Researchers found that essential proteins evolve chiefly by changing how they move, rather than their molecular structure. This discovery has significant implications for the design of antibiotics and other drugs targeting dihydrofolate reductase.
Researchers have identified molecular profiles of tumors with unknown primary sites, allowing for more effective treatment and improved survival rates. The study found that the biology of the tumor is more important than its primary site in determining treatment effectiveness.
Researchers estimate that routine PSA testing can lead to increased impotence and incontinence cases, as well as additional prostate cancer diagnoses. However, the difference in death rates between screened and unscreened men is relatively small, with only 0.07 more deaths attributed to screening.
A tiny MEMS accelerometer chip used in smartphones can detect moderate to strong earthquakes when located near the epicenter. The technology has the potential to increase coverage and accuracy in monitoring strong motion during earthquakes, making it possible to create an urban seismic network that transmits real-time ground motion data.
Researchers have identified 48 new genetic variants linked to multiple sclerosis, nearly doubling the number of known risk factors and shedding light on the immune system's role in the disease. The study, led by the University of Miami Miller School of Medicine, confirms the critical involvement of genetic factors in MS development.
Researchers Yalin Chen and Chang Liu review present evidence on relationships between human number, time and space processing. The study investigates common mechanisms among these processes, with some arguing for multiple magnitude systems and others a common basis.
The researchers validated 1,799 sites and predicted an additional 1,782 sites, resulting in a combined list of 3,581 accurate sites. The team gained insights into the model organism's fundamental biology, including patterns of editing and alternative splicing.
Researchers at the University of Utah created a new organic molecule shaped like rotelle – wagon-wheel pasta – that depolarizes light, increasing LED efficiency. This breakthrough allows for more efficient OLED displays, promising longer battery life in smartphones and TVs.
Scientists at Hebrew University and Bar-Ilan University found that Eilat's corals are more resilient than other sites due to a 'warm-water barrier' in the Red Sea. This barrier allows only heat-tolerant genotypes of corals to enter, making it a unique refuge for coral reefs.
A phase I clinical trial has shown that an anti-PD-L1 monoclonal antibody can produce striking responses in non-small cell lung cancer patients with metastatic disease who have failed to respond to previous chemotherapy. Smokers and former smokers are more likely to benefit from this treatment.
A study at the Weizmann Institute suggests that in a quarter of all leukemias, cancer cells use a balance between a mutated gene and its normal counterpart to keep going. The healthy RUNX1 gene plays a crucial role in blood cell development and maintenance.
Researchers have pinpointed a specific gene responsible for Prader-Willi syndrome, an imprinted disease affecting muscle tone, feeding difficulties, and intellectual disability. The study identified mutations in the MAGEL2 gene, which was found in three additional patients with similar symptoms.
Researchers estimate that Avahan prevented more than half of the infections that would have occurred without the intervention. The initiative targeted high-risk groups with behavioral interventions and adequate provision of prevention commodities.
The European Society for Medical Oncology emphasizes the need for new testing methods to ensure patients benefit from personalized cancer treatments. Researchers are working on developing new approaches to analyze tumour characteristics and select targeted therapies.
A Korean research team developed a novel strategy for microbial gasoline production through metabolic engineering of E. coli, producing 580 mg of gasoline per liter of cultured broth. The platform E. coli strain can be modified to produce other chemicals, offering a sustainable alternative to fossil resources.