Researchers discovered 15 gene mutations that contribute to more aggressive colon cancer in African-Americans, resulting in higher recurrence and metastasis rates. These findings explain the disparity in colorectal cancer rates and death rates between African-Americans and other groups.
Researchers have combined theory and experiment to characterize each chemical reaction step that results in the reduction of oxygen by the enzyme. This study paves the way for efficiently exploiting enzymes from living systems for clean energy production.
Scientists have made detailed atomic-level images of a peroxiredoxin protein and found its peculiar characteristic may form the foundation for a new class of antibiotics. The research reveals that selectively blocking peroxiredoxin function in bacterial cells could kill them without harming normal cells.
Researchers discovered a new mechanism explaining BPH development, linking inflammation and cell proliferation. Deleting the androgen receptor in prostate epithelial cells triggers an inflammatory response promoting luminal cell proliferation.
A recent study published in JAMA Surgery found that gastric bypass surgery resulted in a nearly 30% greater weight loss compared to non-surgical patients after one year. The study also showed that patients who underwent gastric bypass maintained a 21% greater weight loss over 10 years.
Research published in Psychological Science found that cultural values shape environmental behavior. In individualistic countries, personal concerns drive eco-friendly actions, while in collectivistic societies, social norms are a stronger motivator. The study suggests that tailoring messages to local culture is crucial for promoting p...
Researchers at UTA are developing novel catalysts using metal ions to activate simple hydrocarbons and produce more complex molecules. A new portable sensor is also being developed to detect specific gaseous molecules in plant product storage facilities.
A study by researchers at four US medical centers found that common conditions are frequently misdiagnosed as multiple sclerosis, leading patients to receive unnecessary treatment. The study identified five primary diagnoses that mimic MS symptoms, resulting in long-term misdiagnosis for some patients.
Two newer antiepileptic drugs, levetiracetam and topiramate, show no discernible impact on childhood intellectual development. However, valproate is linked to a lower IQ in children whose mothers took high doses during pregnancy.
Human pluripotent stem cells can be directed into functional osteoblasts by adding the molecule adenosine, enabling efficient regeneration of bone tissue. The breakthrough could lead to regenerative treatments for patients with critical bone defects and soldiers with traumatic bone injuries.
A new predictive tool has been developed to help governments make informed decisions on land use and management in developing countries. By combining human perception of the environment with land-use planning and socioeconomic data, the tool aims to provide a more realistic picture of future environmental changes.
Researchers tested an oral rabies vaccine in wild populations of Ethiopian wolves, with promising results. The trials found that 86% of vaccinated wolves had sufficient levels of protective antibodies, and all but one were alive 14 months later.
Researchers have received a grant to study ways of reducing fertilizer use in high-temperature agricultural regions. By modifying fertilization and irrigation practices, nitrogen losses to the atmosphere can be reduced by 50 percent.
Research reviewed 224 studies on Internet and mobile device interventions, finding improved diets, increased physical activity, and modest weight loss over 3-12 months. Programs with goal-setting, self-monitoring, and healthcare provider interactions were most effective.
A study published in Nature found that excess fumarate resulting from enzyme loss leads to epigenetic changes promoting epithelial-to-mesenchymal transition, a process driving tumor metastasis. This understanding may provide key strategies for cancer therapy targeting metastasis caused by fumarate accumulation.
A study by Ohio State University researchers found that taller individuals have a natural advantage when it comes to spatial relations and judging the location of targets in their middle-distance vision. This ability is particularly important in situations with limited visual cues, such as darkness or obstacles.
A study found that individuals with insecure childhood experiences had lower task performance under emotionally negative conditions and less brain activity in response to target letters. This suggests that inefficient emotional regulation strategies may lead to reduced cognitive resources for task completion.
Researchers from Charité have found that high blood selenium levels are associated with a decreased risk of developing liver cancer. Selenium deficiency is identified as a major risk factor for liver cancer, with the third of the population having lowest selenium status facing a five- to ten-fold increased risk.
Researchers at Cardiff University have discovered a new drug treatment that inhibits memories responsible for cocaine cravings, significantly accelerating the end of drug-seeking behavior. The therapy, currently used in cancer trials, targets the brain's limbic system and could potentially speed up clinical development.
Researchers developed an algorithm to analyze single-cell sequencing data, revealing the genetic control of blood cell formation. The 'diffusion pseudotime' method orders cells on a virtual timeline, reconstructing developmental paths and gene expression sequences.
