Researchers found that mitochondria unable to self-repair are responsible for muscle weakness in both long-time alcoholics and patients with mitochondrial disease. The study identified a key protein, Mfn1, involved in skeletal muscle cell fusion.
A study published in Avian Conservation and Ecology reveals that the iconic Blue-footed Booby population has declined by over 50% in less than two decades. The drastic drop is attributed to a lack of sardines in their diet, leading adult birds to elect not to breed, which in turn causes the population to shrink.
Parts of ancient Antarctica reached temperatures similar to today's California coast and Florida heat due to high CO2 levels. The study used a new method to measure past temperatures, providing insights into the sensitivity of the climate system to greenhouse gases.
Researchers applied a geostatistical approach to assess headwater stream chemistry at high resolution, finding patterns that vary over short and long distances. The analysis reveals the influence of landscape processes on stream network chemistry, challenging traditional assumptions about water quality.
Researchers have identified PPAR delta as a crucial molecule linking dietary fats to colon cancer progression. The study found that deleting PPAR delta in a mouse model of colon cancer stopped key steps required for tumor growth, providing new clues for developing therapeutics.
A recent study by Allina Health found that sharing clinical information with other health systems can avoid duplicative diagnostic procedures, such as blood work and imaging. By using the Care Everywhere tool, providers were able to eliminate 560 potentially duplicative diagnostic procedures.
Researchers have discovered a new role for Cullin-5 in killing cancer cells by targeting proteins that drive cell division. The study suggests a possible test to identify responsive patients and develop more effective drugs.
Researchers successfully used a new Krypton-dating technique to confirm the age of a 120,000-year-old sample of Antarctic ice. This technique provides an accurate means of confirming the age of ice samples, and allows scientists to reconstruct climate back as far as 1.5 million years.
A study of 429 crimes committed by 143 offenders with serious mental disorders found that only 7.5% were directly related to symptoms of mental illness. Most offenders who committed crimes with mental illness symptoms also had unrelated crimes for other reasons, such as poverty or substance abuse.
Short-term environmental enrichment exposure induces proliferation, activation and maturation of doublecortin-positive cells in the prefrontal cortex of adult guinea pigs. These alterations may be involved in learning and memory associated with the prefrontal cortex.
University of Houston junior Khanh Nguyen has been recognized as a 2014 Goldwater Scholar for her mathematical neuroscience research. She aims to pursue a Ph.D. in applied mathematics and apply her findings to medical and technological advances.
Wayne State University leads a two-and-a-half-year study on the imagination of high-speed rail in America, examining what motivates decision makers and users to champion or use trains. The research aims to understand how railway futures are shaped by urban growth plans and transportation visions.
Researchers found that activating a receptor, Gpr109a, can inhibit inflammation in the retina and prevent vision damage in diabetes. The new grant will enable long-term studies to evaluate the therapeutic potential of this approach.
New research outlines how regulations on alcohol and tobacco may inform policies on legalizing marijuana. The study aims to help policymakers understand the decisions they face while taking a public health approach.
Research by hydrologists and scientists found that the death of millions of trees in Rocky Mountain regions due to bark beetles increases groundwater flow and changes water quality. The study used water chemistry to identify the source of streamflow and found a significant increase in late-summer groundwater contributions.
Researchers have developed a low-cost material coating technique that mimics the Lotus effect, providing superhydrophobic properties. The technology can minimize fouling in heat exchangers and improve corrosion resistance.
Using the subway analogy, a physicist is applying queuing theory to study protein traffic jams in cells. By understanding these bottlenecks, he aims to discover mechanisms for alleviating them and develop new tools for synthetic biology. This research has the potential to impact areas such as development, inflammation and cancer.
Researchers at the University of Pittsburgh discovered a malfunction in the molecular 'proofreading' machinery that repairs DNA damage caused by ultraviolet (UV) light. The protein UV-DDB makes stops along the DNA strand and transiently attaches to it, causing a proofreading change in its conformation, preventing repair in damaged areas.
