fighting cross-species virus infections. The study will also investigate host immune factors that defend against the virus.
Research identifies a link between the FTO gene and increased hunger-stimulating hormone production in individuals prone to obesity. Additionally, studies show that adult brown fat levels increase with cold exposure, which may provide a new strategy for combating obesity.
A USGS study reveals that threatened loggerhead sea turtles in the northern Gulf of Mexico require broader habitat protection to recover. The research shows that female turtles visit multiple beaches, sometimes hundreds of miles apart, during their reproductive periods.
The new NIST handbook provides a comprehensive guide for planning, designing, constructing, and relocating forensic science laboratories. The document outlines the four-phase cycle for creating new laboratory space and includes tools to support each phase.
A new conversation guide aims to improve physicians' ability to discuss end-of-life care with patients, addressing the growing need for sensitive discussions due to an aging population and chronic illness. The guide provides practical advice on identifying high-risk patients, communicating prognosis, and clarifying patient values.
A randomized trial found that a 1:1:1 blood transfusion protocol is feasible but associated with higher waste of plasma. The study suggests that widespread adoption may lead to significant resource and safety implications due to the scarcity of plasma.
A pilot study from North Carolina State University found that switching seats can keep middle school students engaged in educational gaming tasks. The researchers discovered that the student actively playing the game stayed focused, while the second student on the team often lost interest.
The program aims to study exotic invasive pests and develop sustainable approaches to counter problem organisms threatening biodiversity in central and southern Texas. Researchers will focus on native ant species, such as the fire ant, tawny crazy ant, and Cactoblastis moth, to improve competitiveness of native species.
Researchers used fMRI to investigate the neural origins of hot flashes in postmenopausal women. They found that activity in brain regions like the brain stem and insula rises before and after the hot flash, respectively. The study provides novel insights into the complex brain mechanisms underlying this common menopause symptom.
A new study published in PLOS ONE suggests that standardized vascular health checks could improve health outcomes and reduce costs in Germany, the UK, France, Denmark, Italy, and Poland. The study used the Archimedes Model to simulate a clinical trial comparing seven health check strategies to current levels of care.
Dr. Immanuel Bloch will receive the 2013 Körber European Science Prize for his groundbreaking research on lattice-trapped ultracold atoms, enabling precise monitoring of solid structures and potential applications in superconductors and quantum information processing. The prize includes €750,000 to support his research activities.
A new study estimates that global sea levels will rise 2.3 meters over the next several thousand years for every degree Celsius the planet warms. The four major contributors to sea-level rise on a global scale are melting of glaciers, Greenland ice sheet, Antarctic ice sheet, and ocean expansion as it warms.
Researchers generated a comprehensive list of cancer-specific genetic variations and made them available to the public. The extensive data set has the potential to dramatically enhance understanding of relationships between specific cancer-related genetic variations and drug response.
A study reveals that the acetylcholine-activated inward-rectifying potassium current (IKACh) plays a critical role in regulating cardiac pacemaker activity and heart rate. The research found that mice lacking IKACh displayed a moderate increase in resting heart rate and delayed recovery after stress or exercise.
Long-term aspirin use has been linked to reduced colorectal cancer risk, but alternate-day dosing shows increased gastrointestinal bleeding. Electronic health records adoption led to ambulatory cost savings of 3% per member per month and reductions in radiology costs in experimental pilot communities.
Researchers have identified a new chemical compound, CYM51010, that targets the opioid receptor complex and shows promise as an alternative to morphine. The compound is potent and less likely to result in tolerance and negative side effects.
A study from the University of Michigan found that electronic health records can slow the rise of healthcare costs, with a 3% savings in outpatient care compared to traditional paper records. The study examined data from nine communities and estimated $5.14 in savings per patient per month.
A recent study at Rhode Island Hospital found that acute aortic dissection repair performed in the waning full moon reduces the odds of death, while full moon cycles are associated with shorter length of stay. The study's findings suggest that lunar cycles may play a role in cardiac patient outcomes.
Researchers found that amyloid plaque accumulation in the temporal lobe, rather than total amount, is associated with cognitive decline. This pattern of progression may serve as a more powerful biomarker for early detection of Alzheimer's disease.
A new study found ACS NSQIP hospitals have consistently lower mortality rates for complex surgical procedures compared to non-ACS NSQIP hospitals. The difference in one-year mortality rates was 16%, indicating faster improvement in outcomes at ACS NSQIP hospitals.
A study found that the 'obesity-risk' FTO allele alters hunger-stimulating hormone production, leading to increased food consumption and satiety impairment. The research also reveals a direct link between FTO and ghrelin mRNA demethylation, providing new insights into obesity development.
