A recent study challenged the long-held understanding of how antibiotics work, finding that all antibiotics induce bacterial cells to make compounds called reactive oxygen species, making bacteria susceptible. The results contradict previous findings and suggest a need to re-evaluate the mechanisms of antibiotic action.
A long-term study by Ruhr-University Bochum found that patients who undergo plastic surgery experience improved life satisfaction, self-esteem, and mental health. The results suggest that cosmetic surgery can be a successful treatment for psychological variables, with no adverse effects observed.
Research suggests that moderate coffee and tea consumption during pregnancy may be associated with lower birth weights, which can lead to health complications in the long term. The study, conducted on 59,000 pregnant women, found a correlation between caffeine intake and small for gestational age (SGA) babies.
The Museum of Evolution at Uppsala University is digitizing Carl Thunberg's Japanese plants, made available for the world to study. The project will simplify access for researchers and promote democracy in botanical studies.
Research reveals that female migratory shorebirds can forage deeper into estuary mud than males, allowing them to access larger prey. Human impacts on estuaries may have different effects on males and females, depending on the availability of certain prey sizes.
Researchers have found that inhibiting the Mer receptor increases sensitivity to chemotherapy in leukemia cells, reducing toxic side effects while maintaining effectiveness.
A study by Regenstrief Institute and Indiana University Center for Aging Research found that many older adults resist stopping cancer screenings, even when they may not be beneficial. The researchers suggest developing specific messages for older adults to address concerns about screening and trust in physicians.
A large-scale trial by The Mount Sinai Medical Center found that combination therapy did not improve clinical benefits over single drug treatment in multiple sclerosis patients, but reduced the development of new lesions. Combination therapy with Glatiramer Acetate and Interferon Beta-1a showed a reduction in MRI lesion accumulation.
The Lyncean Compact Light Source is a miniature synchrotron X-ray source that offers high-quality X-ray beams for various applications in biology, chemistry, and materials science. The grant will support further development to enhance its performance.
A new checklist of Cucurbitaceae from India brings up-to-date information on the family's evolution, diversity, and distribution. The list includes 94 species, 79% of which have DNA sequences available in GenBank.
The UK's Antimicrobial Resistance Strategy and Action Plan aims to address the growing concern of antibiotic resistance. The strategy highlights the need for a change in understanding and response to antimicrobial resistance.
Researchers collected the first chemical fingerprints of a distant solar system's four red exoplanets, revealing unique spectra and peculiar characteristics. The findings suggest that the planets are too toxic and hot to sustain life as we know it.
A new syndrome, juvenile-onset small-fiber polyneuropathy (JOSeFINE), has been identified as a possible cause of widespread chronic pain in children. Diagnostic tests including skin biopsies and autonomic function testing have been found to be useful in diagnosing the condition.
A Danish study found that men in same-sex marriages have lower mortality rates than unmarried or divorced men since the 1990s. In contrast, women in same-sex marriages have higher mortality rates, particularly from suicide and cancer, compared to married women of opposite sex.
Deaf individuals need culturally sensitive treatment to avoid misdiagnosis and inappropriate treatment due to communication challenges. Clinicians should seek specific training and education to become culturally competent providers, especially those working with Deaf patients.
A new study found that taking folic acid supplements from four weeks before conception to eight weeks into pregnancy can lower the risk of childhood autism by 40%. The study, based on data from Norway's Mother and Child Cohort Study, suggests that this prevention method is simple, inexpensive, and effective.
GCEP is awarding $6.6 million to seven research teams at Stanford and Carnegie Mellon for innovative projects on clean energy and carbon capture. These projects aim to develop technologies that can reduce greenhouse gas emissions and produce electricity or hydrogen fuel, with potential applications in the coming decades.
A study published in JAMA found that adding aliskiren to standard therapy did not improve long-term outcomes in patients hospitalized for heart failure with reduced left ventricular ejection fraction. The results showed no significant reduction in cardiovascular death or rehospitalization rates at 6 or 12 months after discharge.
Researchers developed a cloud-computing platform called RoboEarth Cloud Engine to accelerate robot learning and adaptation in complex tasks. The platform allows robots to access enterprise-scale computing infrastructure, paving the way for lighter, cheaper, and more intelligent robots.
Researchers found that DNA methylation levels were higher in genes associated with disease in children conceived during periods of food scarcity in West Africa.
New research reveals that poor simulation of cloud cover in the Southern Ocean is the primary contributor to climate models' glitch in tropical rainfall. The study found that excessive sunlight reaching the ocean surface causes heat accumulation, leading to incorrect rainfall forecasts.
