A large US study has found that living in high-poverty areas or being uninsured significantly increase the risk of being diagnosed with breast cancer at a later stage. The study's findings highlight the importance of addressing health insurance coverage and poverty levels as key predictors of late-stage breast cancer diagnosis.
Researchers found that threonyl tRNA synthetase (TARS) plays a critical role in angiogenesis, the formation of new blood vessels, to support cancer growth. A potent inhibitor of TARS activity blocks its induction of angiogenesis.
A comprehensive computer model of human metabolism has been developed, connecting the dots between the human genome and metabolism. The Recon 2 model advances understanding of human metabolism in health and disease, enabling identification of biomarkers and prediction of drug side effects.
Scientists utilize alyssum, pteridaceae, and sinapi mustard to absorb toxic metals from polluted soil through phytoremediation. The extracted poisons are then converted into valuable materials, such as catalytic converters and nanoparticles for cancer treatment.
A new CAMH study shows that alcohol is the third leading cause of disease and injury worldwide, with vast differences in drinking patterns across regions. The research found that North Americans and Canadians drink significantly more than the global average, with a detrimental drinking pattern characterized by bingeing.
The US Department of Homeland Security has developed two new technologies, Pit-BUL and NightHawk, which use remote-controlled spike strips to stop vehicles. These devices can be deployed from a safe distance and provide added safety for law enforcement officers, allowing them to halt speeding vehicles without putting their lives at ris...
The UK's premature mortality rates have worsened, particularly among men older than 55 years, due to increases in drug and alcohol use disorders. The country ranks lower than other nations in several health metrics, including ischaemic heart disease, COPD, and stroke.
Researchers found that floral morphologies are less reliable than other traits in determining the relationships of papilionoid species and genera. Other morphological characteristics may indicate relationships more reliably, according to the study published in the American Journal of Botany.
Conservationists confirm a staggering 62% loss of African forest elephants over the past decade due to poaching. The species' survival is threatened by human density, infrastructure development, and poor governance.
A new study finds that idiopathic brood disease syndrome is the largest risk factor for predicting honey bee colony death, with a risk factor of 3.2. Queen events are also a significant contributor, with a risk factor of 3.1. The study highlights the need for further research into these health issues.
A prospective study found that children with low-risk retinoblastoma do not need postoperative chemotherapy to prevent disease recurrence or metastasis. The results suggest that certain patients with intermediate-risk disease can receive less aggressive adjuvant treatment or even forego it altogether.
A new study by the University of Pennsylvania School of Veterinary Medicine found that maternal stress exposure affects the developing brains of male and female offspring differently. The researchers discovered a biomarker, Ogt, which may signal to the fetus that its mother has experienced stress.
The VOICE study found that daily dosing of tenofovir gel was not effective in reducing HIV acquisition due to low adherence rates. In contrast, coital dosing, where women use the product around the time of sex, showed a significant reduction in HIV infections and herpes genital infections.
At NASA's Goddard Space Flight Center, researchers create ultrathin layers of amorphous ice to replicate extreme chemistry found in space. They find that water helps amino acids last longer when exposed to cosmic radiation, producing new chemical byproducts.
Researchers found that red blood cells in blood stored longer than three weeks gradually lose their flexibility to deliver oxygen-rich cells. The study's findings suggest that the current practice of transfusing blood stored up to six weeks may need reconsideration.
A new regulatory methodology is proposed to improve the evaluation of invasive potential in biofuel feedstocks. The current method has a significant gap in protection against natural areas invasions, leading to massive financial effects.
A recent study published in The Lancet Respiratory Medicine found that a single inhaler therapy using beclometasone/formoterol combination is more effective in preventing asthma attacks than the traditional combination of corticosteroid and rapid-onset long-acting β2 agonist. This approach reduces hospital admissions and healthcare cos...
Two important studies published in the March issue of AIDS found that current CDC HIV screening guidelines may be too conservative, especially for low-risk groups, and that heavy drinking leads to increased HIV risk for men who have sex with men. The studies suggest that frequent testing and addressing risky behaviors can help prevent ...
Scientists aim to understand how promiscuous enzymes can be engineered to tackle new functions, such as removing toxins from the environment. The goal is to develop biodegradable enzymes that can replace toxic chemicals in industrial processes.
Researchers have engineered a unique multilayer material that achieves extraordinary superconducting properties, including increased current-carrying capabilities and improved magnetic field stability. The breakthrough could lead to real-world applications in electronic devices, transportation, and power transmission.
