A new tissue-engineering method allows for forward genetics screening on human tissue, identifying 38 driver genes associated with colorectal cancer progression. The recellularized human colon model replicates key features of CRC and provides a controlled environment to study gene expression.
Researchers found that men with brothers who have had prostate cancer are twice as likely to develop the disease, while those with both a father and brother have a threefold risk. Early screening for these men is recommended starting at age 40.
Researchers found an association between atrial fibrillation and smaller frontal lobe brain volumes in a recent study published in Heart Rhythm. The study examined the relationship between AF and brain volume using MRI, revealing that AF was associated with reduced frontal lobe volumes even after adjusting for other factors.
Researchers discovered a UV-B receptor that activates proteins to build defense mechanisms, allowing plants to tolerate harmful UV-B rays. Plants also use UV-B rays to influence growth and development, making them essential for survival.
A new report highlights the benefits of outdoor learning for children, including improved behavior, social skills, and health. It proposes a framework for governments to integrate outdoor learning into national education policies, aiming to enhance children's long-term prospects.
A new clinical trial funded by the National Institute for Health Research (NIHR) aims to transform early detection of diabetic eye disease by introducing a novel screening method. The trial will enable patients at lower risk to undergo tests only every two years, while those at higher risk can be checked up to twice a year.
Researchers analyzing administrative health records of over 8.8 million individuals found a 32% incidence rate of concussions among 10-19 year olds between 2007 and 2014, with a 60% overall increase in concussion diagnoses during this period
Journalists face increasing threats globally, with physical violence, kidnapping, and murder being used to suppress news. Citizen journalists in Syria are under immense pressure to continue reporting despite the risks.
Researchers at Cold Spring Harbor Laboratory have identified a new pathway in ovarian cancer cells that can be targeted by drugs, reducing metastasis. The newly uncovered pathway depends on activity of protein FER, which activates receptor MET, leading to elevated motility and invasiveness.
Researchers found that an extra-low dose combination of two anticytokines reduced rheumatoid arthritis disease activity and cardiovascular events. The study showed a lower incidence of cardiovascular events in patients treated with the combination, suggesting decreased cardiovascular risk.
Research found that osteochondral allograft transplantation can successfully treat knee cartilage injuries in athletes and highly active patients. After an average follow-up of 6 years, 76% of patients returned to activity, with 90% survivorship of the transplanted grafts.
A study of over 12,000 Australians found that each extra daily portion of fruit and vegetables up to 8 portions per day increased life satisfaction. The researchers concluded that people who changed their diet experienced an increase in life satisfaction equivalent to moving from unemployment to employment.
A study of around 70,000 galaxies reveals that external mechanisms, such as infalling galaxy drag and gas stripping, are only relevant to quenching galaxies during the last eight billion years. Internal mechanisms, including black holes and stellar outflows, dominate star formation shutdown before this time.
The NIH award will support initiatives such as engaging underrepresented persons in clinical trials and developing robust electronic platforms for data warehousing. This will enable the SC CTSI to advance cutting-edge research and scientific breakthroughs in patient and community health.
The Suomi NPP satellite captured a visible image showing Hurricane Blas' eye filled with high clouds, while infrared imagery revealed a pinhole eye. The storm was weakening rapidly, with maximum sustained winds decreasing to near 105 mph.
A new study by Northwestern University finds that moderate-to-vigorous physical activity is associated with improved subjective memory in breast cancer survivors. Higher levels of physical activity are linked to lower distress, less fatigue, and higher self-confidence, which in turn aids memory.
A diagnosis of high cholesterol is associated with reduced mortality and improved survival in four common cancers: lung, breast, prostate, and bowel cancer. Statins are linked to lower risk of death, with significant reductions seen in all four types of cancer.
Researchers used a custom-built robot, mathematical models and studies of amphibious fish to explore the critical evolutionary leap from water to land. They found that stabilizing the body with a tail provided substantial benefits for the first critical step out of an aqueous environment.
Four NYC medical centers, including Columbia and Weill Cornell Medicine, will collaborate on a $46.5 million NIH grant to enroll 1 million+ US volunteers in the Precision Medicine Initiative Cohort Program. The program aims to improve health outcomes by understanding individual differences in lifestyle, environment, and genetics.
Researchers from Oxford University used computer simulations to demonstrate how chaotic bacterial swarming can be organized to power microscopic rotors and devices. The study found that densely packed bacteria can spontaneously assemble into a 'bacterial windfarm' capable of generating persistent mechanical power.
