UT Southwestern researchers discover that a protein overactivity sabotages cellular recycling, leading to heightened cancer growth and chemotherapy resistance. Autophagy inhibition may worsen chemotherapy outcomes for patients with specific cancer mutations, according to the study published in Cell.
Research finds high levels of Fragile X Mental Retardation Protein (FMRP) in human breast tissue correlate with increased risk and spread of breast cancer. FMRP acts as a master regulator controlling aggressive cancer progression.
A new observational study suggests that bioidentical hormones in transdermal patches may be associated with a lower risk of heart attack, while FDA-approved products may carry a slightly lower risk of stroke compared to synthetic hormones. The findings are inconclusive and require confirmation by randomized trials.
Researchers at NC State have developed a technique for personalized searches that can handle complex queries and scale up to support thousands of concurrent users. The new approach uses ambient query context to determine user intent in real-time, allowing for more accurate results and better handling of ambiguous searches.
Researchers at NIST and Applied Research Associates developed a microfluidic technique to recover DNA from complex mixtures like dirt. This method delivers optimal DNA concentrations for human identification procedures, potentially miniaturized for use outside the laboratory.
Researchers have developed a new temperature-regulated delivery system that can release drugs or fragrances in response to body heat, offering greater control over delivery. The system uses microscopic bottle-like structures with melting corks made of fatty acids, which can be tailored to specific temperatures.
According to a recent study, over 43 million adverse events caused by substandard care occur in hospitals annually. The burden is highest in low and middle-income countries, where blood clots are the most common type of substandard care.
Researchers estimate Earth's habitable lifetime to be between 1.75 and 3.25 billion years, after which temperatures will become too high to support liquid water. This timeline suggests that complex life like humans may only emerge within a fraction of the planet's total habitable time.
A research team identified two genes, IRE1 and XBP1, that control response to proteasome inhibitors, which are commonly used to treat multiple myeloma. The study found that these underlying progenitor cells can survive treatment and lead to disease relapse.
A study by James Cook University found that early publication is a key factor in predicting success in scientific research. Women face disadvantages due to language barriers and family responsibilities, hindering their progress. Publishing early and often helps scientists gain a competitive edge and become superstars in their field.
Researchers have discovered that non-coding genes are regulated by protein-DNA interactions and can be targeted with more effective drugs. Using high-resolution technology, scientists identified 150,000 complexes along non-coding stretches of DNA in leukemia cell lines.
A new report from NREL and MIT reveals that China's dominance in solar manufacturing is largely due to its production scale advantages, including access to capital and supply chain benefits. The study suggests that these advantages can be replicated in the US with innovative technology and scale-up.
A new study by Brigham Young University professor Arden Pope found a 35% reduction in deaths and disability attributable to air pollution in the US since 1990. This improvement is attributed to cleaner air quality, with significant reductions in cardiovascular disease and respiratory problems.
Tropical Storm Humberto re-formed over two days, with significant changes observed in rainfall patterns by NASA's TRMM satellite. The HS3 mission uses Global Hawk aircraft to investigate storm processes and gather data on the environment of the storm.
A study from Concordia University's John Molson School of Business found that physical contact and ethical marketing can boost consumer preference. The research shows that utilitarian claims should be paired with practical products, while symbolic claims should be paired with symbolic products.
A new marker called isocitrate dehydrogenase (IDH1) has been identified as a non-invasive diagnostic marker for lung cancer, with high sensitivity and specificity in detecting non-small cell lung cancers (NSCLC). IDH1 levels were found to be significantly higher in patients with lung cancer compared to healthy controls.
A review study of 1,500 patients found that financial incentives can increase exercise amounts, helping to overcome time commitment and discomfort barriers. The study suggests providing short-term incentives can drive long-term behavior change, preventing repeat heart events and saving the health system millions.
A new study finds that replacing coal-fired power plants with wind turbines is the most cost-effective way to cut carbon pollution and reduce health impacts. The switch can also lead to lower electricity generation costs, making clean energy a more economically viable option for powering America's electricity needs.
A recent study by Lawrence Livermore National Laboratory and six other institutions found that human activity has a discernible impact on the thermal structure of the atmosphere. The research compared satellite records with simulations and revealed a unique pattern of global-scale tropospheric warming and stratospheric cooling.
A study found that shy male birds are more likely to join flocks of birds with similar personalities than bold males. Shy birds also have fewer social partners and tend to form more stable relationships.
