A new trial found that routine availability of platelet function testing had a modest impact on selecting and dosing anti-clotting therapy. However, no significant effect was observed on major adverse cardiac events or bleeding complications.
New research reveals that newborns are born without the toll-like receptor 3, a key protein needed to protect against viruses. This impairment makes newborn immune cells unable to recognize and react to certain viruses, increasing their susceptibility to infections like herpes simplex virus.
A new trial found that patients who have no major cardiac events in the first year following coronary stenting may not require extended dual antiplatelet therapy, reducing the risk of bleeding complications. The study suggests a potential shift towards shorter treatment durations for this group of patients.
Chronic snoring during pregnancy linked to poor delivery outcomes, including smaller babies and C-sections. Researchers found that pregnant women with sleep-related breathing problems are more likely to deliver underweight babies and require emergency or elective C-sections.
Researchers have determined the atomic-level structure of the tripartite HIV envelope protein, a complex target for vaccines. The findings provide insights into the process by which the Env trimer assembles and undergoes shape changes during infection.
Researchers found that scar tissue formed by stem cells after spinal cord injury helps to prevent further damage and facilitates the survival of damaged nerve cells. The study suggests that more rather than less stem cell scarring could limit the consequences of a spinal cord injury.
Researchers at Karolinska Institutet found that anti-obesity drugs, meal replacements, and a high protein diet can help maintain weight loss. Exercise had no clear effect on weight loss maintenance, while dietary supplements were not associated with reduced rebound gain.
Researchers at Oregon State University have discovered a new way to produce novel compounds with antibiotic potential by deleting a master regulator gene in a common fungus. This finding opens up the door to studying dozens of new compounds and potentially discovering new antibiotics.
A 15-year study on P. vivax population genetics in South Korea found drastic genetic change occurred between 2002-2003, suggesting parasites were introduced from North Korea. This explains why South Korea was unable to eliminate vivax malaria for 20 years.
The GIANT trial found that identifying slow responders to clopidogrel through genetic profiling and adjusting treatment leads to reduced adverse events and similar ischemic event rates compared to those with a favorable genetic profile. This suggests alternative treatment strategies for patients identified as CYP2C19 poor metabolizers.
A new study found that a patient's immune response may provide better insights into bacterial infections than conventional tests, leading to more accurate diagnoses and appropriate antibiotic treatment. The research identified unique 'immune fingerprints' associated with certain pathogens and predicted the nature of the infection.
Researchers used gaming technology to capture atomic movements in carbohydrates, shedding light on their role in neuronal development, inflammation and cell structure. The study provides a new view of biochemical barcodes and opens opportunities for designing drugs or biomaterials that mimic carbohydrate shape.
A non-invasive alternative to liver biopsy, the French-made FibroScan, has been proven very reliable in a national multi-center study. The device measures liver stiffness to assess fibrosis and guide treatment, providing quick and painless results.
Researchers say Chagas disease remains a leading cause of heart disease in impoverished North American communities, with inadequate healthcare and limited treatment options available. The editorial calls for increased medical awareness, scientific cooperation, and public-private partnerships to develop new tools and treatments.
A new study published in SAGE Open found that people with psychotic disorders such as schizophrenia are more likely to be left-handed. The research team studied 107 individuals from a public outpatient psychiatric clinic and found that 40% of those with schizophrenia were left-handed, compared to 11% of those with mood disorders.
Researchers have generated disease-specific induced pluripotent stem cell lines from a patient with familial transthyretin amyloidosis (ATTR), a lethal protein-folding disorder. The study successfully recreates essential aspects of the disease in vitro, validating this iPSC-based system as a platform for testing therapeutic strategies.
The ABI will offer faster imaging with much higher detail, enabling more accurate forecasts of severe weather and other hazards. The instrument's improved capabilities will help save lives and protect communities from extreme weather events.
The REPRISE II trial demonstrated low rates of complications with the second-generation transcatheter aortic valve, including minimal post-procedure paravalvular aortic regurgitation. The device successfully addressed challenges associated with TAVR, improving outcomes for patients with severe aortic stenosis.
Neurons from the retina connect to the brain first, controlling the abundance of a protein called aggrecan. This allows cortical neurons to get the best spots for connections once two weeks have passed. Understanding this mechanism could help repair damaged neural networks and develop regenerative therapies.
A new study reconstructs Pacific Ocean temperatures over the last 10,000 years and finds that middle-depth waters have warmed 15 times faster than natural fluctuations. This suggests that oceans may be storing heat from human emissions, potentially buying time before climate change accelerates.