Household carbon emissions in Northwestern China are mainly affected by geographic environment, family size, and income, with a relatively low per capita emission of 2.05 tons CO2. Household carbon emission varies between urban and rural households, as well as between provinces.
The study found that a single dose of tenecteplase reduced incidence of circulatory system collapse by 56% in patients with submassive or intermediate-risk pulmonary embolism. Patients under 75 years old had the most benefit and fewer hemorrhagic strokes.
A single dose of an investigational anti-inflammatory drug, inclacumab, reduced damage to heart tissue during angioplasty in a study. The drug, which blocks p-selectin, had significant effects on cardiac markers, including troponin I and CK-MB, in patients with non-ST-elevation myocardial infarction.
A study of over 800 children found that those who avoided scary situations had stable anxiety scores after a year and were more anxious later. The approach may enable identifying kids at risk for anxiety disorders, which cognitive behavior therapy can help address.
A 24-week trial found no significant improvement in exercise capacity or clinical status for patients with heart failure and preserved ejection fraction treated with sildenafil. Renal function worsened and adverse events increased in the sildenafil group, contradicting previous findings on PDE-5 inhibitors.
A new educational tool has demonstrated significant reduction in stress hormones and depressive symptoms among adolescents transitioning to high school. The DeStress for Success Program showed improved mental health outcomes, especially among students with initial high anger levels.
Scientists have discovered a way to revive genetic diversity in Tasmanian devils, allowing them to develop a vaccine against the deadly devil facial tumour disease (DFTD). The vaccine aims to boost the devils' immune system and give them a fighting chance against the contagious cancer.
Research found that UK children are exposed to millions of tobacco images and messages every week on prime time television. This exposure can spark an interest in starting to smoke. Doctors suggest that more stringent controls on tobacco imagery in TV programmes could help curb young people's uptake.
A multi-university research initiative aims to develop new materials for the automotive, building and construction, and energy industries. Researchers will focus on innovative materials with properties such as lightweight construction, new color effects, and bioinspired materials.
A new study published in PNAS shows that automated analysis of Facebook Likes can accurately predict personal details such as race, age, and sexual orientation. The researchers analyzed a dataset of over 58,000 US Facebook users and found accuracy rates of up to 95% for distinguishing between African-American and Caucasian Americans. H...
The Climate-Smart Agriculture Global Science Conference aims to bring together scientists and policymakers from around the world to discuss climate change impacts on agriculture. The conference will focus on science-based policies and actions to slow the effects of climate change while meeting the world's need for food and sustainability.
Researchers from NUS have successfully created a 'superheated' water that can corrode diamonds by attaching a layer of graphene. This novel discovery has wide-ranging industrial applications, including environmentally-friendly degradation of organic wastes and laser-assisted etching of semiconductor or dielectric films.
A global panel of concussion experts has developed new guidelines for evaluating and treating concussions, which emphasize the importance of medical clearance before returning to competition. The guidelines also suggest a gradual return to activities after the first week post-injury.
Researchers found differences in core proteins from a microorganism that lives in a salty lake in Antarctica, enabling it to tolerate high salinity and desiccation. The study reveals potential adaptations for life on Mars, with scientists exploring the use of these protein modifications to engineer novel enzymes and catalysts.
A simple blood test screening and targeted care program effectively prevented heart failure in asymptomatic patients over 40 years old with risk factors for the condition. The five-year study showed a significantly lower number of patients experiencing new onset heart failure requiring hospitalization or left ventricular dysfunction.
The PARTNER study found that transaortic valve replacement (TAVR) and open-heart surgery resulted in similar all-cause and cardiovascular mortality rates at three years, with no increased risk of stroke after 30 days. However, TAVR patients were more likely to experience leaks around the valve.
Researchers at Tel Aviv University found a clear genetic connection between fat and bone mass, which can impact body composition and overall health. The discovery highlights the importance of considering both factors in treatment plans to avoid negative side effects.
A study by Columbia University's Mailman School of Public Health found no consistent advantages for winners in longevity, with access to resources and opportunity being more important. The association between winning and health outcomes was sometimes positive, negative, or nonexistent.
A tiny piece of RNA, mir-125a-5p, plays a crucial role in regulating cyclical gene activity that defines the timing of tissue segment formation. This regulation is essential for proper embryonic tissue development and has implications for treating human conditions affected by embryonic development.
Evolutionary biologists combine traditional methods with genetic techniques to identify new species, revealing cryptic species that show little visible difference. The study uses scale insects as a model organism, analyzing over 400 samples to discover four new species.
