Researchers at UCI found that two circadian-linked proteins, SIRT1 and SIRT6, manage separate and distinct metabolic processes in the liver. This discovery sheds new light on how the body's internal clock influences metabolic functions and could lead to more targeted treatments for liver disease and related disorders.
The study found that Rome, London, and Paris emerged as major cultural centers due to high death rates among intellectuals in these cities. Despite increased travel over the centuries, birth and death locations of notable individuals remained relatively close.
The study reveals that early neurons make many connections but correct mistakes, while later neurons are highly accurate in their target selection skills. The findings provide insight into normal brain development and have implications for understanding autism and other disorders.
A study by NYU CDUHR researchers found that peer group dynamics play a significant role in facilitating the transition from oral and/or intranasal prescription opioid (PO) use to heroin injection. Nonmedical PO users are at high risk of acquiring HIV and/or HCV through injection and sexual risk behaviors associated with drug use.
A new surgical technique using incisions through the upper eyelid has been shown to effectively relieve migraines in patients. The study found a high success rate of 90.7%, with 51.3% of patients experiencing complete elimination of their headaches.
A study published in Ear and Hearing reveals that prolonged exposure to loud noise can lead to permanent damage of the hair cells in the ear. This damage affects the brain's recognition of speech sounds, potentially increasing difficulty in distinguishing them. The researchers used rats to simulate two types of noise trauma and found t...
A study found that goalkeepers dive in the opposite direction of consecutive penalties aimed in the same direction, exploiting the 'gambler's fallacy'. However, kickers failed to capitalize on this pattern, suggesting they focus on their individual kicks rather than the goalkeeper's previous moves.
Research reveals thermokarst lakes in Arctic regions act as climate coolers over longer time scales, storing more carbon than emitting. The study finds that these lakes, which form from thawing permafrost, absorb significant amounts of carbon from the atmosphere, offsetting greenhouse gas emissions.
Research finds that stricter math and science graduation requirements in US high schools are associated with higher dropout rates, especially among certain demographic groups. The study suggests a 'one-size-fits-all' approach to educational policies may not be ideal, as different groups respond differently to increased academic rigor.
A new study published in the Journal of Leukocyte Biology suggests that modulation of B cells may effectively treat and/or prevent periodontitis symptoms related to type 2 diabetes. Researchers used a mouse model to demonstrate the B cell-response's viability as a target for pharmacological intervention.
University of Michigan researchers identified a protein called TRIP13 that enables cancer cells to repair themselves and survive despite chemotherapy. The team found an existing chemical compound that can block this process, potentially increasing the effectiveness of cancer treatment and improving patient survival rates.
A review of over 240 patient cases found transplants to be highly effective in treating severe combined immunodeficiency (SCID) in young children. Early transplantation without infection results in exceptionally good outcomes, with overall five-year survival rates ranging from 77-93%.
Scientists warn of imminent 'solar super-storms' that could cripple critical services like power supplies, transport, and medicine. A predicted Carrington-level event every 150 years poses a significant threat to human health and infrastructure.
A team of scientists at Duke University has discovered a molecule that exploits the body's natural response to fungi and bacteria, using copper to kill microbial pathogens. The findings show promise for developing broad-spectrum antimicrobial agents with minimal harm to healthy cells.
New research in the FASEB Journal suggests that a specific combination of lipids contributes to how living creatures capture sunlight and convert it into energy. This natural combination is strikingly conserved throughout evolution, indicating its importance for ensuring light capture and conversion.
Researchers discovered that the theropod dinosaur lineage, which gave rise to modern birds, underwent an unprecedented phase of shrinking and evolutionary innovation. This transformation allowed bird ancestors to adapt to new environments, such as climbing trees and flying, ultimately helping them survive a deadly meteorite impact.
Researchers found that childhood coxsackie virus infection depletes cardiac stem cells, impairing the heart's ability to tolerate stress and increasing the risk of heart disease later in life. The study suggests a potential link between early viral infections and long-term cardiovascular health.
Physicists at the Joint Quantum Institute have developed an MRI-like diagnostic technique for studying large ensembles of interacting quantum spins. The method reveals spin-spin interaction strengths and energies of various configurations, offering insights into complex phenomena like magnetism.
A team of researchers, led by Dr. Maximilian Schich, reconstructed the migration and mobility patterns of 150,000 individuals over two millennia using network and complexity science. The study found non-intuitive patterns, including laws of migration, and challenged traditional notions of cultural centers.