Scientists have found that a time-dependent coding mechanism is essential for distinguishing between similar smells. By inhibiting signals to olfactory bulb output neurons, researchers showed that mice could no longer differentiate between odor mixtures with slightly different ratios or molecules with similar chemical structures.
Recent exoplanet discoveries by NSF-supported graduate researchers expand our understanding of how planets form and orbit stars. These breakthroughs include the detection of a unique planet in a triple-star system, one of the youngest fully formed exoplanets ever discovered.
Researchers have identified the 'cell of origin' in basal cell carcinoma, a common form of skin cancer, as stem cells. By analyzing clones derived from mutant stem cells, they found that these cells can overcome apoptosis and divide unchecked, leading to cancer growth.
Researchers at H. Lee Moffitt Cancer Center discovered a novel way to control SETDB1 protein activity through monoubiquitination, which inhibits target gene expression and could lead to new cancer therapeutics. This breakthrough suggests E2 enzymes as attractive targets for cancer treatment.
Researchers achieved a 14-fold increase in energy resolution of thermal photodetection, opening doors for ultrasensitive cameras and quantum computing applications. The detector works at extremely low temperatures, detecting single zeptojoule energy packets.
Typhoon Nepartak's cloud top temperatures were as cold as minus 63 degrees Fahrenheit, indicating strong storms. Rainfall totals compiled by Taiwan's Central Weather Bureau confirmed high amounts, with some areas receiving over 500 mm of rain.
Phosphorus pollution remains a major concern globally, with 40% of Europe's lakes failing to meet water quality standards due to high levels of phosphorus. Effective lake restoration approaches are needed to address this issue and protect biodiversity and society.
A qualitative study found that women feign orgasm as a means to end unwanted and unpleasurable sex. Despite being asked about consensual sex, all participants discussed problematic experiences. The research highlights the need for better language to describe women's experiences of unwanted sex.
A recent study suggests that re-wetting dried riverbeds releases dissolved carbon and greenhouse gases, including methane and CO2. This process may also contribute to ocean acidification. However, restoration of wetlands is expected to outweigh the negative effects, supporting biodiversity and mitigating storm erosion.
A group of researchers warns against DIY use of transcranial direct current stimulation (tDCS) due to its unpredictability and potential for unintended consequences. The study highlights the need for caution when applying tDCS outside a lab setting, as it can affect brain function in unforeseen ways.
A national study led by Michigan State University scholar William Chopik found that living among people with opposing political viewpoints can affect ability to form close relationships and accept perspectives. The study also suggests that segregating into 'red' and 'blue' states may stifle healthy political discourse.
Research at the ESA Annual Meeting highlights the complex relationships between mosquitoes and their environments. Mosquito life cycles are connected to temperature and humidity, but warming climates may not always increase disease transmission. A study found that invasive mosquito species can even help break the spread of parasites.
A new study of over 1,000 primary care melanoma screenings found no significant increase in surgical treatments or specialist referrals. The practice did result in a 79% increase in per-patient melanoma diagnoses among the most trained group, but this was not associated with an increase in dermatologist visits or surgeries.
Researchers created a comprehensive map of genetic and epigenetic lesions in human tumors, predicting responses to various cancer drugs. The study integrated 1,000 tumor cell lines with genetic, epigenetic, and expression alterations, validating results in 11,000 additional human samples.
Researchers have created an expandable, open-access database to study human cultural diversity. The D-PLACE database brings together information on over 1,400 societies, allowing users to search and analyze data on language, geography, culture, and environment.
A new study found that wearing a wearable neuromuscular device improved postural control in athletes without limiting performance. The devices, used with regular training programs, also prevented any ACL injuries during the season.
A new study found that people with high sensation-seeking personalities are more likely to engage in prank behavior when encountering the color red. This contradicts previous research suggesting that red leads to compliant behavior. The findings have implications for health campaigns, such as anti-smoking and safe sex initiatives.
Researchers at Jülich have found a way to produce nanomagnets with low zero-point energy, leading to higher stability. They investigated the connection between atomic properties and magnetic fluctuations caused by zero-point energy.
Patients who underwent bariatric surgery experienced a reversal of premature aging, characterized by longer telomeres and reduced inflammation. Two years after surgery, patients had telomeres that were 80% longer than before the procedure.