Researchers found that prior sleep deprivation enhances immune system response and recovery from infection in fruitflies. Flies with adequate recovery sleep after infection showed better survival rates compared to those without it.
The study found that tween TV programs, particularly 'teen scene' and 'action-adventure', reinforce traditional gender roles. Girls are often portrayed as attractive and concerned with appearance, while boys are shown to be brave and handy with technology. This can shape kids' perceptions of available roles in society.
Astronomers confirm first self-lensing binary star system, where the closer star's mass is measured by its magnifying effect on light from its companion. This discovery improves research on white dwarfs and galaxy age, using gravitational lensing to reveal new insights into these celestial objects.
A new approach called DICE aims to reduce behavioral problems in dementia by empowering caregivers, patients, and health providers. The DICE method involves Describe, Investigate, Evaluate, and Create steps to change dementia patients' behavior through environmental modifications and other interventions.
Researchers at Ohio State University found that microRNA-3151 promotes AML-cell growth and survival by blocking tumor-suppressor gene TP53. High expression of miR-3151 is associated with a bad prognosis, while inhibition with the drug bortezomib offers a possible therapy.
Researchers have found that narrowing of the carotid artery in the neck without symptoms is linked to problems in learning, memory, thinking, and decision-making. The study compared people with similar risk factors but no narrowing in the neck artery to those with carotid artery narrowing.
A recent study by Sandia National Laboratories and the TSA aimed to understand how transportation security officers' thought processes influence decisions made during baggage screening. The findings have helped improve the performance of TSA's security officers, particularly in switching between pre-check and standard passenger lanes.
Scientists at the University of Texas at Dallas are investigating the potential human health effects of multi-walled carbon nanotubes, tiny structures used in various products. The researchers will use advanced microscopy techniques to track how these nanotubes interact with human cells and determine their impact on health.
Researchers investigate quantum fluids and their chaotic motion at near-zero temperatures. The study aims to unlock the mysteries of this phenomenon, which has significant implications for daily life and galactic magnetic fields.
A third of Medicare beneficiaries not consistently assigned to the same ACO in both years, highlighting challenges to achieving organizational accountability. About 38% of outpatient care spending billed by ACO physicians was devoted to assigned beneficiaries.
A recent study published by the American Psychological Association found that students who felt threatened by their teachers' messages about failing performed worse on exams than those who did not. The researchers suggest that teachers should consider using more positive and supportive messages to motivate students.
A study by Fernanda Cristofori and colleagues found that 4.4% of children with irritable bowel syndrome (IBS) had celiac disease, compared to 0.3% in those without IBS. The prevalence was highest among IBS patients, who had four times the risk of developing celiac disease.
Researchers at Michigan State University have developed a promising new treatment for Parkinson's disease using a molecular tweezer that prevents protein aggregation. The molecule, CLR01, speeds up protein reconfiguration and has shown success in slowing the first step of aggregation, paving the way for clinical trials.
Researchers found that the river's supply of sand, a key ingredient for rebuilding marshlands, will remain constant for at least 300 years. The study suggests that despite reduced sediment loads, the abundance of sand in the lower Mississippi River channel will continue to replenish wetlands.
The study analyzed 224 strains of Yersinia family members, revealing parallel independent evolution of pathogenicity in species like Yersinia pestis and enterocolitica. The researchers found that acquisition of specific genes and loss of metabolic functions are key traits for pathogenic species.
The American College of Physicians advocates for a patient- and family-centered approach to physician training, recognizing the value of partnerships between healthcare professionals and their loved ones. The organization's proposal includes establishing guidelines for active participation of patients and families in medical care.
An Indiana University study found that immediately after Steve Jobs' death, more than a third of survey participants sought information about cancer in general and 7% sought pancreatic cancer info, highlighting the importance of using celebrities to educate the public about disease prevention and detection.
Scientists have found evidence that the Andes mountain range formed through periodic rapid pulses, not continuous gradual uplift. The Altiplano plateau rose by about 2.5 kilometers between 16 million and 9 million years ago, indicating a rapid rate in geologic terms.
