A new high-resolution method allows analysis of all RNA molecules and provides spatial information, enabling precise identification of tumor cells and studying gene activity with greater resolution than ever before. This innovation has valuable applications for both preclinical research and cancer diagnostics.
A low-cost, tablet-based system allows physicians to assess stroke patients remotely while en route to the hospital. The study found that the system's diagnoses correlated highly with bedside assessments, enabling faster and more accurate treatment.
A study reveals that women are better connected within terrorist organizations than men, acting as a glue to fuel the network's vitality and survival. The researchers found high 'betweenness centrality' among female members, making them critical in passing on vital information.
The study projects that by 2040, there will be 26.1 million cancer survivors in the US, with 73% aged 65 or older. Increasing age increases the chance of comorbid conditions, and gaps exist between men and women in older age groups.
A consensus statement from Project TENDR highlights the link between environmental toxins and neurodevelopmental disorders in children, including intellectual disability, autism spectrum disorder, and learning disabilities. The alliance calls for immediate reduction of toxic chemical exposures through policy changes and industry action.
A team of researchers has sequenced the complete genome of the olive tree, a species domesticated over 6,000 years ago. The findings reveal over 56,000 genes and provide insights into the tree's evolution, longevity, and adaptability to environmental conditions.
Researchers identified human fingerprint on Indo-Pacific warm pool growth using climate model simulations and fingerprinting technique. Human-induced greenhouse gas increase is the dominant cause of IPWP warming and expansion, with a small contribution from natural climate variability.
Scientists have created a tiny, soft, and wirelessly functional biomaterial that can be injected into the body to stimulate nerve cells and manipulate muscle behavior. The material degrades naturally after a few months, eliminating the need for surgery.
A team of researchers from Hokkaido University found that a receptor, known for its role in mediating dioxin toxicity, also regulates the body's innate immune response to viral infections. The activation of this receptor negatively regulates the production of an antiviral protein called type I interferon.
Researchers found that fruit flies adjust their gene expression and metabolism to cope with cold temperatures, with nearly a third of genes altered and half of metabolites changing expression. This adaptation is crucial for insect survival during winter months.
A new study reveals that only 8% of patients with large, apparently benign polyps have cancer, suggesting advanced endoscopic treatments like EMR and ESD as viable options. This finding could improve patient outcomes, reduce complications, and lower healthcare costs.
The Jackson Laboratory's Gene Expression Database (GXD) will receive $10.5 million in funding over five years to support data curation and integration, infrastructure expansion, and enhanced tools.
Researchers developed a fast and non-destructive method to detect Wolbachia bacteria in Aedes mosquitoes using near-infrared spectroscopy. The technique shows high accuracy in detecting the presence of Wolbachia strains, including benign and aggressive forms, with an average accuracy of 96-92%.
A study is underway to understand why some children respond better to cochlear implants than others. Researchers are using measures of brain function to identify clinical interventions that could help children adapt to using the implants. The study involves recruiting children from 18 months to 8 years old who use cochlear implants, as...
Researchers developed an anti-apoE4 specific monoclonal antibody that reverses key brain-related pathological effects of apoE4 and associated cognitive deficits in mice. The treatment also accumulates in the brain and binds to apoE4, suggesting a novel approach for AD therapy.
Researchers found that plants associated with ectomycorrhizal fungi grow bigger in response to high CO2 levels, but those with arbuscular mycorrhizal fungi do not. This study challenges the idea of a universal CO2 fertilization effect and highlights the importance of symbiotic fungi in plant growth.
Researchers have discovered specific cell types and mechanisms responsible for orientation selectivity in the retina of zebrafish, shedding light on how we perceive and recognize visual stimuli. The study reveals that mutating a key protein called Teneurin-3 leads to a loss of orientation selectivity in neurons.
Researchers have developed a computer game and mobile app to help people control unhealthy eating habits and lose weight. The game improves inhibitory control, while the app detects patterns in eating habits and provides personalized strategies to stay on track.
A new study published in JAMA Oncology found that women with BRCA1 mutations are at increased risk for developing aggressive serous/serous-like endometrial cancer after undergoing risk-reducing salpingo-oophorectomy (RRSO). The risk is estimated to be 2.6% by age 70.
In a groundbreaking study, pea plants were found to make choices that take into account environmental variance, similar to animal behavior. The plants grew more roots in pots with variable nutrient levels when conditions were poor and more roots in constant pots when conditions were good.
