Scientists developed guidelines to evaluate laboratory-generated stem cells, finding that no current methods produce truly naïve embryonic cells. The new criteria may aid researchers in achieving this goal, which could benefit both basic research and medical applications of stem cells.
Researchers have found a unique triple-bubble structure in the interstellar medium of galaxy M33, consisting of three concentric supernova shells. This discovery provides insights into the complex feedback processes that govern star formation and the dissemination of metals produced in massive stars.
The National Institute of Food and Agriculture (NIFA) is providing $8.3 million in funding for small businesses to develop advanced research projects. The Small Business Innovation Research program aims to stimulate technological innovations and strengthen federal research support for small businesses.
A recent study published in the American Journal of Transplantation found that gender matching is crucial for successful corneal transplants. Women who receive male donor corneas are more likely to experience rejection and failure, with a higher proportion of mismatched grafts failing or rejecting compared to female-to-female transplan...
Researchers at Hokkaido University have developed a new kind of hydrogel that bonds spontaneously and strongly to defected bones. The gel overcomes the problem of bonding with other surfaces by adding hydroxyapatite to its surface.
Researchers from KU Leuven show that surface composition and atmosphere interaction on exoplanets affect their temperature and habitability. A well-functioning 'air conditioning' system can make even planets with permanent day and night sides potentially habitable.
Researchers have used molecular dynamics simulations to study the spatial and temporal behavior of myoglobin, a protein involved in oxygen transport. The simulations provide insights into the underlying chemical structure and dynamics of metastable intermediates, shedding light on the protein's function.
Research suggests that prisoners are released without access to medications that control their illnesses, leading to a spike in viral loads and increased risk of transmission. Decreasing incarceration rates for people who inject drugs could reduce the burden of HIV among prisoners.
Preschoolers who go to bed by 8 p.m. are half as likely to become obese teenagers as those who turn in late, according to a study from The Ohio State University College of Public Health. Establishing an early bedtime routine can also have positive benefits on behavior and cognitive development.
Researchers developed a mathematical framework to identify key life cycle components driving population growth. This approach can be applied to existing data to provide more robust answers to demographic questions in ecology and evolution.
Scientists at NUS Cancer Science Institute discovered that phosphorylation of the tumour suppressor gene RUNX3 promotes cancer progression by allowing cell division. The study's findings suggest a potential way to increase the effectiveness of cancer therapy by targeting Aurora Kinase, an enzyme involved in the modification.
Researchers identified a key gene in vinegar flies responsible for their waterproof coating, which could provide a new way to control insect pests threatening agriculture and humans. By knocking out this gene, the insects lose their waxy coating and become more vulnerable to environmental stress.
A team of scientists has developed a model that can predict which bat species are most likely to transmit Ebola and other filoviruses. The study highlights new potential hosts and geographic hotspots worthy of surveillance, with the AI algorithm identifying potential carriers in Southeast Asia and Central and South America.
Researchers created a virtual tissue model of diabetes in the eye, predicting how a small protein causes vision loss and blindness. The study aims to develop new treatment methods for diabetic retinopathy, a leading cause of blindness worldwide.
The grant will support Columbia University's Precision Medicine Initiative and integrate special populations into translational research efforts. The Irving Institute aims to increase focus on precision medicine, develop translational therapeutics, and nurture a cadre of junior scientists with diverse backgrounds.
A modeling study suggests that e-cigarettes are likely to provide public health benefits for adults, particularly adolescents and young adults, who use them instead of smoking. The study found a 21% reduction in smoking-attributable deaths and 20% decrease in life years lost due to e-cigarette use.
A study found that weight loss through diet and exercise lowers angiogenesis-related protein levels in postmenopausal women. After 12 months, women in the diet arm and diet+exercise arm had significantly lower levels of these proteins compared to those in the control arm, suggesting a potential link between weight loss and reduced canc...
A study found that American black bears can recognize visual features of objects they know in real life when presented with photographs. This ability has important implications for the use of photographs in computerized studies involving bears and their welfare.
Researchers found that patients with a rare autoimmune disorder produce antibodies that limit immune-related diseases, including type 1 diabetes. These autoantibodies target proteins such as interferons and interleukins, potentially inhibiting the development of type 1 diabetes.
Researchers reviewing Zika's history highlight the need for better understanding of global spread and sustainable control strategies. Most people infected with Zika show no symptoms or minor ones like rashes, but prevention methods like mosquito spraying are crucial.