A new study found that women taking aspirin have a reduced risk of developing melanoma, with the longest users showing the lowest risk. Aspirin's anti-inflammatory effects may help protect against this type of skin cancer.
Researchers found that digoxin was associated with a 34% reduction in 30-day all-cause hospital admission among ambulatory older patients with chronic heart failure. Digoxin also did not increase all-cause mortality during the first 30 days of follow-up.
Researchers found that a clot-busting therapy can benefit some heart attack patients who cannot have immediate angioplasty, reducing all-cause mortality and cardiac rehospitalization. The STREAM trial included 1,915 patients from 15 countries and showed that drug therapy before transfer was at least as effective as angioplasty.
Cognitive Enhancement Therapy (CET) is being tested as a potential treatment for schizophrenia, targeting brain-based impairments and social cognition skills. The study aims to compare CET with Enriched Supportive Therapy in addressing core impairments.
A new study suggests that off-pump bypass surgery, which is done without a heart-lung machine, can lead to better post-operative outcomes for high-risk patients. This technique eliminates the need for blood transfusions and reduces the risk of bleeding, resulting in fewer complications.
A new anti-inflammatory drug, inclacumab, has shown promising results in reducing heart muscle damage during angioplasty. The study involved 530 patients with myocardial infarction and found that a single dose of the drug reduced troponin I levels by 24%, offering great promise for its potential use in treating heart attack patients.
A study of ancient mummies from diverse cultures reveals that hardening of the arteries was a widespread problem globally, contradicting previous assumptions about its occurrence in ancient Egypt and diet-related factors. The research found that nearly half of the examined mummies showed signs of probable or definite atherosclerosis.
A study of 137 mummies from around the world reveals that preindustrial hunter-gatherers suffered from clogged arteries, challenging the assumption that modern lifestyles are the primary cause. The researchers found artery plaque in every single population studied, indicating a more basic connection to inflammation and aging.
A Phase 3 clinical trial by Cleveland Clinic and Sahlgrenska University Hospital found that darbepoetin alfa does not reduce the risk of death from any cause or hospitalization for worsening heart failure in anemic patients. Despite increasing hemoglobin levels, treatment did not provide improved health outcomes.
A recent study published in Natural Climate Change reveals a significant reduction in temperature and vegetation seasonality over northern latitudes. As snow and ice cover diminished, temperatures increased at different rates during the four seasons, causing this region to resemble areas farther south in terms of vegetation patterns.
A large registry study found that aortic stenosis and dissection are uncommon yet critical causes of sudden death in young, competitive athletes, usually during exercise. Many cleared players were allowed to participate despite suspicions of cardiovascular conditions.
Cangrelor, a novel intravenous anti-clotting medication, has been shown to be more effective than clopidogrel in preventing blood clots in patients undergoing coronary stent procedures. The study found that cangrelor reduced the odds of complications by 22% and stent thrombosis by 38%.
Cangrelor demonstrated significant efficacy advantages over clopidogrel in reducing composite incidence of death, myocardial infarction, and ischemia-driven revascularization. It also showed a lower risk of stent thrombosis, with improved safety results across various patient subgroups.
The redesigned Sapien XT valve demonstrated low 30-day death and stroke rates, with an all-cause mortality rate of 3.5% for the new device and 5.1% for the original model. Stroke rates were also significantly lower in both groups.
The risk of cardiovascular sudden death in young competitive athletes is extremely low, occurring only about 30% of the time and in a small percentage of those due to diseases detectable by ECGs. Current screening initiatives have potential impact on 10-15 million young adults but do not provide evidence for necessity of ECGs
A study examining people with MS treated with natalizumab and diagnosed with PML found those without symptoms at diagnosis had improved survival and disability levels. Early detection of the disease may mitigate its consequences, allowing for better patient outcomes.
A new study found that adrenocorticotropic hormone (ACTH) may be effective in treating people with breakthrough multiple sclerosis. Participants who received ACTH had fewer relapses and no psychiatric side effects, compared to those receiving methylprednisolone.
A study of hospital patients found that transfusing donated blood more than three weeks old impairs blood vessel function, a mechanism linked to nitric oxide deficiency. The results suggest that older blood may be detrimental to patient health, particularly in cardiovascular surgery or critical care scenarios.
Scientists have identified enzymes that can reverse a key protein modification involved in breast cancer, cellular stress reactions, and gene regulation. The discovery enables selective manipulation of ADP-ribosylation, which could lead to new treatments for inflammasions and cancers.