Scientists at the Buck Institute used a naturally occurring anti-inflammatory factor called MANF to promote tissue repair and regenerative success in the retina of mice. The discovery holds promise for treating chronic inflammatory diseases of the eye, including macular degeneration.
A new study published in ecancermedicalscience found that online information about ovarian cancer can cause as much worry as comfort for women at high risk. The researchers suggest that patients should seek guidance from healthcare professionals and credible websites to make informed decisions.
Scientists at Hokkaido University developed a new CRISPR/Cas9 technique to unleash silenced genes, changing cell fates. They used DNA repair mechanism MMEJ with CRISPR/Cas9 to replace off-switches with on-switches, enabling efficient gene expression in cultured cells.
Researchers develop CRISPR/Cas9 guide RNA sequences targeting latent herpesvirus DNA in infected human cells, suppressing virus replication. Efficient elimination of EBV genomes was observed, while HCMV replication was impaired with simultaneous editing at multiple critical sites.
A new tool enables easy assessment of small-scale hydropower potential in developing nations, considering climate changes and future energy needs. It allows for more accurate decisions on hydropower development and investment globally.
Researchers at Brown University used a novel MRI technique to induce people to perceive colors that weren't really there, targeting early visual areas of the brain. The study showed that associations were learned strongly enough to persist for up to five months.
A new analysis of UK workers found a significant association between certain occupations and an increased risk of bladder cancer. The study identified the greatest risk in workers within the chemical, rubber, and dye industries, as well as those in electrical, chemical, and transport roles.
This article reviews the impact of pyridine modifications on tubulin inhibitors, highlighting improved binding modes and activity. The study identifies new insights into tubulin targeting and future perspectives for site-specific agents.
A study published in Cell Reports has found that inhibiting the enzyme cdk4 can prevent and reverse the initial stage of Non Alcoholic Fatty Liver Disease (NAFLD). Researchers at Cincinnati Children's Hospital Medical Center used two FDA-approved drugs to inhibit cdk4, significantly reducing hepatic steatosis in mouse models.
A new report by Advancement Project and the University of California, Riverside reveals stark racial disparities in political participation in California. The study finds that people of color make up the majority of the state's population but face significant barriers to engaging in democracy, including lower rates of voter turnout, co...
Climate change is altering inland fish reproduction, growth, and habitats, with both positive and negative impacts on recreational fishing. Studies reveal changes in species ranges, migration timing, and predator-prey dynamics, highlighting the need for conservation and research strategies to sustain resilient fish communities.
Researchers created a new method to switch strontium cobalt oxide between an insulating state and a metal magnet state at room temperature, enabling double the storage capacity of conventional USB flash drives. This technology could increase mobile phone storage by storing more photos and videos.
Physicists have devised a method to distinguish black holes from compact massive objects using the energy spectrum of particles moving in their vicinity. The method involves studying the behavior of scalar particles near these objects and finding discrete energy levels, which are absent in the case of black holes.
A UBC study reveals that undiagnosed hearing loss in seniors aged 60-69 is associated with increased social isolation and cognitive declines equivalent to almost four years of chronological aging. The study found a 52% increase in odds of social isolation for every 10-decibel drop in hearing sensitivity.
A study found that pea plants choose to grow more roots in a pot with variable nutrient levels when the average level is low, accepting more risk. This decision-making ability allows them to adapt and respond to their environment much like humans or other animals.
MIT researchers have developed low-cost chemical sensors that enable smartphones to detect trace amounts of toxic gases. The sensors, made from chemically altered carbon nanotubes, can be worn by soldiers on the battlefield or people working with hazardous chemicals to rapidly detect the presence of chemical weapons.
A survey of 15,000 women and men in Britain found that nearly half who experienced infertility did not seek medical help. The study also found that those who sought help were more likely to have higher educational qualifications and better job prospects.
In times of famine, microalgae switch to efficient metabolism before partially digesting themselves to conserve nutrients. The study reveals the molecular mechanisms behind this process, which also impacts human cancer cells.
The phase III RESORCE trial shows regorafenib achieves improved survival rates compared to placebo in patients with hepatocellular carcinoma. The study demonstrates significant efficacy and safety benefits of the new agent as a second-line treatment option, providing hope for improved patient outcomes.
A new study published in PLOS Computational Biology found that genes involved in cellular remodeling are conserved across honey bees and mammals, suggesting a common origin for social behavior. These findings provide insight into the evolution of complex sociality in animals.