A new study has found that ocean warming is the primary cause of glacier retreat on the western Antarctic Peninsula, with 90% of glaciers retreating since records began. This finding will improve predictions of ice loss and sea-level rise, as the Peninsula contributes significantly to global sea levels.
A new Brown University study found that childcare centers in Rhode Island serving low-income children under the federal nutrition subsidy program serve healthier food than those outside the program. The study's lead author suggests that implementing nutritional guidelines and regulations can improve the quality of food served, particul...
Researchers aim to understand farmers' preferences for cover crop contracts, which could lead to higher adoption rates. Cover crops offer benefits like soil health improvement and nitrogen scavenging, but farmers often face constraints such as conflicting planting dates with cash crops.
Researchers developed a method to revert and maintain human ESCs in a naive state, closely resembling that of mouse ESCs. The team assembled a checklist of characteristics human ESCs must have to be considered naive, including gene expression, DNA methylation, and X chromosome inactivation.
Researchers at the University of Basel have identified a protein called gasdermin D that drives immune cells to pyroptosis, a form of programmed cell death. This process allows macrophages to burst open and expose pathogens, which can then be targeted by the immune system.
Researchers at UMass Amherst have partnered with Chemists Without Borders to create a low-cost test kit for measuring arsenic in rice crops. The team hopes the kit will provide consumers with information on exposure and encourage protective measures, such as rinsing or choosing different varieties.
The dengue virus protein NS1 disrupts the innermost layer of blood vessels, making them more permeable and causing leakage. This disruption leads to fluid accumulation in the lung, a major symptom of severe dengue disease.
Researchers found city birds exhibit higher levels of territorial aggression than rural counterparts, possibly due to limited space but better resources to defend. The study, published in Biology Letters, measured bird responses to simulated intrusions at urban and rural sites.
New research reveals that newborn ducklings can learn to identify and follow abstract relational concepts, such as 'same' and 'different', without reinforcement training. This ability was previously known only in highly intelligent animals like apes and parrots.
Researchers developed a method to measure how the brain responds to electrical stimulation, allowing for more effective deep brain stimulation treatment. This patient-specific approach uses phase response curves to predict and optimize stimulus patterns, potentially improving efficacy and reducing side effects.
A two-year study found that restricting calories by 25% in healthy non-obese individuals reduced markers of chronic inflammation without negatively affecting immune responses. Chronic inflammation is linked to age-related diseases such as cancer, heart disease, and dementia.
A newly released study analyzed the lives of 255 African and Asian elephants in 68 accredited North American zoos, revealing that social interactions and having an array of opportunities to engage with their surroundings may be more important for elephants than space. The research found that spending time alone was a risk factor for el...
Researchers at Stanford University School of Medicine have mapped out biological signals necessary to direct human embryonic stem cells to become pure populations of bone, heart muscle, and cartilage. The ability to generate these cell types quickly is a key step toward regenerative medicine.
Researchers genetically designed a new strain of bacteria to produce extremely thin and highly conductive wires made from non-toxic natural amino acids. The resulting biowire has a conductivity that rivals many chemically produced organic nanowires, with potential applications in biocompatible sensors, computing devices, and solar panels.
A study published in Cancer Research found that obese women who lost weight through diet or exercise significantly lowered levels of angiogenesis-related proteins in their blood. This suggests a potential link between weight loss and reduced cancer risk, although further research is needed to confirm the association.
Researchers at UW-Madison and Purdue University have solved the atomic structure of rhinovirus C, a cold virus linked to severe asthma and respiratory infections in children. The findings provide a foundation for future antiviral drug and vaccine development against the virus.
A team of physicists and astronomers has created the largest-ever three-dimensional map of distant galaxies to measure dark energy's effects on the universe's expansion. The Baryon Oscillation Spectroscopic Survey (BOSS) program reveals the structure of the universe over 650 cubic billion light years.
The Nurses' Health Study has made significant advances in risk prediction for cancer, while also guiding recommendations from the US Surgeon General on smoking's adverse health effects. The study's findings have led to changes in regulation, such as reduced heart disease and diabetes risk associated with trans fats.
A study found that older women with facial injuries are more likely to experience facial fractures, particularly those over 60. Black women were less likely to suffer facial fractures compared to white and Asian women.
