A study by Myriad Genetics presented at the 2014 European Society for Medical Oncology (ESMO) annual meeting shows that its Tumor BRACAnalysis CDx test identifies cancer-causing BRCA1/2 mutations in 44% more patients than germline blood testing. This could expand treatment options for ovarian cancer patients with these genetic mutations.
The DOE JGI Community Science Program selected 32 projects to study microbial communities in various environments, including those affected by hydraulic fracturing and coral reefs. The research will help understand the impact of environmental changes on these ecosystems and develop solutions for major energy and environmental problems.
Atzberger's research focuses on the intersection of math and science, exploring how proteins move within lipid bilayer membranes. He developed a statistical mechanics description that captures essential features of membrane-protein dynamics, allowing for simple yet reliable calculations and simulations.
Researchers from University of Southern Denmark and Institute of Chemical Technology in Prague have successfully created moving alcohol droplets in water, guided by salt concentration gradients. The system displays sophisticated behavior and can be controlled by external temperature stimulus.
A new study at Ohio State University reveals that people with low self-confidence need a vivid picture of their future success to pursue their career goals. The researchers found that students who were given detailed information about the benefits of becoming a business psychologist were more likely to apply for the program and showed ...
Researchers found a 37% reduction in energy consumption when using the Persuasive Technology and Energy Delegate (IPTED) method, which combined real-time feedback with peer social influence. The study showed that this approach can significantly reduce energy use among students if implemented in residential halls.
Phytoplankton are crucial for fish populations and Earth's carbon cycle, with a perpetual dance between predators and prey affecting their growth cycles. Tiny imbalances in this relationship cause massive phytoplankton blooms, impacting ocean productivity, fisheries, and carbon cycling.
Researchers from Brown University have introduced a new element of uncertainty into Burgers' equation to describe turbulence and shocks in fluid flows. This formulation aims to make mathematical models more realistic by accounting for external influences such as terrain, which was previously ignored in standard equations.
A nine-month study found that children who engaged in moderate-to-vigorous physical activity after school showed substantial improvements in attention, distraction avoidance, and cognitive flexibility. Brain imaging revealed widespread changes in brain function related to attention allocation and processing speed.
Researchers will explore interactions between natural gas and electricity systems, power and communication networks, healthcare and cyber infrastructure. The goal is to develop computational models that predict complex behavior in the face of disruptions or disasters.
A Stanford University study links California's ongoing drought to human-caused climate change, finding that a persistent high atmospheric pressure region over the Pacific Ocean is three times more likely to form in the present climate. This blocking ridge prevented winter storms from reaching California during the 2013 and 2014 rainy s...
Researchers have produced detailed maps of bedrock beneath glaciers in Greenland and Antarctica with NASA's support, helping to project future changes to ice sheets and sea level. The data will aid computer models used for glacier projection.
Researchers from CNIO have characterized a key protein interaction that regulates cellular proliferation; this discovery may aid in developing new anti-microtubule drugs to combat cancer. The study's findings provide insights into the molecular basis of microtubule assembly during cell division.
Phanfone is now a threat to various islands, with warnings and watches in effect for Saipan, Tinian, Pagan, and Alamagan. The storm is moving west-northwest at 11 knots, with forecasters expecting it to intensify into a typhoon after passing through the Marianas Islands.
A study found that warmer winters lead to earlier breeding in wood frogs, resulting in fewer eggs and delayed tadpole development. However, more rain and snow appear to increase egg production, potentially counteracting the negative effects of warming.
Granny Smith apples contain high amounts of non-digestible compounds that promote the growth of friendly bacteria in the colon. This can help stabilize metabolic processes and reduce inflammation associated with obesity.
New Tel Aviv University research reveals a single-neuron 'hub' orchestrates the activity of an entire brain circuit. The study finds that timely activation of cells is fundamental for proper operation of hub neurons, which orchestrate entire network dynamics.
A study by researchers links California's ongoing drought to human-caused climate change, showing a persistent region of high atmospheric pressure over the Pacific Ocean is more likely to form in modern greenhouse gas concentrations. The extreme conditions led to unusually low precipitation and triggered wildfires and air pollution.
University of Chicago physicists explain a mysterious effect found in superfluids, revealing it was due to whirlpool-like structures rather than exotic solitons. The result challenged accepted theories and sparked a scientific debate.
Carnegie Mellon researchers show viral DNA transforms from solid to fluid-like state at infection temperature, facilitating infection. This phase transition could be a promising new target for antiviral therapies, which may avoid drug resistance.
