Researchers have found that interferon-beta treatment significantly improves the physical condition of animal models of spinocerebellar ataxia 7, a fatal genetic disorder characterized by coordination problems. The treatment reduces the load of mutant ataxin-7 and leads to increased PML nuclear bodies involved in protein degradation.
Research using MRI scans has identified early changes in the hearts of children who have undergone chemotherapy, allowing for potential preventative therapy. The study used T1 mapping to detect fibrosis and found a correlation with exercise capacity and cumulative dose of anthracyclines.
A joint investigation by BMJ and Channel 4 Dispatches found that evidence of potential harm from new diabetes drugs has not been fully published. This has led to millions of patients worldwide being under-informed about possible risks. Regulators in Europe and the US have faced criticism for their slow response to emerging concerns.
Researchers have sequenced the duck genome and conducted transcriptomic studies to understand the interactive mechanisms between the host and influenza viruses. The study identified novel genes not present in other birds and found alterations in gene expression patterns in response to avian influenza viruses.
Researchers at Michigan State University have developed a new crop modeling system called SALUS to better predict global wheat yields and their impact on the environment. The system integrates multiple crop simulations with improved climate change models, reducing uncertainties and providing more accurate forecasts.
Researchers at Whitehead Institute have identified a protein that is the target of glucocorticoids, which increase red blood cell production in patients with certain types of anemia. The discovery could lead to the development of drugs capable of increasing this protein's production without causing severe side effects.
Scientists at ICFO have developed a method to measure weak forces with sensitivity 50 times higher than previous methods, enabling magnetic resonance imaging of individual molecules. This breakthrough could lead to significant advances in medical imaging and diagnostics.
OCD researchers discovered a mechanism underlying compulsive behaviors in mice, suggesting potential treatments. The study's findings could lead to novel drug development and direct stimulation techniques, including deep brain stimulation.
Maple tree owners can benefit from a new open-access article that provides information on the biology, damage, and management of key pests. The article offers practical integrated pest management (IPM) solutions for each pest, helping to reduce economic and aesthetic value.
A team of researchers created a 3D map of blood vessels in the cerebral cortex, revealing unexpected connections that don't align with neural cell organization. The study's findings have implications for functional brain imaging and our understanding of dementia.
A recent study published in Nature Genetics reveals that self-fertilizing plants like Red Shepherd's Purse accumulate harmful mutations over time, reducing genetic diversity. This can lead to extinction, highlighting the importance of preserving crop genetic variation to avoid yield losses due to mutation accumulation.
Gladstone scientists have mapped the process by which brain cells form long-term memories, revealing how an important protein called Arc regulates neuron activity. The discovery provides new insight into the molecular mechanisms underlying memory formation and may shed light on neurological diseases such as Alzheimer's and autism.