Researchers at Kumamoto University discovered a new method for drastically changing the color and fluorescence of a compound using oxygen and hydrogen gases. The technique uses energy from gases themselves, producing only water as a byproduct and has potential applications in detection sensors and organic semiconductors.
A new study by AAA Foundation for Traffic Safety reveals that nearly 80% of drivers experience significant anger or aggression while driving. The research estimates that approximately eight million U.S. drivers engage in extreme examples of road rage, including physical confrontations with other drivers.
NASA's RapidScat instrument measured strong winds in Hurricane Darby reaching 67 mph near its center, with tropical-storm-force winds extending up to 150 miles from the center.
A study found that nearly all cancer patients overestimate their chances of survival compared to their doctors' estimates. The researchers emphasize the importance of accurate communication between physicians and patients in making informed treatment decisions.
A new discovery has identified cell markers to target HIV reservoirs, opening new treatment perspectives. The study found that using antibodies specifically binding to these markers could destroy HIV reservoirs and potentially cure infected individuals by allowing them to stop antiretroviral therapy.
Scientists have discovered that zebrafish are susceptible to arthritis, mirroring the condition in humans and other mammals. The study uses zebrafish as a model to accelerate therapeutic research into preventing or easing osteoarthritis.
A recent study published in Science found that early farming populations had deep genetic differences, indicating distinct ancestries. The research identified similarities between Neolithic farmer's DNA and living people from southern Asia, suggesting a federal origin of farming.
Scientists developed a novel algorithm to predict synergistic antifungal drug combinations for treating drug-resistant fungal infections. The algorithm, NLLSS, integrates various information types and experimentally validated 7 out of 13 predicted combinations for Candida albicans, providing new treatment options.
A new study found that constant artificial lighting leads to severe disruption of health parameters in mice, including pro-inflammatory activation of the immune system, muscle loss, and early signs of osteoporosis. However, the effects are reversible when the environmental light-dark cycle is restored.
A Johns Hopkins University study finds that areas with high income inequality have fewer good jobs for young adults, leading them to start families without getting married first. The study of 9,000 millennials found that women and men who didn't graduate from college had a higher likelihood of having children outside of marriage.
Researchers identified a limit where dehydration kills cells due to trehalose network rigidity and mechanical force. The study suggests a new working hypothesis for cell injury during dry preservation.
A recent study published in Science reveals that populations in the ancient Fertile Crescent are the ancestors of modern-day South Asians, but not of Europeans. The earliest farmers from the Zagros mountains in Iran showed a genetically distinct group that only very distantly related to the first farmers of western Anatolia and Europe.
Research from Sanford Burnham Prebys Medical Discovery Institute shows that cell recycling in the intestine is crucial for healthy aging, leading to longer lifespans.
Scientists at UC Davis reveal how cells control DNA synthesis in mitochondria and couple it to mitochondrial division. This fundamental discovery has far-reaching implications for understanding cell functions, aging, and a range of diseases.
A new study suggests that donor and recipient gender incompatibility may lead to poorer corneal transplant outcomes for women. Incompatible grafts were found to fail or be rejected more frequently in men-to-female mismatched transplants, highlighting the importance of gender matching in improving patient success rates.
A research team led by Florida State University Professor Scott Steppan has cataloged 56 non-flying mammal species on Luzon Island, 52 of which are endemic to the island. The team's findings reveal exceptional diversity and suggest that there may be many more species in other tropical regions.
A team of researchers has obtained detailed structural information on KDM5 histone demethylase inhibitors, which could inform the design of more potent and selective anticancer drugs. The study found that these inhibitors can stop the growth of certain breast cancer cells, particularly those with specific genetic markers.
Researchers at ETH Zurich have developed a new method for extracting the content of single living cells, enabling scientists to study individual cells at the molecular level. The technique allows for precise extraction of intracellular material, preserving live cells for repeated sampling and analysis.
The new report explores how radiologists can succeed in the new payment landscape under MACRA. It provides a historical context for payment reform and describes the recent MACRA legislation, its impacts on payment, and organizations influencing its evolution.
Researchers have found cold snaps in sub-tropical ecosystems and droughts in rainforests due to human influence. The study also explores new relationships among species arising from global changes, highlighting the need for understanding ecosystem structure and function.
Researchers argue that MDMA's molecular targets could lead to new treatments for disorders like autism and PTSD with less abuse liability. Studies have shown some promise in treating PTSD, aiding patients in forming a stronger bond with a therapist.