A Vanderbilt study found that providing patients with a simple biosketch card about their doctor can improve patient satisfaction scores by 22%. The study showed that patient comfort with care is crucial for recovery, and this intervention is an easy and cost-effective way to enhance the patient experience.
Visceral Leishmaniasis is a severe disease causing spleen, liver, and bone marrow damage if untreated. In Brazil's largest cities, like Belo Horizonte, VL cases are on the rise, with high fatality rates despite available diagnosis and treatment.
Researchers identified barriers to mental health care access, including inadequate community support and lack of tailored psychological interventions. A new model of care, incorporating community groups and well-being services, improved awareness and use of mental health services among underserved populations.
UPV/EHU researchers have developed a new source of light emitter based on defective boron nitride nanotubes, which can emit light across the whole spectrum from infrared to far ultraviolet and control it in a simple way. The device functions on the basis of natural defects in the nanotube, enabling controlled emission.
Researchers have found that oligomeric proanthocyanidin has a protective effect on retinal ganglion cells against oxidative stress-induced injury, providing potential treatment for neural diseases. The compound, enriched in grape seeds, shows promise in preventing cell death in optic neurodegenerative conditions.
A new study published in Biological Psychiatry found that prenatal exposure to glucocorticoids is associated with cortical thinning and increased risk for stress and emotional problems in healthy, full-term children. The findings suggest that glucocorticoid administration may alter the trajectory of brain development.
Researchers at Michigan Medicine have identified two new proteins, Wapal and Synj1, that control T-cell responses and may help reduce graft-vs.-host disease. The study found that blocking these proteins reduced GvHD in mice, suggesting a promising approach for improving bone marrow transplant outcomes.
The UTSA Center for Simulation, Visualization and Real-Time Prediction has developed a virtual training system to aid football kickers through real-time feedback and analysis. The system uses computer sensing and mathematical models to predict football trajectory and analyze kicking mechanics data.
Researchers found that a quick neck injection of local anesthesia can reduce severe hot flashes in women by as much as 50 percent for at least six months. The treatment uses bupivacaine hydrochloride to target the stellate ganglion nerve bundle, providing symptom relief without hormonal therapy.
Researchers at Massachusetts General Hospital have developed a computer-controlled system to automate the process of administering anesthesia, promising more precise and efficient control. The system uses brain activity monitoring to adjust drug infusion and maintain a deep state of anesthesia, reducing the need for manual intervention.
The NIH has developed a candidate vaccine against respiratory syncytial virus (RSV), which elicited high levels of RSV-specific antibodies in animal studies. The vaccine was designed using structural information to inform its development, and early-stage human clinical trials are planned.
A study found that scent marking increases males' mating and reproductive success, as females prefer to mate with males who deposit more conspicuous scent marks. However, surprisingly, female mice tend to socialize with lower-marking males, suggesting a complex relationship between scent marking and social behavior.
Catholic schools do not offer superior academic performance compared to public schools, according to a national study led by Michigan State University. The study found that math scores for Catholic students dropped between kindergarten and eighth grade, while public school students showed slight improvements.
The HYBRID trial found that combining minimally invasive CABG with percutaneous coronary intervention is feasible and safe for patients with multi-vessel disease. At one year, 89.8% of the hybrid group was free from major adverse cardiac events.
Danish researchers have discovered how the body's immune system responds to HIV infection, identifying key proteins and mechanisms that can be targeted for improved treatments. The study's findings aim to enhance the immune system's ability to defend against uncontrolled virus growth.
A new study by Johns Hopkins Medicine found that young and middle-aged women with type 2 diabetes are at a significantly increased risk of coronary artery disease, comparable to men's risk. The study analyzed data from over 10,000 participants and suggests distinct genetic and hormonal factors may contribute to the higher risk.
Researchers at CWRU aim to build nanoparticles that can infiltrate and quash aggressive cancers that survive traditional therapy. They will perfect molecular coatings called ligands to enable nanochains to home in on micrometastases.
A new drug, pimavanserin, has shown significant improvement in reducing psychotic symptoms in Parkinson's disease patients. The study found a 37% improvement in psychotic symptoms compared to placebo, with no worsening of motor symptoms reported.
Researchers have developed a computerized system that can track patients' brain activity and automatically adjust drug dosages to maintain the correct state during medically induced comas. The system uses EEG patterns and real-time feedback to optimize anesthesia levels, eliminating the need for constant monitoring by nurses.
A recent study of diabetic patients who underwent revascularization for multi-vessel coronary artery disease found that insulin-treated patients experienced higher rates of major adverse cardiovascular events, including death, stroke, and myocardial infarction. CABG was found to reduce mortality and myocardial infarction rates compared...
