A meta-analysis of over 11,000 patients showed that hyperfractionated radiotherapy (AFRT) reduces the risk of death by 8% compared to standard fractionation radiotherapy (SFRT). AFRT also improves locoregional control, with a significant increase in five-year survival rates.
The study identifies syndecan-1 as the human cell receptor used by baculovirus to enter cells, shedding light on the mechanisms of infection and facilitating gene therapy development. This breakthrough discovery increases our understanding of baculovirus interactions with human cells.
A new study from Stanford researchers suggests that FDA-approved antidepressants may be effective in combating small-cell lung cancer, a particularly deadly form of the disease. The drugs activated a cellular self-destruct pathway that killed cancer cells, and further investigation showed they work through G-protein-coupled receptors.
Scientists at SLAC National Accelerator Laboratory and Stanford University have demonstrated a 'laser on a chip' technology that accelerates electrons at a rate 10 times higher than conventional methods in a nanostructured glass chip. This breakthrough could lead to compact accelerators for science, medicine, and research applications.
A Rutgers University study finds that the number of children in immigrant families is not the primary reason for child poverty in the US. Instead, local labor market conditions and parental education are major contributors. The study suggests that media coverage on immigration's impact on child poverty overstates the issue.
Recent studies suggest that moderate habitual coffee consumption is unlikely to adversely affect cardiovascular health. Higher green tea and coffee consumption has been inversely associated with the risk of CVD and stroke in the general population. Moderate coffee consumption may also have a favorable effect on plasma cholesterol levels.
Researchers at the University of Wisconsin-Madison have discovered a promising vitamin D-based treatment for multiple sclerosis (MS) that can halt and even reverse the course of the disease in a mouse model. The treatment involves giving mice with MS symptoms a single dose of calcitriol, followed by ongoing vitamin D supplements throug...
Researchers from the University of Sheffield and Mario Negri Institute in Italy investigated two mouse models of MND, identifying key differences in gene expression that may help predict disease duration. The study provides new insights into mechanisms that slow down disease progression.
The TH3RESA trial shows that T-DM1 significantly improves progression-free survival in women with advanced HER2 positive breast cancer, with a nearly three-month increase from 3.3 months to 6.2 months. The treatment also demonstrates a more favorable safety profile compared to standard therapy.
Researchers discovered that the Baoulé breed of cattle has a natural tolerance to a deadly parasite, and developed a method to detect different types of trypanosomes. The study aims to preserve the genetic background of the Baoulé breed to develop more resilient cattle breeds.
Researchers discovered a mutation in a gene can impact offspring and subsequent generations with developmental abnormalities, epigenetic changes, and severe health effects like spina bifida. Folate fortification programs have reduced the risk but not eliminated health problems.
Researchers at Memorial Sloan-Kettering Cancer Center developed a new approach for cancer therapy development using tumor genomic signatures. The study confirms two major hypotheses, showing that a limited number of genetic events cause most tumor subtypes and that oncogenic signatures are largely independent of tissue origin.
Researchers found that the size, shape, and color of a wine glass influence the amount of wine poured. Participants poured around 12% more wine into wide glasses than standard ones. To minimize overconsumption, experts recommend using white wine glasses and pouring when the glass is on a table or counter.
Researchers at Cardiff University have teamed up with Peking University in China to test traditional Chinese medicine's health benefits and explore its potential when combined with chemotherapy. The study found that a traditional Chinese formula can block the spread of cancer cells and improve patient outcomes.
Researchers at Brigham Young University have developed a new breast cancer screening technique using sodium MRI that produces five-times more accurate images than previous methods. The device aims to reduce false positives and unnecessary biopsies by scanning for sodium levels in the breast.
Researchers at Rice University and UTHealth will advance tissue-engineering technologies with a $75 million grant. The goal is to restore or replace damaged tissue and organs, benefiting both military and civilian populations.
Researchers discover that increasing c-Fos expression in the skin promotes the development of squamous cell carcinomas, a highly aggressive type of skin cancer. Anti-inflammatory drugs can decrease tumor progression by blocking the immune response induced by c-Fos.
Researchers reconstructed a 900-year temperature timeline in the Eastern Mediterranean, revealing a medieval warm period and modern warming trend that may not be regional. The study uses stable carbon isotopes in tree rings to analyze environmental conditions and find correlations between temperature fluctuations and tree growth.
A bioinformatics approach identified two antidepressants as potential new treatments for small-cell lung cancer, inducing cell death and inhibiting tumor growth. Imipramine and promethazine showed promise in animal models and preclinical studies, suggesting a new avenue for treating this deadly subtype of lung cancer.
