Researchers found that blood-forming stem cells falter with age due to DNA replication problems, leading to a decline in immune function. However, even old stem cells can repair induced DNA damage efficiently and retain molecular tags associated with DNA damage.
A study published in the British Journal of Cancer found that bladder cancer patients with high levels of the protein HIF-1α are more likely to benefit from a treatment called CON, which makes radiotherapy more effective. High levels of the protein were linked to better survival rates when patients had radiotherapy and CON.
A new open-source pipetting system, iPipet, uses an iPad to guide complex pipetting protocols, sharing expertise across research communities. The system has shown promising results in accuracy and efficiency compared to liquid-handling robots.
DWI-MRI predicts TIA patients who are at higher risk of disabling stroke, which can be prevented with immediate evaluation and treatment. Magnetic resonance imaging has changed the diagnosis of TIA from a time-based definition to a tissue-based one.
A new 'ramp control' anesthetic technique has been developed to simplify preoperative testing for patients with severe sleep apnea. The simplified approach allows doctors to visualize the site of airway obstruction in just four minutes, while achieving minimal drops in blood oxygen levels.
23andMe has received a $1.4 million grant from the National Institutes of Health to develop its web-based database and research engine for genetic discovery. The grant supports the utilization of whole-genome sequence data and imputation to discover rare variants associated with disease.
Rita Charon, a general internist and narratologist at Columbia University, has received the 2014 Gene D. Cohen Research Award in Creativity and Aging. Her work focuses on narrative medicine practice, reflective clinical practice, and health care team effectiveness.
A study published in the American Journal of Geriatric Psychiatry indicates that middle-aged adults with a history of problem drinking are more than twice as likely to suffer from severe memory impairment in later life. The research highlights the link between harmful patterns of alcohol consumption and problems with memory, which may ...
The study implanted 125I seeds into rat dorsal root ganglia to provide relief for neuropathic pain. Results showed elevated mechanical pain threshold without influencing motor functions, suggesting neuronal microdamage as the primary mechanism. The findings have potential implications for developing novel pain management therapies.
NASA's Goddard Space Flight Center team has demonstrated that electrostatically actuated microshutter arrays are as functional as magnetically activated arrays, eliminating macro-moving parts and lowering voltage needs. This advancement makes them suitable for Explorer-class missions and larger fields of view.
The new journal Neurophotonics adds to the rapidly growing understanding of the brain through advanced optical methods and applications. Key findings include photoacoustic tomography techniques that display brain activity with high accuracy, and novel technologies for brain energy metabolism.
Researchers at Cold Spring Harbor Laboratory have discovered a new function of the body's most important tumor-suppressing protein, p53. A previously unknown variant of p53 called p53-psi reduces cell adhesion and promotes metastatic potential by interacting with cyclophillin D and generating reactive oxygen species.
Recent findings at the Alken Enge site reveal a violent sequel to a major battle fought around Christ's birth, with four pelvic bones found tied together and bundles of desecrated bones uncovered. The remains were gathered, cleaned, and then brutally treated before being cast into a lake.
When worms mate with different species, their bodies are unable to tolerate the aggressive sperm, resulting in sterility and death. The sperm's premature fertilization of eggs and subsequent damage to the ovaries lead to these outcomes.
A study published in The Journal of Pediatrics found that preterm children's cognitive abilities as teenagers can be comparable to those born at term, if they experience no brain injury early on. The quality of the home environment plays a crucial role in brain development and cognition.
Researchers have discovered new materials capable of repelling bacteria, which could lead to a significant reduction in hospital infections acquired through implanted medical devices. The polymers have been licensed to a UK SME for clinical trials, aiming to inform rational design of improved bacteria-resistant polymers.
Researchers calculated the precise mass of the Milky Way and Andromeda galaxies, finding that Andromeda is about twice as heavy. The study also measured the expansion of the universe by observing satellite galaxies' motion, confirming cosmic expansion near our local group.
Researchers identified differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury, revealing changes in cell differentiation, cytokinesis, and immune response. The study provides insights into Wallerian degeneration and offers a platform for studying nerve injury and repair.
Researchers analyzed fails-to-deliver trades and found they were not responsible for falling stock prices. Instead, the study showed that these trades had a net beneficial effect on market liquidity and reduced volatility.
