Researchers discovered that tamoxifen blocks symptoms and progression of myeloproliferative neoplasms by targeting hematopoietic stem cells, potentially leading to effective therapy for certain blood disorders.
A study combining data from 12 British studies found that men are stronger than women after adolescence, but both reach peak strength in their thirties before weakening with age. The research provides reference charts for grip strength at different ages, aiding the identification of weak grip strength and potential health risks.
Liron Bar-Peled's research explores how environmental cues regulate eukaryotic cell growth through the mTORC1 signaling pathway. His work has implications for understanding human diseases such as cancer and primary immune disorders.
A large study found that the benefits of regular low-dose aspirin in healthy women are outweighed by its drawbacks. However, limiting its use to women over 65 may lead to a better balance between risk and benefit. The study involved nearly 30,000 women aged 45 and above.
Researchers found that rising greenhouse gas concentrations played a key role in causing more rainfall in two major regions of Africa, transforming desert into grasslands and savannas. The study validated the Community Climate System Model's predictions for future climate changes in Africa.
Scientists found that El Niño fuels intense hurricanes in the region by altering atmospheric conditions, providing additional energy to tropical cyclones. The study reveals an oceanic pathway bringing heat into the basin two or three seasons after winter peak.
A new image processing technique developed by Disney Research Zurich enables video effects like detailed actor faces despite lighting changes. The local tone mapping method preserves rich visual detail while eliminating ghosting and camera noise.
A genetic variant linked to heavy smoking is associated with lower BMI in current smokers but higher BMI in people who have never smoked. This difference suggests the variant influences BMI via pathways other than smoking.
A group of economists and lawyers recommend updating the Social Cost of Carbon estimate every five years to incorporate the latest research, ensuring its reliability. The authors argue that a single estimate should be maintained and shared by all government agencies to provide consistent climate policies.
A recent study found that modern monitoring systems in hospitals generate an alarming number of false positives, leading to alarm fatigue. The researchers collected data on 461 adults and discovered 88.8% of arrhythmia alarms were false positives, mostly due to algorithmic errors or non-actionable events.
A small group of hunter-gatherers in Southern Africa remained isolated and distinct from other African ethnicities for most of the past 150,000 years. Their genetic history reveals limited gene flow with non-Khoisan populations.
Research team led by Miguel Soares discovered that specific bacterial components in the human gut microbiota can trigger a natural defense mechanism against malaria. High levels of circulating anti-alpha-gal antibodies induced by vaccination are highly protective against malaria transmission.
Researchers used X-ray laser to capture PYP photocycle with atomic spatial resolution and ultrafast temporal resolution. The study revealed finer details of the cycle, including steps shorter than 1 picosecond.
The campaign aims to reduce high salt intake in India, which is estimated to be around 10-12 grams per day, contributing to poor sodium to potassium balance. By adopting a healthy lifestyle and restricting salt consumption, experts hope to prevent hypertension, cardiovascular disease and stroke.
Researchers at Vienna University of Technology have redefined the atomic structure of magnetite, a crucial component in electronic devices and medical applications. The study reveals that the surface of magnetite is governed by missing iron atoms, leading to an efficient catalyst for chemical reactions.
A new study from Rice University's Baker Institute finds that NFL players are seeking out unproven stem cell therapies to accelerate recoveries, despite potential risks. The authors suggest the NFL should establish guidelines and regulate these treatments to protect player health.
The SAGE Young Scholars Awards recognize exceptional contributions by young scholars in social-personality psychology. This year's winners, Clayton Critcher, Emily Impett, Nicholas Rule, Jenessa Shapiro, and Jay Van Bavel, will receive $5,000 awards to support their research or travel-related endeavors.
A randomized controlled trial found that intranasal ketamine is effective in treating moderate to severe pain in children with limb injuries. The study showed improved pain relief and satisfaction rates compared to fentanyl, with fewer adverse events reported for ketamine.
Research at Brunel University London found that increasing breastfeeding duration can save the NHS £31m annually by reducing infant illnesses. The study suggests that doubling breastfeeding duration could lead to significant cost savings, with a potential total of £40m per year.
A new study published in The Lancet Diabetes and Endocrinology found that obesity can decrease life expectancy by up to 8 years. Researchers used data from the National Health and Nutrition Examination Survey to develop a model estimating annual risk of diabetes and cardiovascular disease in adults with different body weights.
Scientists have identified 30 new spider species in the Xishuangbanna tropical rainforest, a significant find considering the region's rich biodiversity and untouched terrain. This discovery underscores the importance of preserving these ecosystems, which are home to numerous untapped species.
