A study found a statistically non-significant but clinically significant benefit in adding everolimus to trastuzumab treatment for HER-2 positive early breast cancer. The combination improved clinical response rates, but not pathological response rates, suggesting benefits independent of expected molecular pathways.
A study published in Journal of Nutritional Biochemistry found that grapes reduce heart failure associated with hypertension by increasing antioxidant defense genes in the heart. Grapes are rich in antioxidants and polyphenols, which help improve glutathione levels and reduce oxidative stress.
A PLOS ONE study has confirmed that Droplet Digital PCR (ddPCR) technology is suitable for routine analysis of genetically modified organisms (GMOs) in food, feed, and seeds. The study found that ddPCR is more accurate and reliable than real-time quantitative PCR (qPCR) for quantifying GMOs, especially at low levels.
A large randomised controlled trial found that exercise had no effect on reducing depression among frail elderly care home residents. Despite being well-received by residents and staff, the intervention failed to improve mental health or quality of life.
A recent study published at the 5th IMPAKT Breast Cancer Conference finds that gene expression tests can effectively tailor cancer treatments to individual patients, despite variability in tumor cell types and gene expression. The researchers analyzed 78 biopsies from 26 tumors and found that some genomic tests were more reliable than ...
A new study suggests that young women are more likely to get vaccinated against HPV if the emphasis is on preventing sexually transmitted diseases rather than cancer. The study found that messages focusing on genital warts were more effective in encouraging college-aged women to discuss vaccination with their doctors.
Scientists at Whitehead Institute have developed a new method for creating genetically altered mice using the CRISPR/Cas technique, which can produce mice with multiple mutations in just three to four weeks. This breakthrough enables the study of human diseases in mice more efficiently and cost-effectively.
A new mathematical model developed by researchers at the University of Toronto can pinpoint high-risk areas for cardiac arrests and recommend optimal placement of defibrillators. According to the study, nearly three times as many public cardiac arrests occurred in downtown Toronto than in the rest of the city.
The CU-Boulder instrument package, known as the Extreme Ultraviolet and X-ray Irradiance Sensors (EXIS), is designed to measure energy output from the sun that can affect satellite operations. The EXIS will provide rapid alerts for solar flares and monitor extreme ultraviolet wavelengths to track space weather effects.
Researchers have discovered that two little-known lemur species in Madagascar burrow underground and hibernate for three to seven months. The study suggests that primate hibernation may not be as rare or unique as previously thought, offering insights into the behavior of these close genetic relatives.
Restrictive eating habits increase the brain's response to pleasurable foods, making it harder for dieters to maintain weight loss. Healthy, balanced meals are more effective for sustainable weight management.
Researchers at Massachusetts General Hospital have identified a gene variant that predicts weight loss after gastric bypass surgery. The variant, located on chromosome 15, is associated with an average weight loss of nearly 40% in individuals who carry two copies of the beneficial version.
A Johns Hopkins study found that suppressing a key gene, HMGA1, in tumor cells reduces their aggression and growth. The researchers hope to develop a new therapy based on this principle to treat tumors resistant to current drugs.
The Extreme Ultraviolet and X-ray Irradiance Sensors (EXIS) will monitor extreme solar energy output from the sun, disrupting telecommunications, air travel, and power grids. The GOES-R satellite is expected to launch in 2015, providing more advanced capabilities and frequent images.
A large-scale analysis of out-of-hours emergency admissions in UK pediatric intensive care units found no increased mortality risk. However, winter months saw a statistically significant increase in deaths, possibly due to strain on services.
OpenStax College plans to add six more titles by 2015, bringing the total to 25 books, with estimated savings of $750 million for college students. The nonprofit publisher's textbooks are peer-reviewed and equal in quality to costly alternatives.
Researchers have identified genetic factors behind nearsightedness, a condition characterized by an eye that is too long or the cornea has too much curvature. The SCO2 gene plays a crucial role in regulating copper and oxygen levels in eye tissue.
Researchers have developed a new class of ultra-sensitive photovoltaic devices using graphene and transition metal dichalcogenides. The devices can potentially be used as ultrasensitive photodetectors or very efficient solar cells, generating electricity from sunlight absorbed by exposed walls.
Scientists at UTMB discovered that Ebola short-circuits the immune system using proteins that shut down cellular signaling related to interferon, preventing dendritic cell maturation and generating an ineffective adaptive immune response. The researchers found that specific regions of two different proteins are crucial for this mechanism.