Research found that lower dopamine transporter binding correlates with stronger visual attention bias for food cues, detecting food pictures more quickly among neutral images. Higher dopamine activity was linked to increased food intake over a period of 7 days.
Barbara J. Bowers, PhD, RN, FAAN, of the University of Wisconsin-Madison, has been recognized with the GSA's 2014 Minority Mentorship Award. Her research focuses on frail older adults and quality of care, influencing public policies and organizational practices.
A lack of standards for experimental design and reporting hinders progress in developing therapeutics for spinal cord injuries. Implementing data standards and ontologies can facilitate transparency and analysis in neural plasticity and regeneration.
A new study found that urbanization in rural sub-Saharan Africa is associated with increased risk of cardiovascular and metabolic diseases. Living in more urban villages was linked to poorer lifestyle choices, such as physical inactivity and heavy drinking, despite the benefits of access to education, healthcare, and improved sanitation.
Researchers at Chapman University and Vienna University of Technology successfully separated a neutron from its magnetic field, defying classical notions of particle properties. The experiment utilized neutron interferometry to isolate the particle's spin from its direction of motion.
Scientists have identified a specific electrical pattern in the brains of genetically identical mice that predicts how well individual animals will fare in stressful situations. This finding may help prevent mental illnesses linked with stress, such as post-traumatic stress disorder and depression.
Research reveals maternal obesity alters offspring microflora composition, increasing firmicutes to bacteriodetes ratio and gastrointestinal permeability. This non-genetic factor may contribute to increased susceptibility to obesity and associated metabolic disorders.
Four major health institutions have partnered to create a Clinical Data Research Network, leveraging PCORI's $7 million funding. The network will study patient outcomes for obesity, atrial fibrillation and idiopathic pulmonary fibrosis, expanding research capabilities and collaboration opportunities.
Researchers at Rice University have developed a tough and ultralight foam using atomic-scale materials, with properties including high strain handling and bounce-back ability. The foam can be tailored to any size and shape, and its lightweight density is 400 times less than graphite.
Researchers at University of São Paulo identified INXS RNA, which modulates BCL-X gene and induces programmed cell death. Local injections of plasmid containing INXS reduced subcutaneous malignant tumors by 10-fold in mice.
The University of Maryland Schools of Dentistry and Medicine have received a five-year $10.7 million grant from the National Institutes of Health to study the causes, prevention, and treatment of sexually-transmitted diseases. The study aims to identify novel molecular biomarkers of susceptibility to STIs and disease severity.
A new study by University of Chicago Booth School of Business researchers found that campers who formed close relationships with members from the opposing side developed more positive feelings toward all members of that group. This effect was found to last long after returning home, even months later.
Gitlin, a renowned gerontologist, has made significant contributions to nonpharmacologic approaches in dementia care and aging in place. Her work aims to improve the lives of chronically disabled older adults and their family caregivers.
A recent study published in Conservation Biology found that the bumphead parrotfish, a major coral predator, has both positive and negative effects on reefs. The fish helps reduce algae abundance and disperse small coral fragments, but also consumes coral and reduces its diversity.
Research conducted on adolescent rats reveals that daily consumption of sugar-sweetened beverages can impair learning and memory functions. The study found significant inflammation in the hippocampus, a brain region crucial for memory, suggesting potential long-term effects on cognitive function.
Scientists have precisely measured the mass of the Milky Way for the first time, finding it to be approximately half the weight of Andromeda. The study, led by the University of Edinburgh, used data on galaxy distances and velocities to calculate the total masses of both galaxies.
Research by scientists at the University of Texas at Austin found that diet impacts male and female gut microbiomes differently. In some cases, different bacterial species dominate in one sex versus the other. This difference highlights the need for therapies to be tailored for each sex when it comes to nutrition-based treatments.
A 1996 research paper by Michael Pazzani and colleagues has been selected as the most influential from The Thirteenth National Conference on Artificial Intelligence. The paper introduced a system to personalize internet content based on user profiles, which has since become a common application of artificial intelligence.
Research finds that children of parents who spend more time cooking at home tend to make healthier food choices when eating away from home. Parents' reported food preparation time is inversely associated with energy density in their children's diet.
Research reveals that starting a diet at a younger age predicts several negative health outcomes in adulthood, including extreme weight control behaviors and obesity. The study's findings emphasize the need for public health initiatives promoting wellness behaviors in girls from an early age.