A UT Dallas professor applied robot control theory to create powered prosthetics that can dynamically respond to the wearer's environment, enabling amputees to walk at speeds of over 1 meter per second. The new approach simplifies the human gait cycle into a single variable, allowing for more stable and natural movement.
Researchers found that Old World fruit bats produce bio-sonar clicks with their wings, enabling them to find their way in the dark. The ability is poorer than that of other echolocating species, but provides insight into how echolocation evolved over time.
A UCLA study suggests targeting 'hot zones' in sub-Saharan Africa could significantly reduce the spread of HIV. The research found that focusing on areas with higher risk of infection would prevent 40% more new infections than traditional strategies, making it a cost-effective approach.
Researchers discovered a counter-intuitive current induced by sound waves in a disordered environment. Noise fluctuations lead to directed electron transport behavior and current reversal, paving the way for innovative semi-conductor devices.
Historians, ethnologists, philosophers, and law historians will collaborate to shed light on global historical issues from ancient times to the present day. They aim to compare cultures and epochs to provide highly generalised findings.
A new wireless brain sensor enables researchers to study neural circuit activity in animal models without cables or wires. The device transmits rich neuroscientifically meaningful signals from the brain during sleep, wake, and exercise.
A team of scientists found that a specific chemical modification on RNA plays a key role in determining the ability of embryonic stem cells to adopt different cellular identities. Depleting or knocking out this component blocks stem cells from differentiating into specialized types of cells.
Researchers have developed a method to extract audio information from high-speed video recordings by detecting vibrations caused by sound waves. The technique, reported in the SPIE journal Optical Engineering, uses an image-matching process based on vibration from sound waves and can recover spoken words from videos.
Researchers demonstrate that the innate immune system recognizes weaker cells and activates programmed cell death, eliminating them in a process called cell competition. This phenomenon has implications for cancer research and early disease detection.
A study published in Genetics in Medicine found that most new parents are interested in genomic sequencing for their newborns. The study surveyed 514 parents within 48 hours of birth and found that 82.7% were somewhat, very, or extremely interested in the testing.
Whole-organism performance capacities are subject to life-history trade-offs with other key determinants of fitness. This approach offers significant promise for understanding ecology and evolution of performance traits.
A recent study published in the New England Journal of Medicine found that crizotinib significantly improves symptoms and delays cancer growth in patients with ALK-positive non-small cell lung cancer. The trial involved 343 previously untreated patients, showing promising results without unexpected side effects.
The EU Industrial R&D Investment Scoreboard shows that EU companies invested €162.4 billion in R&D in 2013, while US and Japanese companies invested more. The European Commission is calling for a boost in R&D investment to keep up with global competitors.
A study found that decreased blood levels of Klotho increase the risk of heart disease in mice with chronic kidney disease, suggesting potential treatment strategy to protect kidney disease patients' heart health. If confirmed in humans, increasing Klotho levels may help protect the hearts of patients with chronic kidney disease.
Scientists at VCU Massey Cancer Center use computer modeling to predict which patients are at greatest risk for developing GVHD after stem cell transplantation. The researchers found that minor histocompatibility antigens play a crucial role in shaping the development of T-cell clonal families.
A team of archaeologists has discovered evidence of frankincense being used in Roman burial rites in Britain, shedding new light on the country's funerary practices. The analysis of debris and skeletal remains from across Britain revealed that these precious substances were transported to the empire's northern outpost despite its decline.
Researchers from Leibniz University Hannover and PTB have successfully demonstrated the on-demand emission of electron pairs from a semiconductor quantum dot. The resulting electron pairs were found to be spatially separated with over 90% efficiency, a crucial step towards future applications such as quantum computing and cryptography.
New Caledonian crows exhibit preferences for holding tools on the left or right sides of their beaks due to their unique binocular vision. This adaptation enables each bird to maintain visual control over its tool, with one eye seeing further than the other towards the opposite side of the head.
Researchers found that humans are susceptible to typhoid fever due to the absence of enzyme CMAH, which reconfigures sugar molecules on cell surfaces. This discovery has implications for developing new therapies for typhoid fever.
Resveratrol, a natural substance found in red wine, has anti-inflammatory effects on cardiovascular diseases by binding to the KSRP regulator protein and activating it. This activation reduces the stability of messenger RNA, resulting in lower synthesis of inflammatory mediators.
A new study published in the American Heart Association journal Stroke found that CT scans taken within 24 hours of a mild, non-disabling stroke can identify patterns of damage associated with different levels of risk for a subsequent stroke. The analysis revealed that patients with certain types of brain damage were at a higher risk o...