Researchers at Monash University have developed an ionic liquid-based thermocell that can harness waste heat from power stations and vehicle exhaust pipes to generate electricity.
The newly discovered moon, S/2004 N 1, is estimated to be 12 miles across and is the smallest known moon orbiting Neptune. It was found using archival images taken by Hubble from 2004 to 2009 and noticed a white dot between the orbits of Neptunian moons Larissa and Proteus.
Researchers at The Wistar Institute found that sequential vaccination with distinct influenza strains can stimulate immune responses against multiple strains. This approach offers an alternative to creating a universal flu vaccine by targeting conserved regions of the virus, potentially providing long-term immunity.
The study highlights the need for continuous satellite monitoring to better predict melting and sea-level rise. The ice sheets covering Antarctica and Greenland contain 99.5% of the Earth's glacier ice, with a potential raise of 63m if melted completely.
A new study found that DNA abnormalities, specifically clonal mosaic events, are more common in people with type 2 diabetes than the general population. This increase in CMEs may partly explain why individuals with type 2 diabetes have a higher risk of blood cancers like lymphoma and leukaemia.
The study found that Greenland's ice sheets are losing significant amounts of ice at a rate of about 300 billion tons per year. The accelerated loss of ice mass is attributed to both anthropogenic warming and natural processes such as variations in snowfall and ocean currents.
A study of 256 baseball players who underwent ulnar collateral ligament surgery found that 83% were able to return to competition at the same or higher level, with an average additional 3.6 years of playing time
Research reveals that powdery mildew fungi favor asexually produced offspring for infection, while sexual reproduction is crucial for adaptation to host defense mechanisms. The study suggests an ancient co-evolutionary history between the fungus and its hosts, highlighting the complex dynamics of plant-fungus interactions.
A global single-cell genomic study highlights British Columbia's role as an 'oasis' of microbial biodiversity. The research, published in Nature, provides new insights into the vital biological diversity encoded in microorganisms, shedding light on essential ecosystem functions and services.
Researchers have uncovered the cell death processes that determine regulatory T cell numbers, which can lead to better treatments for autoimmune diseases. The discovery of Bcl-2 family proteins as determinants of regulatory T cell numbers offers new ways to control these cells and potentially suppress autoimmune disease.
Researchers used single-cell genomics to identify 201 distinct microbial genomes, revealing unexpected metabolic features and resolving relationships within and between microbial phyla. The study provides a profound leap of understanding the microbial evolution on our planet.
Researchers at Brookhaven National Laboratory develop method to measure energy required for electrons to pair up and how it varies with direction. The technique reveals directional dependence of the 'glue' holding electron pairs together, shedding light on magnetic superconductivity.
Researchers found that people with Hyper IgE Syndrome have more redundancy in their immune systems than expected, allowing them to respond effectively to most viruses and cancers. This discovery highlights the differences between mouse model work and real human infectious diseases, providing valuable insights for clinical treatment.
Researchers discovered that nearly half of participants with mild to moderate Alzheimer's disease had impaired glucose tolerance or diabetes. The resveratrol study aims to investigate the link between glucose levels and Alzheimer's risk, raising potential for earlier diagnosis and prevention strategies.
Researchers have captured a key step in the molecular 'dance' necessary for cell division by imaging the enzyme that unwinds DNA double helices. The study reveals how this enzyme recruits and interacts with the origin recognition complex, enhancing understanding of essential biological processes.
Researchers found that a transient 'perfect storm' of nutrients and light led to the brief bloom of phytoplankton 14,000 years ago. The study resolves conflicting ideas about the relationship between iron and biological productivity in the North Pacific, with implications for geo-engineering efforts to curb climate change.
A set of proteins involved in the body's natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. In some cancers, these naturally produced mutations can outnumber all other mutations and account for over two-thirds of tumors.
Researchers analyze seismic activity at Alaska's Redoubt Volcano, documenting a sudden increase in tremor frequency just before six eruptions. This unique phenomenon may help scientists refine models and better understand volcanic pressurization.
Researchers at the University of Minnesota have discovered that APOBEC3B, a human antiviral enzyme, causes DNA mutations that lead to several types of cancer. The enzyme was found to be significantly elevated in six types of cancer and produced a unique mutational signature that matches the actual mutation pattern in these cancers.
A new drug candidate, SR9009, has been shown to significantly increase exercise endurance in animal models. The compound works by activating the core biological clock molecule Rev-erbα, which influences lipid and glucose metabolism, fat-storing cell production, and macrophage response during inflammation.
Researchers at Carnegie Mellon University created an artificial cellular system with varying levels of molecular crowding to study its effects on gene expression. The findings suggest that tight quarters enhance gene expression in artificial cells.