The human papillomavirus (HPV) infection affects both men and women, leading to genital warts and various types of cancer. Vaccinating boys against HPV can prevent these health issues and reduce the burden on healthcare systems.
Researchers found that brainwaves from a few individuals can accurately predict preferences of large TV audiences. The study used EEG to measure brain activity while participants watched TV shows and commercials, comparing the results to publicly available social media data and ratings from USA Today's Super Bowl Ad Meter.
Forest fires in the Northwest Territories have destroyed over 893,000 hectares of land, with lightning blamed for most fires. The ongoing wildfires are also affecting residents in Yellowknife, prompting residents to stay indoors due to unhealthy air quality.
A study by Helmholtz Munich found that extreme heat and cold increase mortality rates, particularly among the elderly with pre-existing medical conditions. The researchers observed a significant rise in cardiovascular events and stroke during hot temperatures and up to two weeks after cold weather.
Scientists at the University of Kent have discovered how cells regulate internal structures, known as actin filaments. The research could lead to new therapies for diseases like cancer.
Crohn's and Colitis Canada funds 9 promising research projects exploring genetic, environmental causes, symptoms, and treatment options for these debilitating diseases. The organization aims to improve patient care and quality of life for over 233,000 Canadians affected by Crohn's and colitis.
Researchers at the University of Pennsylvania have developed a new technique to help surgeons see the entire tumor during surgery, increasing the likelihood of a positive outcome. The approach uses an injectable dye that accumulates in cancerous tissues, allowing surgeons to remove the entire malignancy.
Researchers found a red blood cell folate concentration range of 1,000 to 1,300 nmol/L may prevent neural tube defects. This biomarker could inform folic acid fortification programs and monitor their success.
Scientists have developed a new method to monitor rainfall in West Africa using weakened cell phone signals, which could help cities prepare for floods and combat weather-related diseases. Meanwhile, researchers discovered that residual currents persist between lightning strokes, challenging current cutoff models.
The deep sea provides numerous benefits to society, including acting as a greenhouse gas sink, regenerating nutrients, and fueling the marine food web. However, rapid exploitation of its resources poses significant threats to its habitat and global impact, necessitating a global effort to protect and manage these vast habitats.
A comprehensive US study reveals that city governments closely match citizens' politics and policies, with liberal cities taxing and spending more. The research challenges the popular image of local governance being under the sway of machine politics or big-money interests.
A twin study found that brain appetite centers respond more to immediate nutritional needs than genetics and upbringing. The study used fMRI scans to compare identical twins' responses to high- and low-calorie foods, showing a greater response in the twin with lower blood glucose levels.
Researchers at Vienna University of Technology demonstrate a new quantum paradox where neutrons can be separated from their properties, allowing for more precise measurements. This 'Quantum Cheshire Cat' phenomenon shows that particles can exist in multiple states at once, making it ideal for applications requiring high precision.
Researchers will map out BRCA1 protein structures in healthy and mutated forms to identify molecular targets for new treatments. The goal is to improve treatment options for women with hereditary breast cancer.
A new study by Michigan State University finds that Teach for America alumni candidates prioritize both local and national issues in their school board campaigns. The research suggests that supporting TFA alumni to run for local offices is an effective way to advance the organization's agenda.
An international team of researchers devises precise method for calculating galaxy masses using gravity and expansion data. The new study shows the Milky Way has only half the mass of its neighbor Andromeda.
Researchers studied Vietnam War veterans' brain injuries to understand how the brain works. They found that brain regions contributing to social functioning also support general intelligence and emotional intelligence.
Researchers at Harvard-Smithsonian Center for Astrophysics propose that silicon-capped hydrocarbons like SiC3H, SiC4H and SiC5H may be responsible for the diffuse interstellar bands. The team analyzed laboratory spectra and theoretical calculations to support their hypothesis.
A study found that individuals low in satiety responsiveness are more likely to experience poor appetite control and overeat, particularly those with a preference for high-fat foods. Increasing almond consumption may help improve satiety responsiveness and increase control over food intake.
A NASA-funded X-ray instrument has confirmed that a region of million-degree interstellar plasma known as the local hot bubble is the main source of a foggy glow observed over the entire sky. The study also establishes upper limits on soft X-rays produced within our planetary system by solar wind.
Researchers created a model showing how Mercury's core dynamics contribute to its unusual magnetic field, which is three times stronger in the north than south. This finding indicates that planets have multiple ways of generating a magnetic field.