New research from Heriot-Watt University and the University of Southampton shows collective switching or group buying schemes can save UK consumers up to a third of their yearly electricity bills. The study proposes a model to help consumers form more efficient buying groups and minimize switching risks.
Researchers used the Fermi Gamma-ray Space Telescope to discover high-energy gamma rays emitted by an exploding star. The surprising finding dispels the notion that classical nova explosions lack the power to produce such radiation.
Researchers at NYU Langone Medical Center identified a possible new drug target, LUNAR1, for treating childhood blood cancer. Blocking LUNAR1's action stalled leukemia progression and may offer an alternative to standard chemotherapy.
A study found that depressive symptoms and pain in dialysis patients were associated with increased hospitalization rates, emergency department visits, and mortality. The findings suggest that treating these symptoms could improve patient health and reduce healthcare costs.
Researchers at Carnegie Institution found that molybdenum disulfide undergoes structural changes when subjected to high pressure, resulting in a metallic state. The compound's transformation occurs above 197,000 times normal atmospheric pressure and is reversible upon decreasing pressure.
A new study by Michigan State University scholar Aaron M. McCright found the US public increasingly divided on environmental issues, mirroring Congressional polarization since 1992. The gap between conservatives opposing and liberals supporting environmental protection has grown drastically over two decades.
Research suggests that physical responses and deep-seated psychology are at the core of political differences, with conservatives exhibiting a negativity bias towards negative stimuli. This finding is supported by over 50 peer-reviewed articles discussing the study in a leading journal.
Researchers from University of Southern Denmark and Aarhus University have discovered how the PAI-1 protein behaves, revealing a unique shape change mechanism. This knowledge allows for better control over coagulation, reducing risk of bleeding or blood clots.
Research suggests that giant asteroid impacts significantly altered the early Earth, mixing and melting its surface. The findings provide new insights into the role of asteroid bombardments in shaping the Hadean Earth's surface.
The study reveals how hemagglutinin protein reconfigures itself as it infects host cells, providing new insights into the path of the flu virus. This understanding could lead to the development of a universal flu vaccine that lasts a lifetime.
A new international study published in BMJ Open and PLOS ONE found that tree nut consumption significantly decreases triglycerides and fasting blood glucose levels, improving metabolic syndrome criteria and glycemic control in diabetes. Daily tree nut intake of about two ounces was shown to have an overall metabolic benefit.
Karlsruhe Institute of Technology researchers found that corrosion of MOF layers on the surface causes surface barriers, which limit their application opportunities. Water plays a central role in this process, and water-free synthesis strategies are proposed to prevent these barriers.
The Rim Fire study examines the impact of drought and fire suppression on large fires, contrasting with a nearby National Park's natural fire regime. This natural experiment provides insights into the effects of megafires on watersheds under different management regimes.
Researchers at Helmholtz Munich have developed a new approach to treat obesity and type 2 diabetes, targeting the brown adipose tissue. By identifying specific surface proteins, they aim to selectively deliver substances to this tissue to reduce excess weight without side effects.
NYU researchers have engineered a protein that can detoxify organophosphates, commonly used in pesticides and warfare agents. The protein has increased stability and half-life, making it suitable for therapeutic applications, including preventing nerve damage from gas attacks or pesticide exposure.
A new C. difficile vaccine has been shown to be 100 percent effective in protecting animal models from the deadly intestinal disease caused by Clostridium difficile. The vaccine protects against bacterial toxins and could prevent deadly complications such as severe diarrhea and bowel perforation.
Researchers at The Scripps Research Institute have identified a signaling pathway that activates the powerful calorie-burning process in brown fat cells. The study found that a protein called GADD45γ works alongside PGC-1α to boost thermogenesis, offering new possibilities for treating obesity and diabetes.
An analysis of 361 kicks from World Cup and UEFA Euro Cup matches reveals goalkeepers become increasingly likely to dive in the opposite direction after kickers repeatedly kick in one direction. This cognitive fallacy highlights the importance of monitoring sequential behavior in real-world competition.
Researchers from the University of Rochester and others have developed a theory to predict the most likely path a system will take between two quantum states. By tracking millions of quantum trajectories, they were able to demonstrate good agreement between theory and experiment.
Tropical Storm Genevieve weakened to a tropical depression on July 27, but reorganized and became a tropical depression again on July 30. Rainfall rates reached over 28.5 mm/hr near the storm's center.
Researchers investigated the impact of cellular senescence on adipose-derived stem cell morphology and function. The study found that senescence compromises the clinical application of these cells for peripheral nerve regenerative cell therapy. Senescence modulating factors influence adipose-derived stem cell behavior.