Atrial fibrillation, a common irregular heartbeat, is linked to genetic variations in genes controlled by Tbx5 and Pitx2. The study offers insights into the mechanisms underlying heart arrhythmias, potentially leading to targeted treatments for patients with AF.
A new analysis suggests Michelangelo concealed female anatomy symbols in the Sistine Chapel ceiling. This discovery provides valuable context for understanding the historical connection between art and human anatomy.
The use of glutathione for skin bleaching is on the rise in the UK despite potential risks and lack of regulation. The practice has been linked to serious side effects such as Stevens Johnson syndrome and toxic epidermal necrolysis, as well as transmission of infectious diseases like HIV and hepatitis.
Researchers found that bird habitat and parasite interactions significantly impact malaria infection risk, with co-infections occurring in 36% of infected birds. The study advances understanding of parasitic disease in both humans and wildlife.
Satellites show Hurricane Madeline has weakened from a Category 4 storm to a Category 1 storm as it approaches Hawaii. The storm is expected to bring tropical storm conditions, heavy rainfall, and storm surge to the islands, with the potential for dangerous flash floods and mudslides.
The European Medicines Agency's approval process for biosimilars shows variability, but offers insights into implementation. Regulators must balance the need for safety with flexibility to support innovation in new therapies, including personalized treatments and products on the borderline between medicines and other sectors.
Researchers found that similarities between contact calls of female rhesus macaques were predicted by familiarity, not kinship. Call structure was similar among females with similar age or matrilineal membership, suggesting experience has a greater impact on acoustic similarity than genetic background.
Researchers propose a new theory, embryo geometry, that explains how vertebrates evolved from a single cell by mechanical deformation and geometric patterns. The study presents illustrations depicting the formation of various systems in vertebrates.
A combination of formoterol and budesonide found to be safe and effective in treating moderate to severe asthma, with a lower risk of exacerbations than single-therapy budesonide. The therapy showed no significant increase in serious adverse events, providing reassurance for healthcare providers.
Researchers found that levetiracetam and topiramate do not reduce IQs or thinking skills in children, unlike valproate which had lower IQ scores, averaging 11 points lower. The study suggests these newer medications are safer alternatives for pregnant women with epilepsy.
The Stanford Precourt Institute for Energy has awarded $2.7 million to 15 faculty seed grant recipients for groundbreaking research on clean energy. Researchers will develop novel technologies, including battery management systems, perovskite solar cells, smart windows, and thermoelectric technologies.
Scientists at Whitehead Institute developed a novel method to isolate and measure mitochondrial metabolite concentrations, providing greater resolution than traditional methods. The new approach offers improved speed and specificity, allowing for more accurate analysis of mitochondrial function in various disorders.
The new data sheet explores population trends in Europe, highlighting the impact of aging, migration, and pension systems. Eastern European countries show the fastest rate of population aging, while standard indicators suggest a slower rate.
A widely used brain cancer cell line, U87MG, has been found to be of unknown origin and different from the original patient tumor. Researchers used forensic and mitochondrial DNA profiling to trace the cell line's origin, revealing a potential mix-up or cross-contamination.
NASA analyzed Tropical Depression 8 using infrared and visible light, finding cloud top temperatures exceeding minus 63 degrees Fahrenheit. The depression is moving northeast at 15 mph with a possible strengthening into a tropical storm later today.
Ramon Lopez, a professor of physics at the University of Texas at Arlington, has been recognized for his significant contributions to science education. He is being honored for his efforts to improve science literacy among K-12 students, as well as his work in teacher preparation and mentorship.
The Global Precipitation Measurement mission tracked Hurricane Lester as it continued through the Eastern Pacific Ocean, showing extremely heavy rainfall rates of over 7.1 inches per hour. The satellite also revealed a strong hurricane with maximum sustained winds near 140 mph and estimated minimum central pressure of 948 millibars.
Research at Tohoku University reveals genetic variants affecting enzymatic activities in healthy individuals, suggesting that moderate and rare variants contribute to metabolic differences and disease susceptibility. The study identifies five associations between metabolites and gene variants, including four related to metabolic diseases.
A review of existing empirical evidence suggests that food puzzles can improve cats' physical health by aiding weight loss, and their emotional wellbeing by reducing aggression and fear. By introducing food puzzles, owners can provide cats with stimulation and exercise, leading to a more balanced lifestyle.
A Case Western Reserve University researcher proposes a framework to address ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos. The researcher suggests prioritizing animal welfare while enabling scientific progress in areas of biomedical importance.