NMR spectrometer Pulsar offers affordable and accessible analysis of molecular structure and composition, enabling quality control labs and university teaching centers to utilize the technique.
A new mathematical formula developed by researchers at St. Michael's Hospital and the University of Toronto identifies high-risk areas for cardiac arrests and suggests optimal locations for automated external defibrillators (AEDs) to maximize survival rates.
Researchers identified genetic differences in 27 genes responsible for antigen interactions, inflammation, and gene pathways involved between high and low responders. The study provides insights into developing alternative vaccines for individuals who do not respond effectively to the standard rubella vaccine.
A six-month study reveals Adderall mentions spike sharply during final exam periods, with peaks on Dec. 13 and April 30, and peak use among college and university clusters in the northeast and south regions of the US. Tweets also reveal co-ingestion with other substances like alcohol and stimulants.
Two studies from The Cancer Genome Atlas program reveal genomic landscapes of AML and endometrial cancer, providing new insights into molecular underpinnings. The studies identify four novel tumor subtypes in endometrial cancer and show genomic similarities with other types of cancers.
Researchers identified a specific pattern of DNA modifications dependent on HPV presence that correlates with improved survival in patients with OPSCC. A new combination therapy for PEL was found to reactivate virus-induced cell lysis and induce cancer cell death, increasing mouse lifespan.
Researchers suggest using haptic devices early in children fitted with visual prosthetics and for older congenitally blind and late-blind individuals. Haptics provide supplementary information that helps train the brain to understand electrical input from prosthetics, leading to improved outcomes.
Neuraxial anesthesia reduces morbidity, mortality, length of hospital stay, and costs in patients undergoing hip or knee replacement. It lowers rates of pulmonary compromise, pneumonia, infections, and acute renal failure compared to general anesthesia.
A recent study published in Science Translational Medicine has identified a genetic mutation that makes people more susceptible to migraine headaches. This finding is significant because it represents the first demonstration of a genetic cause for migraines, which could lead to new research avenues and potential treatments.
A study by Patricia de Cocq and colleagues found that 'rising trot' reduces the force exerted on a horse's back, decreasing the risk of injury. By analyzing data from experienced dressage riders using both techniques, they showed that rising trot significantly reduced the load on horses' backs.
Researchers found a growing gap between materialism and the desire to work hard among recent high school graduates. Materialism peaked in the 80s and 90s with Generation X, but has continued to stay high. In contrast, work ethic declined, with 39% of students admitting they didn't want to work hard in 2005-07 compared to 25% in 1976-78.
University of Manchester scientists discover sting jets in storms, shedding light on violent windstorms like the Great Storm of 1987 and January 2012 gusts. Their findings provide added knowledge for forecasters.
A study by Michigan State University scientists discovered sex differences in binge eating rates among female and male rats, suggesting biological factors contribute to eating disorder prevalence. The study's findings have implications for understanding risk factors and mechanisms in humans.
Plant scientists are exploring membrane transporters to enhance nutrient uptake and water retention in crops, reducing the need for fertilizers and promoting sustainable agriculture. This research aims to create crops that can thrive in challenging conditions, such as saline soils, to meet the world's growing food demands.
GROVER will collect measurements to study how snow accumulates on the ice sheet, adding layer upon layer over time. The robot carries a ground-penetrating radar to detect the layer of the ice sheet formed after an extreme melt event.
Researchers found that people respond strongly to the voice of smart objects, even if they're not human-like. The study suggests that speech is a social cue that can make objects more social and acceptable.
Research reveals that males exposed to constant rivalry mate for longer, but ultimately die earlier and are less able to mate later in life. Fruit flies that were not exposed to rivals continued to mate into old age.
A literature review highlights the evolution of synthetic playing surfaces and their association with injuries, particularly to the foot, ankle, toe, and knee. The study suggests that optimal shoe-playing surface conditions are level and sport-specific, and further research is needed to improve playing conditions for all athletes.
Researchers have found new evidence on how fluoride compounds reduce tooth decay risk by hardening enamel and reducing bacteria adhesion. This discovery lends credence to alternative theories on fluoride's mechanism of action.
A prescribed burn is being conducted on the 22,000-acre Otis Air National Guard installation to manage habitat and reduce wildfire risk. The burn aims to eliminate dead wood and debris that can act as fuel for wildfires.
Researchers found that a Bortezomib/Vorinostat combination therapy reactivated virus-induced cell lysis and induced PEL cell death, increasing the lifespan of mice with PEL tumors. This treatment combination could potentially be beneficial for immunocompromised patients with KSHV-associated malignancies.