A University of Iowa study found that sleep twitches activate the brains of mammals differently than movements made while awake. Twitches during rapid eye movement (REM) sleep comprise a different class of movement and provide evidence that sleep twitches teach newborns about their limbs.
A new OSU study found that using a gas stove with ventilation reduces the risk of childhood asthma, wheezing, and bronchitis. Children who lived in homes with ventilation were 32-44% less likely to have these respiratory issues.
Researchers found that estrogen pre-activates the unfolded-protein response (UPR), a pathway that prepares cells to divide and grow. UPR activation is linked to cell proliferation and poor survival in estrogen-receptor-positive breast cancer, making it a potential prognostic marker.
A 2,330-year-old skeleton from southern Africa provides clues to early modern human prehistory and evolution. The study sequenced the man's mitochondrial DNA, revealing a unique genetic profile that sheds light on human origins.
Researchers found that adding rapamycin to an immunotherapy approach strengthened the immune response against brain tumor cells, increasing the effect of new therapies. The study also showed increased memory cells, allowing the immune system to attack tumors more effectively.
Researchers found that plant seeds can be pre-colonized with beneficial bacteria, providing enhanced microbial protection. This discovery has significant implications for creating food-safe antimicrobials and understanding the importance of early colonization in establishing a healthy microbiome.
A study of over 600 patients with acute kidney injury after cardiac surgery found that fenoldopam did not decrease the need for dialysis or mortality rates. Instead, it was associated with a higher incidence of low blood pressure.
Research suggests physical activity reduces type 2 diabetes risk, but its effect may vary by genetic factors. Women at high genetic risk show weaker protective effect of physical activity compared to men.
Commentaries in Annals of Internal Medicine argue that Proposition 46's mandatory physician drug testing could deter help-seeking and reporting, potentially harming patients. The authors instead advocate for addressing physician impairment through more nuanced solutions.
Researchers found that oleate, a common dietary fat, restored proper metabolism of fuel in an animal model of heart failure. This improvement enabled the heart muscle to access energy more efficiently and reduced toxic fatty byproducts.
A study by French researchers has found that dolphins are able to discriminate between objects based on their magnetic properties, indicating a magenetic sense. The findings provide new evidence for magnetoreception in cetaceans and suggest they may use this ability to navigate themselves.
Research suggests that self-compassion is crucial for maintaining a positive body image, despite weight fluctuations. Women with higher levels of self-compassion exhibit better eating habits and fewer concerns about weight, body shape or eating.
Human activities, particularly palm oil production, have led to significant fire emissions in Papua and New Guinea. The cleared land, often drained peatlands, dries out during the dry season, catching fire and releasing substantial amounts of greenhouse gases.
Researchers describe a novel liver-directed gene therapy approach that corrects heart symptoms in a model of rare enzyme disorder MPS I. The treatment, using an AAV vector, achieves sustained serum enzyme activity and reduces glycosaminoglycan storage in tissues.
The Brain & Behavior Research Foundation recognized eight scientists with Outstanding Achievement Prizes for their work on psychiatric disorders, affecting one in four people. Recipients include Drs. David Braff and Patrick Sullivan, who pioneered schizophrenia and mood disorder research.
The Growers Nation app offers information on optimal planting times and connects local growers to share tips. It aims to reduce food insecurity by encouraging diverse crops and adaptation to climate change.
Researchers found large droplets of triglycerides within neurons of mice modeling the disease, leading to potential therapies and a new investigative strategy. The study points to triglyceride metabolism as a key factor in hereditary spastic paraplegia.
Researchers used simulations to study primordial supermassive stars that may have exploded as supernovae, leaving no black hole behind. This process could create a distinct observational signature detectable by upcoming telescopes and enrich their host galaxy with heavy elements.
Montefiore Einstein Center for Cancer Care and Albert Einstein Cancer Center have been awarded a $3.4 million grant from the National Cancer Institute to conduct multi-site cancer clinical trials and research focused on reducing healthcare disparities in cancer care. The award will help change the burden of cancer, which is disproporti...
The charity will focus on understanding the root causes of cancer problems in Yorkshire and developing strategies to reduce cancer incidence and mortality rates. The investment will also support research into improving screening methods and increasing access to clinical trials.
In September 2013, Colorado experienced massive flooding triggering over 1,100 debris flows across a 3,400 square kilometer area. The floods were initiated on steep slopes with high areal concentrations of colluvial soils on sedimentary rocks.