A new auto steering device, proposed by Rene Guerster, aims to reduce the risk of accidents caused by sudden turns. The device, which uses computer-mediated steering, would enable drivers to steer around obstacles without releasing the wheel.
New UNH research suggests that employees with a sense of unjustified entitlement are more likely to report abusive supervision and mistreatment by their bosses. This perception can lead to negative psychological and behavioral reactions, impacting the careers and livelihoods of managers.
A study published in Radiology found that patients referred by physicians with financial interest in imaging equipment were more likely to receive negative findings on knee MRI exams. This suggests that financial incentives may drive overuse of high-tech imaging, contributing to escalating medical costs.
A new technology developed by Brown University researchers simplifies biomolecule separation using microfluidics and magnets, increasing accuracy and sensitivity in disease detection. The technique has great applicability for point-of-care platforms and specific applications include testing for HIV and influenza.
Researchers have developed a high-yield method for isolating viable hepatocytes from cryopreserved neonatal livers, showing better thawing recovery than those from adult livers. This breakthrough may provide an alternative source for liver cell transplantation, potentially improving patient outcomes.
Researchers used a simple questionnaire and existing hospital staff to gather data on diarrheal disease outbreaks in the Chobe District of Botswana. The study found that environmental factors, such as water shortages and dirty water, are important drivers of outbreaks, and can inform immediate action.
A new mouse model suggests that overexpressing the Isl1 gene can protect hair cells from degeneration and promote survival after loud noise exposure. This finding has implications for treating age-related and noise-induced hearing loss in humans.
Researchers used brain scans to find an anatomical marker for chronic pain in the brain, which may lead to changes in treatment. The study found a consistent difference in white matter between subjects who recovered and those with persistent pain.
Researchers are studying the effects of urban climates on crop yields to develop new crops adapted to urban gardens and provide recommendations for urban farmers. The benefits of urban agriculture include increased food production, community engagement, and access to healthy fresh produce.
Researchers launched an online platform called Plankton Portal, allowing citizens to classify millions of underwater images to study plankton diversity. The project uses high-resolution digital sensors from the In Situ Ichthyoplankton Imaging System (ISIIS) to detect plankton and other organisms in the open ocean.
Scientists at NIST have developed novel odor-releasing materials to train bomb-sniffing dogs, reducing the need for hazardous samples and ensuring uniformity in training. The system can precisely control the release rate of scents over extended periods, making it ideal for large-scale training.
Researchers at NHCS successfully reversed effects of hERG mutation in patient-specific heart cells, scoring a world's first. The discovery could revolutionize drug development and lead to a potential cure for the life-threatening condition within 5-8 years.
A wide band of strong thunderstorms was detected south of Tropical Storm Usagi's center using infrared data from NASA's Aqua satellite. The cloud top temperatures exceeded -63F/-52C, indicating high thunderstorms with potential for heavy rainfall.
New research from Northwestern University predicts chronic back pain after lower back injuries based on abnormalities in brain structure connections. The study found that specific irregularities in the axons of the brain's white matter can trigger chronic pain with high accuracy, offering new hope for early treatment and prevention.
Researchers developed a high-throughput assay to track cell growth at low nutrient concentrations, revealing metabolic differences among cells of the same strain in the same environment. The study also found significant genetic variation in Sherpa populations' mitochondrial genomes, suggesting an adaptation for low oxygen environments.
A collaboration between NIST and 5 technical journals found that one-third of papers contained erroneous or incomplete chemical property data. A new online tool was developed to identify and eliminate errors in experimental data, using expert software system for data evaluation.
The new MOOCs Forum publication delves into the credibility, standards, and value of Massive Open Online Courses. Key findings include discussions on student identification and security, institutional benefits and liabilities, and platform advancements. The publication provides a voice for key stakeholders to shape the future of MOOCs.
A study published in Gastroenterology found that carbonation can trick the brain into perceiving artificially sweetened drinks as just as sweet as regular ones. This effect may facilitate weight loss by making low-calorie drinks more palatable, but it also increases sugar and food consumption.
A federal study by Rensselaer Polytechnic Institute has shifted daytime delivery truck traffic to off-hours, reducing congestion and improving supply chain management. The program benefits businesses, delivery companies, and the environment, with estimated annual emissions reductions of over 100 tons.
Researchers at Children's National Medical Center have found that the new oral drug VBP15 decreases inflammation and protects muscles, potentially preventing or delaying the onset of symptoms in Duchenne muscular dystrophy patients. Initial clinical trials are planned pending FDA review and approval.
