Sanford-Burnham will present various cancer research findings at the AACR annual meeting, including novel methods of drug delivery and novel targets for breast, melanoma, and prostate cancers. Researchers will also discuss epigenetic mechanisms and cancer metastasis.
A study found that ER doctors often overlook or misdiagnose early signs of stroke in women, minorities, and younger patients, leading to potential harm. The research estimates that tens of thousands of Americans may be affected each year, with prompt treatment crucial for preventing long-term health issues.
Ginsenoside Rb1 attenuates damage to cerebral cortex neurons by downregulating nitric oxide, superoxide, and tumor necrosis factor-α expression in hypoxia-activated microglia. The study suggests that ginsenoside Rb1 is a promising candidate for clinical use in preventing neuronal degeneration following cerebral ischemia.
Researchers have identified a genetic association with facial asymmetry in an ancient cavefish, which may help solve mysteries surrounding cleft palate and hemifacial microsomia. The study used high-tech imaging techniques to compare the craniofacial features of cavefish with those of surface-dwelling fish.
Jean-Marc Kaufman receives prestigious award for his groundbreaking work on osteoporosis and ageing in men. He has advanced our understanding of sex steroids' regulation and action in health and disease.
Researchers at the University of Wisconsin-Madison discovered that calcium waves can transmit information in plant cells, allowing them to respond quickly to environmental stressors. The team found that these waves are involved in processing information and sending rapid signals to help plants adapt to changing conditions.
As baby boomers reach retirement age, states face high workforce turnover and potential disruption to government operations. Research suggests that restructuring deferred retirement incentives can encourage employees to remain on the job longer.
Researchers at the University of Texas MD Anderson Cancer Center found that blocking prolactin signaling can induce autophagy in cancer cells, leading to their death. In preclinical research, treatment with a prolactin-mimicking peptide reduced tumor weight by 50% and led to increased expression of autophagy genes.
A research team developed a force sensing skin that can identify potential bruising locations on a child surrogate to differentiate between accidental trauma and child abuse. The system provides a roadmap documenting a child's exposure to impact, critical for forensic analysis.
A University of Wisconsin-Madison researcher has pinpointed an error in protein formation that could be the root of amyotrophic lateral sclerosis. Motor neurons that control foot muscles are affected due to a shortage of one of three proteins in neurofilaments, leading to tangles and nerve fiber malfunction.
Researchers discovered that Homo's teeth decreased in size as its brain size increased over 2.5 million years, defying evolutionary expectations. The study attributes this phenomenon to a shift towards a higher animal-based diet, which provided essential nutrients for brain development and social advancements.
SRPK1 acts as a tumor suppressor when abundant and promotes cancer when scarce, according to researchers at UC San Diego. This unexpected dual role is crucial for understanding tumorigenesis in humans.
A study published in Cell Reports found that 90% of osteosarcomas, the most common childhood bone tumor, have mutations in the TP53 gene. This alteration helps explain why standard doses of radiation therapy are largely ineffective against these tumors.
A prospective cohort study found that higher total folate intake was associated with a lower risk for exfoliation glaucoma (EG)/suspected exfoliation glaucoma (SEG). The results showed a trend of reduced EG/SEG risk with higher folate intake, particularly from supplements. This supports a possible causal role of homocysteine in EG/SEG.
Scientists have discovered a late Triassic tectono-thermal event in southern Mexico, synchronous with a magmatic arc hiatus, suggesting flat-slab subduction. Additionally, research has found evidence of giant mantle plume activity in ancient Australia and Argentina, providing insight into the Earth's thermal structure.
A new study published in The Lancet found that expensive, intense physiotherapy sessions do not provide additional benefits over a single session of education and advice with phone follow-up. The study supports previous claims that longer physiotherapy programmes offer minimal added benefit for acute whiplash-associated disorders.
The IPCC report highlights the urgent need for actions to adapt to climate change and ensure food production and security. Innovative solutions, such as improved crop varieties and livestock breeds, can significantly lessen negative impacts.
A study of 176 pre-pubertal boys found that high levels of protein intake combined with rigorous physical activity led to increased bone mineral content and density. This synergy between high protein intake and exercise was shown to positively impact bone structure and strength, even from pre-puberty through mid-late adolescence.
A decade-long study reconstructed the hummingbird family tree and found that they have been diversifying rapidly and adapting to novel environments. The researchers discovered nine principal groups or clades, a unique relationship with flowering plants, and continued spread into new geographic areas.
Researchers extracted biochemicals from genetically modified tomatoes and compared them to non-GM varieties. The study found no significant differences overall, but did identify a difference related to fruit ripening. This approach has potential for use in breeding programs and addressing consumer concerns about GM foods.