Joslin researchers found T cells, not B cells, contribute to beta cell proliferation in type 1 diabetes. Immune cells secrete inflammatory cytokines and chemokines that enhance beta cell growth.
The EASE-R3 project aims to increase the longevity of CNC machine tools by developing new and cost-effective systems for repair, renovation, and re-use. The University of Huddersfield team will lead the design and prototype production of a compact module incorporating laser technology to ensure accuracy during renovation.
Research finds that increased government spending on health care is associated with decreased cancer mortality rates in Europe. Eastern European countries tend to have higher mortality rates, while Western Europe has better outcomes due to effective screening programs and treatments.
A meta-analysis found that diabetic patients have an increased risk of developing both breast and colon cancer. The study also showed that diabetic patients are at a higher risk of dying from these cancers, with a 23% increased risk for breast cancer and a 38% increased risk for colon cancer compared to non-diabetic patients.
Researchers are utilizing post-glacial rebound to determine the stability of the Antarctic ice sheet. By studying seismic waves generated by distant earthquakes, scientists can measure the rate at which the ice sheet is losing mass and estimate its future behavior in a warming world.
Research highlights disparities in post-surgical risks among older minority patients, with black patients facing nearly three times the risk as white counterparts. Pre-existing medical conditions significantly contribute to these differences.
A new intravaginal ring has demonstrated a 100% success rate in protecting primates from HIV, offering hope for women in developing nations. The device utilizes a smaller dose of the anti-retroviral drug tenofovir, delivered through a unique polymer construction that increases drug release.
The Phase II study showed that everolimus successfully slowed or prevented disease spread in 59% of patients. Everolimus may represent a new treatment option for advanced papillary kidney cancer, which accounts for 15% of all kidney cancer cases.
A new study has found that treating chest lymph nodes in early breast cancer patients improves overall survival without increasing side effects. The research involved 4004 patients from 43 centres and found that irradiating the IM-MS lymph nodes gave a better patient outcome than radiation therapy to the breast/thoracic wall alone.
A recent study found that colorectal cancer screening programs in European countries have a significant impact on reducing mortality rates. The researchers analyzed data from 11 European countries and found that the scope and take-up of CRC screening activities were strongly related to the reductions in death rates.
Researchers found that participants poured 12% more wine into wide glasses than standard ones, and 9% more when holding the glass while pouring. This highlights the importance of educating people on how to measure a proper serving size of alcohol.
Research attributes high smoking rates among mentally ill to brain susceptibility to addiction, not self-medication. The study found that psychiatric disease makes the brain more vulnerable to nicotine addiction, which has severe health consequences.
A new MRI technique has been developed with a spatial resolution of roughly 10 nanometers, significantly improving sensitivity. The team used a novel protocol and nanoscale metal constriction to overcome obstacles in applying classic pulsed magnetic resonance techniques.
Researchers at University of California, Santa Barbara, have devised a new method for creating high-power white light using a laser diode in combination with inorganic phosphors. The resulting lighting options are high in efficiency and have been shown to achieve a luminous flux comparable to current high-brightness white LEDs.
Nuclear pores serve as transcription factories for genes, regulating their production speed. The discovery reveals a new role for these microscopic structures in the cell nucleus.
A study of 4846 patients treated with ipilimumab reveals that some can survive for up to 10 years, with a plateau in overall survival starting around three years. This finding provides valuable insight into the long-term efficacy of the treatment and its potential as a benchmark for future medicines.
Researchers found that seniors over 90 improved their walking speed, balance, and reduced falls with strength training. The 12-week program boosted muscle power and mass in the lower limbs.
A team of researchers at MIT has developed an accurate 3-D model of streamer propagation, which qualitatively and quantitatively describes the development of electric breakdown in dielectrics. The model offers great promise for applications such as medical imaging, aerospace engineering, and power transmission.
A team of researchers has documented the removal of oxygen from seawater flowing through the deep ocean's rocky crust, suggesting that microbes are scavenging for energy. This finding provides crucial insights into the survival and thrival of life in the 'deep biosphere' beneath the sea floor.
A 12-week yoga class and home practice reduced insomnia in postmenopausal women, while exercise showed similar benefits. However, yoga did not impact hot flashes or night sweats.
The Sunrise mission revealed complex patterns in the chromosphere, including dark regions and bright points thought to be magnetic flux tubes. The ultraviolet radiation from the chromosphere is highly suitable for visualizing detailed structures and processes.