Researchers from Scripps Florida have discovered a link between bipolar disorder and the striatum, a brain region involved in motor planning and reward perception. The study identified 14 genes differentially expressed in bipolar patients compared to non-bipolar controls, suggesting a causal role in the disorder.
Male cicadas use their calls to attract mates, but they also draw in pregnant female flies looking to lay eggs. The study found that both males and females demonstrated reproductive intent and successfully mated with each other.
Scientists with NASA's Dawn mission have identified permanently shadowed regions on the dwarf planet Ceres, which are likely cold enough to trap water ice for a billion years. The regions, occupying about 695 square miles of the northern hemisphere, may be colder than those on Mercury or the moon.
A study found that using hamstring injury prevention programs can reduce hamstring injuries by 40% and lost playing time by up to 45.3% in minor league players, with a 65% reduction in major league players.
A new diagnostic tool uses short-strand DNA library preparation to analyze cell-free DNA in plasma, enabling transplant recipients to get an idea of how their new organ is responding via a simple blood test. This method can help determine whether the transplanted organ is injured or being rejected.
A team of scientists developed a system that forecasts dengue fever outbreaks by analyzing citizens' calling behavior on public-health hotlines. The system achieved high accuracy in predicting disease cases and locations two to three weeks ahead.
Tropical Depression 4E intensified into Tropical Storm Celia, with a better-organized cloud pattern and increased winds. The storm is expected to pass near an area of cooler sea surface temperatures, slowing its intensification before potentially strengthening into a hurricane by Sunday.
A deadly bacteria, Burkholderia pseudomallei, can travel to the brain and spinal cord within 24 hours, according to a new Griffith University study. The findings could lead to discoveries on how other common bacteria enter the spinal cord.
Researchers found a statistically significant 20% increase in childhood asthma cases exposed to the Great Smog in utero or early childhood. The study suggests a strong possibility of a causal link between early childhood exposure to air pollution and later development of adult asthma.
A study mapped the transmission of MERS virus in a South Korean hospital, identifying an 'super-spreader' patient linked to 82 cases. The outbreak highlights the risks of overcrowding and super-spreaders in healthcare settings.
A study published by the Society for Personality and Social Psychology found that agreeableness is a key predictor of prosocial behavior, including helping others. People with high agreeableness are more likely to exhibit empathic concern and volunteer their time to help those in need.
A team of University of Florida researchers has successfully used light to grow gold nanoprisms, enabling better control over the growth process. The discovery has significant implications for pharmaceuticals, medical equipment, and solar panels.
Researchers from RIKEN successfully attach a biologically active molecule to a titanium surface, inspired by the adhesive properties of mussels. The hybrid protein showed strong binding capabilities to the metal, even when washed with water-based solutions.
A new web-based database, AERSMine, has been developed to analyze clinical responses of over 5 million patients to FDA-approved drugs. The tool identifies unexpected benefits and harm, as well as alternative treatment choices for individual patients.
The National Institutes of Health is launching a landmark longitudinal research effort, the Precision Medicine Cohort Program, with $55 million in funding. The program aims to engage 1 million or more U.S. participants to improve disease prevention and treatment based on individual differences in lifestyle, environment, and genetics.
Researchers found that incorporating an unfertilized winter wheat cover crop into annual crop rotations can significantly reduce nitrogen and phosphorus lost from row crops, enhancing downstream water quality. The strategy may also help alleviate the Mississippi River's nutrient load contributing to the Gulf Dead Zone.
A study published in the Journal of Consumer Psychology found that eating the same food as a companion increases sense of closeness and trust. This strategy can be applied to various social situations, such as first dates or business negotiations, and may even influence marketing effectiveness.
CuRE's dental adhesive incorporates copper iodide particles to curb infections and promote healthy tooth bonding. The technology has the potential to reduce secondary caries formation under existing restorations, a major contributor to costly restoration failures.
Researchers at University of Chicago conducted a field experiment with over 14 million players, offering quantity discounts on virtual goods. The results showed that discounts had virtually no effect on the share of players making purchases and actually led to some customers spending less.
Researchers discover northern oak hairstreaks consume non-nectar sources like galls and aphid honeydew. This finding suggests the species may be more common than thought.
A new gene called Wars2 has been identified as a key player in blood vessel formation, providing a potential target for new therapies against cancer and heart disease. The discovery was made by researchers at Duke-NUS Medical School who found that inhibiting Wars2 function impaired blood vessel formation in rats and zebrafish.