A recent study found that Caucasian male children have the highest prevalence of color blindness, with 1 in 20 testing color blind. Researchers also found that African-American males have the lowest rate of color blindness, and girls have a significantly lower prevalence than boys.
A team of researchers from China's State Key Lab of Mechanics and Control of Mechanical Structures introduced innovative strategies for ultrasonic manipulation by employing various acoustic streaming fields. This enables the diversification of manipulation functions and samples, widening the application range of the technique.
A case report documents a 27-week-old premature infant's cardiopulmonary arrest after receiving Cyclomydril eyedrops during retinopathy of prematurity screening. Pediatric ophthalmologists should be equipped to handle such emergencies, as the eyedrops can cause serious side effects due to systemic absorption.
Michigan State University researchers found that attracting wild bees to farms can increase yields by 10-20 percent and boost revenue. The study showed that adding habitat for wild bees can improve pollination in nearby crop fields and is an insurance policy against poor pollination.
A new study from Beth Israel Deaconess Medical Center suggests that upwards of half of high-risk drinkers experience improved behavior post-weight loss surgery. Seven percent of patients who did not show signs of high-risk drinking at baseline later developed the condition, highlighting the need for better screening and monitoring.
A University of Alabama researcher advocates for a greater emphasis on the body's metabolites in understanding illnesses, highlighting their potential to predict heart disease and response to environmental change. The study used fruit flies as animal models and identified nine new metabolites that are good predictors of these traits.
Researchers at the University of Bristol have developed a scheme to enable quantum cryptography on mobile phones, using photons as information carriers. This breakthrough technology has the potential to make secure communication available to the general public.
A new Global Cardiovascular Disease Atlas shows that wealthy countries are reducing their burden of heart disease and stroke, while developing countries are experiencing mixed performance. The atlas uses disability-adjusted life years (DALYs) to measure the burden of CVD in each region and country.
Researchers at Northwestern University are observing the closest approach between Sgr A*, a supermassive black hole, and gas cloud G2, which could reveal insights into black hole growth. The data from Chandra X-ray Observatory and Very Large Array may provide clues about the feeding habits of these massive objects.
A new study found that cigarette smoking among obese women interferes with their ability to taste fats and sweets, making them more likely to consume high-calorie foods. The study suggests that this may contribute to the consumption of more calories, exacerbating weight-related health issues.
A study analyzed 21,741 tweets to understand the instant expression of migraines in social media. The findings showed that females account for 74% of migraine tweets and the US accounts for 58% of global tweets. Migraine attacks impact mood, productivity, and quality of life, with 44% reporting immediate effects.
Researchers at Douglas Mental Health University Institute have discovered that dopamine is present in the hippocampus and plays a key role in this region. This finding opens up new avenues for understanding psychiatric diseases such as schizophrenia and may lead to the development of new therapeutic approaches to improve symptoms.
Researchers developed a new computer model to help plant scientists breed better soybean crops, achieving 8.5% productivity gains while reducing water usage by 13%. The model uses numerical optimization to explore structural traits like leaf distribution and reflectivity.
Researchers engineered trees to break down lignin, a polymer found in wood that hinders paper production, using genetic modification. This breakthrough aims to reduce chemical use and create fewer environmental pollutants, making paper production more sustainable.
Fencing for wildlife conservation has costs, including the loss of predators and other species, which can lead to further local extinctions. Alternative approaches, such as improved animal husbandry and community-based crop-guarding, can be more effective in mitigating human-wildlife conflict.
Researchers have discovered a mid-Cretaceous greenhouse world, with superhigh sea-surface temperatures that prevailed during the Oceanic Anoxic Event 1a. Additionally, scientists have identified impact spherules in Karelia, Russia, which may be linked to the 2.02 Ga Vredefort impact event.
The University of Liverpool has been awarded £2M for a state-of-the-art DNA synthesis facility, GeneMill, to support genome engineering in academia and industry. The lab will provide rapid, cost-effective, and accessible fabrication facilities for DNA parts, enabling researchers to focus on designing and testing re-engineered organisms.
Researchers at Lund University have developed a technique using magnetically controlled nanoparticles to selectively kill cancer cells while sparing healthy tissue. This method has the potential to revolutionize cancer treatment by reducing side effects associated with traditional therapies.
The International Osteoporosis Foundation (IOF) awarded the IOF President's Award to six osteoporosis experts from Asia-Pacific, Eastern Europe, Latin America, Middle East, Western Europe, and North America. The winners were recognized for their outstanding contributions to education and awareness of osteoporosis worldwide.