Ramy Arnaout has been awarded a two-year grant to analyze antibody repertoires of over 1,000 Americans to clarify the link between antibodies, cardiovascular disease, and aging. The goal is to determine individual treatment needs for patients with cardiovascular disease.
A study found that fear of police, language barriers, and lack of knowledge about cardiac arrest symptoms hinder Latinos from seeking emergency medical help. The participants also expressed strong reticence about performing CPR due to cultural fears and misconceptions.
The study will enroll 200 Rhode Island Family Court-involved girls between 12-18 in either VOICES, a gender-responsive program or other community-based services. Researchers aim to identify the program's effect on reducing drug use and sexual risk behaviors.
A new study from the University of Florida and Northwestern University found that children with higher birth weights perform better in school, regardless of family background. The research, which analyzed data from over 1.6 million children, suggests that early health struggles may play a significant role in educational outcomes.
EPFL scientists have found that replacing glucose with starch from rice can reduce the toxicity of the cholera bacterium, Vibrio cholerae, and may lead to a 30% reduction in cholera cases. Oral rehydration therapy using rice starch could significantly improve treatment outcomes.
Researchers found no evidence of asymptomatic myocardial dysfunction or deterioration of systolic function in patients taking pramipexole and ropinirole. This suggests that non-ergot derived dopamine agonists may be safe for the heart, contradicting previous concerns about an increased risk of heart failure.
A study published in JAMA Ophthalmology found that teleophthalmology did not result in worse visual outcomes, even though it led to longer wait times for treatment reinitiation. The teleophthalmology approach was cost-effective and reliable for patients with another eye disease, diabetic retinopathy.
Doubling breastfeeding duration for 7-18 months can save the NHS at least £31 million, while doubling neonatal unit breastfeeding rates saves an extra £6 million. Helping existing mothers extend breastfeeding periods is key to achieving these cost savings.
A new study from the University of Notre Dame develops a more sensitive and affordable tool for detecting Asian Carp DNA using environmental DNA (eDNA) monitoring. The new method detects Asian Carp eDNA 95% of the time, compared to less than 5% with current methods.
A study published in The Lancet Diabetes & Endocrinology found that obesity is associated with a dramatic increase in risk of developing type 2 diabetes and cardiovascular disease. As a result, adults who are overweight or obese may lose up to 19 years of healthy life, while those who are very obese may lose up to 8 years.
Indiana University researchers are developing a computational model to predict acetaminophen-induced liver failure, using advanced microscopic and computational technologies. The model aims to reduce the use of animals in toxicity studies while enabling realistic scientific predictions for environmental and human health problems.
A mid-level solar flare, peaking at M6.1-class, was emitted by the sun on Dec. 4, 2014, potentially disturbing Earth's atmosphere. The Solar Dynamics Observatory captured the event, which is classified as a less intense flare compared to X-class flares.
A recent study by Point Blue Conservation Science found that changing grazing practices to give land more time to rest improved the health of native grasslands in California. This approach increased the growth of native perennial grasses, allowing water to better infiltrate soil and reducing erosion.
A researcher at American University has constructed a three-dimensional computer model of a receptor protein linked to human growth, which may lead to the development of drugs to treat conditions such as gigantism and dwarfism. The study was led by researchers from the Eunice Kennedy Shriver National Institute of Child Health & Human D...
A new technology, known as FISH investigation protocol, optimizes flow cytometry to reveal RNA transcription in cells. This breakthrough enables researchers to study the mechanisms causing diseases and establish drug efficacy.
Researchers have identified new ways to regulate and control the growth of various cell and tissue types by analyzing individual stem cells' genetic makeup. The findings reveal a complex
Geneticists identified double minutes in glioblastoma cells with specific oncogenes, which amplify malignancy and give cancer cells an adaptive edge. The presence of these mini-chromosomes is detected in most aggressive cancers.
A study of healthcare professionals reveals persistent barriers to effective transitional care, emphasizing the importance of patient education and provider accountability in reducing complications and rehospitalizations among older adults
A novel ultrafast quantum chemical method called FMO-DFTB enables rapid simulations of complex molecular systems, achieving a huge improvement over traditional methods. The method has successfully evaluated large molecules including polypeptides, DNA segments, small proteins, and fullerite surfaces.
A study published in Cell found that leptin, the 'satiety hormone', is linked to obesity-induced high blood pressure. Researchers discovered that obese individuals lacking leptin or its receptor had lower blood pressure despite being heavy.