A new study reveals that rising rates of obesity among young adults are contributing to an increase in knee replacement surgeries. Younger patients are more obese and experience the same level of pain and functional disability as older patients, according to researchers at UMass Chan Medical School.
Researchers create cleanest graphene by making electrical contact only along its 1D edge and using a contamination-free assembly technique. This results in improved performance, including high electron mobility and low sheet resistivity, making it suitable for electronic devices.
A new study reveals that the honey bee sex determiner gene has 87-145 alleles, a significant increase in genetic diversity compared to previous estimates of 20 alleles. This discovery is crucial for apiculture, as it helps minimize the risk of inbreeding and produces diploid drones.
Percutaneous repair of paravalvular prosthetic regurgitation can mitigate known risks associated with increases in implanted valves, particularly in patients at high-risk of cardiac surgery. The technique has shown durable symptom relief and reduced mortality rates in selected patients.
The HyperSpectral Imager for Climate Science (HySICS) has made its inaugural engineering balloon flight, collecting radiance data for nearly half of its eight and a half hour flight. This technology advance enables climate predictions and trends to be seen with higher accuracy using shorter duration data sets.
A Phase 1B study of MK-3475, an anti-PD-1 immunotherapy drug, showed encouraging results in treating non-small cell lung cancer, with a 24% response rate and median overall survival of 51 weeks. The drug, developed by Merck, allows the immune system to detect and attack cancer cells.
The DUTCH PEERS (TWENTE II) trial found that two third-generation permanent polymer-based drug-eluting stents had low rates of adverse clinical events, establishing the non-inferiority of a zotarolimus-eluting stent. The study also showed no significant differences in individual components of the primary endpoint.
The Strategies to Overcome and Prevent Obesity Alliance offers guidance for nonprofit hospitals to implement obesity programs addressing the needs of adults. Effective partnerships and multi-level strategies are crucial in combating this complex issue.
A study published in Journal of General Internal Medicine found that long-term opioid use is linked to a higher risk of developing major depression. Patients who used opioids for 180 days or longer were at a 53% increased risk, while those using them for 90-180 days had a 25% increased risk.
Scientists from the University of Glasgow have developed a range of new pizza recipes that meet public health goals without compromising taste. The pizzas contained at least 30% of all required nutrients, including carbohydrates, vitamins, and minerals, making them suitable as healthy meals.
The OPTIMIZE trial found that shortening dual antiplatelet therapy after drug-eluting stent implantation may reduce bleeding risks and treatment costs. Patients who received shorter-term therapy had similar rates of NACCE as those on longer-term therapy.
A new study suggests that stress eaters show dynamic patterns of eating behavior, with 'munchers' eating more after being stressed but less when pleased, while 'skippers' do the reverse. This challenges the idea that stress eaters need to regulate their eating habits to prevent weight gain.
Researchers at NYU-Poly used underwater robots to examine how golden shiner fish interact with a robot's coloration, size, and movement. The results show that the fish are drawn to a robot mimicking their natural colors and movement patterns, influencing their swimming behavior.
Scientists from the University of Sheffield have partnered with an Indian team to develop a new technology that can rapidly diagnose and treat corneal infections, potentially saving thousands of patients' eyesight. The technology uses polymers that trap bacteria or fungi in place, allowing for easy removal.
Researchers at Simon Fraser University found that a mutation in the CNK2 gene affects cilia length, leading to misinterpreted signals and fatal diseases. The study provides new insights into the importance of cilia disassembly speed in determining cell function.
Researchers at Johns Hopkins Medicine have discovered that the gene SRPX2 is necessary for vocalizations and synapse formation in mice. The study adds to scientific understanding of how language develops and how synapses are formed.
A new study finds that geoengineering approaches to mitigate global warming could result in reduced rainfall and snowfall worldwide. The research suggests that these techniques would not only fail to address the root problem of climate change but also have unintended consequences, such as altered regional precipitation patterns.
The supposedly widespread liverwort species was found to be a complex of geographically restricted species, with implications for biogeography studies. The study's results also highlight the importance of accurately identifying plant species, as it can lead to the discovery of new bioactive compounds.
Researchers at City College of New York develop novel edge-contact geometry to bridge 3D world to 2D graphene without contaminating its properties. The technique enables remarkably low contact resistance, opening possibilities for device applications and pure physics studies.
Researchers at Johns Hopkins Medicine have identified a critical gene that guides the separation of two types of motion-sensing cells in the retina, shedding light on cellular layering and its implications for brain function.