Researchers discovered reduced dimensions of key cerebral veins after deep brain stimulation in Parkinson's disease patients. This finding suggests that bilateral subthalamic nucleus stimulation affects cerebral venous blood flow.
Researchers have developed a new drug delivery method that targets cancer cells using nanoballoons encapsulating anti-cancer drugs. The nanoballoons release the drugs when struck by a red laser, limiting interactions with healthy bodily systems and reducing side effects.
Researchers developed tiny biomolecular tweezers to study mechanical forces' impact on cell and protein activity. The devices precisely stretch cells and molecules, allowing simultaneous analysis of multiple samples, enabling high-throughput assessment of force effects on a broad scale.
Frail elderly people living in residential care facilities are at increased risk of severe illness or death from viral gastroenteritis. Prompt notification of outbreaks to public health units led to a shorter outbreak duration.
A new study from Michigan Medicine and the Veterans Affairs Ann Arbor Healthcare System found that a record 72% of elderly Americans completed living wills in 2010, up from 47% in 2000. Despite this increase, hospitalization rates and deaths in the hospital remained largely unchanged over the decade.
Scientists discovered a relationship between the time of the Moon-forming event and material added to Earth, forming a 'clock' to date the Moon. The new method estimates the Moon's age to be 95 ±32 million years after the beginning of the solar system.
A recent study by Manja Voss challenged the validity of the extinct sea cow species Halitherium schinzii, citing a single tooth as insufficient evidence. The proposed rejection of this specific terminus aims to better handle the known diversity of the sirenian order.
The Ocean Health Index assesses ocean health across 10 categories, with Brazil scoring lowest in Natural Products and Food Provision. The index provides a framework for strategic management of ocean resources, with opportunities for improvement identified in various states.
Researchers at Dartmouth developed a more accurate and safer treatment for pancreatic cancer by analyzing pre-treatment CT scans. The study found that blood volume in tumors is a key predictor of treatment response, making PDT easier, faster, and more effective.
A San Francisco State University study reveals that consumers prioritize value over happiness when making purchasing decisions, leading them to spend on material items. Researchers found that people underestimate the monetary value of life experiences, which can be difficult to quantify.
Researchers developed a novel tree-planting technique to combat desertification by protecting seedlings from high temperatures. The technique involves using tubes to reduce soil temperature and increase survival rates of desert plants like Haloxylon ammodendron.
The Joint Programme on Antimicrobial Resistance (JPIAMR) has presented a strategic research agenda to tackle the growing threat of antibiotic-resistant bacteria. The initiative brings together 19 countries and aims to improve current antibiotics, diagnostics, and prevention strategies to minimize the spread of resistance.
Researchers at Lifespan have developed a blood test that can predict a person's risk of sudden cardiac death with high accuracy, enabling more targeted and efficient assessment of patients' needs for implantable cardiac defibrillators. The test is expected to refine the need for such devices and reduce overuse of ICDs.
A healthy diet may improve health outcomes in older adults, reducing hospital stays, but increases spending on outpatient services and preventive care. The study highlights the need for nutrition policies that address socioeconomic disparities.
A team of Brown University researchers have developed a methodology to integrate mindfulness experiences with brain imaging, allowing for the formation of testable hypotheses about the science and mental health benefits of meditation. By employing structured coding of self-reported personal experience, they can correlate mental states ...
A study of over 7,000 children found that most had eczema symptoms persisting into their 20s, suggesting the condition is likely to be a lifelong illness. The study suggests physicians should inform children with mild to moderate AD that it is a lifelong illness.
A study found that two days of larval food restriction can reduce adult monarch butterfly wing size by approximately 2% and affect wing pigmentation. Limited access to milkweed stunts monarch wings, which could impact migration success.
Research from the Children of the 90s study at the University of Bristol found that men who started smoking before age 11 had sons with significantly higher body fat content compared to those who started smoking later. This study suggests a potential transgenerational effect of tobacco exposure on metabolic changes in the next generation.
Researchers successfully tested a compact radar system on a small Unmanned Aircraft System to map glacial topography beneath rapidly moving glaciers. The technology promises to make high-resolution ice measurements more accessible to the research community.
The study found that positive thinkers had less brain activity during a task where they were asked to put a positive spin on graphic images, while worriers showed increased activity. This suggests that positive thinking may be harderwired in the brain and could have implications for how negative thinkers approach difficult situations.
Physician Emil J Freireich and scientist Jim Allison have been elected as fellows of the American Association for Cancer Research Academy, known for their contributions to cancer treatment and immunotherapy. Their work has driven significant innovation and progress against cancer, leading to improved survival rates for patients.