Researchers found that on young worlds, the Habitable Zone is located farther away from the star than previously thought. This means that infant planets can be spotted earlier by next-generation telescopes when their star is still young.
Scientists at Disney Research Zurich developed a technique to capture detailed eye features, including shape, texture, and iris deformation. This enables the creation of realistic digital eyes that can respond to lighting changes.
Ebola virus disease is a febrile illness with severe gastrointestinal symptoms that can cause profound water and electrolyte depletion leading to circulatory collapse and death. Implementing practical protocols for managing fluids and electrolytes has not been given sufficient priority, which could substantially reduce the death rate.
A team of Michigan State University scientists has discovered an enzyme, called POPB, which converts toxins into cyclic peptides with missile-like precision in the human liver. This breakthrough could lead to single-minded medicines with zero side effects by harnessing the distinct properties of POPB.
A Penn Medicine study found that people with mental illness are more likely to have been tested for HIV than those without. The study also found that those with schizophrenia and bipolar disease had the highest rate of HIV testing.
A groundbreaking study by Australian researchers has discovered that leptin hormone secreted by fat cells elevates blood pressure in obesity. The hormone acts in the brain to increase blood pressure, making it a promising target for treating obesity-induced hypertension and cardiovascular diseases.
A new study found that endocrine disrupting chemicals can interfere with thyroid hormone action in pregnant women and may travel across the placenta to affect fetal brain development. The study used a prospective birth cohort of 164 pregnant women and found associations between high levels of CYP1A1 enzyme and thyroid disruption.
Researchers found that immune mechanisms triggered by viruses differ depending on entry route, with Toll pathway activated for feeding-related infections. The study suggests that understanding these differences can help find targets to block human diseases transmitted by insects.
Researchers have discovered that electric eels use a Taser-like system to locate and incapacitate their prey. The eel emits high-frequency pulses that cause muscle contractions, temporarily paralyzing the prey within three to four milliseconds.
Scientists create versatile model to predict stalagmite-like structures in nuclear processing plants and kettle scaling, reducing manual inspections and improving safety. The new model has potential applications in other industrial and domestic situations where salt solutions precipitate out and cause problems.
Researchers propose that a hot layer above the Earth's mantle, known as the asthenosphere, is responsible for volcanic eruptions in mid-plate regions. This challenge traditional theory, which posits that volcanoes are caused by plate movement and heat from deep within the Earth.
NASA's Terra satellite and GPM/TRMM satellites provide valuable data on Super Typhoon Hagupit's rainfall patterns and cloud height. Forecasters expect the storm to reach peak intensity and weaken, while warnings are issued for the Philippines due to typhoon-force winds.
Researchers at Kent State University found that college students who spent more time on their smartphones during leisure activities experienced decreased enjoyment and increased stress. The study suggests that excessive phone use can diminish the experience of daily leisure, leading to feelings of uptightness and anxiety.
Researchers discovered that Ranbp9 controls the correct processing of mRNA molecules after their synthesis from thousands of genes involved in sperm production. This finding places Ranbp9 as a master regulator of sperm production.
A University at Buffalo researcher has found that mice can distinguish between partial sound waves, similar to how humans recognize word onsets. This discovery could help better understand human hearing loss and strengthen the use of mice as models for human communication.
Scientists have developed a new technique to capture the fast dynamics of biomolecules using high-speed X-ray lasers, revealing subtle processes with unprecedented clarity. The study used the photoactive yellow protein as a model system and achieved snapshots of molecular movements at atomic resolution.
A new study from the University of Chicago Crime Lab and the University of Pennsylvania found that a public summer jobs program for high school students from disadvantaged neighborhoods in Chicago reduced violent crime arrests by 43 percent. The program offered eight weeks of part-time employment at Illinois minimum wage, accompanied b...
Researchers found that people can guess how others learn about themselves, even without explicit communication. This skill increases the chances of success in competitive social interactions. The study also explores its potential impact on individuals with autism spectrum disorders and neuropsychiatric conditions.
Researchers from Spain and India found that pulsars with black holes are ideal for testing general relativity, but two cases reduce their value. The 'holy grail' pair is a normal black hole, which has yet to be discovered.
New research finds Antarctic seawater temperatures are rising, causing accelerated glacial melting and potential sea-level rise. The study also reveals that warmer waters could impact ocean biodiversity.
Researchers found an association between smoking and loss of the Y chromosome in blood cells, which may explain why men have a shorter life expectancy. Heavy smokers showed more frequent loss of the Y chromosome than moderate smokers.