Infants born to HIV-infected mothers are at risk due to limited access to formula and breastfeeding challenges. Researchers advocate for immune-based interventions, including vaccines and nutritional supplements, to prevent postnatal HIV-1 transmission. The development of novel prophylaxis strategies is crucial to achieving an HIV-free...
Researchers at Dana-Farber Cancer Institute found that subgroups within tumors drive growth, rather than the fastest-proliferating cells. Targeting these growth-driving cells could improve treatment outcomes and prevent tumor expansion.
A new ecological model, called a mean field model for competition, incorporates the 'Red Queen Effect' and improves understanding of species evolution. The model predicts that new species with competitive advantages will evolve and outcompete current species.
A study analyzing 10 years of data on children with severe combined immune deficiency (SCID) found that early detection through newborn screening and transplantation significantly improves survival rates. Children transplanted before 3.5 months old had excellent survival, regardless of donor source or infection status.
Researchers from Clemson University have discovered that lipids play a crucial role in the adhesion mechanism of barnacle cyprid larvae, paving the way for novel anti-fouling paint for ships and boats. The findings also provide insight into the development of new bio-adhesives for medical and industrial applications.
Researchers from the University of New Hampshire found that decreased carbon dioxide levels led to the initiation of Antarctic glaciation 34 million years ago, contradicting a long-held theory. The study suggests that CO2-driven cooling played a crucial role in generating the ice sheet.
Researchers create colored plastics by designing surface structures at the nanoscopic level, manipulating light to produce a wide spectrum of colors. This new approach reduces the need for dyes and pigments, decreasing plastic waste and improving recyclability.
Eating about two servings of tree nuts daily improved blood sugar markers in participants with Type 2 diabetes. Tree nuts replaced refined carbohydrates rather than saturated fats yielded the best results.
Researchers at the University of East Anglia have developed a new diagnostic tool to distinguish between different types of dementia and memory damage. The model takes into account both semantic and autobiographical memories, leading to better approaches for rehabilitation.
Astronomers discovered a young binary star system with wildly misaligned planet-forming disks, providing the clearest picture yet of protoplanetary disks around a double star. The system's unique configuration suggests that planets may be influenced by the gravitational pull of a second star, leading to unusual orbits.
A study of over 4,100 New York State residents aged 60+ found that 2.7% were financially exploited in the past year, with 78% having their money or property stolen. Family members, particularly adult children, are the most common perpetrators.
A new study from the University of Toronto's Rotman School of Management found that institutional investors and analysts tend to overlook social norms when investing in 'sin' companies, such as tobacco, alcohol, and gaming firms. However, when performance expectations rise, these investors become more willing to compromise on their val...
Ancient insect inclusions in Baltic Sea amber reveal a surprising similarity with Asian forms, dating back 40-50 million years. This discovery fills a long-standing gap in the understanding of species migration between continents.
Drug-resistant malaria parasites have spread to critical border regions of Southeast Asia, posing a significant threat to global malaria control efforts. The study found artemisinin resistance in several countries, including Cambodia, Thailand, Vietnam, and Myanmar, with signs of emerging resistance in other areas.
A new study indicates that depression is a true risk factor for dementia and that targeting depression may help prevent cognitive decline. People with mild cognitive impairment were more likely to have higher levels of depression symptoms before diagnosis.
The black truffle genome contains a high rate of methylation, with transposon elements being more likely to be methylated than genes. Reversible epigenetic processes allow the truffle to adapt to its surroundings, increasing its plasticity and potentially playing a role in controlling traits like aroma and color.
A study published in Global Heart explores the prevalence of atherosclerosis across ancient populations, revealing that genetic susceptibility is present in all cultures. Environmental factors such as diet, lifestyle, and physical activity play a crucial role in determining when and how quickly atherosclerosis develops.
A Rutgers study found that household income is the primary factor influencing avoidable hospital visits in New Jersey, with higher incomes associated with lower rates of hospitalizations. The research also identified some low-income areas where hospital systems perform better than expected, suggesting that social determinants such as a...
A new study published in the American Journal of Psychiatry found that depressed preschoolers are more likely to suffer from depression in elementary and middle school years. The researchers followed 246 children and found that those diagnosed with depression as preschoolers were 2.5 times more likely to develop the condition later on.
A new study published in Menopause finds that lifelong soy consumption helps prevent atherosclerosis and improves cholesterol levels in premenopausal monkeys. After menopause, switching to a soy diet can also improve cholesterol levels, but has limited effect on plaque progression.