Researchers at Stanford Medicine have developed a highly sensitive and specific blood test that can accurately identify stage-1 lung cancer patients and detect rare cancer mutations. The CAPP-Seq technique analyzes tumor DNA in the blood to provide non-invasive monitoring of cancer progression and treatment responses.
Researchers at Arizona State University have developed a technique to identify amino acids, including subtly modified variants, by analyzing electrical activity signals. This breakthrough advances the prospect of clinical protein sequencing and discovery of new biomarkers for diseases such as cancer and Alzheimer's.
Researchers have found several molecular alterations that drive the cancer, including mutations and epigenetic changes. The study identifies potential new targets for drug treatments, including existing drugs that could block specific mutations.
Researchers developed an optical diode with nonreciprocal light transmission, eliminating backflow of light. The device enhances light transmission in one direction, leading to faster and cooler computers.
Researchers from Fox Chase Cancer Center found that NEDD9 protein activates oncogenic signaling pathways in cancer cells, encouraging metastases. The study suggests the protein plays an important role in initial development and dissemination of ovarian cancer.
Researchers use optogenetics to study skin cells called Merkel cells, which play a crucial role in sensing fine details and textures. The discovery may lead to the development of new prosthetics and treatments for skin diseases.
A clinical trial found that six months of hormone therapy added to radiotherapy significantly reduces the risk of prostate cancer relapse and progression. Men who received both treatments had a nearly 50% lower risk of biochemical progression compared to those treated with radiotherapy alone.
Research published in Diabetologia suggests Sweden may have 2-3 times more adolescents and young adults with type 1 diabetes than estimated. The study used a new method to estimate incidence rates among young people, finding a significant disparity between previous estimates.
A gene therapy approach using adeno-associated virus (AAV) successfully treated heart disease in mice with Friedreich's ataxia, restoring full functionality to the hearts. The treatment, which introduced a normal copy of the FXN gene, prevented the development of heart disease and even fully cured advanced-stage cases.
Researchers develop a technique to trick prostate cancer cells into using more glucose for imaging via PET scans, reducing the need for repeated biopsies. This method has potential therapeutic applications by cutting off cancer cells' energy supply from lipids.
Researchers found that arid ecosystems, which cover nearly half the earth's land surface, can take up a significant amount of carbon as CO2 levels rise. The study suggests that these ecosystems could account for 15-28% of current carbon absorption, potentially offsetting 4-8% of current emissions by 2050.
A third of ICU survivors develop depression manifesting as physical symptoms, such as weakness and fatigue, rather than psychological symptoms. Depression is four times more common than PTSD after critical illness, highlighting the need for new treatment approaches focusing on physical rehabilitation.
Researchers found that women who underwent radiotherapy for breast cancer have a small but significantly increased risk of developing a primary lung tumour. The risk increases with the amount of radiation absorbed by the tissue, with an estimated relative risk of 8.5% per delivered Gy to the lung.
A field study has demonstrated that elevated carbon dioxide inhibits the conversion of nitrate into protein in a field-grown crop, compromising the nutritional quality of food crops. This finding indicates that the nutritional quality of food will suffer as climate change intensifies.
Researchers at Scripps Research Institute discover a dual-sensor system for the sense of touch, involving Merkel cells and nerves. The study provides new insights into how gentle touch sensations are detected by the skin.
A combined computational and experimental study reveals arrays of gear-like molecular-scale machines that rotate in unison when pressure is applied to self-assembled silver-based superlattices. The superlattice structures form layers with hydrogen bonds acting as 'hinges' to facilitate rotation.
Renal cancer cells grow rapidly when placed in a pro-growth matrix supported by an enzyme typically found in the brain. Inhibiting this kinase halts cancer cell division and spread, suggesting its role in cancer growth.
Researchers from the University of Otago used mapping methods to track smoking visibility in public areas of downtown Wellington. They found that up to 116 smokers could be seen outside bars and cafés, highlighting the need for smokefree policies to reduce the normalisation of smoking.
Researchers have discovered new mutations linked to high-grade glioma brain tumors in young children, which most often occur in the youngest patients. The study found that ACVR1 mutations were present in 32% of DIPG patients and NTRK fusion genes drove tumor development in non-brainstem HGGs.
Researchers found that circumcised men were 45% less at risk of developing prostate cancer than uncircumcised men. The protective effect was strongest among black men, who were 60% less likely to develop the disease if circumcised after age 35.