A team of Chinese scientists has developed a new global wetland suitability map to help protect these vital ecosystems. The map, which matches individual wetland sites with local water table depth, shows that the total area of global wetlands is approximately 3.316×107km2.
Scientists at NTU and Penn State University have discovered one of modern human's ancient lineages by sequencing the genome of five living individuals from a hunter/gatherer tribe in Southern Africa. The study found that these individuals are genetically distinct from Europeans, Asians, and all other Africans.
The four-part iBooks Textbook series explores climate change, its impacts on ecosystems, and strategies for adaptation. The books align with Next Generation Science Standards and Climate Literacy, offering a real-life experience for students to engage in discussion.
A CAMH survey found that 2.2% of Ontario adults seriously contemplated suicide in the last year, with significant increases in self-rated poor mental health and cannabis use. The report also showed declining rates of non-medical prescription opioid use and a decrease in smoking prevalence.
Researchers found that insecticides increase slug populations and reduce crop yields by poisoning insects that eat slugs. The neonicotinoids can have unintended costs, even within crop production.
A simple 5-variable model accurately predicts most cases of kidney failure in socially disadvantaged individuals with moderate or advanced chronic kidney disease. The model can help guide approaches to reduce socioeconomic disparities in kidney disease care.
An article in Breastfeeding Medicine suggests that bed-sharing restrictions may hinder breastfeeding frequency and exclusivity. The AAP's recommendations have been criticized for being unrealistic and potentially detrimental to breastfeeding outcomes.
A study reveals that white blood cells can cause increased blood pressure and impaired blood flow in the brain, leading to death from cerebral malaria in mice. The researchers used a mouse model of Plasmodium berghei ANKA-induced cerebral malaria to investigate the role of white blood cells in this disease.
A study published in Cognitive Therapy and Research found that individuals who sleep for shorter periods and go to bed later experience more repetitive negative thoughts. This association suggests that prioritizing regular sleep schedules may help mitigate anxiety symptoms.
Researchers at the University of Houston are using a patented equation to assess the effects of antibiotics on bacteria and develop more effective treatments. They plan to use image analysis technology to automatically record data, reducing the need for physicians to run excessive tests.
The Multiple Myeloma Research Foundation has made landmark genomic and clinical data from the CoMMpass Study available to researchers via the MMRF's Researcher Gateway. This data includes patient-level biomarker and clinical data, genomic information, and treatment responses, offering new avenues for research into multiple myeloma.
Researchers used positron emission tomography (PET) and computed tomography (CT) imaging to monitor antibiotic treatment effects in TB-infected monkeys and humans. Changes in PET/CT scans over time accurately predicted treatment outcomes, potentially shortening clinical trials and saving resources.
A new review article suggests that domperidone can increase breast milk production, but also poses a risk of irregular heartbeat and sudden cardiac death in women. The study found that moderate improvements in milk production were observed with lower doses, but higher doses increased the odds of cardiac complications.
The National Science Foundation has awarded rapid response grants to support researchers in understanding the fundamental nature of Ebola and its impact on public safety. The grants will fund projects that explore new methods for virus detection, disinfection, and medical response, as well as research into risk assessment and behavior.
A study found that high sugar diets in male fruit flies can cause obesity in their offspring through epigenetic changes affecting gene expression. Researchers also discovered a similar system regulating obesity susceptibility in mice and humans.
A recent study has linked African rainfall increases to greenhouse gas concentrations thousands of years ago. The research team used computer simulations and geologic records to recreate past moisture conditions, finding that changes in carbon dioxide and methane led to the African Humid Period.
Researchers discovered that tamoxifen, a breast cancer drug, can target and control the survival and proliferation of stem cells responsible for blood cancers. The study found that activation of estrogen receptors with tamoxifen could block the excessive production of abnormal white blood cells in mice with blood neoplasms.
Almost 40% of people with first-episode psychosis in community clinics may benefit from medication treatment changes. Current prescribing practices highlight the need for more education on first-episode specific medication practices at community facilities.
Scientists observe rising water temperatures on the West Antarctic shelf, accelerating glacial melting and potentially increasing global sea levels. The warming trend is linked to changes in wind systems over the southern hemisphere and may have significant environmental implications for the region.
Researchers used tree-ring data and computer programs to create a finely scaled map of ideal Southwest growing regions for the past 2,000 years. The study suggests that localized climate change contributed to the depopulation of ancestral Pueblo people in southwest Colorado, with some areas becoming highly suitable for maize agriculture.