Physicists at University of Rochester and University of Ottawa have made direct measurements of light's polarization states for the first time. This breakthrough overcomes key challenges to Heisenberg's Uncertainty Principle, enabling faster quantum information processing.
A team of international researchers has created an instruction manual for the human genome, providing a framework to understand the relationship between genetic makeup and lifestyle. The model explains how individual biological parts operate differently within each person, paving the way for tailored treatments in personalized medicine.
UT MD Anderson scientists found that a common substance in cancer vaccines facilitates a buildup of T cells at the vaccination site, summoning more T cells and causing lesions. Switching to saline adjuvant reversed the effect, allowing T cells to target tumors. A new clinical trial is expected to test this concept.
Researchers have identified seven new genetic regions associated with AMD, explaining up to 65% of the genetics of the disease. The study combined existing data from over 17,000 patients and 60,000 people without AMD, revealing genes involved in immune system signaling, lipid metabolism, and blood vessel development.
A University of Michigan researcher has developed a new early warning system that can predict malaria epidemics in northwest India up to four months in advance using sea surface temperature forecasts. The system improves public health by increasing lead time for disease prevention strategies.
The study identified seven new loci near genes that are associated with increased risk of age-related macular degeneration. The analysis included data from over 17,000 people with advanced AMD and 60,000 without, revealing a variety of biological functions implicated in the disease.
Researchers at Albert Einstein College of Medicine have discovered how the most common genetic mutations in familial Parkinson's disease damage brain cells. The study found that abnormal LRRK2 protein disrupts a 'garbage-disposal' process, leading to toxic levels of alpha-synuclein and neuronal death.
Researchers discovered mutations in two genes, hnRNPA2B1 and hnRNPA1, that lead to the death of nerve cells in ALS and other neurodegenerative diseases. The study found these proteins play a crucial role in normal RNA functioning and have been linked to cancer.
The study found that green leafy vegetables interact with a cell surface receptor to switch on the T-bet gene, producing innate lymphoid cells crucial for immune surveillance and gut health. These immune cells may aid in treating bacterial infections, promoting good bacteria, and preventing bowel cancers.
Researchers have found new candidate disease proteins for neurodegenerative disorders, including two RNA-binding proteins with prion-like segments associated with inherited forms of ALS and multisystem proteinopathy. Mutations in these proteins accelerate the formation of self-organizing fibrils that contribute to disease.
A new virtual reconstruction of human metabolism, Recon 2, has been built to identify causes of diseases and develop new treatments. The model provides a detailed map of metabolic pathways, allowing researchers to pinpoint specific gene expressions and their effects on disease progression.
Researchers at Weill Cornell Medicine have made a breakthrough in treating diffuse large B-cell lymphoma by targeting the master regulatory transcription factor Bcl6. By shutting down this protein, patients may experience fewer side effects and improved treatment outcomes.
Researchers have discovered seven new genetic loci associated with increased risk of age-related macular degeneration (AMD), a condition that affects central vision and can lead to blindness. The study, supported by the National Eye Institute, represents the most comprehensive genome-wide analysis of AMD genetics.
A team of researchers describes the first case of a functional HIV cure in an infant, achieved through prompt antiviral therapy within 30 hours of birth. The infant remained virus-free for over a year without treatment.
Researchers detect never-before-seen phenomenon in Earth's magnetosphere, revealing a long-lived zone of high-energy electrons stored between the Van Allen radiation belts. This finding may impact the planning of future space missions.
A new CU-Boulder study suggests that volcanic aerosols, rather than industrial pollution, have counteracted as much as 25% of human-caused global warming since 2000. The research, led by Ryan Neely, used sophisticated computer models to separate coal-burning emissions from Asia from volcanic contributions worldwide.
A study published in The Journal of Immunology found that inhibiting a group of proteins can decrease inflammatory responses associated with diseases like obesity, type 2 diabetes, cancer, and sepsis. This suggests that targeting these proteins could be a potential treatment for various diseases.
Researchers found that hospital management fails to engage frontline clinicians in improving patient satisfaction, despite most believing it's achievable. Clinicians reported receiving feedback only 34% of the time, highlighting the need for more structured plans and active role from hospital management.
Researchers at Michigan Technological University have developed a process to recycle old milk jugs into plastic filament for 3D printing, reducing energy consumption and costs. The open-source RecycleBot process uses free software and low-cost materials to produce usable plastic filament.
A new study by the University of Iowa confirms that pregnancy leads to permanent changes in a woman's feet, including increased length and width. The arch of the foot flattens out, potentially contributing to an increased risk of arthritis in women.
