Researchers at Plymouth University are developing a new graphene-based diagnostic technique to detect biomarkers of dementia in bodily fluids. The technology aims to provide real-time data and conclusive test results within minutes, increasing the accuracy of dementia detection and tracking disease progression.
A recent study published in Nature Neuroscience found that digoxin, a medication used to treat heart failure, may have a strong effect on treating amyotrophic lateral sclerosis (ALS) by blocking an enzyme that destroys nerve cells. The research suggests that reducing the activity of this enzyme or limiting its production can prevent th...
Researchers identified RNF43 mutations in 20% of colorectal and endometrial cancers, suggesting a potential biomarker for targeted treatments. The mutation affects the Wnt signaling pathway, making tumors sensitive to new inhibitors currently in clinical trials.
Researchers have identified a novel way to target newly manufactured proteins to the correct location in cells, utilizing a previously unknown compartment called an acidocalcisome. This discovery has implications for understanding protein function and regulation.
Researchers at Columbia University Irving Medical Center found that dietary flavanols can improve cognitive function and reverse age-related memory decline in healthy adults. The study showed noticeable improvements in the function of a specific brain region and significant performance on a memory test.
A study of 35,000 participants found that genetic predisposition to elevated LDL-C was associated with aortic valve calcium and narrowing, supporting a causal association. Lowering cholesterol early in the disease process may provide protection from developing aortic valve disease.
The International Myeloma Working Group has updated its criteria for diagnosing multiple myeloma, allowing for earlier diagnosis without symptoms. The new guidelines incorporate validated biomarkers to identify patients at risk of progression, enabling targeted therapy and improved patient outcomes.
Researchers have developed CNiFERs cells to track dopamine signaling, providing a real-time readout of neurochemical activity associated with learning, memory and reward. The study reveals that dopamine release is linked to classical conditioning and anticipatory behavior.
Scientists have successfully demonstrated the flow of electrical current through long DNA molecules, paving the way for the development of DNA-based programmable circuits. The breakthrough could lead to more sophisticated, cheaper and simpler computer circuits.
Researchers at Brown University have discovered an exotic superconducting state that can arise when a superconductor is exposed to a strong magnetic field. The team found that unpaired, spin-up electrons form Andreev bound states, enabling transport of supercurrents through non-superconducting regions.
Researchers at Northwestern University discovered that activity in dendrites is crucial for storing memories, contradicting current thought that cell body and dendrites serve the same function. The study used high-resolution microscopy to image individual neurons in a living animal navigating a virtual reality maze.
Researchers developed a miniature device that measures methotrexate levels in patient blood, providing accurate results in under 1 minute and costing around $10,000 compared to traditional equipment at $100,000.
Researchers at Georgia State University's Center for High Angular Resolution Astronomy observed a nova's early fireball stage and revealed its complex expansion. The study, published in Nature, used the CHARA Array to create high-resolution images of the explosion, shedding new light on the structure of ejected material.
A team of researchers has made a breakthrough in understanding how a powerful antibiotic agent is produced in nature. They found that a special enzyme called dehydratase plays a crucial role in giving the antibiotic its final shape and function.
Ludwig researchers find ASPP2 acts as a molecular switch to regulate EMT and MET, crucial processes in cancer progression. Poor ASPP2 expression correlates with lower patient survival rates in liver and breast tumors.
A large study of over 35,000 participants found that genetic risk scores for elevated plasma lipids are associated with increased aortic valve calcium and new cases of aortic stenosis. The study suggests a causal link between high LDL-C levels and early stages of aortic valve disease.
Princeton engineers found that carefully restricting power delivery to certain areas within a laser can boost its output significantly. By targeting specific modes, they showed improvements in efficiency ranging from 100-fold to 10,000-fold, allowing for more control over frequency and spatial pattern of light emission.
South African epidemiologist Quarraisha Abdool Karim wins TWAS-Lenovo Science Prize for her groundbreaking work on HIV prevention in women. Her discovery of a topical anti-HIV gel has the potential to save millions of lives, particularly in Sub-Saharan Africa where women are disproportionately affected by the epidemic.