Researchers have developed a new mouse model to study the role of the entorhinal cortex in spatial memory. The model showed that silencing the entorhinal cortex led to scrambled memory codes and impaired navigation. This study provides insights into how dysfunction of this circuit may contribute to memory loss in Alzheimer's disease.
Researchers have discovered that a variety of normally harmless bacteria can cause bleaching disease in seaweeds when stressed. Three new pathogens from the Alteromonas, Aquimarina and Agarivorans genera were identified as the culprits.
Researchers at UT Southwestern Medical Center have identified a key regulatory mechanism of insulin signaling, linking it to the timing of cell division. Three spindle checkpoint proteins, crucial for accurate cell division, also regulate metabolism through their impact on insulin receptors.
Scientists at Hokkaido University found that ARL3 facilitates STAT3 transport into the nucleus, regulating gene expression and cell proliferation. This discovery offers promising candidates for novel therapies targeting STAT3-related diseases.
A meta-analysis of 22 studies found a weak link between media consumption and teen sexual behavior, with parents playing a greater role in shaping moral values. The study suggests that parents should be encouraged to discuss sex with their children, while media may have limited influence on actual behavior.
The Baylor College of Medicine has been awarded over $1 million from the National Institutes of Health to lead a study on people infected with Zika virus. The study aims to inform diagnostic and infection control measures, as well as Zika vaccine development.
Dr. K. Donald Shelbourne has made a lasting impact on sports medicine through his work on ACL rehabilitation and long-term outcomes research. He is recognized as one of the pioneers in this field, with over 6,500 successful ACL reconstructions performed.
Researchers have developed a novel approach to disrupting bacterial biofilms, which are nearly impossible to eradicate when pathogenic. The technique targets extracellular DNA and DNABII proteins in biofilms, resulting in the collapse of bacterial communities and bacterial clearance.
Researchers are studying exercise's effects on muscle loss and weakness in people with chronic kidney disease, a condition affecting 20 million Americans. They aim to determine the optimal dose of exercise and explore whether it can mitigate disease progression.
Researchers have identified RBPJ as a key control point for controlling blood vessel growth in the adult heart, which may lead to new treatments for heart disease. The discovery suggests that blocking RBPJ could promote new blood supplies and improve heart attack outcomes.
Researchers at Jackson Laboratory aim to develop clinical adjuvants that boost vaccine effectiveness in vulnerable populations, with a focus on elderly and immunosuppressed patients. The $3.4 million grant will support the screening of new adjuvant combinations and investigation into their mechanisms of action.
Researchers from the University of Missouri suggest farmers use buffers between crops and trees to reduce soil runoff, while maintaining good growing conditions. The study found that utilizing Conservation Reserve Program (CRP) land strategically creates effective buffers.
A major international review found that radiation levels in oceans are decreasing, except near the Fukushima plant where ongoing releases remain a concern. The report highlights the need for continued radiation assessment to understand changing risks.
Researchers at the University of Michigan have discovered a protein that acts as a powerful protectant against free radicals, which cause cell damage and death. The protein is activated by excessive free radicals and helps to regulate autophagy, a process that reduces oxidative stress and slows down aging.
A new psychology study found that the ability to withhold a response to stimuli, or self-control, is a key factor in predicting binge drinking behavior. The study used regression model analysis to measure the impact of different inhibition subcomponents on binge drinking habits among young adults.
A study by Dr. Chantel Prat and colleagues found that a five-minute measurement of resting-state brain activity can predict how quickly adults pick up a second language. Participants with larger 'beta' networks in their brains learned French twice as quickly, suggesting a link between brain activity and language learning speed.
The Adélie penguin population in Antarctica is facing significant threats from climate change, with some colonies expected to decline by 30% by 2060 and 60% by 2099. Climate warming in certain regions has led to population declines, while cooling conditions have resulted in stable or increasing populations.
Stanley M. Gartler, PhD, receives the 2016 Victor A. McKusick Leadership Award for his extensive research in X chromosome inactivation, somatic cells, and tumor biology. He has made significant discoveries and connections across multiple fields.
The Ultra-Deep Survey (UDS) has mapped an area four times the size of the full Moon to unprecedented depth, revealing over 250,000 galaxies detected within the first billion years after the Big Bang. Astronomers will study early stages of galaxy formation and evolution using these images.
The updated guidelines highlight the importance of early diagnosis and treatment for invasive aspergillosis, a potentially deadly fungal infection. New therapies, including isavuconazole and posaconazole, have improved care, but aggressive diagnosis is still critical.