Obstructive sleep apnea affects 25 million adults in the US, increasing risk of high blood pressure, heart disease, and depression. Effective treatment with CPAP therapy can reduce these risks and improve brain and heart health.
Alpha-synuclein regulates neuronal communication by self-association, clustering synaptic vesicles and restricting neurotransmission to manage communication. This newfound understanding may be critical for therapeutic interventions targeting alpha-synuclein levels and activity in Parkinson's disease.
MIT researchers develop a scaling law to estimate the risk of brain injury for humans and animals, revealing that humans are more vulnerable due to thinner skulls. The method may aid in diagnosing traumatic brain injury and developing protective helmets.
Researchers from CNIO have identified a new marker for cancer stem cells using riboflavin, a pigment that emits green fluorescence. This discovery enables the tracking of cancer stem cells in tumors, which are responsible for chemical resistance and tumor growth.
A phase 3 trial found that combining dabrafenib with trametinib significantly reduces disease progression and death risk in metastatic melanoma patients. The therapy results in a 67% complete or partial response rate compared to 51% on monotherapy.
A study at the University of Wisconsin-Madison examines how attorney representation and limited legal assistance shape access to justice for low-income civil litigants. The research aims to inform policy and intervention strategies to address the 'justice gap' faced by three-quarters of unrepresented individuals in the US.
Scientists at UC San Diego and Hebrew University found that nitrogen fingerprints in biomolecules can be explained by chemistry within the solar system. By generating ammonia with skewed ratios of nitrogen-15, they recreated the conditions that produce life's fundamental molecules.
Tropical Storm Kammuri is transitioning into an extra-tropical storm, characterized by a cold core and elongated strong storms moving from southwest to northeast. The storm's maximum sustained winds were near 45 knots on Sept. 29, and it is expected to continue weakening over the open ocean.
Hurricane Rachel strengthened into a hurricane on Sept. 27 but weakened back into a tropical storm by Sept. 29. NASA's Aqua satellite captured an image of the storm before it weakened, showing its organized bands of thunderstorms and cloud-filled eye.
Researchers will sequence the genomes of 10,000 people with European, Hispanic, and African-American ancestry to better understand two mental health disorders. The goal is to identify genetic targets for drug development and improve disease prediction.
A new preclinical trial will begin to confirm the HIV vaccine candidate's excellent results, led by Dr. Ruth Ruprecht and funded by the Bill & Melinda Gates Foundation. The study aims to provide mucosal protection and blood antibodies against infection.
Preliminary data from a phase III trial suggest nivolumab achieves better response rates and longer response durations than standard chemotherapy in patients with unresectable metastatic melanoma. The drug has a lower toxicity profile compared to chemotherapy, promoting a sustained immune response.
A study found that most FDA-clearanced implanted medical devices lack publicly available scientific evidence of substantial equivalence, safety, or effectiveness. The FDA has a process requiring companies to submit evidence, but it is often not publicly available, hindering independent judgment and public health.
The Greenland Ice Sheet is more sensitive to climate change due to the role of soft ground beneath it, which affects its dynamics and leads to increased ice loss. This study reveals that the ice sheet is vulnerable not only to warming temperatures but also to extreme meteorological events like heavy rainfall and heat waves.
Researchers found compounds in Camelina sativa seed that increase liver detoxification enzymes fivefold, showcasing its potential as a nutritional supplement and anti-cancer agent. The bioactive ingredients work synergistically when combined, similar to sulforaphane in broccoli.
Scientists from Brown University and MIT have discovered new details on how ADEPs bind to the ClpP complex in Mtb, a crucial step towards optimizing these compounds for TB treatment. Novel ADEP analogs show improved binding and activation of ClpP, paving the way for designing new drugs.
MaxBin facilitates genomic analysis of uncultivated microbial populations by automatically sorting their genomes from metagenomic sequences. The software uses an expectation-maximization algorithm to classify metagenomic sequences into discrete bins representing individual microbial species.
Rates of intestinal superbug C. difficile infections rose from 4.5 to 8.2 discharges per 1,000 hospitalizations between 2001 and 2010, despite no improvement in patient mortality rates. Antibiotic exposure remains the leading risk factor for CDI incidence.
Scientists discovered genes in humans that make repressor proteins to shut down specific jumping genes, a type of retrotransposon. The findings suggest an ongoing battle between mobile DNA sequences and the genes that control them, leading to the evolution of greater genomic complexity.