Researchers at MGH and BIDMC found changes in gene expression related to inflammation, energy metabolism, and insulin secretion during a single session of relaxation response practice. The study suggests that the relaxation response induces physiological hubs that may contribute to its benefits for stress reduction and wellness.
Researchers found genetic mutations that could impact treatment plans and tumor classification for endometrial cancer patients. The study suggests reclassifying endometrial cancers into four categories based on copy number alterations and mutations.
A new study published in Plastic and Reconstructive Surgery found that 98% of women undergoing breast augmentation surgery reported meeting or exceeding their expectations. The study also found improvements in self-esteem and quality of life after the procedure.
Researchers at University at Buffalo have found a breast milk protein complex, HAMLET, that can help restore sensitivity to antibiotics in drug-resistant bacteria. The study showed that HAMLET can lower the dose of antibiotics needed by a factor of eight or more, making it a promising treatment option for superbugs like MRSA.
A new camera inspired by insect compound eyes has been developed, featuring a wide field of view and infinite depth of field. The camera uses stretchable electronics and a hemispherical lens design to eliminate distortion.
Researchers developed a hemispherical digital camera inspired by the fly eye, featuring nearly 200 tiny lenses for exceptional wide-angle views. The camera can capture images across nearly 180 degrees, offering powerful capabilities in surveillance and endoscopic procedures.
A team of scientists, including a Michigan State University professor, has examined a nakhlite meteorite formed on Mars over a billion years ago. The study found mineral and chemical signatures indicating terrestrial weathering, which could provide valuable clues about Mars' habitability conditions.
A study proposes that a group of carnivores died intentionally in an ancient Spanish cave due to a lack of exit points. The researchers suggest that the scarcity of herbivore remains indicates the cavity was clearly visible and avoided by these animals.
Researchers found that female cowbirds unable to recognize high-quality male songs alter flock behavior, affecting both males and females. The study highlights the interconnected nature of individual behavior and social environments in bird species.
Researchers demonstrated PET/CT's ability to identify lesions along the complete intestinal wall, detecting advanced inflammatory changes and unmasking subepithelial disease activity. The technique showed promise in serially assessing IBD activity, potentially benefiting patients with chronic-remittent conditions.
A major international study has found that sequence differences in a gene crucial to chromosome integrity predispose individuals to certain cancers. The study, published in Nature Genetics, identified variations in the TERT gene as influencing telomere length and breast and ovarian cancer risk.
A recent study investigated public perception of how waste disposal sites affect residents living nearby, particularly odor and local pollution concerns. The study found that odour perception diminished over time as the facilities were closed, and older residents reported more concern about health impacts.
A new framework combining engineering criteria with ecological and social concerns could minimize the impacts of hydrocarbon development in the Amazon. Extended Reach Drilling and other best practice components may reduce project-related deforestation by over 75%, according to a recent study.
New research from Johns Hopkins finds that high doses of vitamin D supplements do not confer additional benefits on cardiovascular health or longevity in healthy adults. However, elderly individuals, postmenopausal women, and those with kidney disease may still benefit from higher blood levels of the sunshine vitamin.
The Early Start Denver Model has been shown to improve social skills and brain responses in toddlers with ASD, while minimizing therapies required through the school years. The study found that ESDM-receiving children required significantly fewer hours of special education services and individual therapies.
A recent study at Lund University has discovered a key factor behind gastric bypass surgery's ability to rapidly send type 2 diabetes into remission. The researchers found that insulin levels and intestinal hormones increase significantly after the procedure, suggesting a new potential treatment avenue for diabetes patients.
Scientists at Albert Einstein College of Medicine have found that the hypothalamus controls aging throughout the body, opening up new avenues for treating age-related diseases. Activating specific pathways can accelerate or slow down aging, and blocking them may increase longevity by up to 20 percent.
Researchers studied over 900 patients with dementia and found that receiving general anesthesia for procedures after age 45 is not a risk factor for developing dementia. The study's findings provide reassurance for elderly patients undergoing surgery.
Researchers from Australia have achieved a breakthrough in detecting the spin state of a single atom using a novel combined optical and electrical approach. This innovation brings closer the prospect of a global quantum internet, which could revolutionize secure communications for various industries.
A recent horse meat detection incident in European food products led to concerns in the US. The incident involved tiny amounts of horse meat mistakenly added to beef products due to equipment issues. The American Chemical Society discusses the issue and its implications for the US market.