Researchers at Princeton University found that bacteria can clog medical devices like stents in a short period of time by forming sticky biofilms. The study used controlled environments with rough surfaces and pressure-driven fluid, demonstrating the need for real-world conditions to understand device failures.
MIT researchers have developed an algorithm that solves graph Laplacians in nearly linear time, using a spanning tree to simplify the calculation. This approach has significant implications for various applications, including scheduling, image processing, and online product recommendation.
Researchers identified a 1,500km-long fragment of an ancient continent called Mauritia beneath the Indian Ocean. The micro-continent contains rocks dated up to 2 billion years old, challenging the formation timeline of the ocean.
Mother Teresa's image was constructed through a media relations campaign, with facts such as her dubious care for the sick, questionable political contacts, and suspicious management of funds uncovered. Despite these issues, she built an image of holiness through mass media promotion, including a eulogistic film and numerous awards.
Researchers at Moffitt Cancer Center found that healthy adolescent females have predetermined expectations for becoming parents but worry about fertility and childbearing due to a life-threatening illness like cancer. The study validated a tool to assess teenage girls' hopes and feelings about reproduction.
Researchers at Yale University identified a molecular mechanism by which the growth of new blood vessels and heart muscle are coordinated. Nitric oxide triggers the destruction of RGS4, allowing for physiological changes associated with the relaxation of blood vessels, while promoting cardiac growth.
A team of graduate students from Concordia University developed a watchdog tool to evaluate the level of compliance between urban planning goals and environmental impact assessments of development projects. The study found that the proposal adopted in 2009 for the Turcot highway interchange was inadequate for long-term sustainability.
A team of researchers at Saarland University developed the Hadoop Aggressive Indexing Library (HAIL), a technique that enables fast and efficient searching in large datasets. By generating indexes for multiple criteria, HAIL can query big datasets up to 100 times faster than traditional methods.
Scientists identified nitric oxide's role in degrading a protein that attenuates cardiac growth, linking vascular changes to heart size. A nanogel-based treatment targeting an immunosuppressive drug directly to tissues associated with immune cells may help treat systemic lupus erythematosus.
Researchers have discovered a chemical probe, UNC1215, to investigate the role of malignant brain tumor domains in biology and disease. The probe targets L3MBTL3 methyl-lysine reader domain proteins, which play a fundamental role in gene expression and cancer development.
A large-scale study found that wild insects consistently enhance fruit set for a broad range of crops and agricultural practices on all continents. The researchers concluded that losses of wild insects from agricultural landscapes will likely impact both natural heritage and harvests.
Researchers at ETH Zurich discovered a link between prenatal infections, stress during puberty, and schizophrenia-relevant brain changes. The study suggests that the combination of these two factors significantly contributes to the development of the disorder.
A shortage of TDP-43 protein leads to muscle wasting, stunted nerve cells, and vascular dysfunction in ALS and FTD patients. The study found that the loss of function plays a critical role in neurodegenerative diseases, including Alzheimer's.
Researchers discovered melanoma tumors deliberately create conditions to knock out the body's 'premier' immune defense and attract a weaker immune response. Higher levels of IgG4 antibodies in patients' blood are linked to a less favorable prognosis.
Residents of a town struck by a tornado reported being less vulnerable to injury from future tornadoes, but their numerical estimates were pessimistic. Living in neighborhoods affected by the storm initially increased optimism, which decreased over time.
A new study from Lund University in Sweden shows that roach fish migrate to surrounding streams and wetlands to escape cormorant predators, highlighting the first evidence of migration as a strategy to avoid predation. The researchers used innovative tracking methods to determine which fish were eaten by cormorants.
Researchers developed a nanogel-based delivery system targeting immunosuppressive drug mycophenolic acid at tissues associated with immune cells. The treatment showed improved survival rates and delayed kidney damage in mouse models of lupus.
Researchers found an association between early childhood BPA exposure and elevated risk for asthma in young children. Post-natal exposure was associated with increased risk of wheeze and asthma, while BPA exposure during pregnancy had an inverse association with risk of wheeze at age 5.
US East Coast regions will be disproportionately affected by ocean acidification, with the Gulf of Maine being particularly vulnerable. The study found that waters with low alkalinity to DIC ratios are more susceptible to acidification, and the Labrador Coastal Current may contribute to this effect.
Researchers at Saarland University developed an automated testing system called 'Webmate' to identify security vulnerabilities in complex web applications. The system discovers connections between application components and generates test scenarios to ensure compatibility.