The Munich Compact Light Source (MuCLS) has been evaluated for its performance, demonstrating its ability to conduct state-of-the-art X-ray imaging. The mini-synchrotron technology enables local measurements and is paving the way for potential clinical applications.
A study by Heather Shaw found that Android users are perceived as more honest and humble, but this was not reflected in reality. In contrast, women are twice as likely to own an iPhone, while iPhone users prioritize high-status phones.
A study of 6,120 Danish women found that high alcohol intake was associated with a slight decrease in fertility, while low to moderate consumption showed no effect. The authors recommend abstinence from alcohol during the fertile window until pregnancy is ruled out.
A new data-cleaning tool called ActiveClean analyzes a user's prediction model to identify mistakes and update the model as it works. By minimizing human error, ActiveClean improves model accuracy and reduces statistical biases, making it an essential tool for building better prediction models.
A commonly used cell line, U87MG, was found to have a different DNA profile than the original tumour it was established from. Genetic analysis revealed that the cell line likely originated from a human glioma tumour, highlighting the need for proper identification of cultured cells.
A team of Carnegie scientists has discovered three giant planets in a binary star system composed of stellar 'twins' that are also effectively siblings of our Sun. The findings may help explain the influence that giant planets like Jupiter have over a solar system's architecture.
A study of 1,787 veterans found that those who underwent Roux-en-Y gastric bypass surgery lost an average of 21% of their baseline weight at 10 years after surgery. In comparison, nonsurgical matches experienced a smaller estimated weight loss of around 11-12%.
Researchers have developed a method to utilize CRISPR/Cas9 technology to diagnose and inactivate cancer mutations. The study found that over 80% of reported cancer mutations can be targeted with the CRISPR/Cas9 system, enabling the rapid separation of driver from passenger mutations.
Researchers conducted focus groups with Special Operations personnel and found that female soldiers' experiences refute stereotypes about women's ability to serve in combat units. The study suggests that the military needs to shift its mindset and train soldiers to address underlying assumptions of male soldiers.
A study published in JAMA Cardiology found that over half of women and nearly half of men aged 18-55 experience sexual function problems after a heart attack. Women were less likely to resume sex and reported higher rates of sexual dysfunction compared to men.
A study published in Journal of Applied Ecology found that juvenile desert tortoises released into habitat with vegetation, rocks, and animal burrows had lower mortality rates. The researchers also discovered that tortoises on rocky ground were less likely to disperse away from their release site.
A study by Purdue University researchers reveals that overactive Notch signaling can drive the formation of cancerous fatty tumors, while normal signaling is required for healthy cell differentiation. The findings suggest a potential new approach for treating a subtype of liposarcomas and other metabolic conditions.
Hurricane Gaston has a large cloudless eye surrounded by powerful thunderstorms, according to NASA's Suomi NPP satellite. The storm is moving northeast at 9 mph and may affect the Azores Islands later in the week.
A new report reveals that nearly half a million B.C. residents struggled to afford food in 2011-12, with families and children facing extreme hardship. Provincial government actions are needed to address this issue.
After a heart attack, both men and women experience impaired sexual function, but women are less likely to be counseled on their capabilities, leading to higher problem rates. Physicians must address these issues for high-quality life outcomes.
Researchers at La Jolla Institute for Immunology discovered a novel mechanism by which neutrophil receptors latch onto vessel walls, dampening inflammation. Integrins assume an unorthodox shape that exposes the high affinity patch but maintains a bent conformation, preventing it from binding to ICAM-1 expressed on blood vessel cells.
Berkeley Lab scientists create direct method to study electrochemical double layer using 'tender' X-rays, revealing changes in electric potential and charge properties. This breakthrough advances materials design and development of improved electrochemical systems.
The research aims to define the core molecular components of the Permeability Transition, a phenomenon that causes cell death during stress conditions. By understanding this process, novel treatment strategies can be designed to target specific non-proteinaceous components and prevent mPTP opening.
Researchers at Washington State University have found that hyperbaric oxygen therapy can relieve opioid withdrawal symptoms in mice, with a significant reduction in severe withdrawal signs. The study suggests implications for treating heroin addiction and could lead to new clinical evidence supporting FDA approval for the treatment.
A recent study reconstructs the history of human migration to the Tibetan Plateau and discusses possible mechanisms involved. Humans first arrived in the Northeastern Tibetan Plateau from the adjacent Western Loess Plateau via the He-Huang Valley, spreading southwards over four stages.