Hospitalized patients with severe infections like meningitis and C. diff. experience improved outcomes and shorter hospital stays when treated by infectious diseases specialists. ID consultation reduces readmission rates, ICU days, and total Medicare costs.
Researchers have developed a numerical simulation to study wind-sand movement in straw checkerboard barriers (SCB) and their surrounding area. The results show that SCBs can decrease sand transport rates and reduce the strength of wind-sand flow eddies, leading to increased sand fixation.
A study found that motion-generated optic flow information compensates for the lack of image details and enables effective event perception. Participants correctly identified events in nearly 90% of attempts when viewing moving images, compared to less than 30% when viewing blurred static images.
A new survey of nearly 5,000 tumor samples has identified 140 regions with scrambled genetic code believed to contain many undiscovered cancer genes. The mapping gives researchers a starting point to search for oncogenes and tumor-suppressor genes.
A new study found that Americans in higher socio-economic groups have a 13% greater chance of surviving subarachnoid hemorrhage than those in lower-income groups. However, this status did not influence mortality rates in Canada, where universal health insurance may play a role in improving outcomes.
Researchers at Drexel University are developing a smartphone app to track individuals' patterns of eating and binge-eating behavior, alerting them at risk. A new evidence-based approach to small-group behavioral therapy also aims to equip patients with psychological tools to adhere to standard treatments.
Researchers at the University of Missouri have identified a beneficial relationship between crops and bacteria that could lead to reduced nitrogen fertilizer use. By understanding how legume crops interact with rhizobia bacteria, scientists hope to develop new methods for improving plant nutrition and reducing waste.
Two new species of southern Indian leaf beetles, Orthaltica eugenia and Orthaltica terminalia, have been discovered using existing holes in leaves to construct shelters. The beetles also modify and use artificially made holes, partitioning them with their own fecal pellets to create optimal hideouts.
A large-scale analysis of 20,034 patients found that young age is associated with worse overall survival and progression-free survival in those with metastatic colorectal cancer. The study suggests that these patients have a poorer prognosis if their disease has metastasized.
A new study from researchers at Rice University found that a school outreach program reduced the mobility of African-American students by 29 percent. The program enhanced relationships between families and school personnel, improving trust and reducing negative outcomes such as lower test scores and substance abuse.
The NIH has awarded nine new contracts to strengthen the scope of its Vaccine and Treatment Evaluation Units, increasing funding from eight to nine institutions. The VTEUs will expand their ability to conduct research in domestic and international locations, including resource-poor settings.
A new study from the University of Exeter and international collaborators finds that smaller reefs with nearly full lagoons have potential for new island development. This could provide alternative land options in the region as sea levels rise.
A new study led by Oxford University researchers explains the dual natures of the 'Jekyll-and-Hyde' protein E2F, which can boost tumour cell growth and suppress it. The discovery provides a potent target for developing new cancer drugs, with compounds blocking E2F's change into 'Mr Hyde' resulting in cancer cell death
Researchers at Scripps Research Institute have developed a new method, called Extensive Combinatorial Refinement (ExCoR), that combines existing formulas to create more accurate computer models of molecules. This process can help identify the best algorithms for refining structural details and improve the development of drug candidates.
A study published in Global Heart finds that echocardiography is increasing detection rates of definite and borderline rheumatic heart disease globally. Using echocardiography increases detection rates by many-fold, revealing a higher true global prevalence than current estimates.
A study by the University of Cambridge reveals that folic acid deficiency not only affects immediate offspring but also has detrimental health effects on subsequent generations. Researchers found that epigenetic changes caused by a specific gene mutation led to developmental abnormalities in great, great grandchildren.
A lack of awareness about rheumatic heart disease (RHD) in low-income countries is a major concern. Raising awareness that untreated sore throat caused by group A streptococcal infection can lead to acute rheumatic fever (ARF)/RHD is crucial for prevention and control.
Researchers isolated and identified a naturally occurring analgesic compound from the root bark of Nauclea latifolia, identical to commercially available Tramadol. The discovery confirms high concentrations of Tramadol in the plant, providing new prospects for local populations and validating traditional medicine.
Current estimates of rheumatic heart disease deaths globally are likely underestimates, with new studies underway to address data gaps and inform control strategies. The authors propose re-evaluating the burden of disease in two categories: symptomatic and asymptomatic disease.
Duke Medicine has been named a Vaccine and Treatment Evaluation Unit (VTEU) to evaluate vaccines, treatments, and diagnostics. The VTEU will focus on vaccine development for diseases other than HIV, with potential annual funding of up to $135 million.