A team from IRB Barcelona discovered Mitofusin 2 plays a crucial role in measuring cellular stress levels. Removing Mfn2 leads to disrupted stress response pathways, reducing the capacity of cells to overcome stress.
A recent study published in JAMA Network found that chronic care management did not result in increased abstinence from alcohol among individuals with alcohol and other drug dependence. The study compared participants receiving chronic care management with those receiving usual primary care, but no significant difference was found.
Researchers have discovered that heavily logged forests in Borneo still support a significant number of species, challenging the notion that logging depletes ecosystems. The study suggests that some species can thrive even in highly degraded environments.
Nanodiamonds have been found to promote bone growth and deliver proteins to treat osteonecrosis, a debilitating disease that causes bones to break down. The tiny diamonds can be administered non-invasively, potentially revolutionizing dental implant procedures.
Researchers found that mesenchymal stem cell transplantation can promote recovery from simulated childbirth injury and reduce symptoms of stress urinary incontinence. The treatment uses multipotent cells found in connective tissues, which home to damaged pelvic organs and release trophic factors to stimulate repair.
A Johns Hopkins analysis found that epidural steroid injections are only twice as effective as injections of any fluid, including anesthetics and saline, for treating lower back pain. The study suggests that smaller doses of steroids may be just as beneficial, and larger studies are needed to confirm these findings.
The NJIT Flood Mitigation Engineering Resource Center will investigate alternative measures for flood mitigation in the Hackensack/Moonachie/Little Ferry area. The project aims to enhance existing efforts and provide a comprehensive strategy for protecting citizens from future floods through innovative engineering measures.
Professor Alexander Balandin receives MRS Medal for his groundbreaking work on graphene's thermal properties and development of a new materials characterization technique. His discoveries have led to major advances in understanding phonon transport and the application of graphene in heat removal and thermal management.
Researchers have developed a new optical imaging technique to track molecular movement, cell abnormalities, and fluid dynamics within tumors. This approach combines two high-tech methods to provide unprecedented insights into human cancer biology and aid in drug discovery.
A novel vaccine approach against human cytomegalovirus (CMV) has been shown to be safe and more effective than previous vaccines in an animal model. The vaccine targets CMV's ability to hijack the immune system, inducing broader immunological protection.
Researchers found strong selection for MC1R gene variants in South Europeans, associated with fair skin and increased melanoma risk. The V60L allele variant has been linked to both benefits and drawbacks, highlighting evolutionary trade-offs.
A recent study has revealed a significant increase in coeliac disease cases among Scottish children under the age of 16. The rate of new diagnoses rose from 1.7 per 100,000 to 11.8 per 100,000 between 1990 and 2009.
The OptSwap method enables scientists to predict and optimize microbial strain designs for increased yield of valuable biobased chemicals. Researchers identified optimal strain designs for L-alanine, succinate, acetate, and D-lactate production under modeled conditions.
A study published in Annals of Surgery found that immediate surgery reduces complications and shortens hospital stays by up to 50% compared to delaying surgery. Patients who underwent early surgery had fewer complaints and were discharged earlier, resulting in lower hospitalization costs.
Researchers found that blades with equal chord length, angled at 79 degrees and moving at 1.5 times the current speed can extract maximum energy from tidal currents. A Norwegian company's pilot project is already generating 28 kilowatts of power.
A recent study found that California adults with Medicaid coverage had the largest increase in emergency department visits from 2005 to 2010. This rise may be attributed to decreased access to primary care, which was reflected in higher rates of ambulatory care sensitive conditions among Medicaid patients.
A new study by Henry Ford Hospital researchers found that mental state and thinking abilities can predict early hospital readmissions in heart patients. Depression, anxiety, and cognitive impairments are related to increased risk of hospital admissions and readmissions.
TRMM satellite data revealed heaviest rainfall in the Gulf of Mexico, with rates reaching 2 inches per hour, and moderate rainfall stretching inland over eastern Mexico. The remnants of Ingrid are expected to produce significant flooding and mudslides in eastern Mexico, with totals ranging from 10-15 inches.
A literature review found that one in four people develop hip arthritis before age 85, contributing to groin pain. Contributing factors include sports-related injuries, prior surgery, and traumatic occupational history. A detailed medical history and examination are crucial for diagnosing the source of groin pain.
Researchers at Tel Aviv University found that viral respiratory infections may be behind the seasonal spike in sleep-disordered breathing among children. The study, published in Sleep Medicine, suggests that winter months are when pediatric sleep-disordered breathing worsens, contrary to previous assumptions about asthma and allergies.