Researchers used amino-functionalized carbon nanotubes to deliver nerve growth factor, improving complex dispersibility and reducing toxicity. This improved the promotion of cell differentiation in PC12 cells and chick embryo dorsal root ganglion.
Scientists have successfully directed charges through single molecules using a bi-layer arrangement of organic molecules, enabling precise control over electronic properties. This breakthrough brings us closer to nanoscale circuitry, which could be used in various applications such as OLEDs and biomedical devices.
A study reveals that SIRT1 is required for correct and safe cell reprogramming, ensuring healthy functioning of induced pluripotent stem cells. The protein helps maintain telomeres and prevents chromosome aberrations and DNA damage.
Researchers have identified a potential new class of nonsteroidal anti-inflammatory drugs that target the mPGES-1 enzyme, which reduces oxidative damage and slows atherosclerosis in macrophages. This could lead to safer pain relief options without increasing heart disease risk.
Researchers have developed a new technique using radiometric krypton dating to accurately determine the age of Antarctic ice, dating back up to 1.5 million years. This breakthrough could help reconstruct Earth's climate history and understand the mechanisms that trigger ice ages.
A team of researchers found that losartan, a commonly used hypertension drug, prevents post-traumatic seizures in a rodent model of the disease. The study suggests that blocking the TGF-beta receptor with losartan stops the cascade of steps that lead to localized inflammation and permanent brain damage.
A new study from UCSF found that codeine is frequently prescribed to children in US emergency rooms, with up to 877,000 prescriptions per year. The researchers recommend using safer alternatives like ibuprofen or hydrocodone, and changing prescribing patterns to reduce codeine use.
Common edible flowers in China have excellent antioxidant capacity due to their high phenolic content, which has anti-inflammatory activity and a reduced risk of cardiovascular disease and certain cancers.
Researchers developed an assay to analyze poly-G repeat mutations in human cancer samples, revealing evolutionary relationships among tumor sites. The study found that individual patients had varying levels of genetic differences between primary tumors and metastases, suggesting early or late metastatic spread.
Women with false-positive mammogram results experienced moderate to extreme anxiety, yet remained more likely to undergo future breast cancer screening. The study found a significant association between false-positives and increased anxiety, but not necessarily changed plans for future screening.
Researchers at Lomonosov Moscow State University and Pittsburgh University have identified a new biosynthetic pathway for lipid mediators, producing molecules that regulate inflammation and cell death. The study's findings could lead to the development of new anti-inflammatory drugs.
Tropical Cyclone Jack strengthened quickly after forming on April 20, but strong vertical wind shear is expected to weaken the storm. The Joint Typhoon Warning Center notes that despite this, the storm continued to build thunderstorms and elongate to the southeast.
A recent study published in The ANNALS found that more than 30% of undocumented migrant laborers are victims of labor trafficking, while 55% experience other forms of labor abuse. The research highlights the importance of improving working conditions for vulnerable workers and addressing the root causes of exploitation.
Researchers found that participants were more likely to forget justifications for atrocities committed by Afghan soldiers than American soldiers. However, they showed no memory impairment for unrepeated justifications when the perpetrator was American, highlighting the role of in-group membership in shaping memories.
Researchers found three key binding sites that contribute to the induction of the anesthetic response, affecting sodium channel function and inducing anesthesia. The study's findings provide new insights into the molecular basis of general anesthesia.
Research by Sang-Moo Kang of Georgia State University found that ginseng can improve survival rates of human lung epithelial cells infected with the influenza A virus. Red ginseng extract also reduced inflammation and improved immune response. Additionally, Korean red ginseng extract inhibited RSV replication and suppressed inflammator...
An international team of researchers, led by a plant scientist at the University of California, Davis, reports that the domesticated chili pepper originated in central-east Mexico. The region, extending from southern Puebla and northern Oaxaca to southeastern Veracruz, was previously thought to be less suitable for the crop's origins.